Harold M Frost
Biographic Data
| ID | 4290337 |
|---|---|
| NAME | Harold M Frost |
| GIVEN NAMES | Harold M |
| FAMILY NAME | Frost |
| SIGNATURE | FROST H M |
| AFFILIATIONS | Southern Colorado Clinic |
| VERIFIED | No |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 49 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1968 |
| LATEST PUBLICATION YEAR | 2001 |
| H-INDEX | 3 |
Cybernetic aspects of bone modeling and remodeling, with special reference to osteoporosis and whole‐bone strength
Assume mythical physiologists were taught that renal physiology and its disorders depend on “kidney cells” and their regulation by nonmechanical factors, but were taught nothing about nephrons. For decades they “knew” that idea was correct, just as Ptolemy “knew” the universe centers on our planet. But then others began to describe nephrons, their roles in renal physiology and disorders, and problems they revealed in former views, so doubts and c…
Cybernetic aspects of bone modeling and remodeling, with special reference to osteoporosis and whole-bone strength
Assume mythical physiologists were taught that renal physiology and its disorders depend on "kidney cells" and their regulation by nonmechanical factors, but were taught nothing about nephrons. For decades they "knew" that idea was correct, just as Ptolemy "knew" the universe centers on our planet. But then others began to describe nephrons, their roles in renal physiology and disorders, and problems they revealed in former views, so doubts and c…
An approach to estimating bone and joint loads and muscle strength in living subjects and skeletal remains
Skeletal physiology that clarified after 1990 shows that bone modeling normally makes a bone strong enough to keep its loads from causing strains above a "modeling threshold". That arrangement adapts bone strength to the largest loads on a bone, which are usually brief and infrequent. Accordingly, in bone adapted chiefly to uniaxial compression loads, the modeling threshold's value and the cross-sectional amount of that bone could suggest the siz…
An approach to estimating bone and joint loads and muscle strength in living subjects and skeletal remains
Skeletal physiology that clarified after 1990 shows that bone modeling normally makes a bone strong enough to keep its loads from causing strains above a “modeling threshold”. That arrangement adapts bone strength to the largest loads on a bone, which are usually brief and infrequent. Accordingly, in bone adapted chiefly to uniaxial compression loads, the modeling threshold's value and the cross-sectional amount of that bone could suggest the siz…
Changing concepts in skeletal physiology
According to the Utah paradigm of skeletal physiology: (1) mechanical forces on skeletons generate signals in skeletal organs that control the biologic mechanisms that determine the architecture and strength of those organs, (2) these occur in ways that let the organs endure their voluntary mechanical usage for life without hurting or breaking, (3) to work properly, these mechanisms need nonmechanical factors (hormones, vitamins, calcium, genes, …
Bone “mass” and the “mechanostat”
The observed fit of bone mass to a healthy animal's typical mechanical usage indicates some mechanism or mechanisms monitor that usage and control the three longitudinal growth, bone modeling, and BMU‐based remodeling activities that directly determine bone mass. That mechanism could be named a mechanostat. Accumulated evidence suggests it includes the bone itself, plus mechanisms that transform its mechanical usage into appropriate signals, plus…
Secondary osteon populations
This algorithm explains how bone growth, modeling, and chronological age can affect the mean tissue age of compact bone and suggests how to measure and quantitate those effects. Since a given secondary osteon population density equals the mean annual number of new osteons being created, multiplied by the time over which those creations occur, and that time equals the mean tissue age of the compacta containing the osteons, quantitating age would a…
Secondary osteon population densities
A given number of secondary osteons—an osteon population—reflects two kinds of direct influences: the length of time during which new osteons were being created and the mean annual number of such creations. While in principle dividing an observed osteon population by the age of the background bone would provide the mean annual creations, as the number of secondary osteons increases in a given diaphyseal cross section, new ones can begin to remove…
The “new bone”
Discovery of the skeletal intermediary organization in 1964 led to recognition of many functions and purposes served by its mechanisms in living skeletons and some of the action principles and agents that control them. Collectively they determine the macroscopic and microscopic anatomy of skeletons during growth and in adult life. Growing understanding of how and why those mechanisms affect skeletal structure now allows many features of their con…
Tetracycline bone labeling in anatomy
Tetracyclines are deposited in vivo at centers of active bone formation, and can be seen by fluorescence microscopic examination of undecalcified bone sections. With this marker, the rate of bone formation at the level of the osteon can be measured, and is taken to indicate the speed of bone formation at the level of the osteoblast. When the number of bone‐forming centers is then counted, it becomes possible to compute: ( 1 ) the number of new ce…
Secondary osteon populations
This algorithm explains how bone growth, modeling, and chronological age can affect the mean tissue age of compact bone and suggests how to measure and quantitate those effects. Since a given secondary osteon population density equals the mean annual number of new osteons being created, multiplied by the time over which those creations occur, and that time equals the mean tissue age of the compacta containing the osteons, quantitating age would a…
Secondary osteon population densities
A given number of secondary osteons—an osteon population—reflects two kinds of direct influences: the length of time during which new osteons were being created and the mean annual number of such creations. While in principle dividing an observed osteon population by the age of the background bone would provide the mean annual creations, as the number of secondary osteons increases in a given diaphyseal cross section, new ones can begin to remove…
The “new bone”
Discovery of the skeletal intermediary organization in 1964 led to recognition of many functions and purposes served by its mechanisms in living skeletons and some of the action principles and agents that control them. Collectively they determine the macroscopic and microscopic anatomy of skeletons during growth and in adult life. Growing understanding of how and why those mechanisms affect skeletal structure now allows many features of their con…
Tetracycline bone labeling in anatomy
Tetracyclines are deposited in vivo at centers of active bone formation, and can be seen by fluorescence microscopic examination of undecalcified bone sections. With this marker, the rate of bone formation at the level of the osteon can be measured, and is taken to indicate the speed of bone formation at the level of the osteoblast. When the number of bone‐forming centers is then counted, it becomes possible to compute: ( 1 ) the number of new ce…
Tetracycline bone labeling in anatomy
Tetracyclines are deposited in vivo at centers of active bone formation, and can be seen by fluorescence microscopic examination of undecalcified bone sections. With this marker, the rate of bone formation at the level of the osteon can be measured, and is taken to indicate the speed of bone formation at the level of the osteoblast. When the number of bone‐forming centers is then counted, it becomes possible to compute: ( 1 ) the number of new ce…
The “new bone”
Discovery of the skeletal intermediary organization in 1964 led to recognition of many functions and purposes served by its mechanisms in living skeletons and some of the action principles and agents that control them. Collectively they determine the macroscopic and microscopic anatomy of skeletons during growth and in adult life. Growing understanding of how and why those mechanisms affect skeletal structure now allows many features of their con…
Bone “mass” and the “mechanostat”
The observed fit of bone mass to a healthy animal's typical mechanical usage indicates some mechanism or mechanisms monitor that usage and control the three longitudinal growth, bone modeling, and BMU‐based remodeling activities that directly determine bone mass. That mechanism could be named a mechanostat. Accumulated evidence suggests it includes the bone itself, plus mechanisms that transform its mechanical usage into appropriate signals, plus…
Secondary osteon populations
This algorithm explains how bone growth, modeling, and chronological age can affect the mean tissue age of compact bone and suggests how to measure and quantitate those effects. Since a given secondary osteon population density equals the mean annual number of new osteons being created, multiplied by the time over which those creations occur, and that time equals the mean tissue age of the compacta containing the osteons, quantitating age would a…
Secondary osteon population densities
A given number of secondary osteons—an osteon population—reflects two kinds of direct influences: the length of time during which new osteons were being created and the mean annual number of such creations. While in principle dividing an observed osteon population by the age of the background bone would provide the mean annual creations, as the number of secondary osteons increases in a given diaphyseal cross section, new ones can begin to remove…
Changing concepts in skeletal physiology
According to the Utah paradigm of skeletal physiology: (1) mechanical forces on skeletons generate signals in skeletal organs that control the biologic mechanisms that determine the architecture and strength of those organs, (2) these occur in ways that let the organs endure their voluntary mechanical usage for life without hurting or breaking, (3) to work properly, these mechanisms need nonmechanical factors (hormones, vitamins, calcium, genes, …
An approach to estimating bone and joint loads and muscle strength in living subjects and skeletal remains
Skeletal physiology that clarified after 1990 shows that bone modeling normally makes a bone strong enough to keep its loads from causing strains above a "modeling threshold". That arrangement adapts bone strength to the largest loads on a bone, which are usually brief and infrequent. Accordingly, in bone adapted chiefly to uniaxial compression loads, the modeling threshold's value and the cross-sectional amount of that bone could suggest the siz…
An approach to estimating bone and joint loads and muscle strength in living subjects and skeletal remains
Skeletal physiology that clarified after 1990 shows that bone modeling normally makes a bone strong enough to keep its loads from causing strains above a “modeling threshold”. That arrangement adapts bone strength to the largest loads on a bone, which are usually brief and infrequent. Accordingly, in bone adapted chiefly to uniaxial compression loads, the modeling threshold's value and the cross-sectional amount of that bone could suggest the siz…
Cybernetic aspects of bone modeling and remodeling, with special reference to osteoporosis and whole‐bone strength
Assume mythical physiologists were taught that renal physiology and its disorders depend on “kidney cells” and their regulation by nonmechanical factors, but were taught nothing about nephrons. For decades they “knew” that idea was correct, just as Ptolemy “knew” the universe centers on our planet. But then others began to describe nephrons, their roles in renal physiology and disorders, and problems they revealed in former views, so doubts and c…
Cybernetic aspects of bone modeling and remodeling, with special reference to osteoporosis and whole-bone strength
Assume mythical physiologists were taught that renal physiology and its disorders depend on "kidney cells" and their regulation by nonmechanical factors, but were taught nothing about nephrons. For decades they "knew" that idea was correct, just as Ptolemy "knew" the universe centers on our planet. But then others began to describe nephrons, their roles in renal physiology and disorders, and problems they revealed in former views, so doubts and c…
Anatomy (8 works) · Medicine (8 works) · Biology (6 works) · Bone health and osteoporosis research (5 works) · Anatomy (4 works) · Biomedical Engineering (4 works) · Bone Metabolism and Diseases (4 works) · Cortical bone (4 works) · Bone remodeling (3 works) · Computer Science (3 works)