Amanda J Macfarlane
Dados Biográficos
| ID | 4891759 |
|---|---|
| NOME | Amanda J Macfarlane |
| PRENOMES | Amanda J |
| SOBRENOME | Macfarlane |
| ASSINATURA | MACFARLANE A J |
| AFILIAÇÕES | Health Canada |
| ORCID | 0000-0002-3208-3483 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 12 |
| TOTAL DE CITAÇÕES | 10 |
| TOTAL COMO AUTOR | 12 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1883 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 2 |
Folate and global health
Folate and global health review series, part 4
Background: Autoimmune diseases and bone density loss (osteopenia and osteoporosis) are chronic conditions of complex aetiology that affect diverse populations. Folate may be associated with a higher risk of these disorders due to its essential role in one-carbon metabolism required for nucleotide synthesis, homocysteine metabolism, and methylation processes. However, the evidence on this association is inconclusive. Methods: We searched MEDLINE,…
Folate and global health umbrella review series, part 1
Background: Folate is essential for normal growth and in human health throughout the lifecycle. Clinical deficiency of folate impairs DNA synthesis and results in megaloblastic anaemia, while suboptimal folate status before and in early pregnancy results in an elevated risk of neural tube defects (NTD). The evidence on the association of folate status with other health outcomes is largely fragmented and understudied. We conducted a series of umbr…
Folate and global health review series, part 3
Background: Cardiovascular and metabolic diseases account for an increasing share of morbidity and mortality globally. Folic acid supplementation has been linked to a lowered risk of stroke and some metabolic indicators due to its involvement in homocysteine and one-carbon metabolism and its role in the production of nitric oxide; however, the evidence on these associations is inconclusive. Methods: We searched MEDLINE, Embase, CINAHL, the Cochra…
Folate and global health umbrella review series, part 2
Background: Folate has been examined extensively in relation to carcinogenesis due to its role in one-carbon metabolism impacting the synthesis of DNA and RNA, methylation processes, and genomic integrity. Current evidence on the relationship between folate status and the risk of cancer is equivocal: low or deficient folate status may contribute to an increased risk of cancers, while high-dose folic acid supplementation may have adverse effects o…
Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes
Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we mea…
Reply to Verhoef et al
Hyperhomocysteinemia in patients with cardiovascular manifestations
The determinants of maternal homocysteine in pregnancy
Objective: Observational studies have linked elevated homocysteine to vascular conditions. Folate intake has been associated with lower homocysteine concentration, although randomised controlled trials of folic acid supplementation to decrease the incidence of vascular conditions have been inconclusive. We investigated determinants of maternal homocysteine during pregnancy, particularly in a folic acid-fortified population. Design: Data were from…
Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women
Objective To examine the association between BMI and folate concentrations in serum and red blood cells (RBC) in pregnant women. Design A cross-sectional comparison of folate concentrations in serum and RBC sampled simultaneously from the same individual. Setting The Ottawa Hospital and Kingston General Hospital, Ontario, Canada. Subjects Pregnant women recruited between 12 and 20 weeks of gestation. Results A total of 869 pregnant women recruite…
Socio-demographic and lifestyle factors associated with folate status among non-supplement-consuming Canadian women of childbearing age
Analysis of Relationships of Consanguinity and Affinity
Analysis of Relationships of Consanguinity and Affinity
Socio-demographic and lifestyle factors associated with folate status among non-supplement-consuming Canadian women of childbearing age
Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women
Objective To examine the association between BMI and folate concentrations in serum and red blood cells (RBC) in pregnant women. Design A cross-sectional comparison of folate concentrations in serum and RBC sampled simultaneously from the same individual. Setting The Ottawa Hospital and Kingston General Hospital, Ontario, Canada. Subjects Pregnant women recruited between 12 and 20 weeks of gestation. Results A total of 869 pregnant women recruite…
The determinants of maternal homocysteine in pregnancy
Objective: Observational studies have linked elevated homocysteine to vascular conditions. Folate intake has been associated with lower homocysteine concentration, although randomised controlled trials of folic acid supplementation to decrease the incidence of vascular conditions have been inconclusive. We investigated determinants of maternal homocysteine during pregnancy, particularly in a folic acid-fortified population. Design: Data were from…
Hyperhomocysteinemia in patients with cardiovascular manifestations
Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes
Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we mea…
Reply to Verhoef et al
Folate and global health
Folate and global health review series, part 4
Background: Autoimmune diseases and bone density loss (osteopenia and osteoporosis) are chronic conditions of complex aetiology that affect diverse populations. Folate may be associated with a higher risk of these disorders due to its essential role in one-carbon metabolism required for nucleotide synthesis, homocysteine metabolism, and methylation processes. However, the evidence on this association is inconclusive. Methods: We searched MEDLINE,…
Folate and global health umbrella review series, part 1
Background: Folate is essential for normal growth and in human health throughout the lifecycle. Clinical deficiency of folate impairs DNA synthesis and results in megaloblastic anaemia, while suboptimal folate status before and in early pregnancy results in an elevated risk of neural tube defects (NTD). The evidence on the association of folate status with other health outcomes is largely fragmented and understudied. We conducted a series of umbr…
Folate and global health review series, part 3
Background: Cardiovascular and metabolic diseases account for an increasing share of morbidity and mortality globally. Folic acid supplementation has been linked to a lowered risk of stroke and some metabolic indicators due to its involvement in homocysteine and one-carbon metabolism and its role in the production of nitric oxide; however, the evidence on these associations is inconclusive. Methods: We searched MEDLINE, Embase, CINAHL, the Cochra…
Folate and global health umbrella review series, part 2
Background: Folate has been examined extensively in relation to carcinogenesis due to its role in one-carbon metabolism impacting the synthesis of DNA and RNA, methylation processes, and genomic integrity. Current evidence on the relationship between folate status and the risk of cancer is equivocal: low or deficient folate status may contribute to an increased risk of cancers, while high-dose folic acid supplementation may have adverse effects o…
Folate and B Vitamins Research (8 obras) · Biology (5 obras) · folic acid (5 obras) · Medicine (5 obras) · MEDLINE (5 obras) · Internal Medicine (4 obras) · Environmental health (3 obras) · Genetics (3 obras) · Gestational Diabetes Research and Management (3 obras) · Global health (3 obras)