Nanette R Lee
Biographic Data
| ID | 4293174 |
|---|---|
| NAME | Nanette R Lee |
| GIVEN NAMES | Nanette R |
| FAMILY NAME | Lee |
| SIGNATURE | LEE N R |
| AFFILIATIONS | Office of Population Studies Foundation University of San Carlos Cebu City Philippines |
| ORCID | 0000-0003-4860-325X |
| VERIFIED | Yes |
| TOTAL WORKS | 16 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 16 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2010 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Recalled Adverse Childhood Experiences Predict Behavioral Traits Associated With an Accelerated Life History in Cebu, Philippines
OBJECTIVES: Adverse childhood experiences (ACEs) have long been associated with poor health in adulthood, with many researchers interpreting these findings as evidence of a "fast" life history. In this study we utilize data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) to test the expectations of this framework among inhabitants of the Cebu metropolitan area in the Philippines. METHODS: Data on development, behavior, and reproduc…
Patterns of Chronic Stress in Diurnal Salivary Cortisol Already Predict Epigenetic Age Acceleration in Young Adults in the Cebu Longitudinal Health and Nutrition Survey
Epigenetic clocks estimate biological aging through age‐related DNA methylation patterns and are known to accelerate in response to adversity. While cortisol links stress experiences to cellular aging, the relationship between circadian cortisol and epigenetic age acceleration (EAA) remains unclear. To address this gap, we use data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) to explore linear relationships between diurnal saliv…
Intergenerational educational mobility and mental health: Evidence from a Filipino birth cohort
Evidence suggests that associations between educational attainment and mental health may vary according to educational mobility (i.e., changes in educational attainment across generations). This evidence is largely limited to high-income countries. Using data from an ongoing birth cohort (Cebu Longitudinal Health and Nutrition Survey), we assessed the associations with mental health for both own educational attainment and intergenerational educat…
Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation
Helicobacter pylori ( H. pylori ) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological factors associated with H. pylori seropositivity ( n = 124) and the relationship between seropositivity and systemic inflammation ( n = 116) among adults in Metro Cebu, Philippines. Data were drawn from the Cebu Lon…
Intimate partner violence, depression, and chronic low‐grade inflammation among middle‐aged women in Cebu, Philippines
OBJECTIVES: Recent discussions in human biology have highlighted how local ecological contexts shape the relationship between social stressors and health across populations. Chronic low-grade inflammation has been proposed as a pathway linking social stressors to health, with evidence concentrated in high-income Western contexts. However, it remains unclear whether this is an important pathway in populations where prevalence is lower due to lower…
Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines
OBJECTIVES: The drivers of human life expectancy gains over the past 200 years are not well-established, with a potential role for historical reductions in infectious disease. We investigate whether infectious exposures in infancy predict biological aging using DNA methylation-based markers that forecast patterns of morbidity and mortality later in life. METHODS: N = 1450 participants from the Cebu Longitudinal Health and Nutrition Survey-a prosp…
Reply to Nwanaji‐Enwerema , 2023, “Exposome and low birthweight selection bias considerations in early life infections and epigenetic age relationships”
Health selection on self-rated health and the healthy migrant effect: Baseline and 1-year results from the health of Philippine Emigrants Study
Studies of migration and health focus on a “healthy migrant effect” whereby migrants are healthier than individuals not migrating. Health selection remains the popular explanation of this phenomenon. However, studies are mixed on whether selection occurs and typically examine migrants post-departure. This study used a novel pre-migration dataset to identify which health and social domains differ between migrants and their non-migrant counterparts…
Stunting, IQ, and final school attainment in the Cebu Longitudinal Health and Nutrition Survey birth cohort
School attainment is an important aspect of human capital, and a key determinant of long-term health and well-being. Early life deprivation and poor nutritional status are well known predictors of school entry and progression. We examine the persistence of early life influences and subsequent socioeconomic disadvantage (SED) across the multiple school continuation decisions that lead to final school attainment. Using data from a Philippine birth …
Predictors of maternal‐origin microchimerism in young women in the Philippines
OBJECTIVES: Microchimerism is the presence of a small quantity of cells or DNA from a genetically distinct individual. This phenomenon occurs with bidirectional maternal-fetal exchange during pregnancy. Microchimerism can persist for decades after delivery and have long-term health implications. However, little is known about why microchimerism is detectable at varying levels in different individuals. We examine the variability and the following …
Evolutionary life history theory as an organising framework for cohort studies: Insights from the Cebu Longitudinal Health and Nutrition Survey
By tracking a group of individuals through time, cohort studies provide fundamental insights into the developmental time course and causes of health and disease. Evolutionary life history theory seeks to explain patterns of growth, development, reproduction and senescence, and inspires a range of hypotheses that are testable using the longitudinal data from cohort studies. Here we review two decades of life history theory-motivated work conducted…
Early life growth and adult telomere length in a Filipino cohort study
OBJECTIVE: We investigated the relationship between early life growth patterns and blood telomere length (TL) in adulthood using conditional measures of lean and fat mass growth to evaluate potentially sensitive periods of early life growth. METHODS: This study included data from 1562 individuals (53% male; age 20-22 years) participating in the Cebu Longitudinal Health and Nutrition Survey, located in metropolitan Cebu, Philippines. Primary expos…
Ankle brachial index (ABI) in a cohort of older women in the Philippines: Prevalence of peripheral artery disease and predictors of ABI
The prevalence of PAD is low in Cebu Longitudinal Health and Nutrition Survey participants, and ABI was related to few CVD risk factors. Past reports of lower PAD risk in relation to BMI may reflect confounding by lean mass, which has protective relationships with ABI
Health of Philippine Emigrants Study (HoPES): Study design and rationale
Migrants enrolled in the study appear to be representative of recent Filipino migrants to the U.S. Additionally, migrant and non-migrant study participants are comparable on several characteristics that we attempted to balance at baseline, including age, gender, and education. HoPES is a unique study that approximates a natural experiment from which to study the effects of immigration on obesity and other health problems. A number of innovative m…
Genetic studies of body mass index yield new insights for obesity biology
Change in waist circumference over 11 years and current waist circumference independently predict elevated CRP in Filipino women
C‐reactive protein, a marker of chronic, low‐grade inflammation, is strongly associated with current central adiposity, and has been linked to elevated risk of cardiovascular disease. Less is known about the contribution of longitudinal change in waist circumference to current inflammation. We evaluated the extent to which current waist circumference and change over an 11‐year interval contribute independently to low‐grade systemic inflammation m…
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Change in waist circumference over 11 years and current waist circumference independently predict elevated CRP in Filipino women
C‐reactive protein, a marker of chronic, low‐grade inflammation, is strongly associated with current central adiposity, and has been linked to elevated risk of cardiovascular disease. Less is known about the contribution of longitudinal change in waist circumference to current inflammation. We evaluated the extent to which current waist circumference and change over an 11‐year interval contribute independently to low‐grade systemic inflammation m…
Genetic studies of body mass index yield new insights for obesity biology
Health of Philippine Emigrants Study (HoPES): Study design and rationale
Migrants enrolled in the study appear to be representative of recent Filipino migrants to the U.S. Additionally, migrant and non-migrant study participants are comparable on several characteristics that we attempted to balance at baseline, including age, gender, and education. HoPES is a unique study that approximates a natural experiment from which to study the effects of immigration on obesity and other health problems. A number of innovative m…
Early life growth and adult telomere length in a Filipino cohort study
OBJECTIVE: We investigated the relationship between early life growth patterns and blood telomere length (TL) in adulthood using conditional measures of lean and fat mass growth to evaluate potentially sensitive periods of early life growth. METHODS: This study included data from 1562 individuals (53% male; age 20-22 years) participating in the Cebu Longitudinal Health and Nutrition Survey, located in metropolitan Cebu, Philippines. Primary expos…
Ankle brachial index (ABI) in a cohort of older women in the Philippines: Prevalence of peripheral artery disease and predictors of ABI
The prevalence of PAD is low in Cebu Longitudinal Health and Nutrition Survey participants, and ABI was related to few CVD risk factors. Past reports of lower PAD risk in relation to BMI may reflect confounding by lean mass, which has protective relationships with ABI
Evolutionary life history theory as an organising framework for cohort studies: Insights from the Cebu Longitudinal Health and Nutrition Survey
By tracking a group of individuals through time, cohort studies provide fundamental insights into the developmental time course and causes of health and disease. Evolutionary life history theory seeks to explain patterns of growth, development, reproduction and senescence, and inspires a range of hypotheses that are testable using the longitudinal data from cohort studies. Here we review two decades of life history theory-motivated work conducted…
Stunting, IQ, and final school attainment in the Cebu Longitudinal Health and Nutrition Survey birth cohort
School attainment is an important aspect of human capital, and a key determinant of long-term health and well-being. Early life deprivation and poor nutritional status are well known predictors of school entry and progression. We examine the persistence of early life influences and subsequent socioeconomic disadvantage (SED) across the multiple school continuation decisions that lead to final school attainment. Using data from a Philippine birth …
Predictors of maternal‐origin microchimerism in young women in the Philippines
OBJECTIVES: Microchimerism is the presence of a small quantity of cells or DNA from a genetically distinct individual. This phenomenon occurs with bidirectional maternal-fetal exchange during pregnancy. Microchimerism can persist for decades after delivery and have long-term health implications. However, little is known about why microchimerism is detectable at varying levels in different individuals. We examine the variability and the following …
Health selection on self-rated health and the healthy migrant effect: Baseline and 1-year results from the health of Philippine Emigrants Study
Studies of migration and health focus on a “healthy migrant effect” whereby migrants are healthier than individuals not migrating. Health selection remains the popular explanation of this phenomenon. However, studies are mixed on whether selection occurs and typically examine migrants post-departure. This study used a novel pre-migration dataset to identify which health and social domains differ between migrants and their non-migrant counterparts…
Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines
OBJECTIVES: The drivers of human life expectancy gains over the past 200 years are not well-established, with a potential role for historical reductions in infectious disease. We investigate whether infectious exposures in infancy predict biological aging using DNA methylation-based markers that forecast patterns of morbidity and mortality later in life. METHODS: N = 1450 participants from the Cebu Longitudinal Health and Nutrition Survey-a prosp…
Reply to Nwanaji‐Enwerema , 2023, “Exposome and low birthweight selection bias considerations in early life infections and epigenetic age relationships”
Intimate partner violence, depression, and chronic low‐grade inflammation among middle‐aged women in Cebu, Philippines
OBJECTIVES: Recent discussions in human biology have highlighted how local ecological contexts shape the relationship between social stressors and health across populations. Chronic low-grade inflammation has been proposed as a pathway linking social stressors to health, with evidence concentrated in high-income Western contexts. However, it remains unclear whether this is an important pathway in populations where prevalence is lower due to lower…
Intergenerational educational mobility and mental health: Evidence from a Filipino birth cohort
Evidence suggests that associations between educational attainment and mental health may vary according to educational mobility (i.e., changes in educational attainment across generations). This evidence is largely limited to high-income countries. Using data from an ongoing birth cohort (Cebu Longitudinal Health and Nutrition Survey), we assessed the associations with mental health for both own educational attainment and intergenerational educat…
Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation
Helicobacter pylori ( H. pylori ) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological factors associated with H. pylori seropositivity ( n = 124) and the relationship between seropositivity and systemic inflammation ( n = 116) among adults in Metro Cebu, Philippines. Data were drawn from the Cebu Lon…
Recalled Adverse Childhood Experiences Predict Behavioral Traits Associated With an Accelerated Life History in Cebu, Philippines
OBJECTIVES: Adverse childhood experiences (ACEs) have long been associated with poor health in adulthood, with many researchers interpreting these findings as evidence of a "fast" life history. In this study we utilize data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) to test the expectations of this framework among inhabitants of the Cebu metropolitan area in the Philippines. METHODS: Data on development, behavior, and reproduc…
Patterns of Chronic Stress in Diurnal Salivary Cortisol Already Predict Epigenetic Age Acceleration in Young Adults in the Cebu Longitudinal Health and Nutrition Survey
Epigenetic clocks estimate biological aging through age‐related DNA methylation patterns and are known to accelerate in response to adversity. While cortisol links stress experiences to cellular aging, the relationship between circadian cortisol and epigenetic age acceleration (EAA) remains unclear. To address this gap, we use data from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) to explore linear relationships between diurnal saliv…
Medicine (12 works) · Demography (10 works) · Cohort (7 works) · Cohort study (7 works) · Gerontology (7 works) · Internal Medicine (7 works) · Environmental health (6 works) · Population (6 works) · Biology (5 works) · Birth, Development, and Health (5 works)