Takeshi Yoneshiro
Biographic Data
| ID | 4319459 |
|---|---|
| NAME | Takeshi Yoneshiro |
| GIVEN NAMES | Takeshi |
| FAMILY NAME | Yoneshiro |
| SIGNATURE | YONESHIRO T |
| AFFILIATIONS | Tohoku University |
| ORCID | 0000-0001-5298-5831 |
| VERIFIED | Yes |
| TOTAL WORKS | 5 |
| TOTAL CITATIONS | 2 |
| AUTHOR COUNT | 5 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2022 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
The contribution of ancient genomes to the variation of brown fat thermogenesis in the modern Japanese
Background: Brown adipose tissue (BAT) plays a role in non-shivering thermogenesis, yet its activity varies significantly among individuals and across seasons. We previously reported that BAT thermogenesis is lower and more seasonally plastic in Japanese individuals compared with continental East Asians. Objective: Given the unique genetic ancestry of the Japanese, we hypothesized that genome variation inherited from the Jomon people, prehistoric…
An adaptive variant of SLC25A11 enhances brown adipose tissue activity in humans
Background: Brown adipose tissue (BAT) counteracts obesity primarily by enhancing energy expenditure. Although substantial individual variation in BAT activity suggests the involvement of genetic factors, reports on specific genetic variants remain limited. Objective: To identify genetic determinants of human BAT activity by integrating adipose tissue eQTL data and natural selection metrics for genes differentially expressed between BAT and WAT. …
Brown fat thermogenesis and cold adaptation in humans
Brown adipose tissue (BAT) is a site of non-shivering thermogenesis (NST) in mammals. Since the rediscovery of BAT in adult humans, there has been a remarkable advance in human BAT researches, revealing the significant roles of this thermogenic tissue in cold-induced NST and cold adaptation. Cold stress influences BAT in various time spans: acute cold exposure promptly activates BAT to induce NST, which contributes to immediate maintenance of bod…
Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations
Background Adaptation to cold was essential for human migration across Eurasia. Non-shivering thermogenesis through brown adipose tissue (BAT) participates in cold adaptation because some genes involved in the differentiation and function of BAT exhibit signatures of positive natural selection in populations at high latitudes. Whether these genes are associated with the inter-individual variability in BAT thermogenesis remains unclear. In this st…
The Effects of 10-Week Strength Training in the Winter on Brown-like Adipose Tissue Vascular Density
There is no evidence of the effect of exercise training on human brown-like adipose tissue vascular density (BAT-d). Here, we report whether whole-body strength training (ST) in a cold environment increased BAT-d. The participants were 18 men aged 20-31 years. They were randomly assigned to two groups: one that performed ST twice a week at 75% intensity of one-repetition maximum for 10 weeks during winter (EX; n = 9) and a control group that did …
Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations
Background Adaptation to cold was essential for human migration across Eurasia. Non-shivering thermogenesis through brown adipose tissue (BAT) participates in cold adaptation because some genes involved in the differentiation and function of BAT exhibit signatures of positive natural selection in populations at high latitudes. Whether these genes are associated with the inter-individual variability in BAT thermogenesis remains unclear. In this st…
The Effects of 10-Week Strength Training in the Winter on Brown-like Adipose Tissue Vascular Density
There is no evidence of the effect of exercise training on human brown-like adipose tissue vascular density (BAT-d). Here, we report whether whole-body strength training (ST) in a cold environment increased BAT-d. The participants were 18 men aged 20-31 years. They were randomly assigned to two groups: one that performed ST twice a week at 75% intensity of one-repetition maximum for 10 weeks during winter (EX; n = 9) and a control group that did …
Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations
Background Adaptation to cold was essential for human migration across Eurasia. Non-shivering thermogenesis through brown adipose tissue (BAT) participates in cold adaptation because some genes involved in the differentiation and function of BAT exhibit signatures of positive natural selection in populations at high latitudes. Whether these genes are associated with the inter-individual variability in BAT thermogenesis remains unclear. In this st…
Brown fat thermogenesis and cold adaptation in humans
Brown adipose tissue (BAT) is a site of non-shivering thermogenesis (NST) in mammals. Since the rediscovery of BAT in adult humans, there has been a remarkable advance in human BAT researches, revealing the significant roles of this thermogenic tissue in cold-induced NST and cold adaptation. Cold stress influences BAT in various time spans: acute cold exposure promptly activates BAT to induce NST, which contributes to immediate maintenance of bod…
The contribution of ancient genomes to the variation of brown fat thermogenesis in the modern Japanese
Background: Brown adipose tissue (BAT) plays a role in non-shivering thermogenesis, yet its activity varies significantly among individuals and across seasons. We previously reported that BAT thermogenesis is lower and more seasonally plastic in Japanese individuals compared with continental East Asians. Objective: Given the unique genetic ancestry of the Japanese, we hypothesized that genome variation inherited from the Jomon people, prehistoric…
An adaptive variant of SLC25A11 enhances brown adipose tissue activity in humans
Background: Brown adipose tissue (BAT) counteracts obesity primarily by enhancing energy expenditure. Although substantial individual variation in BAT activity suggests the involvement of genetic factors, reports on specific genetic variants remain limited. Objective: To identify genetic determinants of human BAT activity by integrating adipose tissue eQTL data and natural selection metrics for genes differentially expressed between BAT and WAT. …
Adipose tissue (3 works) · Adipose Tissue and Metabolism (3 works) · Biology (3 works) · Brown adipose tissue (3 works) · Gene (3 works) · Thermogenesis (3 works) · Exercise and Physiological Responses (2 works) · Genetic variation (2 works) · Genetics (2 works) · Natural selection (2 works)