P Lucarelli
Biographic Data
| ID | 4290270 |
|---|---|
| NAME | P Lucarelli |
| GIVEN NAMES | P |
| FAMILY NAME | Lucarelli |
| SIGNATURE | LUCARELLI P |
| AFFILIATIONS | National Research Council |
| VERIFIED | No |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 25 |
| WORKS AS AUTHOR | 10 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1975 |
| LATEST PUBLICATION YEAR | 2005 |
| H-INDEX | 2 |
Adaptation to past malarial endemia and susceptibility to common diseases in modern populations
We carried out a study of adenosine deaminase (ADA) and MN blood group genetic polymorphisms in relation to past malarial morbidity in Sardinia and in relation to susceptibility to allergic asthma (a Th2 disorder) and Crohn's disease (a Th1 disorder) in the population of Rome. Eight hundred and eight schoolchildren, aged 7–14 years from 14 Sardinian villages located in the central area of the island, were considered. One hundred and twenty‐two ch…
Birth weight and parental PGM1 alleles
A deviation of the maternal–neonatal joint phosphoglucomutase locus 1 (PGM1) distribution from Hardy–Weinberg expectation has been reported. It was suggested that selection on PGM1 during intrauterine life might account for these deviations and that maternal and paternal PGM1 alleles might have different associations with intrauterine survival. This study considered possible associations between the joint mother–newborn PGM1 genotype and intraute…
ACP1 and human adaptability
Acid Phosphatase locus 1 (ACP1) is a polymorphic enzyme controlled by a locus on chromosome 2 with three common codominant alleles: *A, *B, and *C. ACP1 shows two major isoforms, F and S. The ratio of their concentration differs markedly among genotypes. Two functions have been proposed for the enzyme: flavin‐mononucleotide phosphatase and tyrosine phosphatase activity. An association between ACP1 polymorphism and past malarial morbidity in Sardi…
Birth weight and parental PGM1 alleles
A deviation of the maternal–neonatal joint phosphoglucomutase locus 1 (PGM1) distribution from Hardy–Weinberg expectation has been reported. It was suggested that selection on PGM1 during intrauterine life might account for these deviations and that maternal and paternal PGM1 alleles might have different associations with intrauterine survival. This study considered possible associations between the joint mother–newborn PGM1 genotype and intraute…
Adenosine deaminase-acid phosphatase association and the environment
Three hundred fifty newborns from Rome and 351 from Penne were studied in continental Italy. Medium high altitude above sea level and cold winters characterize the area of Penne, while low altitude and very mild winters characterize the area of Rome. An effect of environmental conditions on the association between adenosine deaminase (ADA) and acid phosphatase (ACP1), previously shown in Sardinia, has been confirmed in continental Italy. When com…
PGM1 and TF subtypes and C3 polymorphisms in Continental Italy and Sardinia. Data on the world distribution of these genetic markers
PGM1, TF and C3 polymorphisms have been examined in two Italian samples, collected in continental Italy and in Sardinia (Cagliari). The PGM1 and TF subtypes were determined by isoelectric focusing while the C3 was studied by conventional methods. A significant difference in the gene frequencies of PGM1 and TF systems between our two samples has been observed. In addition, data on the world distribution of PGM1, TF and C3 polymorphisms have been p…
Placental alkaline phosphatase
The analysis of human placental alkaline phosphatase polymorphism in Sardinia has shown a further difference in the genetic structure of this population in comparison with the populations of Continental Italy and Western Europe. Ethnic and geographic variations in world distribution of placental alkaline phosphatase gene frequencies suggest the considerable anthropological value of this genetic marker
A study of nine polymorphic systems in the population of the Po Delta
The present work reports a study of nine genetic polymorphic systems in the area of the Po Delta where malaria was endemic since the XIV century. Our data confirm some characteristics of this population already reported by other authors such as the high prevalence of thalassemia, the low prevalence of the rh (d) gene and the presence of G‐6‐PD deficiency. Among the other systems studied, i.e., AP, PGM 1 ADA and AK, only AP frequencies of Po Delta…
Genetic differentiation among Sardinian villages
The present study reports an analysis of genetic differentiation among 14 Sardinian villages located mainly in the center of the island. Chisquare tests show significant genetic heterogeneity among villages, and analyses by F‐ and R‐ statistics indicate an essentially random pattern of differentiation for all alleles. Using the kinship methods of Morton, a matrix, R, with elements r ij describing the correlations between the gene frequencies of v…
Red cell acid phosphatase
The frequency of P C allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and Gd Med prevalence. The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying P A allele for acid phosphatase…
Genetic differentiation among Sardinian villages
The present study reports an analysis of genetic differentiation among 14 Sardinian villages located mainly in the center of the island. Chisquare tests show significant genetic heterogeneity among villages, and analyses by F‐ and R‐ statistics indicate an essentially random pattern of differentiation for all alleles. Using the kinship methods of Morton, a matrix, R, with elements r ij describing the correlations between the gene frequencies of v…
Red cell acid phosphatase
The frequency of P C allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and Gd Med prevalence. The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying P A allele for acid phosphatase…
Placental alkaline phosphatase
The analysis of human placental alkaline phosphatase polymorphism in Sardinia has shown a further difference in the genetic structure of this population in comparison with the populations of Continental Italy and Western Europe. Ethnic and geographic variations in world distribution of placental alkaline phosphatase gene frequencies suggest the considerable anthropological value of this genetic marker
Genetic differentiation among Sardinian villages
The present study reports an analysis of genetic differentiation among 14 Sardinian villages located mainly in the center of the island. Chisquare tests show significant genetic heterogeneity among villages, and analyses by F‐ and R‐ statistics indicate an essentially random pattern of differentiation for all alleles. Using the kinship methods of Morton, a matrix, R, with elements r ij describing the correlations between the gene frequencies of v…
Red cell acid phosphatase
The frequency of P C allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and Gd Med prevalence. The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying P A allele for acid phosphatase…
A study of nine polymorphic systems in the population of the Po Delta
The present work reports a study of nine genetic polymorphic systems in the area of the Po Delta where malaria was endemic since the XIV century. Our data confirm some characteristics of this population already reported by other authors such as the high prevalence of thalassemia, the low prevalence of the rh (d) gene and the presence of G‐6‐PD deficiency. Among the other systems studied, i.e., AP, PGM 1 ADA and AK, only AP frequencies of Po Delta…
Placental alkaline phosphatase
The analysis of human placental alkaline phosphatase polymorphism in Sardinia has shown a further difference in the genetic structure of this population in comparison with the populations of Continental Italy and Western Europe. Ethnic and geographic variations in world distribution of placental alkaline phosphatase gene frequencies suggest the considerable anthropological value of this genetic marker
PGM1 and TF subtypes and C3 polymorphisms in Continental Italy and Sardinia. Data on the world distribution of these genetic markers
PGM1, TF and C3 polymorphisms have been examined in two Italian samples, collected in continental Italy and in Sardinia (Cagliari). The PGM1 and TF subtypes were determined by isoelectric focusing while the C3 was studied by conventional methods. A significant difference in the gene frequencies of PGM1 and TF systems between our two samples has been observed. In addition, data on the world distribution of PGM1, TF and C3 polymorphisms have been p…
Adenosine deaminase-acid phosphatase association and the environment
Three hundred fifty newborns from Rome and 351 from Penne were studied in continental Italy. Medium high altitude above sea level and cold winters characterize the area of Penne, while low altitude and very mild winters characterize the area of Rome. An effect of environmental conditions on the association between adenosine deaminase (ADA) and acid phosphatase (ACP1), previously shown in Sardinia, has been confirmed in continental Italy. When com…
Birth weight and parental PGM1 alleles
A deviation of the maternal–neonatal joint phosphoglucomutase locus 1 (PGM1) distribution from Hardy–Weinberg expectation has been reported. It was suggested that selection on PGM1 during intrauterine life might account for these deviations and that maternal and paternal PGM1 alleles might have different associations with intrauterine survival. This study considered possible associations between the joint mother–newborn PGM1 genotype and intraute…
ACP1 and human adaptability
Acid Phosphatase locus 1 (ACP1) is a polymorphic enzyme controlled by a locus on chromosome 2 with three common codominant alleles: *A, *B, and *C. ACP1 shows two major isoforms, F and S. The ratio of their concentration differs markedly among genotypes. Two functions have been proposed for the enzyme: flavin‐mononucleotide phosphatase and tyrosine phosphatase activity. An association between ACP1 polymorphism and past malarial morbidity in Sardi…
Birth weight and parental PGM1 alleles
A deviation of the maternal–neonatal joint phosphoglucomutase locus 1 (PGM1) distribution from Hardy–Weinberg expectation has been reported. It was suggested that selection on PGM1 during intrauterine life might account for these deviations and that maternal and paternal PGM1 alleles might have different associations with intrauterine survival. This study considered possible associations between the joint mother–newborn PGM1 genotype and intraute…
Adaptation to past malarial endemia and susceptibility to common diseases in modern populations
We carried out a study of adenosine deaminase (ADA) and MN blood group genetic polymorphisms in relation to past malarial morbidity in Sardinia and in relation to susceptibility to allergic asthma (a Th2 disorder) and Crohn's disease (a Th1 disorder) in the population of Rome. Eight hundred and eight schoolchildren, aged 7–14 years from 14 Sardinian villages located in the central area of the island, were considered. One hundred and twenty‐two ch…
Biology (9 works) · Genetics (8 works) · Gene (7 works) · Allele (5 works) · Biochemistry (5 works) · Enzyme (5 works) · Genetics (5 works) · Biochemistry (4 works) · Genotype (4 works) · Acid phosphatase (3 works)