David S Sheps
Biographic Data
| ID | 4889655 |
|---|---|
| NAME | David S Sheps |
| GIVEN NAMES | David S |
| FAMILY NAME | Sheps |
| SIGNATURE | SHEPS D S |
| AFFILIATIONS | University of North Carolina at Chapel Hill |
| VERIFIED | No |
| TOTAL WORKS | 39 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 39 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1991 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 0 |
Relationship of Psychological Characteristics to Daily Life Ischemia
OBJECTIVE: Cardiac ischemia during daily life is associated with an increased risk of adverse outcomes. Mental stress is known to provoke cardiac ischemia and is related to psychological variables. In this multicenter cohort study, we assessed whether psychological characteristics were associated with ischemia in daily life. METHODS: This study examined patients with clinically stable coronary artery disease (CAD) with documented cardiac ischemia…
The Mental Stress Ischemia Prognosis Study
OBJECTIVE: Mental stress-induced myocardial ischemia (MSIMI) is a common phenomenon in patients with coronary artery disease (CAD), but contemporary studies of its prognostic significance and its underlying pathophysiology are limited. METHODS: We prospectively enrolled patients with confirmed CAD in the Mental Stress Ischemia Prognosis Study (MIPS) between 2011 and 2014. All patients underwent mental stress testing using a standardized public sp…
Association of Vitamin D Status With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease
BACKGROUND: Mental stress-induced (MSIMI) or physical stress-induced (PSIMI) myocardial ischemia portends a worse prognosis in patients with coronary artery disease (CAD). Vitamin D insufficiency is associated with adverse cardiovascular outcomes, but its relationship to myocardial ischemia remains unclear. We hypothesized that vitamin D insufficiency will be associated with a higher prevalence of myocardial ischemia in patients with CAD. METHODS…
Myocardial Ischemia and Angiotensin-Converting Enzyme Inhibition
OBJECTIVE: Mental stress provokes myocardial ischemia in many patients with stable coronary artery disease (CAD). Mental stress-induced myocardial ischemia (MSIMI) portends a worse prognosis, independent of standard cardiac risk factors or outcome of traditional physical stress testing. Angiotensin II plays a significant role in the physiological response to stress, but its role in MSIMI remains unknown. Our aim was to evaluate whether the use of…
A Noninvasive Clinically Useful Predictor for Mental Stress-Induced Ischemia
Hassan, Mustafa MD; Quyyumi, Arshed A. MD, FRCP; Sheps, David S. MD, MSPH Author Information
When Husband and Wife Become Doctor and Patient
Atlanta VA Medical Center; Division of Cardiology; Emory University School of Medicine; Atlanta, Georgia Dr. Zaret's article is an unusual one for this journal—we rarely publish essays or clinical vignettes. We are interested in whether our readers would like to see similar articles published on an occasional basis in Psychosomatic Medicine. Please respond by email to [email protected]. Address correspondence and reprint requests to David S. Shep…
What’s in a Name? Psychosomatic Medicine and Biobehavioral Medicine
Freedland, Kenneth E. PhD; de Geus, Eco J.C. PhD; Golden, Robert N. MD; Kop, Willem J. PhD; Miller, Gregory E. PhD; Vaccarino, Viola MD, PhD; Brumback, Babette PhD; Llabre, Maria M. PhD; White, Victoria J. MA; Sheps, David S. MD, MSPH Author Information
Depression, the Metabolic Syndrome and Cardiovascular Risk
BACKGROUND: The relationship between depression and the metabolic syndrome is unclear, and whether metabolic syndrome explains the association between depression and cardiovascular disease (CVD) risk is unknown. METHODS: We studied 652 women who received coronary angiography as part of the Women's Ischemia Syndrome Evaluation (WISE) study and completed the Beck Depression Inventory (BDI). Women who had both elevated depressive symptoms (BDI > or …
Social Networks and Incident Stroke Among Women With Suspected Myocardial Ischemia
OBJECTIVE: To describe the prospective relationship between social networks and nonfatal stroke events in a sample of women with suspected myocardial ischemia. Social networks are an independent predictor of all-cause and cardiovascular mortality, but their relationship with stroke events in at-risk populations is largely unknown. METHOD: A total of 629 women (mean age = 59.6 +/- 11.6 years) were evaluated at baseline for cardiovascular disease r…
Depressive Symptoms Predict Heart Rate Recovery After Exercise Treadmill Testing in Patients With Coronary Artery Disease
BACKGROUND: Depression is associated with increased risk of death among patients with coronary disease. Cardiovascular autonomic dysregulation may be one of the mechanisms by which depression exerts its effects on cardiovascular function. The purpose of this study was to determine whether depressive symptoms are associated with low heart rate variability (HRV) and prolonged HR recovery after exercise testing in patients with coronary artery disea…
Psychosomatic Medicine Reviewers
Psychosomatic Medicine: February 2008 - Volume 70 - Issue 2 - p 266-267 doi: 10.1097/PSY.0b013e3181684025
Psychosomatic Medicine Goes (Almost) Monthly
Editor-in-Chief, Division of Cardiovascular Medicine, University of Florida, Gainesville A version of this article appeared in the American Psychosomatic Society newsletter 2006, Volume 17, Issue No. 2
Psychological Stress and Myocardial Ischemia
Sheps, David S. MD, MSPH; Soufer, Robert MD; Freedland, Kenneth E. PhD Author Information
Coronary Artery Disease and Depression
OBJECTIVE: To investigate the relationship between symptoms of depression and cardiovascular reactivity during mental stress in patients with coronary artery disease (CAD). Depressive symptoms are common in patients with CAD and are related to an increased risk of cardiac events and death. Some researchers have proposed that negative outcomes in depressed patients with CAD may be related to exaggerated cardiovascular reactivity and psychological …
Do Men and Women Differ on Measures of Mental Stress-Induced Ischemia
Objective: To consider the effects of gender on ischemia in a larger sample, with broadly defined coronary artery disease (CAD). Mental stress has been shown to cause transient myocardial ischemia in a significant percentage of people with CAD. However, little is known about the effects of mental stress on ischemic processes in women. Most studies to date either had few women or required a positive exercise stress test. Methods: Participants (61 …
Panic Attacks, Daily Life Ischemia, and Chest Pain in Postmenopausal Women
Background: Chest pain is a common symptom of panic attacks, but little is known about the relationship in older women among panic attacks, chest pain, and daily life ischemia. Methods: The authors conducted a cross-sectional survey of 3063 community-dwelling, generally healthy postmenopausal women enrolled between 1997 and 2000 in the Myocardial Ischemia and Migraine Study in 10 clinical centers of the 40-center Women’s Health Initiative. Partic…
Assessment and Treatment of Depression in Patients With Cardiovascular Disease
Objective: The National Heart, Lung, and Blood Institute convened an interdisciplinary working group of experts to develop recommendations for the assessment and treatment of depression in patients with coronary heart disease (CHD). Method: Consensus of experts. Results: Our current recommendations are that the Beck Depression Inventory-I be employed for epidemiological studies of depression and CHD, that the Patient Health Questionnaire 2-item v…
The Great Debate, Revisited
Freedland, Kenneth E. PhD; Miller, Gregory E. PhD; Sheps, David S. MD, MSPH Author Information
Statistical Guidelines for Psychosomatic Medicine
During the past two years, Psychosomatic Medicine joined many of the leading medical journals in adopting the CONSORT, MOOSE, QUOROM, and STARD guidelines for reporting clinical trials, meta-analyses, and diagnostic studies. This year, we are implementing our own set of statistical analysis guidelines. In doing so, we are joining a much smaller number of journals. Whether we are setting a trend, or simply going out on a limb, remains to be seen. …
Rivers of Research
Department of Psychiatry; Washington University School of Medicine; St. Louis, Missouri; [email protected] (Freedland) Department of Medicine, Division of Cardiovascular Medicine; University of Florida, Malcom Randall VA Medical Center; Gainesville, Florida (Sheps)
From Feeling Blue to Clinical Depression
From the Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Malcom Randall VA Medical Center, Gainesville, Florida D.S.S.); and the Division of Cardiology, St. Luke's–Roosevelt Hospital Center, and the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY (A.R.). Address correspondence and reprint requests to David S. Sheps, MD, MSPH, Department of Medicine, Division of Cardi…
The Interheart Study
Sheps, David S. MD, MSPH; Frasure-Smith, Nancy PhD; Freedland, Kenneth E. PhD; Carney, Robert M. PhD Author Information
Depression is a Risk Factor for Mortality in Coronary Heart Disease
Carney, Robert M. PhD; Freedland, Kenneth E. PhD; Sheps, David S. MD, MSPH Author Information
Chest Pain in Patients With Cardiac and Noncardiac Disease
Objective: To describe factors influencing chest pain expression in patients with cardiac or noncardiac disease. Methods: The authors conducted a case presentation and review of literature. Results: Causes of chest pain are diverse. Psychologic factors influence chest pain expression commonly in patients with or without cardiac disease. Conclusions: Physicians and other therapists must be aware of psychologic influences on chest pain expression t…
Mini-Series on Timing of Death
Psychosomatic Medicine: May 2004 - Volume 66 - Issue 3 - p 372 doi: 10.1097/01.PSY.0000129696.13858.43
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Depression and type A behavior pattern in patients with coronary artery disease
A sample of 45 patients with a history of coronary heart disease and documented myocardial ischemia during exercise testing were evaluated in an investigation of the possible relationships between psychological factors (depression and Type A behavior pattern), plasma beta-endorphin response and pain experience during maximal exercise-induced ischemia. Depression was assessed using the MMPI-D subscale, while Type A was evaluated using the Structur…
Heart Rate Variability in Patients with Coronary Artery Disease
OBJECTIVE: This study tested the hypothesis that coronary artery disease patients with higher depression scores have lower heart rate variability during daily life. METHOD: Thirty-three men and nine women, ranging in age from 46 to 79, with coronary artery disease and exercise-induced ischemia were studied. The standard deviation of normal R-R intervals (SDNN) and average heart rate were obtained from 24-hour ambulatory electrocardiographic monit…
Ischemic but Not Thermal Pain Sensitivity Varies Across the Menstrual Cycle
OBJECTIVE AND METHOD: Findings from both animal and human research suggest that pain sensitivity changes across the menstrual cycle; however, among humans the nature of these menstrual cycle effects remains unclear. The present study used a repeated-measures design to evaluate changes in thermal and ischemic pain responses during three phases of the menstrual cycle, midfollicular (postmenstrual), ovulatory, and mid-to-late luteal (premenstrual), …
The Psychophysiological Investigations of Myocardial Ischemia (Pimi) Study
OBJECTIVE: This study evaluated physiological, neuroendocrine, and psychological status and functioning of patients with coronary artery disease in order to clarify their role in the expression of symptoms during myocardial ischemia (MI), and to establish repeatability of responses to mental stress. Design and methods of the study are presented. METHODS: One hundred ninety-six coronary artery disease patients were examined during physical and men…
Depressive Symptoms and Heart Rate Variability
Sheffield, D. PhD; Sheps, D.S. MD; Light, K.C. PhD; Freedland, K.E. PhD; Carney, R.M. PhD; Coghlan, C.G. MD; Cohen, J.D. MD; Goldberg, A.D. MD; Pepine, C.J. MD; Stone, P.H. MD; Kaufmann, P.G. PhD; McMahon, R.P. PhD Author Information
Reproducibility of Mental Stress-Induced Myocardial Ischemia in the Psychophysiological Investigations of Myocardial Ischemia (Pimi)
OBJECTIVE: Many patients with coronary artery disease (CAD) develop myocardial ischemia in response to mental stress. This has been documented both in the natural environment and in the laboratory. However, the reproducibility of laboratory mental stress-induced ischemia has not been investigated. METHOD: Sixty patients with documented CAD and a positive exercise stress test discontinued cardiac medications and underwent two standardized mental s…
Symposium Synopsis
s of Papers for 1999 Annual Meeting: Debate: Is Depression A Major Risk Factor for CAD? Pro Vs. Con
Blood Pressure Responses to Marital Support
s of Papers for 1999 Annual Meeting: Symposium: Social Interactions, Relationships, and Cardiovascular Response
Race and Sex Differences in Cutaneous Pain Perception
OBJECTIVE: The purpose of this study was to determine race and sex differences in cutaneous pain perception. METHODS: Pain perception was measured using a suprathreshold evaluation of pain intensity and pain unpleasantness to a series of thermal stimuli in 27 whites (14 men and 13 women) and 24 African Americans (12 men and 12 women). Blood pressure, depressive symptoms, anxiety state levels, and negative mood were assessed before pain testing to…
Psychological Correlates of Mental Stress-induced Ischemia in the Laboratory
Participants consisted of 184 patients (160 males, 24 females) with positive angiograms or prior myocardial infarctions who displayed at least 1 mm of ST segment depression on a standardized treadmill test. Mean scores on the Reward Dependence subscale of the Tridimensional Personality Questionnaire were higher in patients displaying ischemia during mental stress. Patients who reported higher levels of irritability/anger in response to the Speech…
Increasing the Impact of Psychosomatic Medicine
ENRICHD and Sadhart
Sheps, David S. MD, MSPH; Freedland, Kenneth E. PhD; Golden, Robert N. MD; McMahon, Robert P. PhD Author Information
Changes in the Air at Psychosomatic Medicine
Division of Cardiovascular Medicine Department of Medicine University of Florida Gainesville, FL 32610 Email: [email protected]
The Interheart Study
Sheps, David S. MD, MSPH; Frasure-Smith, Nancy PhD; Freedland, Kenneth E. PhD; Carney, Robert M. PhD Author Information
Depression is a Risk Factor for Mortality in Coronary Heart Disease
Carney, Robert M. PhD; Freedland, Kenneth E. PhD; Sheps, David S. MD, MSPH Author Information
Chest Pain in Patients With Cardiac and Noncardiac Disease
Objective: To describe factors influencing chest pain expression in patients with cardiac or noncardiac disease. Methods: The authors conducted a case presentation and review of literature. Results: Causes of chest pain are diverse. Psychologic factors influence chest pain expression commonly in patients with or without cardiac disease. Conclusions: Physicians and other therapists must be aware of psychologic influences on chest pain expression t…
Mini-Series on Timing of Death
Psychosomatic Medicine: May 2004 - Volume 66 - Issue 3 - p 372 doi: 10.1097/01.PSY.0000129696.13858.43
In the Statistical Corner
This issue of Psychosomatic Medicine marks the debut of the Statistical Corner. The goals of this new feature are to promote good statistical practices, to introduce readers to advanced statistical methods, to provide practical guides to specific techniques, and to address methodological issues in psychosomatic research. The articles will be invited and peer reviewed. We decided to launch this feature because there is a growing statistics gap in …
Statistical Guidelines for Psychosomatic Medicine
During the past two years, Psychosomatic Medicine joined many of the leading medical journals in adopting the CONSORT, MOOSE, QUOROM, and STARD guidelines for reporting clinical trials, meta-analyses, and diagnostic studies. This year, we are implementing our own set of statistical analysis guidelines. In doing so, we are joining a much smaller number of journals. Whether we are setting a trend, or simply going out on a limb, remains to be seen. …
Rivers of Research
Department of Psychiatry; Washington University School of Medicine; St. Louis, Missouri; [email protected] (Freedland) Department of Medicine, Division of Cardiovascular Medicine; University of Florida, Malcom Randall VA Medical Center; Gainesville, Florida (Sheps)
From Feeling Blue to Clinical Depression
From the Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Malcom Randall VA Medical Center, Gainesville, Florida D.S.S.); and the Division of Cardiology, St. Luke's–Roosevelt Hospital Center, and the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY (A.R.). Address correspondence and reprint requests to David S. Sheps, MD, MSPH, Department of Medicine, Division of Cardi…
Panic Attacks, Daily Life Ischemia, and Chest Pain in Postmenopausal Women
Background: Chest pain is a common symptom of panic attacks, but little is known about the relationship in older women among panic attacks, chest pain, and daily life ischemia. Methods: The authors conducted a cross-sectional survey of 3063 community-dwelling, generally healthy postmenopausal women enrolled between 1997 and 2000 in the Myocardial Ischemia and Migraine Study in 10 clinical centers of the 40-center Women’s Health Initiative. Partic…
Assessment and Treatment of Depression in Patients With Cardiovascular Disease
Objective: The National Heart, Lung, and Blood Institute convened an interdisciplinary working group of experts to develop recommendations for the assessment and treatment of depression in patients with coronary heart disease (CHD). Method: Consensus of experts. Results: Our current recommendations are that the Beck Depression Inventory-I be employed for epidemiological studies of depression and CHD, that the Patient Health Questionnaire 2-item v…
The Great Debate, Revisited
Freedland, Kenneth E. PhD; Miller, Gregory E. PhD; Sheps, David S. MD, MSPH Author Information
Psychosomatic Medicine Goes (Almost) Monthly
Editor-in-Chief, Division of Cardiovascular Medicine, University of Florida, Gainesville A version of this article appeared in the American Psychosomatic Society newsletter 2006, Volume 17, Issue No. 2
Medicine (35 works) · Psychology (30 works) · Cardiac Health and Mental Health (25 works) · Internal Medicine (23 works) · Internal Medicine (22 works) · Cardiology (15 works) · Psychiatry (14 works) · Ischemia (13 works) · Coronary artery disease (11 works) · Depression (economics) (9 works)