J Dee Higley
Biographic Data
| ID | 4496906 |
|---|---|
| NAME | J Dee Higley |
| GIVEN NAMES | J Dee |
| FAMILY NAME | Higley |
| SIGNATURE | HIGLEY J D |
| AFFILIATIONS | National Institute on Alcohol Abuse and Alcoholism |
| ORCID | 0000-0002-3745-3893 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 3 |
| AUTHOR COUNT | 14 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1992 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 1 |
Behavioral inhibition in a translational nonhuman primate model: A pilot study of Kagan’s behavioral inhibition paradigm modified for use in infant rhesus macaques (Macaca mulatta)
Behavioral inhibition (BI), a temperamental trait first described by Jerome Kagan, is characterized by wariness to unfamiliar persons and novel situations. BI is a moderately stable trait, with biological and genetic underpinnings. Kagan's methodology for assessing BI is widely used in humans. Although this paradigm could be readily translated for use in nonhuman primates, thereby increasing generalizability from nonhuman primates to humans and f…
Neonatal temperament and neuromotor differences are predictive of adolescent alcohol intake in rhesus monkeys ( Macaca mulatta )
Identifying predictors of teenage alcohol use disorder (AUDs) is a major health initiative, with studies suggesting that there are distinct personality‐related traits that underlie patterns of alcohol intake. As temperament is biologically based, identifiable early in life, and stable across time, it is considered the foundation of personality. As such, we hypothesized that neonatal temperament traits would predict anxiety‐mediated adolescent alc…
Quantitative Genetics of Response to Novelty and Other Stimuli by Infant Rhesus Macaques (Macaca mulatta) Across Three Behavioral Assessments
Serotonergic influences on life‐history outcomes in free‐ranging male rhesus macaques
Several studies have demonstrated that nonhuman primate males with low cerebrospinal fluid (CSF) levels of the serotonin metabolite 5‐hydroxyindoleacetic acid (5‐HIAA) exhibit antisocial behavior patterns. Included in these deleterious patterns are impulse control deficits associated with violence and premature death. No studies to date have longitudinally studied the long‐term outcome of young subjects with low CSF 5‐HIAA concentrations as they …
Primate Psychology
Program and Conference Schedule
Relationships among CSF monoamine metabolite levels, alcohol sensitivity, and alcohol‐related aggression in rhesus macaques
A relationship between alcohol intake and aggressive behavior has been demonstrated in both associational and laboratory studies. Among the factors that contribute to aggression during intoxication are a history of violence and the level of alcohol‐induced stimulation. In humans, excessive alcohol intake and alcoholism are predicted by decreased sensitivity, or a low level of response (LOR), to alcohol. In addition, aggressive behavior, LOR, and …
Relationship between platelet‐activating factor concentration in rhesus monkey ( Macaca mulatta ) spermatozoa and sperm motility
Platelet‐activating factor (PAF) is a potent signaling phospholipid that has been implicated in a number of biological activities. PAF concentration in primate spermatozoa has a positive correlation with fertility. While PAF is present in rhesus spermatozoa, there are no relational reports on its concentration and the cell’s motility. The study objective was to determine if PAF concentration in rhesus spermatozoa was correlated with motility indi…
Rhesus Macaque (Macaca mulatta) group formation and housing: Wounding and reproduction in a specific pathogen free (SPF) colony
In the present report, we examined the effects of group formation strategy and corral design on wounding and reproduction rates in rhesus macaques. Specifically, we examined group formation using a staged strategy, in which small groups of animals were introduced incrementally over a period of weeks, and a rapid formation strategy, in which all animals were introduced in 1 day. We also examined group formation using a divided corral design that f…
Rhesus Macaque (Macaca mulatta) group formation and housing: Wounding and reproduction in a specific pathogen free (SPF) colony
In the present report, we examined the effects of group formation strategy and corral design on wounding and reproduction rates in rhesus macaques. Specifically, we examined group formation using a staged strategy, in which small groups of animals were introduced incrementally over a period of weeks, and a rapid formation strategy, in which all animals were introduced in 1 day. We also examined group formation using a divided corral design that f…
Trait‐like immunological and hematological measures in female rhesus across varied environmental conditions
In this 2-year longitudinal study, 45 2-year-old female rhesus were observed as they were captured and removed from a free-ranging setting (Phase I), single caged for 1 year (Phase II), and housed in small, stable social groups for an additional year (Phase III). During the study, eight blood samples were taken, and hematological, immunological, and hormonal variables were assayed to determine whether 1) any of the measures would exhibit trait-li…
Trait-like immunological and hematological measures in female rhesus across varied environmental conditions
In this 2-year longitudinal study, 45 2-year-old female rhesus were observed as they were captured and removed from a free-ranging setting (Phase I), single caged for 1 year (Phase II), and housed in small, stable social groups for an additional year (Phase III). During the study, eight blood samples were taken, and hematological, immunological, and hormonal variables were assayed to determine whether 1) any of the measures would exhibit trait-li…
CBC and serum chemistry differences between Indian-derived and Chinese–Indian hybrid rhesus monkey infants
Hematological and clinical biochemistry measures are commonly utilized as indicators of the health status of nonhuman primates. Among individuals in a population of a given species, there may be considerable variation in these parameters. Still wider variation may be found among different strains or subspecies of some orders. To date, few studies have addressed this phenomenon among strains of nonhuman primates of a given species. Blood samples f…
Peers as primary attachment sources in yearling rhesus monkeys (Macaca mulatta)
Peer bonds were examined in 2 experiments using juvenile rhesus monkeys to determine (a) whether specific attachment bonds are formed between age-mates, (b) whether preferred age-mates can provide a secure base, and (c) whether a previous attachment bond affects the quality of subsequent attachment bonds
Quantitative Genetics of Response to Novelty and Other Stimuli by Infant Rhesus Macaques (Macaca mulatta) Across Three Behavioral Assessments
Peers as primary attachment sources in yearling rhesus monkeys (Macaca mulatta)
Peer bonds were examined in 2 experiments using juvenile rhesus monkeys to determine (a) whether specific attachment bonds are formed between age-mates, (b) whether preferred age-mates can provide a secure base, and (c) whether a previous attachment bond affects the quality of subsequent attachment bonds
Peers as primary attachment sources in yearling rhesus monkeys (Macaca mulatta)
Peer bonds were examined in 2 experiments using juvenile rhesus monkeys to determine (a) whether specific attachment bonds are formed between age-mates, (b) whether preferred age-mates can provide a secure base, and (c) whether a previous attachment bond affects the quality of subsequent attachment bonds
CBC and serum chemistry differences between Indian-derived and Chinese–Indian hybrid rhesus monkey infants
Hematological and clinical biochemistry measures are commonly utilized as indicators of the health status of nonhuman primates. Among individuals in a population of a given species, there may be considerable variation in these parameters. Still wider variation may be found among different strains or subspecies of some orders. To date, few studies have addressed this phenomenon among strains of nonhuman primates of a given species. Blood samples f…
Rhesus Macaque (Macaca mulatta) group formation and housing: Wounding and reproduction in a specific pathogen free (SPF) colony
In the present report, we examined the effects of group formation strategy and corral design on wounding and reproduction rates in rhesus macaques. Specifically, we examined group formation using a staged strategy, in which small groups of animals were introduced incrementally over a period of weeks, and a rapid formation strategy, in which all animals were introduced in 1 day. We also examined group formation using a divided corral design that f…
Rhesus Macaque (Macaca mulatta) group formation and housing: Wounding and reproduction in a specific pathogen free (SPF) colony
In the present report, we examined the effects of group formation strategy and corral design on wounding and reproduction rates in rhesus macaques. Specifically, we examined group formation using a staged strategy, in which small groups of animals were introduced incrementally over a period of weeks, and a rapid formation strategy, in which all animals were introduced in 1 day. We also examined group formation using a divided corral design that f…
Trait‐like immunological and hematological measures in female rhesus across varied environmental conditions
In this 2-year longitudinal study, 45 2-year-old female rhesus were observed as they were captured and removed from a free-ranging setting (Phase I), single caged for 1 year (Phase II), and housed in small, stable social groups for an additional year (Phase III). During the study, eight blood samples were taken, and hematological, immunological, and hormonal variables were assayed to determine whether 1) any of the measures would exhibit trait-li…
Trait-like immunological and hematological measures in female rhesus across varied environmental conditions
In this 2-year longitudinal study, 45 2-year-old female rhesus were observed as they were captured and removed from a free-ranging setting (Phase I), single caged for 1 year (Phase II), and housed in small, stable social groups for an additional year (Phase III). During the study, eight blood samples were taken, and hematological, immunological, and hormonal variables were assayed to determine whether 1) any of the measures would exhibit trait-li…
Relationship between platelet‐activating factor concentration in rhesus monkey ( Macaca mulatta ) spermatozoa and sperm motility
Platelet‐activating factor (PAF) is a potent signaling phospholipid that has been implicated in a number of biological activities. PAF concentration in primate spermatozoa has a positive correlation with fertility. While PAF is present in rhesus spermatozoa, there are no relational reports on its concentration and the cell’s motility. The study objective was to determine if PAF concentration in rhesus spermatozoa was correlated with motility indi…
Relationships among CSF monoamine metabolite levels, alcohol sensitivity, and alcohol‐related aggression in rhesus macaques
A relationship between alcohol intake and aggressive behavior has been demonstrated in both associational and laboratory studies. Among the factors that contribute to aggression during intoxication are a history of violence and the level of alcohol‐induced stimulation. In humans, excessive alcohol intake and alcoholism are predicted by decreased sensitivity, or a low level of response (LOR), to alcohol. In addition, aggressive behavior, LOR, and …
Program and Conference Schedule
Primate Psychology
Serotonergic influences on life‐history outcomes in free‐ranging male rhesus macaques
Several studies have demonstrated that nonhuman primate males with low cerebrospinal fluid (CSF) levels of the serotonin metabolite 5‐hydroxyindoleacetic acid (5‐HIAA) exhibit antisocial behavior patterns. Included in these deleterious patterns are impulse control deficits associated with violence and premature death. No studies to date have longitudinally studied the long‐term outcome of young subjects with low CSF 5‐HIAA concentrations as they …
Quantitative Genetics of Response to Novelty and Other Stimuli by Infant Rhesus Macaques (Macaca mulatta) Across Three Behavioral Assessments
Neonatal temperament and neuromotor differences are predictive of adolescent alcohol intake in rhesus monkeys ( Macaca mulatta )
Identifying predictors of teenage alcohol use disorder (AUDs) is a major health initiative, with studies suggesting that there are distinct personality‐related traits that underlie patterns of alcohol intake. As temperament is biologically based, identifiable early in life, and stable across time, it is considered the foundation of personality. As such, we hypothesized that neonatal temperament traits would predict anxiety‐mediated adolescent alc…
Behavioral inhibition in a translational nonhuman primate model: A pilot study of Kagan’s behavioral inhibition paradigm modified for use in infant rhesus macaques (Macaca mulatta)
Behavioral inhibition (BI), a temperamental trait first described by Jerome Kagan, is characterized by wariness to unfamiliar persons and novel situations. BI is a moderately stable trait, with biological and genetic underpinnings. Kagan's methodology for assessing BI is widely used in humans. Although this paradigm could be readily translated for use in nonhuman primates, thereby increasing generalizability from nonhuman primates to humans and f…
Biology (10 works) · Medicine (8 works) · Primate Behavior and Ecology (7 works) · Psychology (7 works) · Developmental psychology (6 works) · Immunology (5 works) · Macaque (5 works) · Rhesus macaque (5 works) · Stress Responses and Cortisol (5 works) · Zoology (5 works)