Takashi Okada
Biographic Data
| ID | 4337084 |
|---|---|
| NAME | Takashi Okada |
| GIVEN NAMES | Takashi |
| FAMILY NAME | Okada |
| SIGNATURE | OKADA T |
| AFFILIATIONS | Nagoya University |
| ORCID | 0000-0002-2910-3797 |
| VERIFIED | Yes |
| TOTAL WORKS | 12 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 12 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1995 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 0 |
Association between decreased taurine levels in the anterior cingulate cortex and restricted and repetitive behaviors in autism spectrum disorder: A cross-sectional study
These findings suggest that reduced taurine levels in the ACC of children with ASD, alongside unchanged GSH levels, may indicate distinct biosynthetic pathways and functional roles of these metabolites in oxidative stress defense mechanisms associated with ASD pathology. Taurine depletion may disrupt physiological processes associated with RRBs and could serve as a potential therapeutic target for symptom management
Reduced prefrontal hemodynamic responses measured using near-infrared spectroscopy in adults with autism spectrum disorder
Adults with ASD have reduced prefrontal hemodynamic responses as measured using near-infrared spectroscopy and the reduced activity of the frontal pole in particular is related to reduced attentional function
Psychiatric comorbidities of attention deficit/hyperactivity disorder in Japan: A nationwide population-based study
ADHD was comorbid with various psychiatric disorders in Japan. In children and adolescents with ADHD, ASD was often diagnosed prior to ADHD. Psychiatric disorders, especially mood disorders and sleep disorders, were frequently diagnosed prior to the initial ADHD diagnosis in adults. The likelihood of comorbid ADHD should be considered when diagnosing adult patients with psychiatric disorders
Effects of others' gaze and facial expression on an observer's microsaccades and their association with ADHD tendencies
Background The aim of this study was to examine the effect of others' gaze on an observer's microsaccades. We also aimed to conduct preliminary investigations on the relationship between the microsaccadic response to a gaze and a gazer's facial expression and attention-deficit/hyperactivity disorder (ADHD) tendencies. Methods Twenty healthy undergraduate and graduate students performed a peripheral target detection task by using unpredictable gaz…
Perceived Social Support Partially Mediates the Impact of Temperament and Character on Postpartum Depression
Results indicate that poor social support worsens depressive symptoms in women with high HA during pregnancy. Limitations include a possible selection bias due to the limited target facilities; most variables being evaluated based on self-report questionnaires, and different number of samples available for analysis between harm avoidance and SD
Trajectories of Healthcare Utilization Among Children and Adolescents With Autism Spectrum Disorder and/or Attention-Deficit/Hyperactivity Disorder in Japan
Continuous healthcare needs were common and psychiatric comorbidities were associated with complex trajectory among adolescents. The promotion of early intervention and prevention of comorbidities are important
Psychological Status Associated With Low Quality of Life in School-Age Children With Neurodevelopmental Disorders During Covid-19 Stay-At-Home Period
Background: This study seeks to ascertain how the COVID-19 stay-at-home period has affected the quality of life (QOL) of children with neurodevelopmental disorders (NDDs) who had experienced sleep schedules alteration and clarify what psychological status predicted low QOL in children with and without altered sleep patterns. Materials and Methods: Study participants were 86 children between 8 and 17 years of age (mean age, 11.7 years; 70 boys, 16…
The Risk Factors Predicting Suicidal Ideation Among Perinatal Women in Japan
Based on these results, effective preventive interventions, such as increasing the quality of social support and confirming the history of depression, should be carried out in pregnant depressive women at the early stage of the perinatal period
Relation Between Perinatal Depressive Symptoms, Harm Avoidance, and a History of Major Depressive Disorder: A Cohort Study of Pregnant Women in Japan
Introduction: The relationship between perinatal depressive symptoms, harm avoidance (HA), and a history of major depressive disorder (MDD) was examined in a prospective cohort study. Methods: This study was conducted from May 1, 2011, to December 31, 2016. A history of MDD was evaluated using the Inventory to Diagnose Depression, Lifetime version during pregnancy. Depressive state and HA were evaluated during pregnancy and at 1 month postnatal u…
Validation and Factor Analysis of the Japanese Version of the Highs Scale in Perinatal Women
Background: The Highs scale has been developed to evaluate hypomanic symptoms in the first postpartum week. However, it has not been elucidated whether this scale is also applicable to pregnant women. To address this issue, we confirmed the factor structure, reliability, and validity of the Japanese version of the Highs scale for pregnant and postpartum women. Methods: 418 women provided effective responses to both the Highs scale and the Edinbur…
Aripiprazole in the Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorder in Japan: A Randomized, Double-blind, Placebo-controlled Study
We evaluated the efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents (6-17 years) with autism spectrum disorder (ASD) in a randomized, double-blind, placebo-controlled 8-week study in Japan. Patients received flexibly dosed aripiprazole (1-15 mg/day) or placebo. Ninety-two patients were randomized to placebo (n = 45) or aripiprazole (n = 47). Aripiprazole produced a significant improvement in the mean …
Temporal distribution of drinking in variable time schedule-induced drinking in rats
The aim of this experiment is to study the effect of the length of the inter-food interval (IFI) on immediately following adjunctive drinking in rats, under variable time 112.5 s schedule. The U-shaped relation was found between the length of the IFI and the latency of immediately following licking. The animals began to drink earlier and stopped drinking earlier following intermediate IFI than following shorter or longer IFIs. No systematic relat…
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Temporal distribution of drinking in variable time schedule-induced drinking in rats
The aim of this experiment is to study the effect of the length of the inter-food interval (IFI) on immediately following adjunctive drinking in rats, under variable time 112.5 s schedule. The U-shaped relation was found between the length of the IFI and the latency of immediately following licking. The animals began to drink earlier and stopped drinking earlier following intermediate IFI than following shorter or longer IFIs. No systematic relat…
Aripiprazole in the Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorder in Japan: A Randomized, Double-blind, Placebo-controlled Study
We evaluated the efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents (6-17 years) with autism spectrum disorder (ASD) in a randomized, double-blind, placebo-controlled 8-week study in Japan. Patients received flexibly dosed aripiprazole (1-15 mg/day) or placebo. Ninety-two patients were randomized to placebo (n = 45) or aripiprazole (n = 47). Aripiprazole produced a significant improvement in the mean …
Validation and Factor Analysis of the Japanese Version of the Highs Scale in Perinatal Women
Background: The Highs scale has been developed to evaluate hypomanic symptoms in the first postpartum week. However, it has not been elucidated whether this scale is also applicable to pregnant women. To address this issue, we confirmed the factor structure, reliability, and validity of the Japanese version of the Highs scale for pregnant and postpartum women. Methods: 418 women provided effective responses to both the Highs scale and the Edinbur…
Relation Between Perinatal Depressive Symptoms, Harm Avoidance, and a History of Major Depressive Disorder: A Cohort Study of Pregnant Women in Japan
Introduction: The relationship between perinatal depressive symptoms, harm avoidance (HA), and a history of major depressive disorder (MDD) was examined in a prospective cohort study. Methods: This study was conducted from May 1, 2011, to December 31, 2016. A history of MDD was evaluated using the Inventory to Diagnose Depression, Lifetime version during pregnancy. Depressive state and HA were evaluated during pregnancy and at 1 month postnatal u…
The Risk Factors Predicting Suicidal Ideation Among Perinatal Women in Japan
Based on these results, effective preventive interventions, such as increasing the quality of social support and confirming the history of depression, should be carried out in pregnant depressive women at the early stage of the perinatal period
Psychological Status Associated With Low Quality of Life in School-Age Children With Neurodevelopmental Disorders During Covid-19 Stay-At-Home Period
Background: This study seeks to ascertain how the COVID-19 stay-at-home period has affected the quality of life (QOL) of children with neurodevelopmental disorders (NDDs) who had experienced sleep schedules alteration and clarify what psychological status predicted low QOL in children with and without altered sleep patterns. Materials and Methods: Study participants were 86 children between 8 and 17 years of age (mean age, 11.7 years; 70 boys, 16…
Perceived Social Support Partially Mediates the Impact of Temperament and Character on Postpartum Depression
Results indicate that poor social support worsens depressive symptoms in women with high HA during pregnancy. Limitations include a possible selection bias due to the limited target facilities; most variables being evaluated based on self-report questionnaires, and different number of samples available for analysis between harm avoidance and SD
Trajectories of Healthcare Utilization Among Children and Adolescents With Autism Spectrum Disorder and/or Attention-Deficit/Hyperactivity Disorder in Japan
Continuous healthcare needs were common and psychiatric comorbidities were associated with complex trajectory among adolescents. The promotion of early intervention and prevention of comorbidities are important
Effects of others' gaze and facial expression on an observer's microsaccades and their association with ADHD tendencies
Background The aim of this study was to examine the effect of others' gaze on an observer's microsaccades. We also aimed to conduct preliminary investigations on the relationship between the microsaccadic response to a gaze and a gazer's facial expression and attention-deficit/hyperactivity disorder (ADHD) tendencies. Methods Twenty healthy undergraduate and graduate students performed a peripheral target detection task by using unpredictable gaz…
Psychiatric comorbidities of attention deficit/hyperactivity disorder in Japan: A nationwide population-based study
ADHD was comorbid with various psychiatric disorders in Japan. In children and adolescents with ADHD, ASD was often diagnosed prior to ADHD. Psychiatric disorders, especially mood disorders and sleep disorders, were frequently diagnosed prior to the initial ADHD diagnosis in adults. The likelihood of comorbid ADHD should be considered when diagnosing adult patients with psychiatric disorders
Association between decreased taurine levels in the anterior cingulate cortex and restricted and repetitive behaviors in autism spectrum disorder: A cross-sectional study
These findings suggest that reduced taurine levels in the ACC of children with ASD, alongside unchanged GSH levels, may indicate distinct biosynthetic pathways and functional roles of these metabolites in oxidative stress defense mechanisms associated with ASD pathology. Taurine depletion may disrupt physiological processes associated with RRBs and could serve as a potential therapeutic target for symptom management
Reduced prefrontal hemodynamic responses measured using near-infrared spectroscopy in adults with autism spectrum disorder
Adults with ASD have reduced prefrontal hemodynamic responses as measured using near-infrared spectroscopy and the reduced activity of the frontal pole in particular is related to reduced attentional function
Psychology (10 works) · Medicine (8 works) · Psychiatry (8 works) · Anxiety (4 works) · Attention Deficit Hyperactivity Disorder (4 works) · Autism (4 works) · Clinical Psychology (4 works) · Clinical Psychology (4 works) · Internal Medicine (4 works) · Maternal Mental Health During Pregnancy and Postpartum (4 works)