Sybil Hosek
Biographic Data
| ID | 4720628 |
|---|---|
| NAME | Sybil Hosek |
| GIVEN NAMES | Sybil |
| FAMILY NAME | Hosek |
| SIGNATURE | HOSEK S |
| AFFILIATIONS | John H. Stroger, Jr. Hospital of Cook County |
| ORCID | 0000-0001-5230-0759 |
| VERIFIED | Yes |
| TOTAL WORKS | 48 |
| TOTAL CITATIONS | 13 |
| AUTHOR COUNT | 48 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2007 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 2 |
A Systematic Review of Barriers and Facilitators to the Uptake and Adherence of Injectable PrEP Among Adolescent Girls and Young Women in Sub-Saharan Africa
A turning point for youth HIV care in the United States
A Narrative Review of Remote Biospecimen Collection Product and Implementation Considerations for Sexual Health Clinical Research
Remote biospecimen collection (RBSC), such as home-based HIV testing and self-collection of dried blood spots (DBS) to assess adherence to antiretroviral drug regimens, has become an important tool to support clinical research because it can facilitate participant reach, lower participant burden, and reduce discomfort with attending research visits in clinic spaces. RBSC is common in sexual health clinical intervention trials to assess the impact…
Using the Framework for Reporting Adaptation and Modifications-Expanded (FRAME) to Adapt an Evidence-Based HIV-Prevention Intervention for Zambian Adolescent Girls and Young Women
Despite substantial global efforts, adolescent girls and young women (AGYW) in Southern Africa remain disproportionately affected by HIV. In Zambia, the HIV prevalence among AGYW is nearly three times that of their male peers. The Informed Motivated Aware and Responsible Adolescents and Adults (IMARA) program, an evidence-based HIV/STI prevention intervention initially developed in the United States and later adapted in South Africa, demonstrated…
Association between substance use and PrEP adherence among adolescent girls and young women enrolled in an HIV prevention study in Southern Africa
Adolescent girls and young women (AGYW) in sub-Saharan Africa are at substantial risk of HIV acquisition and could benefit from oral pre-exposure prophylaxis (PrEP) for HIV prevention. Substance use may result in poor adherence, diminishing PrEP effectiveness. The effects of substance use on PrEP adherence in AGYW within the African context have not been extensively studied. We sought to determine the prevalence of substance use and its associati…
Dispositional moral attribution and association avoidance
A hybrid effectiveness implementation trial testing an HIV and STI prevention program for mother figures and their adolescent girls and young women delivered by peer leaders
ClinicalTrials.gov, NCT06503666, Registered on 10 July 2024
Motivations for Starting and Stopping PrEP
Oral PrEP effectiveness depends on consistent use during periods of potential HIV exposure, but adolescent girls and young women (AGYW) find this challenging. Data on PrEP use decision-making and alignment with risk among AGYW are limited. From 2016 to 2018, we conducted in-depth interviews with participants in HPTN 082, an open-label PrEP study in South Africa and Zimbabwe, to explore reasons for PrEP starts, stops, and restarts. Of 60 PrEP acce…
The Association Between Use of Adherence Support Interventions and Adherence to HIV Preexposure Prophylaxis Among Young South African and Zimbabwean Women in HPTN 082
We assessed the association between PrEP adherence support interventions and intracellular tenofovir-diphosphate (TFV-DP) levels, a biomarker for PrEP adherence, using data from 368 South African and Zimbabwean adolescent girls and young women enrolled in the HIV Prevention Trials Network 082 trial from 2016 to 2018. Group-based trajectory modeling identified trajectories of TFV-DP levels and adherence support interventions, including weekly two-…
Acceptability and Feasibility of Remote PrEP Visits for Adolescent Girls and Young Women in South Africa
Study-to-Clinic Transition and Daily Oral PrEP Access Experiences Among Agyw in Eastern Cape, South Africa
The Impacts of Substance Use and Depression on HIV Pre-Exposure Prophylaxis Use and Adherence Among Sexual and Gender Minority Adolescents and Young Adults in the Keeping it Lite Cohort
Youth-friendly services was the magic
Adherence to daily oral pre-exposure prophylaxis (PrEP) for HIV prevention has been challenging for adolescent girls and young women (AGYW). As part of The Community PrEP Study (CPS), AGYW were randomised to HIV-prevention empowerment counselling (intervention) or basic medication pick-up (control). In this qualitative sub-study, we interviewed AGYW participants ( n = 39) to explore PrEP use and study experiences by study arm, and study staff ( n…
Hoping to Adhere? Examining the Relationship Between Hope and Pre-exposure Prophylaxis Willingness, Adherence, and Persistence Among Young Women in South Africa and Zimbabwe (HPTN 082)
Hope is a powerful psychological construct which is linked to positive health. Greater hope is associated with improved antiretroviral therapy adherence; however, less is known about the impact of hope on oral pre-exposure prophylaxis (PrEP) outcomes. HIV Prevention Trials Network 082, was an open-label PrEP study among young women (ages 16-25) in South Africa and Zimbabwe. Hope was measured at baseline and follow-up using a subset of the Hope fo…
“I know why I am taking this pill”
There is limited understanding of the dynamic interplay between adolescent girl’s and young women’s (AGYW) disclosure and social support for using oral pre-exposure prophylaxis (PrEP) and adherence. Towards this, we conducted interviews with 42 AGYW enrolled in The Community PrEP Study who exhibited either high or low blood concentrations of tenofovir-diphosphate (TFV-DP) in dried blood spots. Guided by Theories of Practice, interviews and analys…
Access to healthcare among sexual and gender minority youth at risk for HIV
This study examined experiences of healthcare inaccessibility and lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+) discrimination among sexual and gender minority youth at elevated risk for HIV in the United States. Participants for this cross-sectional survey study (N = 3330) were cisgender men, transgender men and women, and nonbinary individuals ages 18–34 recruited for a larger study examining HIV risk behavior between December 2017 …
They’re not feeling the love they need to feel”
Interventions to ameliorate intersectional stigma and its effects are needed to improve primary and secondary HIV prevention in the HBC
It’s already in your body and it’s preventing”
ClinicalTrials.gov ( NCT02404038 ). Registered March 31, 2015-Registered
The Effect of Disclosure of PrEP Use on Adherence Among African Young Women in an Open-Label PrEP Study
To develop effective PrEP adherence interventions, it is important to understand the interplay between disclosure of pre-exposure prophalxis (PrEP) use, social support, and PrEP adherence. We leveraged the HPTN 082 study conducted among 451 adolescent girls and young women (AGYW) (ages 16 to 25 years, 2016 to 2019) in South Africa and Zimbabwe. Among the 349 who had month three disclosure and PrEP adherence data, 60% (n = 206) felt supported by a…
Individual and structural-level Correlates of Pre-exposure Prophylaxis (PrEP) lifetime and current use in a nationwide sample of young sexual and gender minorities
Factors influencing adolescent girls and young women’s uptake of community-based PrEP services following home-based HIV testing in Eastern Cape, South Africa
Experiences of Online Racialized Sexual Discrimination among Sexual and Gender Minorities in the United States
This study sought to analyze prevalence and correlates of online racialized sexual discrimination (RSD), or sexualized discriminatory treatment, in the context of sexualized encounters, among cisgender men and transgender individuals who have sex with men at risk for HIV. Data were collected as part of a baseline survey from a large national sample ( N = 2,166). Among participants of color ( N = 1,042), 84.9% had experienced RSD in the past 6 mon…
The influence of HIV‐related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082
Socio-structural Factors Associated with Mental Health, Substance Use, and HIV Risk Among Black Sexual and Gender Minorities in the House and Ball Community
It’s a Kiki
Younger members of the House and Ball Community (HBC) have created an emerging social scene called "Kiki" that has shared elements with the HBC. Given the growing popularity of the Kiki scene in urban communities with large numbers of Black gay, bisexual, and transgender (GBT) adolescents and emerging adults, it is important to understand the developmental benefits of the Kiki scene. We conducted individual in-depth interviews with 30 GBT adolesc…
Experiences of Online Racialized Sexual Discrimination among Sexual and Gender Minorities in the United States
This study sought to analyze prevalence and correlates of online racialized sexual discrimination (RSD), or sexualized discriminatory treatment, in the context of sexualized encounters, among cisgender men and transgender individuals who have sex with men at risk for HIV. Data were collected as part of a baseline survey from a large national sample ( N = 2,166). Among participants of color ( N = 1,042), 84.9% had experienced RSD in the past 6 mon…
It’s a Kiki
Younger members of the House and Ball Community (HBC) have created an emerging social scene called "Kiki" that has shared elements with the HBC. Given the growing popularity of the Kiki scene in urban communities with large numbers of Black gay, bisexual, and transgender (GBT) adolescents and emerging adults, it is important to understand the developmental benefits of the Kiki scene. We conducted individual in-depth interviews with 30 GBT adolesc…
Narrative sexual histories and perceptions of HIV risk among young women taking PrEP in southern Africa
Reconciling Reality With Fantasy
Studies involving the House Ball Community (HBC) have found high rates of HIV prevalence and undiagnosed HIV infection, as well as unique social and sexual network-related HIV risk and protective behaviors (Murrill et al., 2008; Sanchez et al., 2010). Efforts to understand culturally-appropriate and effective methods of HIV prevention services within the relatively understudied HBC are scarce (Phillips et al., 2011). This qualitative study, utili…
Preliminary results from Hlanganani (Coming Together)
Preferences for Injectable PrEP Among Young U.S. Cisgender Men and Transgender Women and Men Who Have Sex with Men
Stigma and social barriers to medication adherence with urban youth living with HIV
Youth adherence to highly active anti-retroviral therapy (HAART) is poor, and little research exists that identifies the reasons youth have difficulty adhering to medications. Given that complete adherence is necessary for favourable health outcomes, it is essential to examine the obstacles youth face in adhering to HAART. The present investigation sought to identify these barriers and to systematically examine the experiences and attitudes youth…
Development of an easy to use tool to assess HIV treatment readiness in adolescent clinical care settings
Optimal management of HIV disease requires high levels of lifelong adherence once a patient initiates highly active antiretroviral therapy (HAART). Because suboptimal adherence to HAART is associated with adverse consequences, many providers are hesitant to prescribe HAART for patients whom they perceive as not being ready to initiate treatment. Accurately predicting HIV treatment readiness is challenging. Despite the importance of this construct…
The Role of Multiple Identities in Adherence to Medical Appointments Among Gay/Bisexual Male Adolescents Living with HIV
Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men
Preliminary results from Hlanganani (Coming Together)
An HIV intervention tailored for black young men who have sex with men in the House Ball Community
Black young men who have sex with men (BYMSM) are the group most disproportionately impacted by HIV in the USA and most in need of efficacious interventions to address community-level factors that increase their vulnerability to HIV. The House Ball Community (HBC) is a distinct social network within the larger BYMSM community that may be particularly vulnerable to social norms and stigma around HIV. This study tailored an evidence-based, communit…
Acceptability of drug detection monitoring among participants in an open-label pre-exposure prophylaxis study
In the world of HIV pre-exposure prophylaxis (PrEP) research, there is emerging interest in providing study participants with pharmacokinetic results from drug level testing to guide adherence counseling. The iPrEx randomized control trial was the first study to produce meaningful results of PrEP in humans. In the iPrEx open-label extension (OLE) study, blood plasma samples collected in the first 12 weeks of study participation were tested for th…
Reconciling Reality With Fantasy
Studies involving the House Ball Community (HBC) have found high rates of HIV prevalence and undiagnosed HIV infection, as well as unique social and sexual network-related HIV risk and protective behaviors (Murrill et al., 2008; Sanchez et al., 2010). Efforts to understand culturally-appropriate and effective methods of HIV prevention services within the relatively understudied HBC are scarce (Phillips et al., 2011). This qualitative study, utili…
A Randomized Controlled Trial of Power
The Effect of Depressive Symptoms on Adherence to Daily Oral PrEP in Men who have Sex with Men and Transgender Women
An HIV Preexposure Prophylaxis Demonstration Project and Safety Study for Young MSM
BACKGROUND: Young men who have sex with men (YMSM) are a key population for implementation of preexposure prophylaxis (PrEP) interventions. This open-label study examined adherence to PrEP and assessed sexual behavior among a diverse sample of YMSM in 12 US cities. METHODS: Eligible participants were 18- to 22-year-old HIV-uninfected MSM who reported HIV transmission risk behavior in the previous 6 months. Participants were provided daily tenofov…
Ballroom itself can either make you or break you’ – Black GBT Youths’ psychosocial development in the House Ball Community
Social context plays a significant role in adolescent identity development, particularly for youth lacking traditional systems of support. Using ecological and symbolic interactionism perspectives, this study qualitatively explored the psychosocial identity development of Black gay, bisexual, or transgendered youth participating in the House Ball Community (HBC). The HBC is a diverse network of family-like structures called 'houses', as well as a…
Tobacco Use and Sustained Viral Suppression in Youth Living with HIV
Risk, safety and sex among male PrEP users
Recent advances in biomedical HIV prevention have led to optimistic projections of a dramatic worldwide reduction of new infections by 2030. This optimism is counterbalanced by concerns that the protective benefits of one such technology, HIV pre-exposure prophylaxis (PrEP), may be negated by increases in other behaviours that offset these benefits (risk compensation). To contribute to a deeper understanding of concepts of safety and risk in the …
Integrated Next Step Counseling (iNSC) for Sexual Health and PrEP Use Among Young Men Who Have Sex with Men
Pre-exposure prophylaxis (PrEP) for the prevention of HIV infection among young men who have sex with men is a critical part of the HIV prevention landscape in the US. Given the unique challenges and resources of young MSM negotiating safer sex practices, including PrEP, counseling and supportive discussions to optimize both PrEP use and sexual health protection more generally may facilitate reaching HIV prevention goals. Within the context of a …
Project Accept
Age Cohort Differences in Sexual Behaviors Among Black Men Who Have Sex With Men and Women
Little attention has focused on generational or age-related differences in human immunodeficiency virus/sexually transmitted infection (HIV/STI) risk behaviors among Black men who have sex with men and women (BMSMW). We examined sexual risk behaviors between BMSMW ages 40 and under compared to over age 40. Analysis was conducted using Centers for Disease Control and Prevention (CDC)-sponsored intervention data among BMSMW in Los Angeles, Chicago,…
Preferences for Injectable PrEP Among Young U.S. Cisgender Men and Transgender Women and Men Who Have Sex with Men
HIV Acquisition and Transmission Potential Among African American Men Who Have Sex with Men and Women in Three U.S. Cities
HIV pre‐exposure prophylaxis for adolescent girls and young women in Africa
Debrief Reports to Expedite the Impact of Qualitative Research
A measure to assess HIV treatment readiness among adolescents and young adults
HIV infections among adolescents and young adults continue to grow and clinical guidelines recommend the immediate start of life-saving antiretroviral therapy (ART). Unfortunately, suboptimal medication adherence among youth is common and can lead to poorer health outcomes as well as onward transmission of HIV to sexual partners. Clinical tools to assess treatment readiness are needed and can assist with adherence intervention strategies for yout…
The influence of HIV‐related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082
Socio-structural Factors Associated with Mental Health, Substance Use, and HIV Risk Among Black Sexual and Gender Minorities in the House and Ball Community
It’s a Kiki
Younger members of the House and Ball Community (HBC) have created an emerging social scene called "Kiki" that has shared elements with the HBC. Given the growing popularity of the Kiki scene in urban communities with large numbers of Black gay, bisexual, and transgender (GBT) adolescents and emerging adults, it is important to understand the developmental benefits of the Kiki scene. We conducted individual in-depth interviews with 30 GBT adolesc…
HIV/AIDS Research and Interventions (40 works) · Medicine (39 works) · Family medicine (32 works) · Men who have sex with men (25 works) · Psychology (24 works) · Adolescent Sexual and Reproductive Health (22 works) · Public health (22 works) · Human immunodeficiency virus (HIV (21 works) · Psychiatry (20 works) · Health psychology (18 works)