Madhukar H Trivedi
Biographic Data
| ID | 4879524 |
|---|---|
| NAME | Madhukar H Trivedi |
| GIVEN NAMES | Madhukar H |
| FAMILY NAME | Trivedi |
| SIGNATURE | TRIVEDI M H |
| AFFILIATIONS | The University of Texas Southwestern Medical Center |
| ORCID | 0000-0002-2983-1110 |
| VERIFIED | Yes |
| TOTAL WORKS | 24 |
| TOTAL CITATIONS | 17 |
| AUTHOR COUNT | 24 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1995 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 2 |
Innovative Development of Research Engagement Manual: Strategies to Enhance Recruitment and Retention of Black Individuals in Clinical Trials for Substance Use Disorders
Background: The participation of Black individuals in clinical trials remains lower than that of other racial and ethnic groups. Substance abuse adds additional barriers to recruitment and retention. While significant attention has been devoted to identifying barriers to recruitment/retention, efforts have been largely unsuccessful in increasing the participation of Black individuals in clinical trials. This article details Phase 1 efforts to dev…
Pilot evaluation on an adapted tele-behavioral activation to increase physical activity in persons with depression: A single-arm pilot study
ClinicalTrials.gov NCT04990401, Registered July 21, 2021
Characterizing Measurement-Based Care in the Texas Youth Depression and Suicide Research Network (TX-YDSRN)
Integration of measurement-based care (MBC) into clinical practice has shown promise in improving treatment outcomes for depression. Yet, without a gold standard measure of MBC, assessing fidelity to the MBC model across various clinical settings is difficult. A central goal of the Texas Youth Depression and Suicide Research Network (TX-YDSRN) was to characterize MBC across the state of Texas through the development of a standardized tool to asse…
Shifting From Best Practice to Standard Practice: Implementing Measurement-Based Care in Health Systems
Integration of Measurement-Based Care for Youth Depression and Suicidality Using VitalSign6
Depression and suicidality are prevalent in youth and are associated with a range of negative outcomes. The current study aimed to evaluate a measurement-based care (MBC) software (VitalSign 6 ) tool to improve the screening and treatment of depression and suicidality in youth aged 8-17 years within a rural, underserved population. To assess for depression and suicidality, the Patient Health Questionnaire-2 was administered as an initial screen, …
The 9-item Concise Health Risk Tracking – Self-Report (CHRT-SR9) measure of suicidal risk: Performance in adult primary care patients
The CHRT-SR 9 is a brief self-report evaluating suicidality with excellent psychometric properties that is sensitive to change over time
Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants
BACKGROUND: The treatment of depression in children and adolescents is a substantial public health challenge. This study examined artificial intelligence tools for the prediction of early outcomes in depressed children and adolescents treated with fluoxetine, duloxetine, or placebo. METHODS: The study samples included training datasets (N = 271) from patients with major depressive disorder (MDD) treated with fluoxetine and testing datasets from p…
Circulating microRNA associated with future relapse status in major depressive disorder
Major depressive disorder (MDD) is an episodic condition with relapsing and remitting disease course. Elucidating biomarkers that can predict future relapse in individuals responding to an antidepressant treatment holds the potential to identify those patients who are prone to illness recurrence. The current study explored relationships between relapse risk in recurrent MDD and circulating microRNAs (miRNAs) that participate in RNA silencing and …
Psychometric Evaluation of the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire in a General Youth Population
Brain regulation of emotional conflict predicts antidepressant treatment response for depression
Racial and ethnic differences in treatment outcomes among adults with stimulant use disorders after a dosed exercise intervention
The current study examined differences in substance abuse treatment outcomes among racial and ethnic groups enrolled in the Stimulant Reduction Intervention using Dosed Exercise (STRIDE) trial, a multisite randomized clinical trial implemented through the National Institute on Drug Abuse's (NIDA's) Clinical Trials Network (CTN). STRIDE aimed to test vigorous exercise as a novel approach to the treatment of stimulant abuse compared to a health edu…
Comorbidities and Race/Ethnicity Among Adults with Stimulant Use Disorders in Residential Treatment
Comorbid physical and mental health problems are associated with poorer substance abuse treatment outcomes; however, little is known about these conditions among stimulant abusers at treatment entry. This study compared racial and ethnic groups on baseline measures of drug use patterns, comorbid physical and mental health disorders, quality of life, and daily functioning among cocaine and stimulant abusing/dependent patients. Baseline data from a…
Relationship Between Obesity and Depression: Characteristics and Treatment Outcomes With Antidepressant Medication
OBJECTIVE: Obesity and major depressive disorder often co-occur. However, differences between obese and normal-weight depressed patients and the moderating effect of obesity on antidepressant treatment outcome are not well studied. METHODS: Adults (n = 662) with major depressive disorder in the Combining Medications to Enhance Depression Outcomes study were randomized to treatment with escitalopram plus placebo, bupropion plus escitalopram, or ve…
Research staff training in a multisite randomized clinical trial: Methods and recommendations from the stimulant reduction intervention using dosed exercise (STRIDE) trial
Practical recommendations are provided for training research staff and are particularly applicable to the challenges encountered with large, multisite trials
Risk for Partner Victimization and Marital Dissatisfaction Among Chronically Depressed Patients
Functional Connectivity of Brain Structures Correlates with Treatment Outcome in Major Depressive Disorder
Identifying biosignatures to assess the probability of response to an antidepressant for patients with major depressive disorder (MDD) is critically needed. Functional connectivity MRI (fcMRI) offers the promise to provide such a measure. Previous work with fcMRI demonstrated that the correlation in signal from one region to another is a measure of functional connectivity. In this pilot work, a baseline non-task fcMRI was acquired in 14 adults wi…
Course and Severity of Maternal Depression: Associations with Family Functioning and Child Adjustment
Ethnicity/Race and Outcome in the Treatment of Depression: Results From STAR*D
OBJECTIVES: This secondary analysis of data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study compared rates of remission and response for blacks (n = 495), whites (n = 1853), and Hispanics (n = 327) with nonpsychotic major depressive disorder who were treated with citalopram. METHODS: STAR*D included representative outpatients treated in 23 psychiatric and 18 primary care centers. Participants received flexible doses…
Evaluation of Outcomes With Citalopram for Depression Using Measurement-Based Care in STAR*D: Implications for Clinical Practice
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression, but the rates, timing, and baseline predictors of remission in "real world" patients are not established. The authors' primary objectives in this study were to evaluate the effectiveness of citalopram, an SSRI, using measurement-based care in actual practice, and to identify predictors of symptom remission in outpatients with major depressive disorder.…
Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
OBJECTIVE: This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. METHOD: A broadly representative adult outpatient sample with nonpsychotic major depressive disorder received one (N=3,671) to four (N=123) successive acute treatment steps. Those not achieving remission with or unable…
Reductions in Stress and Depressive Symptoms in Mothers of Substance-Exposed Infants, Participating in a Psychosocial Program
The 16-Item quick inventory of depressive symptomatology (Qids), clinician rating (Qids-C), and self-report (Qids-SR): A psychometric evaluation in patients with chronic major depression
Physical activity dose-response effects on outcomes of depression and anxiety
PURPOSE: The purpose of this study was to examine the scientific evidence for a dose-response relation of physical activity with depressive and anxiety disorders. METHODS: Computer database searches of MEDLINE, PsychLit, and Internet and personal retrieval systems to locate population studies, randomized controlled trials (RCTs), observational studies, and consensus panel judgments were conducted. RESULTS: Observational studies demonstrate that g…
Dream recall and major depression: A preliminary report
Dream recall and major depression: A preliminary report
Physical activity dose-response effects on outcomes of depression and anxiety
PURPOSE: The purpose of this study was to examine the scientific evidence for a dose-response relation of physical activity with depressive and anxiety disorders. METHODS: Computer database searches of MEDLINE, PsychLit, and Internet and personal retrieval systems to locate population studies, randomized controlled trials (RCTs), observational studies, and consensus panel judgments were conducted. RESULTS: Observational studies demonstrate that g…
The 16-Item quick inventory of depressive symptomatology (Qids), clinician rating (Qids-C), and self-report (Qids-SR): A psychometric evaluation in patients with chronic major depression
Reductions in Stress and Depressive Symptoms in Mothers of Substance-Exposed Infants, Participating in a Psychosocial Program
Evaluation of Outcomes With Citalopram for Depression Using Measurement-Based Care in STAR*D: Implications for Clinical Practice
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression, but the rates, timing, and baseline predictors of remission in "real world" patients are not established. The authors' primary objectives in this study were to evaluate the effectiveness of citalopram, an SSRI, using measurement-based care in actual practice, and to identify predictors of symptom remission in outpatients with major depressive disorder.…
Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
OBJECTIVE: This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. METHOD: A broadly representative adult outpatient sample with nonpsychotic major depressive disorder received one (N=3,671) to four (N=123) successive acute treatment steps. Those not achieving remission with or unable…
Ethnicity/Race and Outcome in the Treatment of Depression: Results From STAR*D
OBJECTIVES: This secondary analysis of data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study compared rates of remission and response for blacks (n = 495), whites (n = 1853), and Hispanics (n = 327) with nonpsychotic major depressive disorder who were treated with citalopram. METHODS: STAR*D included representative outpatients treated in 23 psychiatric and 18 primary care centers. Participants received flexible doses…
Course and Severity of Maternal Depression: Associations with Family Functioning and Child Adjustment
Functional Connectivity of Brain Structures Correlates with Treatment Outcome in Major Depressive Disorder
Identifying biosignatures to assess the probability of response to an antidepressant for patients with major depressive disorder (MDD) is critically needed. Functional connectivity MRI (fcMRI) offers the promise to provide such a measure. Previous work with fcMRI demonstrated that the correlation in signal from one region to another is a measure of functional connectivity. In this pilot work, a baseline non-task fcMRI was acquired in 14 adults wi…
Risk for Partner Victimization and Marital Dissatisfaction Among Chronically Depressed Patients
Relationship Between Obesity and Depression: Characteristics and Treatment Outcomes With Antidepressant Medication
OBJECTIVE: Obesity and major depressive disorder often co-occur. However, differences between obese and normal-weight depressed patients and the moderating effect of obesity on antidepressant treatment outcome are not well studied. METHODS: Adults (n = 662) with major depressive disorder in the Combining Medications to Enhance Depression Outcomes study were randomized to treatment with escitalopram plus placebo, bupropion plus escitalopram, or ve…
Research staff training in a multisite randomized clinical trial: Methods and recommendations from the stimulant reduction intervention using dosed exercise (STRIDE) trial
Practical recommendations are provided for training research staff and are particularly applicable to the challenges encountered with large, multisite trials
Comorbidities and Race/Ethnicity Among Adults with Stimulant Use Disorders in Residential Treatment
Comorbid physical and mental health problems are associated with poorer substance abuse treatment outcomes; however, little is known about these conditions among stimulant abusers at treatment entry. This study compared racial and ethnic groups on baseline measures of drug use patterns, comorbid physical and mental health disorders, quality of life, and daily functioning among cocaine and stimulant abusing/dependent patients. Baseline data from a…
Racial and ethnic differences in treatment outcomes among adults with stimulant use disorders after a dosed exercise intervention
The current study examined differences in substance abuse treatment outcomes among racial and ethnic groups enrolled in the Stimulant Reduction Intervention using Dosed Exercise (STRIDE) trial, a multisite randomized clinical trial implemented through the National Institute on Drug Abuse's (NIDA's) Clinical Trials Network (CTN). STRIDE aimed to test vigorous exercise as a novel approach to the treatment of stimulant abuse compared to a health edu…
Brain regulation of emotional conflict predicts antidepressant treatment response for depression
Psychometric Evaluation of the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire in a General Youth Population
Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants
BACKGROUND: The treatment of depression in children and adolescents is a substantial public health challenge. This study examined artificial intelligence tools for the prediction of early outcomes in depressed children and adolescents treated with fluoxetine, duloxetine, or placebo. METHODS: The study samples included training datasets (N = 271) from patients with major depressive disorder (MDD) treated with fluoxetine and testing datasets from p…
Circulating microRNA associated with future relapse status in major depressive disorder
Major depressive disorder (MDD) is an episodic condition with relapsing and remitting disease course. Elucidating biomarkers that can predict future relapse in individuals responding to an antidepressant treatment holds the potential to identify those patients who are prone to illness recurrence. The current study explored relationships between relapse risk in recurrent MDD and circulating microRNAs (miRNAs) that participate in RNA silencing and …
The 9-item Concise Health Risk Tracking – Self-Report (CHRT-SR9) measure of suicidal risk: Performance in adult primary care patients
The CHRT-SR 9 is a brief self-report evaluating suicidality with excellent psychometric properties that is sensitive to change over time
Pilot evaluation on an adapted tele-behavioral activation to increase physical activity in persons with depression: A single-arm pilot study
ClinicalTrials.gov NCT04990401, Registered July 21, 2021
Characterizing Measurement-Based Care in the Texas Youth Depression and Suicide Research Network (TX-YDSRN)
Integration of measurement-based care (MBC) into clinical practice has shown promise in improving treatment outcomes for depression. Yet, without a gold standard measure of MBC, assessing fidelity to the MBC model across various clinical settings is difficult. A central goal of the Texas Youth Depression and Suicide Research Network (TX-YDSRN) was to characterize MBC across the state of Texas through the development of a standardized tool to asse…
Shifting From Best Practice to Standard Practice: Implementing Measurement-Based Care in Health Systems
Integration of Measurement-Based Care for Youth Depression and Suicidality Using VitalSign6
Depression and suicidality are prevalent in youth and are associated with a range of negative outcomes. The current study aimed to evaluate a measurement-based care (MBC) software (VitalSign 6 ) tool to improve the screening and treatment of depression and suicidality in youth aged 8-17 years within a rural, underserved population. To assess for depression and suicidality, the Patient Health Questionnaire-2 was administered as an initial screen, …
Innovative Development of Research Engagement Manual: Strategies to Enhance Recruitment and Retention of Black Individuals in Clinical Trials for Substance Use Disorders
Background: The participation of Black individuals in clinical trials remains lower than that of other racial and ethnic groups. Substance abuse adds additional barriers to recruitment and retention. While significant attention has been devoted to identifying barriers to recruitment/retention, efforts have been largely unsuccessful in increasing the participation of Black individuals in clinical trials. This article details Phase 1 efforts to dev…
Medicine (19 works) · Psychiatry (19 works) · Psychology (17 works) · Clinical Psychology (15 works) · Clinical Psychology (12 works) · Anxiety (9 works) · Treatment of Major Depression (8 works) · Antidepressant (6 works) · Depression (economics (6 works) · Depression (economics) (6 works)