Shu‐feng Lei
Biographic Data
| ID | 4350484 |
|---|---|
| NAME | Shu‐feng Lei |
| GIVEN NAMES | Shu‐feng |
| FAMILY NAME | Lei |
| SIGNATURE | LEI S F |
| AFFILIATIONS | Soochow University |
| ORCID | 0000-0003-1453-8082 |
| VERIFIED | Yes |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2006 |
| LATEST PUBLICATION YEAR | 2023 |
| H-INDEX | 0 |
Air pollution, genetic factors and the risk of osteoporosis
Purpose To reveal relationship between air pollution exposure and osteoporosis (OP) risk. Methods Based on large-scale data from the UK Biobank, we evaluated the relationship between OP risk and several air pollutants. Then air pollution scores (APS) were constructed to assess the combined effects of multiple air pollutants on OP risk. Finally, we constructed a genetic risk score (GRS) based on a large genome-wide association study of femoral nec…
Establishment of reference intervals for bone turnover markers in healthy Chinese older adults
This study established age- and sex-specific reference intervals for BTMs in a large sample of healthy Chinese participants ≥ 50 and < 80 years of age and explored the correlations between BTMs and BMD, which provides an effective reference for the assessment of bone turnover in the clinical practice of osteoporosis
Systematic evaluation for the causal effects of blood metabolites on osteoporosis
Purpose Osteoporosis is associated with metabolic alterations, but the causal roles of serum metabolites on osteoporosis have not been identified. Methods Based on the large individual-level datasets from UK Biobank as well as GWAS summary datasets, we first constructed genetic risk scores (GRSs) for 308 of 486 human serum metabolites and evaluated the effect of each GRS on 2 major osteoporosis phenotypes, i.e., estimated bone miner density (eBMD…
Does obesity mediate the relationship between diabetes and osteoporosis in Chinese elderly population
OBJECTIVES: Diabetes mellitus (DM), osteoporosis (OP), and obesity (OB) are three complex diseases. OB is associated with both DM and OP, but it is unclear whether OB mediates association between DM and OP. The study aimed to investigate the potential mediation effects of OB on association between DM and bone mineral density (BMD) by the causal inference tests (CIT). METHODS: A total of 5682 Chinese aged over 65 years were enrolled in an ongoing …
Differences of height and body mass index of youths in urban vs rural areas in Hunan province of China
There are significant differences in height and BMI between youths raised in urban vs rural areas, and positive growth trends of height and BMI over time (1990s vs 2000s) in youths in Hunan Province of China
Differences of height and body mass index of youths in urban vs rural areas in Hunan province of China
Anthropometric indices as the predictors of trunk obesity in Chinese young adults
Both BMI and WC are more effective predictors of trunk obesity than WHR and C index in Chinese young adults
The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults
Bone geometry may adapt primarily to mechanical load as represented by TBLM, but TBFM seemed to have no independent effect on bone geometry in Chinese overweight subjects
Genetic and Environmental Correlations Between Bone Mineral Density and Bone Size in Caucasians
To explore the magnitude of common genetic and environmental effects shared by bone mineral density (BMD) and bone size (BS) in a large sample of 4,489 subjects (2,667 females and 1,822 males) from 582 Caucasian pedigrees, we performed a bivariate variance decomposition analysis to evaluate genetic correlation (rhoG), environmental correlation (rhoE), and phenotypic correlation (rhoP) between BMD and BS at the spine and hip, as well as their "syn…
The genetic, environmental and phenotypic correlations of bone phenotypes at the spine and hip in Chinese
The obtained results suggested that bone size may be used as another surrogate phenotype independently of BMD for eventual elucidation of the pathogenesis of osteoporosis because of the limited correlations between BMD and bone size
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The genetic, environmental and phenotypic correlations of bone phenotypes at the spine and hip in Chinese
The obtained results suggested that bone size may be used as another surrogate phenotype independently of BMD for eventual elucidation of the pathogenesis of osteoporosis because of the limited correlations between BMD and bone size
The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults
Bone geometry may adapt primarily to mechanical load as represented by TBLM, but TBFM seemed to have no independent effect on bone geometry in Chinese overweight subjects
Genetic and Environmental Correlations Between Bone Mineral Density and Bone Size in Caucasians
To explore the magnitude of common genetic and environmental effects shared by bone mineral density (BMD) and bone size (BS) in a large sample of 4,489 subjects (2,667 females and 1,822 males) from 582 Caucasian pedigrees, we performed a bivariate variance decomposition analysis to evaluate genetic correlation (rhoG), environmental correlation (rhoE), and phenotypic correlation (rhoP) between BMD and BS at the spine and hip, as well as their "syn…
Anthropometric indices as the predictors of trunk obesity in Chinese young adults
Both BMI and WC are more effective predictors of trunk obesity than WHR and C index in Chinese young adults
Differences of height and body mass index of youths in urban vs rural areas in Hunan province of China
There are significant differences in height and BMI between youths raised in urban vs rural areas, and positive growth trends of height and BMI over time (1990s vs 2000s) in youths in Hunan Province of China
Differences of height and body mass index of youths in urban vs rural areas in Hunan province of China
Systematic evaluation for the causal effects of blood metabolites on osteoporosis
Purpose Osteoporosis is associated with metabolic alterations, but the causal roles of serum metabolites on osteoporosis have not been identified. Methods Based on the large individual-level datasets from UK Biobank as well as GWAS summary datasets, we first constructed genetic risk scores (GRSs) for 308 of 486 human serum metabolites and evaluated the effect of each GRS on 2 major osteoporosis phenotypes, i.e., estimated bone miner density (eBMD…
Does obesity mediate the relationship between diabetes and osteoporosis in Chinese elderly population
OBJECTIVES: Diabetes mellitus (DM), osteoporosis (OP), and obesity (OB) are three complex diseases. OB is associated with both DM and OP, but it is unclear whether OB mediates association between DM and OP. The study aimed to investigate the potential mediation effects of OB on association between DM and bone mineral density (BMD) by the causal inference tests (CIT). METHODS: A total of 5682 Chinese aged over 65 years were enrolled in an ongoing …
Air pollution, genetic factors and the risk of osteoporosis
Purpose To reveal relationship between air pollution exposure and osteoporosis (OP) risk. Methods Based on large-scale data from the UK Biobank, we evaluated the relationship between OP risk and several air pollutants. Then air pollution scores (APS) were constructed to assess the combined effects of multiple air pollutants on OP risk. Finally, we constructed a genetic risk score (GRS) based on a large genome-wide association study of femoral nec…
Establishment of reference intervals for bone turnover markers in healthy Chinese older adults
This study established age- and sex-specific reference intervals for BTMs in a large sample of healthy Chinese participants ≥ 50 and < 80 years of age and explored the correlations between BTMs and BMD, which provides an effective reference for the assessment of bone turnover in the clinical practice of osteoporosis
Medicine (10 works) · Internal Medicine (8 works) · Bone health and osteoporosis research (7 works) · Biology (6 works) · Body mass index (6 works) · Osteoporosis (6 works) · Bone Metabolism and Diseases (4 works) · Bioinformatics (3 works) · Body weight (3 works) · Demography (3 works)