Luke W Hyde
Biographic Data
| ID | 4637274 |
|---|---|
| NAME | Luke W Hyde |
| GIVEN NAMES | Luke W |
| FAMILY NAME | Hyde |
| SIGNATURE | HYDE L W |
| AFFILIATIONS | University of Michigan |
| ORCID | 0000-0002-5947-7896 |
| VERIFIED | Yes |
| TOTAL WORKS | 26 |
| TOTAL CITATIONS | 20 |
| AUTHOR COUNT | 26 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2008 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 3 |
The nature and nurture of primary and secondary callous–unemotional traits
BACKGROUND: Callous-unemotional (CU) traits identify youth with more severe and chronic trajectories of conduct problems. However, the etiology of CU traits may be heterogeneous, undermining the search for effective treatments. The level of co-occurring anxiety has been used to identify "primary" (lower anxiety) versus "secondary" (higher anxiety) variants of CU traits. The primary variant has been hypothesized to emerge from strong genetic influ…
Annual Research Review
During the toddler and preschool period, nearly all children engage in some level of aggression, defiance, stealing, and temper tantrums. While the frequency and intensity of these behaviors tends to decrease across early childhood, a subset of children engage in these conduct problem behaviors at a higher intensity early in life and/or do not desist from these behaviors. Instead, these behaviors escalate across childhood and adolescence into ser…
A person‐centered and genetically informed approach toward characterizing multidomain resilience to neighborhood disadvantage in youth
BACKGROUND: Examining resilience to adversity across multiple behavioral domains (e.g., psychological well-being, social functioning) can better characterize positive development and inform novel prevention and intervention efforts. However, few studies have employed person-centered methods to examine individual profiles of resilience across multiple domains in youth. Further, research exploring contextual predictors of resilience has rarely used…
Both stressors and assets moderated the etiology of mothers’ parenting during the pandemic
We sought to illuminate whether and how pandemic-related experiences shaped the genetic and environmental influences on mothering behavior to better understand the effects of stress on parenting. Participants included 710 mothers of twins ( M age = 47.00; SD age = 5.59; White: 84.8%, Black: 7%, Hispanic: 1.1%, Asian American and Pacific Islander: 0.8%, Native American: 0.8%, biracial: 0.3%, other: 3%, and not reported: 2.1%) from the Michigan Sta…
The dynamic and relational nature of parent–child conflict from childhood into emerging adulthood
Although the parent-child relationship is widely regarded as a foundational context for youth development, the developmental origins of this relationship remain unknown. The present study addressed these gaps, leveraging longitudinal and genetically informed methods to illuminate the developmental origins of mother-child conflict as it unfolds from middle childhood into emerging adulthood. Participants consisted of 2,060 twins in 1,030 twin famil…
Person-Centered Combinations of Individual, Familial, Neighborhood, and Structural Risk Factors Differentially Relate to Antisocial Behavior and Psychopathology
Research highlights risk factors across systems, from person to community, for understanding antisocial behavior. However, limited research used person-centered analyses to investigate how individual, familial, neighborhood, and structural risk factors cluster and relate to antisocial behavior. We applied latent profile analysis to questionnaires and Census-derived data ( N = 478; Northeast sample). A five-profile solution fit best (1: Low Risk; …
Exposure to community violence as a mechanism linking neighborhood disadvantage to amygdala reactivity and the protective role of parental nurturance
Emerging literature links neighborhood disadvantage to altered neural function in regions supporting socioemotional and threat processing. Few studies, however, have examined the proximal mechanisms through which neighborhood disadvantage is associated with neural functioning. In a sample of 7- to 19-year-old twins recruited from disadvantaged neighborhoods (354 families, 708 twins; 54.5% boys; 78.5% White, 13.0% Black, 8.5% other racial/ethnic g…
Functional brain network organization and multidomain resilience to neighborhood disadvantage in youth
Though youth living in disadvantaged neighborhoods experience greater risk for poor behavioral and mental health outcomes, many go on to show resilience in the face of adversity. A few recent studies have identified neural markers of resilience in cognitive and affective brain networks, yet the broader network organization supporting resilience in youth remains unknown, particularly in relation to neighborhood disadvantage. Moreover, most studies…
Adolescent functional network connectivity prospectively predicts adult anxiety symptoms related to perceived Covid ‐19 economic adversity
BACKGROUND: Stressful events, such as the COVID-19 pandemic, are major contributors to anxiety and depression, but only a subset of individuals develop psychopathology. In a population-based sample (N = 174) with a high representation of marginalized individuals, this study examined adolescent functional network connectivity as a marker of susceptibility to anxiety and depression in the context of adverse experiences. METHODS: Data-driven network…
Parent Mental Health Before and During the Covid-19 Pandemic
Parenting moderates the etiology of callous‐unemotional traits in middle childhood
BACKGROUND: Callous-unemotional (CU) traits are associated with chronic and escalating trajectories of antisocial behavior. Extant etiologic studies suggest that heritability estimates for CU traits vary substantially, while also pointing to an environmental association between parenting and CU traits. METHODS: We used twin modeling to estimate additive genetic (A), shared environmental (C), and nonshared environmental (E) influences on CU traits…
Intimate Partner Violence and Parenting
An ecological approach to understanding the developing brain
We describe an ecological approach to understanding the developing brain, with a focus on the effects of poverty-related adversity on brain function. We articulate how combining multilevel ecological models from developmental science and developmental psychopathology with human neuroscience can inform our approach to understanding the developmental neuroscience of risk and resilience. To illustrate this approach, we focus on associations between …
Evaluation of a longitudinal family stress model in a population‐based cohort
The Family Stress Model (FSM) is an influential family process model that posits that socioeconomic disadvantage impacts child outcomes via its effects on parents. Existing evaluations of the FSM are constrained by limited measures of socioeconomic disadvantage, cross-sectional research designs, and reliance on non-population-based samples. The current study tested the FSM in a subsample of the Fragile Families and Child Wellbeing Study ( N = 2,9…
Parental substance use and child reward-driven eating behaviors
Intimate partner violence exposure predicts antisocial behavior via pro‐violence attitudes among males with elevated levels of cortisol
The present study tested whether attitudes toward violence mediate the association between intimate partner violence exposure and antisocial behavior across adolescence, and whether cortisol level moderates these pathways in an ethnically diverse sample of 190 boys from low-income, urban families. Results suggest that a pathway from intimate partner violence exposure at age 12 to antisocial behavior at age 17 is explained by pro-violence attitude…
Amygdala reactivity as a marker of differential susceptibility to socioeconomic resources during early adulthood
Models of differential susceptibility hypothesize that neural function may be a marker of differential susceptibility to context, but no studies have tested this hypothesis. Using a sample of 310 young men from low-income urban neighborhoods, this study investigated amygdala reactivity to facial expressions as a moderator of the relations between socioeconomic resources and later antisocial behavior (AB) and income. For individuals with high amyg…
Toward an Understanding of the Role of the Environment in the Development of Early Callous Behavior
Key to understanding the long‐term impact of social inequalities is identifying early behaviors that may signal higher risk for later poor psychosocial outcomes, such as psychopathology. A set of early‐emerging characteristics that may signal risk for later externalizing psychopathology is callous‐unemotional (CU) behavior. CU behavior predicts severe and chronic trajectories of externalizing behaviors in youth. However, much research on CU behav…
Does early childhood callous-unemotional behavior uniquely predict behavior problems or callous-unemotional behavior in late childhood
Callous-unemotional (CU) behavior has been linked to behavior problems in children and adolescents. However, few studies have examined whether CU behavior in early childhood predicts behavior problems or CU behavior in late childhood . This study examined whether indicators of CU behavior at ages 2-4 predicted aggression, rule-breaking, and CU behavior across informants at age 9.5. To test the unique predictive and convergent validity of CU behav…
An Imaging Gene by Environment Interaction (IG×E) Approach to Understanding Youth Antisocial Behavior
An examination of the complex interplay of genes, environmental experience, and the brain is critical to understanding psychopathology, violence, and aggression. This essay reviews the gene–environment (G×E) interaction and imaging genetics literature relating to the development of youth antisocial behavior (AB). A model is proposed that bridges these approaches within an imaging gene×environment (IG×E) interaction framework. The potential applic…
Adaptive Interventions and SMART Designs
Heterogeneity between and within people necessitates the need for sequential personalized interventions to optimize individual outcomes. Personalized or adaptive interventions (AIs) are relevant for diseases and maladaptive behavioral trajectories when one intervention is not curative and success of a subsequent intervention may depend on individual characteristics or response. AIs may be applied to medical settings and to investigate best preven…
Understanding youth antisocial behavior using neuroscience through a developmental psychopathology lens
Deviancy and Normative Training Processes in Experimental Groups of Delinquent and Nondelinquent Male Adolescents
The goal of this study was to identify the predictors and the moderators of group characteristics that influence deviancy and normative training processes in delinquent male adolescents. The authors experimentally tested the effects of group composition on deviant talk interaction processes among groups in which all members presented delinquent behaviors (“pure” delinquent group condition), those that included adolescents with no delinquent behav…
Longitudinal Prediction of Disruptive Behavior Disorders in Adolescent Males from Multiple Risk Domains
Developmental Precursors of Moral Disengagement and the Role of Moral Disengagement in the Development of Antisocial Behavior
Evaluation of a longitudinal family stress model in a population‐based cohort
The Family Stress Model (FSM) is an influential family process model that posits that socioeconomic disadvantage impacts child outcomes via its effects on parents. Existing evaluations of the FSM are constrained by limited measures of socioeconomic disadvantage, cross-sectional research designs, and reliance on non-population-based samples. The current study tested the FSM in a subsample of the Fragile Families and Child Wellbeing Study ( N = 2,9…
Deviancy and Normative Training Processes in Experimental Groups of Delinquent and Nondelinquent Male Adolescents
The goal of this study was to identify the predictors and the moderators of group characteristics that influence deviancy and normative training processes in delinquent male adolescents. The authors experimentally tested the effects of group composition on deviant talk interaction processes among groups in which all members presented delinquent behaviors (“pure” delinquent group condition), those that included adolescents with no delinquent behav…
Adaptive Interventions and SMART Designs
Heterogeneity between and within people necessitates the need for sequential personalized interventions to optimize individual outcomes. Personalized or adaptive interventions (AIs) are relevant for diseases and maladaptive behavioral trajectories when one intervention is not curative and success of a subsequent intervention may depend on individual characteristics or response. AIs may be applied to medical settings and to investigate best preven…
Intimate Partner Violence and Parenting
Amygdala reactivity as a marker of differential susceptibility to socioeconomic resources during early adulthood
Models of differential susceptibility hypothesize that neural function may be a marker of differential susceptibility to context, but no studies have tested this hypothesis. Using a sample of 310 young men from low-income urban neighborhoods, this study investigated amygdala reactivity to facial expressions as a moderator of the relations between socioeconomic resources and later antisocial behavior (AB) and income. For individuals with high amyg…
Does early childhood callous-unemotional behavior uniquely predict behavior problems or callous-unemotional behavior in late childhood
Callous-unemotional (CU) behavior has been linked to behavior problems in children and adolescents. However, few studies have examined whether CU behavior in early childhood predicts behavior problems or CU behavior in late childhood . This study examined whether indicators of CU behavior at ages 2-4 predicted aggression, rule-breaking, and CU behavior across informants at age 9.5. To test the unique predictive and convergent validity of CU behav…
The relations among cumulative risk, parenting, and behavior problems during early childhood
Background: This study examined relations among cumulative risk, nurturant and involved parenting, and behavior problems across early childhood. Methods: Cumulative risk, parenting, and behavior problems were measured in a sample of low‐income toddlers participating in a family‐centered program to prevent conduct problems. Results: Path analysis was utilized to examine longitudinal relations among these constructs, with results supporting an indi…
Developmental Precursors of Moral Disengagement and the Role of Moral Disengagement in the Development of Antisocial Behavior
Longitudinal Prediction of Disruptive Behavior Disorders in Adolescent Males from Multiple Risk Domains
Understanding youth antisocial behavior using neuroscience through a developmental psychopathology lens
Deviancy and Normative Training Processes in Experimental Groups of Delinquent and Nondelinquent Male Adolescents
The goal of this study was to identify the predictors and the moderators of group characteristics that influence deviancy and normative training processes in delinquent male adolescents. The authors experimentally tested the effects of group composition on deviant talk interaction processes among groups in which all members presented delinquent behaviors (“pure” delinquent group condition), those that included adolescents with no delinquent behav…
An Imaging Gene by Environment Interaction (IG×E) Approach to Understanding Youth Antisocial Behavior
An examination of the complex interplay of genes, environmental experience, and the brain is critical to understanding psychopathology, violence, and aggression. This essay reviews the gene–environment (G×E) interaction and imaging genetics literature relating to the development of youth antisocial behavior (AB). A model is proposed that bridges these approaches within an imaging gene×environment (IG×E) interaction framework. The potential applic…
Adaptive Interventions and SMART Designs
Heterogeneity between and within people necessitates the need for sequential personalized interventions to optimize individual outcomes. Personalized or adaptive interventions (AIs) are relevant for diseases and maladaptive behavioral trajectories when one intervention is not curative and success of a subsequent intervention may depend on individual characteristics or response. AIs may be applied to medical settings and to investigate best preven…
Does early childhood callous-unemotional behavior uniquely predict behavior problems or callous-unemotional behavior in late childhood
Callous-unemotional (CU) behavior has been linked to behavior problems in children and adolescents. However, few studies have examined whether CU behavior in early childhood predicts behavior problems or CU behavior in late childhood . This study examined whether indicators of CU behavior at ages 2-4 predicted aggression, rule-breaking, and CU behavior across informants at age 9.5. To test the unique predictive and convergent validity of CU behav…
Toward an Understanding of the Role of the Environment in the Development of Early Callous Behavior
Key to understanding the long‐term impact of social inequalities is identifying early behaviors that may signal higher risk for later poor psychosocial outcomes, such as psychopathology. A set of early‐emerging characteristics that may signal risk for later externalizing psychopathology is callous‐unemotional (CU) behavior. CU behavior predicts severe and chronic trajectories of externalizing behaviors in youth. However, much research on CU behav…
Intimate partner violence exposure predicts antisocial behavior via pro‐violence attitudes among males with elevated levels of cortisol
The present study tested whether attitudes toward violence mediate the association between intimate partner violence exposure and antisocial behavior across adolescence, and whether cortisol level moderates these pathways in an ethnically diverse sample of 190 boys from low-income, urban families. Results suggest that a pathway from intimate partner violence exposure at age 12 to antisocial behavior at age 17 is explained by pro-violence attitude…
Amygdala reactivity as a marker of differential susceptibility to socioeconomic resources during early adulthood
Models of differential susceptibility hypothesize that neural function may be a marker of differential susceptibility to context, but no studies have tested this hypothesis. Using a sample of 310 young men from low-income urban neighborhoods, this study investigated amygdala reactivity to facial expressions as a moderator of the relations between socioeconomic resources and later antisocial behavior (AB) and income. For individuals with high amyg…
An ecological approach to understanding the developing brain
We describe an ecological approach to understanding the developing brain, with a focus on the effects of poverty-related adversity on brain function. We articulate how combining multilevel ecological models from developmental science and developmental psychopathology with human neuroscience can inform our approach to understanding the developmental neuroscience of risk and resilience. To illustrate this approach, we focus on associations between …
Evaluation of a longitudinal family stress model in a population‐based cohort
The Family Stress Model (FSM) is an influential family process model that posits that socioeconomic disadvantage impacts child outcomes via its effects on parents. Existing evaluations of the FSM are constrained by limited measures of socioeconomic disadvantage, cross-sectional research designs, and reliance on non-population-based samples. The current study tested the FSM in a subsample of the Fragile Families and Child Wellbeing Study ( N = 2,9…
Parental substance use and child reward-driven eating behaviors
Intimate Partner Violence and Parenting
Parenting moderates the etiology of callous‐unemotional traits in middle childhood
BACKGROUND: Callous-unemotional (CU) traits are associated with chronic and escalating trajectories of antisocial behavior. Extant etiologic studies suggest that heritability estimates for CU traits vary substantially, while also pointing to an environmental association between parenting and CU traits. METHODS: We used twin modeling to estimate additive genetic (A), shared environmental (C), and nonshared environmental (E) influences on CU traits…
Adolescent functional network connectivity prospectively predicts adult anxiety symptoms related to perceived Covid ‐19 economic adversity
BACKGROUND: Stressful events, such as the COVID-19 pandemic, are major contributors to anxiety and depression, but only a subset of individuals develop psychopathology. In a population-based sample (N = 174) with a high representation of marginalized individuals, this study examined adolescent functional network connectivity as a marker of susceptibility to anxiety and depression in the context of adverse experiences. METHODS: Data-driven network…
Parent Mental Health Before and During the Covid-19 Pandemic
Person-Centered Combinations of Individual, Familial, Neighborhood, and Structural Risk Factors Differentially Relate to Antisocial Behavior and Psychopathology
Research highlights risk factors across systems, from person to community, for understanding antisocial behavior. However, limited research used person-centered analyses to investigate how individual, familial, neighborhood, and structural risk factors cluster and relate to antisocial behavior. We applied latent profile analysis to questionnaires and Census-derived data ( N = 478; Northeast sample). A five-profile solution fit best (1: Low Risk; …
Exposure to community violence as a mechanism linking neighborhood disadvantage to amygdala reactivity and the protective role of parental nurturance
Emerging literature links neighborhood disadvantage to altered neural function in regions supporting socioemotional and threat processing. Few studies, however, have examined the proximal mechanisms through which neighborhood disadvantage is associated with neural functioning. In a sample of 7- to 19-year-old twins recruited from disadvantaged neighborhoods (354 families, 708 twins; 54.5% boys; 78.5% White, 13.0% Black, 8.5% other racial/ethnic g…
Functional brain network organization and multidomain resilience to neighborhood disadvantage in youth
Though youth living in disadvantaged neighborhoods experience greater risk for poor behavioral and mental health outcomes, many go on to show resilience in the face of adversity. A few recent studies have identified neural markers of resilience in cognitive and affective brain networks, yet the broader network organization supporting resilience in youth remains unknown, particularly in relation to neighborhood disadvantage. Moreover, most studies…
Both stressors and assets moderated the etiology of mothers’ parenting during the pandemic
We sought to illuminate whether and how pandemic-related experiences shaped the genetic and environmental influences on mothering behavior to better understand the effects of stress on parenting. Participants included 710 mothers of twins ( M age = 47.00; SD age = 5.59; White: 84.8%, Black: 7%, Hispanic: 1.1%, Asian American and Pacific Islander: 0.8%, Native American: 0.8%, biracial: 0.3%, other: 3%, and not reported: 2.1%) from the Michigan Sta…
The dynamic and relational nature of parent–child conflict from childhood into emerging adulthood
Although the parent-child relationship is widely regarded as a foundational context for youth development, the developmental origins of this relationship remain unknown. The present study addressed these gaps, leveraging longitudinal and genetically informed methods to illuminate the developmental origins of mother-child conflict as it unfolds from middle childhood into emerging adulthood. Participants consisted of 2,060 twins in 1,030 twin famil…
The nature and nurture of primary and secondary callous–unemotional traits
BACKGROUND: Callous-unemotional (CU) traits identify youth with more severe and chronic trajectories of conduct problems. However, the etiology of CU traits may be heterogeneous, undermining the search for effective treatments. The level of co-occurring anxiety has been used to identify "primary" (lower anxiety) versus "secondary" (higher anxiety) variants of CU traits. The primary variant has been hypothesized to emerge from strong genetic influ…
Annual Research Review
During the toddler and preschool period, nearly all children engage in some level of aggression, defiance, stealing, and temper tantrums. While the frequency and intensity of these behaviors tends to decrease across early childhood, a subset of children engage in these conduct problem behaviors at a higher intensity early in life and/or do not desist from these behaviors. Instead, these behaviors escalate across childhood and adolescence into ser…
Psychology (24 works) · Developmental psychology (21 works) · Clinical Psychology (16 works) · Child and Adolescent Psychosocial and Emotional Development (14 works) · Medicine (14 works) · Clinical Psychology (10 works) · Psychiatry (10 works) · Poison control (7 works) · Social Psychology (7 works) · Child Abuse and Trauma (6 works)