Kumarasamy Thangaraj
Biographic Data
| ID | 4329448 |
|---|---|
| NAME | Kumarasamy Thangaraj |
| GIVEN NAMES | Kumarasamy |
| FAMILY NAME | Thangaraj |
| SIGNATURE | THANGARAJ K |
| AFFILIATIONS | Centre for Cellular and Molecular Biology |
| ORCID | 0000-0002-0075-0106 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 12 |
| AUTHOR COUNT | 14 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2004 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 2 |
Prevalence of Low EPHX1 Activity‐Associated Genotypes in Himalayan Populations of India
Objectives The EPHX1 gene encodes human microsomal epoxide hydrolase 1, which helps in biotransformation processes. Its activity is influenced by combinations of genotypes at its polymorphic sites. There are no data on the EPHX1 gene variants in the Indian Himalayan and adjoining populations (HAAPs). Therefore, this study aims to investigate the activity‐associated genotypes of the EPHX1 gene variants in the HAAPs. Materials and Methods The EPHX1…
Signatures of high altitude adaptation in Tibeto‐Burman tribes of the Darjeeling Hill Region
Objectives The long‐term isolation, endogamy practices, and environmental adaptations have shaped the enormous human diversity in India. The genetic and morphological variations in mainland Indians are well studied. However, the data on the Indian Himalayan populations are scattered. Thus, the present study attempts to understand variations in the selected parameter among four Tibeto‐Burman speaking ethnic tribal populations from the Darjeeling H…
The formation of human populations in South and Central Asia
Ancient human movements through Asia Ancient DNA has allowed us to begin tracing the history of human movements across the globe. Narasimhan et al. identify a complex pattern of human migrations and admixture events in South and Central Asia by performing genetic analysis of more than 500 people who lived over the past 8000 years (see the Perspective by Schaefer and Shapiro). They establish key phases in the population prehistory of Eurasia, incl…
The influences of genes, the environment, and social factors on the evolution of skin color diversity in India
OBJECTIVES: Skin color is a highly visible and variable trait across human populations. It is not yet clear how evolutionary forces interact to generate phenotypic diversity. Here, we sought to unravel through an integrative framework the role played by three factors-demography and migration, sexual selection, and natural selection-in driving skin color diversity in India. METHODS: Skin reflectance data were collected from 10 diverse socio-cultur…
The Simons Genome Diversity Project: 300 Genomes From 142 Diverse Populations
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergenc…
Ancient human genomes suggest three ancestral populations for present-day Europeans
Molecular Genetic Perspectives on the Origin of the Lyngngam Tribe of Meghalaya, India
Meghalaya, one of the Northeast Indian states, is inhabited by two major tribal clusters, Khasi and Garo. The disputed origin of the Lyngngam tribe of Meghalaya is a result of their geographic distribution, which is sandwiched between that of the above two major tribal clusters. Our earlier analysis of ethnohistoric, linguistic and demographic data suggested the neighbouring Khasi and Garo as the putative parental population(s) of Lyngngam. In th…
Reconstructing Indian population history
Mitochondrial DNA variation and substructure among the tribal populations of Andhra Pradesh, India
We analyzed mtDNA HVR-I variation among six tribal populations-Andh, Pardan, Gond, Naikpod, Kolam and Chenchu--from Andhra Pradesh. These tribes belong to the Dravidian and Indo-European linguistic group. Except for Chenchu, the rest of the tribal samples were collected from two or more than two locations. The analysis of molecular variance (AMOVA) of the sequences yields a significant F(ST) value (0.045), suggesting a fair degree of genetic diff…
Single nucleotide polymorphisms in alcohol dehydrogenase genes among some Indian populations
Seven ADH genes, identified until now, located in the long arm of human chromosome 4, produce seven different isozymes involved in the metabolism of ethanol to acetaldehyde. Of the more than 500 SNPs reported in the coding and non‐coding regions of these genes in the world databases, 11 are more extensively studied. Three SNPs, ADH1B Arg47His (Exon3), ADH1B Arg369Cys (Exon9) and ADH1C Val349Ile (Exon8), are functionally validated in terms of phen…
Asian and non‐Asian origins of Mon‐Khmer‐ and Mundari‐speaking Austro‐Asiatic populations of India
In the present study, we analyzed 1,686 samples from 31 tribal populations of India for the mitochondrial DNA 9‐base‐pair deletion/insertion polymorphism, and characterized them based on the relevant mitochondrial DNA coding‐region single nucleotide polymorphisms and hypervariable region I motifs, to test the genetic origins of the ethnically and linguistically heterogeneous Austro‐Asiatic tribes of India. A comparative analysis of our results wi…
Reconstructing the Origin of Andaman Islanders
The origin of the Andaman "Negrito" and Nicobar "Mongoloid" populations has been ambiguous. Our analyses of complete mitochondrial DNA sequences from Onges and Great Andaman populations revealed two deeply branching clades that share their most recent common ancestor in founder haplogroup M, with lineages spread among India, Africa, East Asia, New Guinea, and Australia. This distribution suggests that these two clades have likely survived in gene…
Microsatellite Diversity in Andhra Pradesh, India: Genetic Stratification Versus Social Stratification
DNA samples of 948 individuals belonging to 27 populations from southern Andhra Pradesh were analyzed for nine AmpFlSTR Profiler Plus loci. The nature and extent of genomic diversity within and between these populations have been examined with reference to socioeconomic and geographic affiliations. The results suggest that the average heterozygosity is uniformly high in these populations (>0.80) and that the patterns of allele distributions are s…
Genetic Diversity and Relationships among the Tribes of Meghalaya Compared to Other Indian and Continental Populations
The autosomal AmpFLSTR markers validated and widely used for forensic applications are used in this study to examine the extent of diversity and genetic relationships among nine Meghalaya populations. Altogether, 932 chromosomes from 9 populations were analyzed using 9 tetrameric AmpFLSTR loci. The included populations were all seven subtribes of the Austro-Asiatic Mon-Khmer-speaking Khasi and the neighboring Tibeto-Burman Garo. The Lyngngam, whi…
Microsatellite Diversity in Andhra Pradesh, India: Genetic Stratification Versus Social Stratification
DNA samples of 948 individuals belonging to 27 populations from southern Andhra Pradesh were analyzed for nine AmpFlSTR Profiler Plus loci. The nature and extent of genomic diversity within and between these populations have been examined with reference to socioeconomic and geographic affiliations. The results suggest that the average heterozygosity is uniformly high in these populations (>0.80) and that the patterns of allele distributions are s…
Genetic Diversity and Relationships among the Tribes of Meghalaya Compared to Other Indian and Continental Populations
The autosomal AmpFLSTR markers validated and widely used for forensic applications are used in this study to examine the extent of diversity and genetic relationships among nine Meghalaya populations. Altogether, 932 chromosomes from 9 populations were analyzed using 9 tetrameric AmpFLSTR loci. The included populations were all seven subtribes of the Austro-Asiatic Mon-Khmer-speaking Khasi and the neighboring Tibeto-Burman Garo. The Lyngngam, whi…
Genetic Diversity and Relationships among the Tribes of Meghalaya Compared to Other Indian and Continental Populations
The autosomal AmpFLSTR markers validated and widely used for forensic applications are used in this study to examine the extent of diversity and genetic relationships among nine Meghalaya populations. Altogether, 932 chromosomes from 9 populations were analyzed using 9 tetrameric AmpFLSTR loci. The included populations were all seven subtribes of the Austro-Asiatic Mon-Khmer-speaking Khasi and the neighboring Tibeto-Burman Garo. The Lyngngam, whi…
Reconstructing the Origin of Andaman Islanders
The origin of the Andaman "Negrito" and Nicobar "Mongoloid" populations has been ambiguous. Our analyses of complete mitochondrial DNA sequences from Onges and Great Andaman populations revealed two deeply branching clades that share their most recent common ancestor in founder haplogroup M, with lineages spread among India, Africa, East Asia, New Guinea, and Australia. This distribution suggests that these two clades have likely survived in gene…
Microsatellite Diversity in Andhra Pradesh, India: Genetic Stratification Versus Social Stratification
DNA samples of 948 individuals belonging to 27 populations from southern Andhra Pradesh were analyzed for nine AmpFlSTR Profiler Plus loci. The nature and extent of genomic diversity within and between these populations have been examined with reference to socioeconomic and geographic affiliations. The results suggest that the average heterozygosity is uniformly high in these populations (>0.80) and that the patterns of allele distributions are s…
Asian and non‐Asian origins of Mon‐Khmer‐ and Mundari‐speaking Austro‐Asiatic populations of India
In the present study, we analyzed 1,686 samples from 31 tribal populations of India for the mitochondrial DNA 9‐base‐pair deletion/insertion polymorphism, and characterized them based on the relevant mitochondrial DNA coding‐region single nucleotide polymorphisms and hypervariable region I motifs, to test the genetic origins of the ethnically and linguistically heterogeneous Austro‐Asiatic tribes of India. A comparative analysis of our results wi…
Single nucleotide polymorphisms in alcohol dehydrogenase genes among some Indian populations
Seven ADH genes, identified until now, located in the long arm of human chromosome 4, produce seven different isozymes involved in the metabolism of ethanol to acetaldehyde. Of the more than 500 SNPs reported in the coding and non‐coding regions of these genes in the world databases, 11 are more extensively studied. Three SNPs, ADH1B Arg47His (Exon3), ADH1B Arg369Cys (Exon9) and ADH1C Val349Ile (Exon8), are functionally validated in terms of phen…
Mitochondrial DNA variation and substructure among the tribal populations of Andhra Pradesh, India
We analyzed mtDNA HVR-I variation among six tribal populations-Andh, Pardan, Gond, Naikpod, Kolam and Chenchu--from Andhra Pradesh. These tribes belong to the Dravidian and Indo-European linguistic group. Except for Chenchu, the rest of the tribal samples were collected from two or more than two locations. The analysis of molecular variance (AMOVA) of the sequences yields a significant F(ST) value (0.045), suggesting a fair degree of genetic diff…
Reconstructing Indian population history
Molecular Genetic Perspectives on the Origin of the Lyngngam Tribe of Meghalaya, India
Meghalaya, one of the Northeast Indian states, is inhabited by two major tribal clusters, Khasi and Garo. The disputed origin of the Lyngngam tribe of Meghalaya is a result of their geographic distribution, which is sandwiched between that of the above two major tribal clusters. Our earlier analysis of ethnohistoric, linguistic and demographic data suggested the neighbouring Khasi and Garo as the putative parental population(s) of Lyngngam. In th…
Ancient human genomes suggest three ancestral populations for present-day Europeans
The Simons Genome Diversity Project: 300 Genomes From 142 Diverse Populations
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergenc…
The influences of genes, the environment, and social factors on the evolution of skin color diversity in India
OBJECTIVES: Skin color is a highly visible and variable trait across human populations. It is not yet clear how evolutionary forces interact to generate phenotypic diversity. Here, we sought to unravel through an integrative framework the role played by three factors-demography and migration, sexual selection, and natural selection-in driving skin color diversity in India. METHODS: Skin reflectance data were collected from 10 diverse socio-cultur…
The formation of human populations in South and Central Asia
Ancient human movements through Asia Ancient DNA has allowed us to begin tracing the history of human movements across the globe. Narasimhan et al. identify a complex pattern of human migrations and admixture events in South and Central Asia by performing genetic analysis of more than 500 people who lived over the past 8000 years (see the Perspective by Schaefer and Shapiro). They establish key phases in the population prehistory of Eurasia, incl…
Signatures of high altitude adaptation in Tibeto‐Burman tribes of the Darjeeling Hill Region
Objectives The long‐term isolation, endogamy practices, and environmental adaptations have shaped the enormous human diversity in India. The genetic and morphological variations in mainland Indians are well studied. However, the data on the Indian Himalayan populations are scattered. Thus, the present study attempts to understand variations in the selected parameter among four Tibeto‐Burman speaking ethnic tribal populations from the Darjeeling H…
Prevalence of Low EPHX1 Activity‐Associated Genotypes in Himalayan Populations of India
Objectives The EPHX1 gene encodes human microsomal epoxide hydrolase 1, which helps in biotransformation processes. Its activity is influenced by combinations of genotypes at its polymorphic sites. There are no data on the EPHX1 gene variants in the Indian Himalayan and adjoining populations (HAAPs). Therefore, this study aims to investigate the activity‐associated genotypes of the EPHX1 gene variants in the HAAPs. Materials and Methods The EPHX1…
Biology (13 works) · Demography (11 works) · Geography (11 works) · Forensic and Genetic Research (10 works) · Population (10 works) · Gene (9 works) · History (8 works) · Sociology (8 works) · Evolutionary biology (7 works) · Genetic diversity and population structure (7 works)