Ricardo M Cerda‐flore
Biographic Data
| ID | 4296786 |
|---|---|
| NAME | Ricardo M Cerda‐flore |
| GIVEN NAMES | Ricardo M |
| FAMILY NAME | Cerda‐flore |
| SIGNATURE | FLORE R M C |
| AFFILIATIONS | Mexican Social Security Institute |
| ORCID | 0000-0002-5275-2592 |
| VERIFIED | Yes |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 30 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1992 |
| LATEST PUBLICATION YEAR | 2015 |
| H-INDEX | 3 |
Admixture and genetic relationships of Mexican Mestizos regarding Latin American and Caribbean populations based on 13 Codis-STRs
Pre‐Hispanic Mesoamerican demography approximates the present‐day ancestry of Mestizos throughout the territory of Mexico
Over the last 500 years, admixture among Amerindians, Europeans, and Africans, principally, has come to shape the present‐day gene pool of Mexicans, particularly Mestizos, who represent about 93% of the total Mexican population. In this work, we analyze the genetic data of 13 combined DNA index system‐short tandem repeats (CODIS‐STRs) in 1,984 unrelated Mestizos representing 10 population samples from different regions of Mexico, namely North, We…
The mitochondrial DNA landscape of modern Mexico
Mexico is a rich source for anthropological and population genetic studies with high diversity in ethnic and linguistic groups.The country witnessed the rise and fall of major civilizations, including the Maya and Aztec, but resulting from European colonization, the population landscape has dramatically changed.Today, the majority of Mexicans do not identify themselves as Indigenous but as admixed, and appear to have very little in common with th…
Genetic structure of Mexican Mestizo women with breast cancer based on three STR loci
The aim of this population genetics study was to compare the genetic structure of Mexican women with breast cancer (BrCa) with previously reported data of four random populations (Nuevo León, Hispanics, Chihuahua, and Central Region of Mexico). A sample of 115 unrelated women with BrCa and whose four grandparents were born in five zones of Mexico were interviewed at a reference hospital in Northeastern Mexico. Noncodifying STRs D7S820, D13S317, a…
Genetic admixture of eight Mexican indigenous populations: Based on five polymarker, HLA‐DQA1, ABO, and RH loci
This study explores the genetic admixture of eight Mexican indigenous populations (Otomi‐Ixmiquilpan, Otomi‐Actopan, Tzeltales, Nahua‐Milpa‐Alta, Nahua‐Xochimilco, Nahua‐Zitlala, Nahua‐Ixhuatlancillo, and Nahua‐Coyolillo) on the basis of five PCR‐based polymorphic DNA loci (LDLR, GYPA, HBGG, D7S8, GC), HLA_DQA1, and the blood groups ABO and Rh (CcDEe). Among the indigenous populations, the highest gene frequencies for O and D were 0.9703 and 1.00…
Characterization of mtDNA Haplogroups in 14 Mexican Indigenous Populations
In this descriptive study we investigated the genetic structure of 513 Mexican indigenous subjects grouped in 14 populations (Mixteca- Alta, Mixteca-Baja, Otomi, Purépecha, Tzeltal, Tarahumara, Huichol, Nahua- Atocpan, Nahua-Xochimilco, Nahua-Zitlala, Nahua-Chilacachapa, Nahua- Ixhuatlancillo, Nahua-Necoxtla, and Nahua-Coyolillo) based on mtDNA haplogroups. These communities are geographically and culturally isolated; parents and grandparents wer…
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico: Preliminary Report from the Gemm Family Study
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
FMR1 CGG Repeat Distribution and Linked Microsatellite-SNP Haplotypes in Normal Mexican Mestizo and Indigenous Populations
The (CGG)n repeat size distribution in the FMR1 gene was studied in healthy individuals: 80 X chromosomes of Mexican Mestizos from Mexico City and 33 X chromosomes of Mexican Amerindians from three indigenous communities (Purepechas, Nahuas, and Tzeltales), along with alleles and haplotypes defined by two microsatellite polymorphic markers (DXS548 and FRAXAC1) and two single nucleotide polymorphisms (FMRA and FMRB). Genetic frequencies of Mestizo…
Genetic structure of seven Mexican indigenous populations based on five polymarker loci
This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas‐Guerrero, Nahuas‐Xochimilco, and Tzeltales) on the basis of five PCR‐based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (H T ) can be attributed …
Genetic admixture in three mexican mestizo populations based on D1S80 and HLA‐DQA1 Loci
This study compares genetic polymorphisms at the D1S80 and HLA‐DQA1 loci in three Mexican Mestizo populations from three large states (Nuevo León, Jalisco, and the Federal District). Allele frequency distributions are relatively homogenous in the three samples; only the Federal District population shows minor differences of the HLA‐DQA1 allele frequencies compared with the other two. In terms of genetic composition, these Mestizo populations show…
Maximum likelihood estimates of admixture in northeastern Mexico using 13 short tandem repeat loci
Tetrameric short tandem repeat (STR) polymorphisms are widely used in population genetics, molecular evolution, gene mapping and linkage analysis, paternity tests, forensic analysis, and medical applications. This article provides allelic distributions of the STR loci D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, CSF1PO, TPOX, TH01, and D16S539 in 143 Mestizos from Northeastern Mexico, estimates of contributions of genes of…
Prevalence of NIDDM in Mexicans with paraphyletic and polyphyletic surnames
It has been hypothesized that the greater prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in Mexicans may be related to their greater degree of Amerindian genetic admixture (AGA). The aim of this unmatched case-control study was to correlate the prevalence of NIDDM with AGA in 10 Mexican Mestizo populations non-randomly selected by surname. A sample of 1,699 unrelated persons, >44 years and residing in the state of Nuevo León, was s…
Vitamin D receptor polymorphisms and bone mineral density in Mexican women without osteoporosis
Polymorphisms corresponding to Apa I, Bsm I, and Taq I restriction endonucleases at the vitamin D receptor (VDR) gene and bone mineral density (BMD) at lumbar spine (L2-L4) and proximal femur (neck, Ward's triangle and trochanteric region) sites were examined in a sample of 98 Mexican women (age 55 +/- 10 years). None of the subjects were pregnant or nursing and none had a previous diagnosis of osteoporosis. Polymorphisms were assessed by the res…
Critical appraisal of the estimation of body composition via two-, three-, and four-compartment models
Withers RT, Laforgia J, Heymsfield SB. 1999. Critical appraisal of the estimation of body composition via two-, three-, and four-compartment models. Am J Hum Biol 11:175-185. Line 4 of Validity of assumptions should read, 1.565 g/cm(3) instead of, 1.555 g/cm(3). The authors regret this error
Estimation of nonpaternity in the Mexican population of Nuevo Leon: A validation study with blood group markers
A method for estimating the general rate of nonpaternity in a population was validated using phenotype data on seven blood groups (A1A2BO, MNSs, Rh, Duffy, Lutheran, Kidd, and P) on 396 mother, child, and legal father trios from Nuevo León, Mexico. In all, 32 legal fathers were excluded as the possible father based on genetic exclusions at one or more loci (combined average exclusion probability of 0.694 for specific mother-child phenotype pairs)…
Worldwide genetic diversity at the HLA-DQA1 locus
Genotype, gene, or phenotype frequency data, obtained by PCR analysis with sequence specific oligonucleotide probes at the HLA-DQA1 locus, in 176 population samples, each consisting of 30 or more individuals, from all around the world were analyzed. The sampled populations were assigned to the following nine groups: African, Afro-American, American Native, American Mestizo, Asian, American Caucasian, European Caucasian, Caucasian from other regio…
Genetic variation by birth cohorts in Mexican Americans of Starr County, Texas
Mexican Americans residing in Starr County, Texas, were grouped by their year of birth (1896-1925, 1926-1955, and 1956-1985) to determine the extent of birth cohort-related genetic variation within this population and the genetic differences, if any, from the Mexican population residing in the Metropolitan Monterrey Area (MMA), Nuevo León, México. Twenty-one genetic markers were analyzed which indicate that the three birth cohort groups are genet…
Gene diversity and estimation of genetic admixture among Mexican-Americans of Starr County, Texas
The Mexican-Americans of Starr County, Texas, classified by sex and birthplace, were studied to determine the extent of genetic variation and contributions from ancestral populations such as Spanish, Amerindian and West African. Using 21 genetic marker systems, genetic distance and diversity analyses indicate that subpopulations of Mexican-Americans in Starr County are similar, and that more than 99% of the total gene diversity (HT) can be attrib…
Pre‐Hispanic Mesoamerican demography approximates the present‐day ancestry of Mestizos throughout the territory of Mexico
Over the last 500 years, admixture among Amerindians, Europeans, and Africans, principally, has come to shape the present‐day gene pool of Mexicans, particularly Mestizos, who represent about 93% of the total Mexican population. In this work, we analyze the genetic data of 13 combined DNA index system‐short tandem repeats (CODIS‐STRs) in 1,984 unrelated Mestizos representing 10 population samples from different regions of Mexico, namely North, We…
Characterization of mtDNA Haplogroups in 14 Mexican Indigenous Populations
In this descriptive study we investigated the genetic structure of 513 Mexican indigenous subjects grouped in 14 populations (Mixteca- Alta, Mixteca-Baja, Otomi, Purépecha, Tzeltal, Tarahumara, Huichol, Nahua- Atocpan, Nahua-Xochimilco, Nahua-Zitlala, Nahua-Chilacachapa, Nahua- Ixhuatlancillo, Nahua-Necoxtla, and Nahua-Coyolillo) based on mtDNA haplogroups. These communities are geographically and culturally isolated; parents and grandparents wer…
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico: Preliminary Report from the Gemm Family Study
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
FMR1 CGG Repeat Distribution and Linked Microsatellite-SNP Haplotypes in Normal Mexican Mestizo and Indigenous Populations
The (CGG)n repeat size distribution in the FMR1 gene was studied in healthy individuals: 80 X chromosomes of Mexican Mestizos from Mexico City and 33 X chromosomes of Mexican Amerindians from three indigenous communities (Purepechas, Nahuas, and Tzeltales), along with alleles and haplotypes defined by two microsatellite polymorphic markers (DXS548 and FRAXAC1) and two single nucleotide polymorphisms (FMRA and FMRB). Genetic frequencies of Mestizo…
Gene diversity and estimation of genetic admixture among Mexican-Americans of Starr County, Texas
The Mexican-Americans of Starr County, Texas, classified by sex and birthplace, were studied to determine the extent of genetic variation and contributions from ancestral populations such as Spanish, Amerindian and West African. Using 21 genetic marker systems, genetic distance and diversity analyses indicate that subpopulations of Mexican-Americans in Starr County are similar, and that more than 99% of the total gene diversity (HT) can be attrib…
Genetic variation by birth cohorts in Mexican Americans of Starr County, Texas
Mexican Americans residing in Starr County, Texas, were grouped by their year of birth (1896-1925, 1926-1955, and 1956-1985) to determine the extent of birth cohort-related genetic variation within this population and the genetic differences, if any, from the Mexican population residing in the Metropolitan Monterrey Area (MMA), Nuevo León, México. Twenty-one genetic markers were analyzed which indicate that the three birth cohort groups are genet…
Worldwide genetic diversity at the HLA-DQA1 locus
Genotype, gene, or phenotype frequency data, obtained by PCR analysis with sequence specific oligonucleotide probes at the HLA-DQA1 locus, in 176 population samples, each consisting of 30 or more individuals, from all around the world were analyzed. The sampled populations were assigned to the following nine groups: African, Afro-American, American Native, American Mestizo, Asian, American Caucasian, European Caucasian, Caucasian from other regio…
Vitamin D receptor polymorphisms and bone mineral density in Mexican women without osteoporosis
Polymorphisms corresponding to Apa I, Bsm I, and Taq I restriction endonucleases at the vitamin D receptor (VDR) gene and bone mineral density (BMD) at lumbar spine (L2-L4) and proximal femur (neck, Ward's triangle and trochanteric region) sites were examined in a sample of 98 Mexican women (age 55 +/- 10 years). None of the subjects were pregnant or nursing and none had a previous diagnosis of osteoporosis. Polymorphisms were assessed by the res…
Critical appraisal of the estimation of body composition via two-, three-, and four-compartment models
Withers RT, Laforgia J, Heymsfield SB. 1999. Critical appraisal of the estimation of body composition via two-, three-, and four-compartment models. Am J Hum Biol 11:175-185. Line 4 of Validity of assumptions should read, 1.565 g/cm(3) instead of, 1.555 g/cm(3). The authors regret this error
Estimation of nonpaternity in the Mexican population of Nuevo Leon: A validation study with blood group markers
A method for estimating the general rate of nonpaternity in a population was validated using phenotype data on seven blood groups (A1A2BO, MNSs, Rh, Duffy, Lutheran, Kidd, and P) on 396 mother, child, and legal father trios from Nuevo León, Mexico. In all, 32 legal fathers were excluded as the possible father based on genetic exclusions at one or more loci (combined average exclusion probability of 0.694 for specific mother-child phenotype pairs)…
Prevalence of NIDDM in Mexicans with paraphyletic and polyphyletic surnames
It has been hypothesized that the greater prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in Mexicans may be related to their greater degree of Amerindian genetic admixture (AGA). The aim of this unmatched case-control study was to correlate the prevalence of NIDDM with AGA in 10 Mexican Mestizo populations non-randomly selected by surname. A sample of 1,699 unrelated persons, >44 years and residing in the state of Nuevo León, was s…
Genetic admixture in three mexican mestizo populations based on D1S80 and HLA‐DQA1 Loci
This study compares genetic polymorphisms at the D1S80 and HLA‐DQA1 loci in three Mexican Mestizo populations from three large states (Nuevo León, Jalisco, and the Federal District). Allele frequency distributions are relatively homogenous in the three samples; only the Federal District population shows minor differences of the HLA‐DQA1 allele frequencies compared with the other two. In terms of genetic composition, these Mestizo populations show…
Maximum likelihood estimates of admixture in northeastern Mexico using 13 short tandem repeat loci
Tetrameric short tandem repeat (STR) polymorphisms are widely used in population genetics, molecular evolution, gene mapping and linkage analysis, paternity tests, forensic analysis, and medical applications. This article provides allelic distributions of the STR loci D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, CSF1PO, TPOX, TH01, and D16S539 in 143 Mestizos from Northeastern Mexico, estimates of contributions of genes of…
Genetic structure of seven Mexican indigenous populations based on five polymarker loci
This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas‐Guerrero, Nahuas‐Xochimilco, and Tzeltales) on the basis of five PCR‐based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (H T ) can be attributed …
FMR1 CGG Repeat Distribution and Linked Microsatellite-SNP Haplotypes in Normal Mexican Mestizo and Indigenous Populations
The (CGG)n repeat size distribution in the FMR1 gene was studied in healthy individuals: 80 X chromosomes of Mexican Mestizos from Mexico City and 33 X chromosomes of Mexican Amerindians from three indigenous communities (Purepechas, Nahuas, and Tzeltales), along with alleles and haplotypes defined by two microsatellite polymorphic markers (DXS548 and FRAXAC1) and two single nucleotide polymorphisms (FMRA and FMRB). Genetic frequencies of Mestizo…
Characterization of mtDNA Haplogroups in 14 Mexican Indigenous Populations
In this descriptive study we investigated the genetic structure of 513 Mexican indigenous subjects grouped in 14 populations (Mixteca- Alta, Mixteca-Baja, Otomi, Purépecha, Tzeltal, Tarahumara, Huichol, Nahua- Atocpan, Nahua-Xochimilco, Nahua-Zitlala, Nahua-Chilacachapa, Nahua- Ixhuatlancillo, Nahua-Necoxtla, and Nahua-Coyolillo) based on mtDNA haplogroups. These communities are geographically and culturally isolated; parents and grandparents wer…
Heritability and Genetic Correlations of Metabolic Disease-Related Phenotypes in Mexico: Preliminary Report from the Gemm Family Study
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on…
The mitochondrial DNA landscape of modern Mexico
Mexico is a rich source for anthropological and population genetic studies with high diversity in ethnic and linguistic groups.The country witnessed the rise and fall of major civilizations, including the Maya and Aztec, but resulting from European colonization, the population landscape has dramatically changed.Today, the majority of Mexicans do not identify themselves as Indigenous but as admixed, and appear to have very little in common with th…
Genetic structure of Mexican Mestizo women with breast cancer based on three STR loci
The aim of this population genetics study was to compare the genetic structure of Mexican women with breast cancer (BrCa) with previously reported data of four random populations (Nuevo León, Hispanics, Chihuahua, and Central Region of Mexico). A sample of 115 unrelated women with BrCa and whose four grandparents were born in five zones of Mexico were interviewed at a reference hospital in Northeastern Mexico. Noncodifying STRs D7S820, D13S317, a…
Genetic admixture of eight Mexican indigenous populations: Based on five polymarker, HLA‐DQA1, ABO, and RH loci
This study explores the genetic admixture of eight Mexican indigenous populations (Otomi‐Ixmiquilpan, Otomi‐Actopan, Tzeltales, Nahua‐Milpa‐Alta, Nahua‐Xochimilco, Nahua‐Zitlala, Nahua‐Ixhuatlancillo, and Nahua‐Coyolillo) on the basis of five PCR‐based polymorphic DNA loci (LDLR, GYPA, HBGG, D7S8, GC), HLA_DQA1, and the blood groups ABO and Rh (CcDEe). Among the indigenous populations, the highest gene frequencies for O and D were 0.9703 and 1.00…
Pre‐Hispanic Mesoamerican demography approximates the present‐day ancestry of Mestizos throughout the territory of Mexico
Over the last 500 years, admixture among Amerindians, Europeans, and Africans, principally, has come to shape the present‐day gene pool of Mexicans, particularly Mestizos, who represent about 93% of the total Mexican population. In this work, we analyze the genetic data of 13 combined DNA index system‐short tandem repeats (CODIS‐STRs) in 1,984 unrelated Mestizos representing 10 population samples from different regions of Mexico, namely North, We…
Admixture and genetic relationships of Mexican Mestizos regarding Latin American and Caribbean populations based on 13 Codis-STRs
Biology (16 works) · Demography (14 works) · Population (12 works) · Genetics (10 works) · Allele (8 works) · Forensic and Genetic Research (8 works) · Gene (8 works) · Geography (8 works) · Genetics (7 works) · Sociology (7 works)