Catherine Orrell

Biographic Data

ID	4871559
NAME	Catherine Orrell
GIVEN NAMES	Catherine
FAMILY NAME	Orrell
SIGNATURE	ORRELL C
AFFILIATIONS	Desmond Tutu HIV Foundation
ORCID	0000-0003-1134-7475
VERIFIED	Yes
TOTAL WORKS	24
TOTAL CITATIONS	1
AUTHOR COUNT	24
EDITOR COUNT	0
FIRST PUBLICATION YEAR	2010
LATEST PUBLICATION YEAR	2026
H-INDEX	1

Suicidal thoughts and behaviours in Cape Town
Open AccessMpho Tlali, Reshma Kassanjee et al.ARTICLESSM - Mental Health2026
Suicidal thoughts and behaviours (STBs) are traditionally attributed to mental disorders; however, increasing evidence indicates that social determinants contribute to suicide risk. We examined STBs and their socioeconomic, psychosocial and clinical correlates in two communities in Cape Town. We conducted psychiatric diagnostic interviews (MINI) at three public-sector facilities (2023-2024). Adults aged ≥18 years, with and without HIV, were recru…
Interest in long-acting injectable antiretroviral therapy (ART) among adults living with HIV newly starting or restarting ART in Cape Town, South Africa
Open AccessTamsin K Phillips, Mpumelelo Zondo et al.ARTICLEAIDS Care2026
Long-acting injectable antiretroviral therapy (LAI ART) has proven effective in maintaining viral suppression among people living with HIV but recommendations to switch to LAI ART are limited to individuals stable and virologically suppressed on oral ART. Understanding LAI perceptions among diverse populations living with HIV is essential. In a cross-sectional survey at two peri-urban clinics in Cape Town, adults starting or restarting treatment …
Brief Report
Open AccessPaul D’Avanzo, Christopher M Ferraris et al.ARTICLEAIDS and Behavior2025
Complexity of Adherence Challenges
Open AccessJeanette L Kaiser, Erin Trowbridge et al.ARTICLEAIDS and Behavior2025
Negative clinic experiences as a barrier to care for people with HIV and their impact on patient preferences for intervention support
Clare Killian, Rebecca West et al.ARTICLEAIDS Care2024
We conducted qualitative research among people with HIV (PWH) and care providers in Cape Town, South Africa to understand the impact of negative clinic experiences on adherence and support preferences. In-depth interviews were conducted with 41 patients with an unsuppressed viral load or a treatment gap, and focus group discussions with physicians, nurses, counselors, and community health workers. Questions addressed treatment history and adheren…
Social networks and HIV treatment adherence among people with HIV initiating treatment in rural Uganda and peri-urban South Africa
Open AccessAlison B Comfort, Stephen Asiimwe et al.ARTICLESSM - Population Health2024
Timely initiation of and adherence to antiretroviral therapy (ART) is critical for improving HIV outcomes and reducing HIV transmissibility. Social networks, or the social relationships individuals have with each other, have been linked with positive health outcomes, but less is known about the extent to which social network composition and structure are associated with improved ART adherence among people living with HIV (PLWH). We conducted an e…
A prospective randomised controlled trial investigating household Sars-CoV-2 transmission in a densely populated community in Cape Town, South Africa – the transmission of Covid-19 in crowded environm…
Open AccessPhilip Smith, Francesca Little et al.ARTICLEBMC Public Health2024
Participants had significant exposure to SARS-CoV-2 infections prior to the study. In this setting, household transmission mitigation was ineffective. However, CHWs may have facilitated other important healthcare and social referrals
A Mixed Methods, Cluster-Randomised Study Protocol to Design and Test WhatsApp Group-Based HIV Microlearning for Rural South African Healthcare Workers
Open AccessBriony Sue Chisholm, Marc Blockman et al.ARTICLEInternational Journal of…2024References: 74
Treatment of HIV in South Africa is informed by national guidelines, which are regularly updated. Ongoing training of healthcare workers is vital for optimal patient care, but is challenging, due to human, financial and infrastructural constraints. There is a need for innovative solutions to meet training and support needs. With 93.2% of South African adults using WhatsApp, it is an ideal platform for training, even in the most remote clinics. Th…
Acceptability of using the medication monitor and experience of a differentiated care approach for TB treatment adherence among people living with TB in South Africa
Open AccessRachel Mukora, Barack Ahumah et al.ARTICLEPLOS Global Public Health2023
Background The introduction of digital adherence technologies (DATs) such as medication monitors in tuberculosis (TB) programmes supports treatment adherence among people with tuberculosis (PWTB). We evaluated the acceptability of using medication monitors (Wisepill evriMED) prompting a stepwise differentiated care approach (DCA), involving short message service (SMS), phone calls, home visits and motivational counselling, among PWTB in South Afr…
Perspectives of people living with HIV and health workers about a point-of-care adherence assay
Open AccessAbenathi Mcinziba, Dillon T Wademan et al.ARTICLEAIDS Care2023
Current antiretroviral therapy (ART) adherence monitoring is premised on patients’ self-reported adherence behaviour (prone to recall error) and verified by blood viral load measurement (which can delay results). A newly developed Urine Tenofovir Rapid Assay (UTRA) assesses tenofovir in urine at point-of-care and is a novel tool to test and immediately respond to adherence levels of people living with HIV (PLHIV). We explored PLHIV and health wor…
Acceptability and Feasibility of Providing Adherence Feedback Based on Tenofovir Diphosphate in Dried Blood Spots
Open AccessChristopher M Ferraris, Paul D’Avanzo et al.ARTICLEAIDS and Behavior2023
Patients’ and Providers’ Views on Optimal Evidence-Based and Scalable Interventions for Individuals at High Risk of HIV Treatment Failure
Open AccessLora Sabin, Allen L Gifford et al.ARTICLEAIDS and Behavior2022
Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa
Open AccessJennifer M Belus, John A Joska et al.ARTICLEAIDS and Behavior2022
Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adherence and AOD reduction. We enrolled 61 participants from HIV care and examined outcomes at 3- and 6-months compared to enhanced treatment as usual (…
Understanding Repeat Positive HIV Testing in South Africa Under Changing Treatment Guidelines
Open AccessMaria F Nardell, Bethany Hedt-Gauthier et al.ARTICLEAIDS and Behavior2021
Community acceptability of dolutegravir-based HIV treatment in women
Open AccessYussif Alhassan, Adelline Twimukye et al.ARTICLEBMC Public Health2020
Dolutegravir-based regimens were found to be generally acceptable for use in women except during pregnancy. Interest in a dolutegravir-based regimen was linked with its perceived potential to enhance health, privacy and reduce stigma while concerns about neural tube defects were the main potential barrier to dolutegravir uptake in women. In order to optimise the community acceptability and uptake of acceptability-based regimen among women it is c…
Influences on Adherence to Antiretroviral Therapy (ART) in Early-Stage HIV Disease
Open Accessthe META Study Team, N C Ware et al.ARTICLEAIDS and Behavior2020
The Treatment Ambassador Program
Open AccessIngrid T Katz, Laura M Bogart et al.ARTICLEAIDS and Behavior2020
Trajectories of HIV-related internalized stigma and disclosure concerns among art initiators and noninitiators in South Africa
Open AccessBrian T Chan, Brendan Maughan-Brown et al.ARTICLEStigma and Health2019
Among ART-eligible South African PLHIV entering into HIV care, internalized stigma modestly declined over time but disclosure concerns persisted. PLHIV who initiated ART were more likely to have persistent disclosure concerns over time as compared with those who did not start ART
Biomarker-Measured Unhealthy Alcohol Use in Relation to CD4 Count Among Individuals Starting ART in Sub-Saharan Africa
Open Accessthe META team, Jessica F Magidson et al.ARTICLEAIDS and Behavior2018
Individuals are initiating antiretroviral therapy (ART) at earlier HIV disease stages. Unhealthy alcohol use is a known barrier to successful HIV treatment outcomes, yet it is unclear whether the problem varies by disease stage. We measured alcohol use with an objective biomarker (phosphatidylethanol [PEth]), comparing individuals (n = 401) with early (CD4 > 350 cells/mL, WHO Stage 1) versus late (CD4 2 = 9.30; p < 0.01). Addressing unhealthy alc…
Exploring Treatment Needs and Expectations for People Living with HIV in South Africa
Open AccessValerie A Earnshaw, Laura M Bogart et al.ARTICLEAIDS and Behavior2018
Factors that Motivated Otherwise Healthy HIV-Positive Young Adults to Access HIV Testing and Treatment in South Africa
Open AccessR Frederick Lambert, Catherine Orrell et al.ARTICLEAIDS and Behavior2017
CD4 count at antiretroviral therapy initiation and the risk of loss to follow-up
Anna Grimsrud, Morna Cornell et al.ARTICLEJournal of Epidemiology and…2016Cited by: 1References: 21
BACKGROUND: Antiretroviral therapy (ART) initiation is now recommended irrespective of CD4 count. However data on the relationship between CD4 count at ART initiation and loss to follow-up (LTFU) are limited and conflicting. METHODS: We conducted a cohort analysis including all adults initiating ART (2008-2012) at three public sector sites in South Africa. LTFU was defined as no visit in the 6 months before database closure. The Kaplan-Meier esti…
Guidelines for Improving Entry Into and Retention in Care and Antiretroviral Adherence for Persons With HIV
Open AccessMelanie Thompson, Melanie A Thompson et al.ARTICLEAnnals of Internal Medicine2012
DESCRIPTION: After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). Adherence to ART is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of drug resistance. The International Association of Physicians in AIDS Care convened a panel to develop evidence-based recommendations to optimize entry …
Standard Measures are Inadequate to Monitor Pediatric Adherence in a Resource-Limited Setting
Open AccessAlex Müller, Alexandra D Müller et al.ARTICLEAIDS and Behavior2010
This study aims to compare the use and cost of objective and subjective measures of adherence to pediatric antiretroviral treatment in a primary care facility in South Africa. In a 1-month longitudinal study of 53 caregiver-child dyads, pharmacy refill (PR), measurement of returned syrups (RS), caregiver self-report (3DR) and Visual Analogue Scale (VAS) were compared to Medication Event Monitoring System (MEMS). Adherence was 100% for both VAS an…