Lifang Hou
Datos Biográficos
| ID | 5082435 |
|---|---|
| NOMBRE | Lifang Hou |
| NOMBRES | Lifang |
| APELLIDO | Hou |
| FIRMA | HOU L |
| AFILIACIONES | Northwestern University |
| ORCID | 0000-0003-4877-0031 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 15 |
| TOTAL DE CITAS | 1 |
| TOTAL COMO AUTOR | 15 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2016 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 1 |
Assessing differences in epigenetic aging markers between sexual or gender minority and straight cisgender adults using the Coronary Artery Risk Development in Young Adults cohort
Developing a Novel Index for Individual-Level Social Determinants and Cardiovascular Diseases in the Coronary Artery Risk Development in Young Adults (Cardia) Study
Higher iSDH indices in early adulthood were associated with increased LVMI values in midlife. The association between the iSDH index and CVD was stronger among Black adults than with White adults
Community cervical cancer screening and precancer risk in women living with HIV in Jos Nigeria
The majority of indigent women receiving care at HIV clinics had their first Pap test screening, and lack of organized screening among older and post-menopausal women with HIV, puts women at a higher risk of developing severe cervical precancer lesions
Sustaining the momentum for global cancer research and career development in the Covid-19 era
Cervical cancer is the fourth commonest cancer affecting almost 600 000 women annually worldwide with over 300 000 deaths [1]. Over 70% of these cases are in sub-Saharan Africa with correspondingly high mortality due to late presentation of cases and poor infrastructure for treatment of invasive cancer. Yet, this is one cancer that the natural history is [...]
Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men
OBJECTIVE: Higher optimism is associated with reduced mortality and a lower risk of age-related chronic diseases. DNA methylation (DNAm) may provide insight into mechanisms underlying these relationships. We hypothesized that DNAm would differ among older individuals who are more versus less optimistic. METHODS: Using cross-sectional data from two population-based cohorts of women with diverse races/ethnicities ( n = 3816) and men (only White, n …
Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria
Background Invasive cervical cancer (ICC) is a serious public health burden in Nigeria, where human immunodeficiency virus (HIV) remains highly prevalent. Previous research suggested that epigenetic age acceleration (EAA) could play a role in detection of HIV-associated ICC. However, little research has been conducted on this topic in Africa where the population is most severely affected by HIV-associated ICC. Here, we investigated the associatio…
Harnessing student involvement
Sexual harassment and misconduct, particularly against female students and employees, is a significant problem in tertiary academic institutions in most countries. For students and trainees who rely on mentorship to move their careers forward, reporting harassment and misconduct by a mentor can alter the opportunities made available to them and ultimately their career path. For [...]
Rare genetic variants explain missing heritability in smoking
Impact of the Covid-19 pandemic on global health research training and education
ince January 2020 billions of people across the world have been "locked down" and hundreds of thousands have died because of the COVID-19 global pandemic. The pandemic is creating enormous adverse economic and social consequences throughout the world, with direct and indirect impacts on global health activities -particularly through the participation of health care workers, clinicians, investigators, technologists, and students in research traini…
DNA methylation GrimAge strongly predicts lifespan and healthspan
Using large scale validation data from thousands of individuals, we demonstrate that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease (Cox P=6.2E-24), time-to-cancer (P= 1.3E-12), its strong relationship with computed tomography data for fatty liver/excess visceral fat, and age-at-menopause (P=1.6E-12). AgeAccelGrim is strongly …
Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration
DNA methylation may play a critical role in aging and age-related diseases. DNA methylation phenotypic age (DNAmPhenoAge) is a new aging biomarker and predictor of chronic disease risk. While smoking is a strong risk factor for chronic diseases and influences methylation, its influence on DNAmPhenoAge is unknown. We investigated associations of self-reported and epigenetic smoking indicators with DNAmPhenoAge acceleration in a longitudinal aging …
An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. U…
Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes
Objective Obesity and insulin resistance play important roles in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Mg intake is linked to a reduced risk of metabolic syndrome and insulin resistance; people with NAFLD or alcoholic liver disease are at high risk of Mg deficiency. The present study aimed to investigate whether Mg and Ca intakes were associated with risk of fatty liver disease and prediabetes by alcohol drinking status. …
Body mass index is negatively associated with telomere length
Public Health Impact and Economic Costs of Volkswagen’s Lack of Compliance with the United States’ Emission Standards
The U.S. Environmental Protection Agency (EPA) recently issued a notice of violation against Volkswagen (VW) for installing a defective device in certain models of diesel cars to circumvent emission tests for nitrogen oxides (NOx). We quantified the health and economic impacts of extra NOx emissions attributable to non-compliant vehicles in the U.S. using the EPA's Co-Benefits Risk Assessment model. We estimated that the total extra NOx emitted o…
Public Health Impact and Economic Costs of Volkswagen’s Lack of Compliance with the United States’ Emission Standards
The U.S. Environmental Protection Agency (EPA) recently issued a notice of violation against Volkswagen (VW) for installing a defective device in certain models of diesel cars to circumvent emission tests for nitrogen oxides (NOx). We quantified the health and economic impacts of extra NOx emissions attributable to non-compliant vehicles in the U.S. using the EPA's Co-Benefits Risk Assessment model. We estimated that the total extra NOx emitted o…
An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. U…
Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes
Objective Obesity and insulin resistance play important roles in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Mg intake is linked to a reduced risk of metabolic syndrome and insulin resistance; people with NAFLD or alcoholic liver disease are at high risk of Mg deficiency. The present study aimed to investigate whether Mg and Ca intakes were associated with risk of fatty liver disease and prediabetes by alcohol drinking status. …
Body mass index is negatively associated with telomere length
DNA methylation GrimAge strongly predicts lifespan and healthspan
Using large scale validation data from thousands of individuals, we demonstrate that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease (Cox P=6.2E-24), time-to-cancer (P= 1.3E-12), its strong relationship with computed tomography data for fatty liver/excess visceral fat, and age-at-menopause (P=1.6E-12). AgeAccelGrim is strongly …
Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration
DNA methylation may play a critical role in aging and age-related diseases. DNA methylation phenotypic age (DNAmPhenoAge) is a new aging biomarker and predictor of chronic disease risk. While smoking is a strong risk factor for chronic diseases and influences methylation, its influence on DNAmPhenoAge is unknown. We investigated associations of self-reported and epigenetic smoking indicators with DNAmPhenoAge acceleration in a longitudinal aging …
Impact of the Covid-19 pandemic on global health research training and education
ince January 2020 billions of people across the world have been "locked down" and hundreds of thousands have died because of the COVID-19 global pandemic. The pandemic is creating enormous adverse economic and social consequences throughout the world, with direct and indirect impacts on global health activities -particularly through the participation of health care workers, clinicians, investigators, technologists, and students in research traini…
Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria
Background Invasive cervical cancer (ICC) is a serious public health burden in Nigeria, where human immunodeficiency virus (HIV) remains highly prevalent. Previous research suggested that epigenetic age acceleration (EAA) could play a role in detection of HIV-associated ICC. However, little research has been conducted on this topic in Africa where the population is most severely affected by HIV-associated ICC. Here, we investigated the associatio…
Harnessing student involvement
Sexual harassment and misconduct, particularly against female students and employees, is a significant problem in tertiary academic institutions in most countries. For students and trainees who rely on mentorship to move their careers forward, reporting harassment and misconduct by a mentor can alter the opportunities made available to them and ultimately their career path. For [...]
Rare genetic variants explain missing heritability in smoking
Sustaining the momentum for global cancer research and career development in the Covid-19 era
Cervical cancer is the fourth commonest cancer affecting almost 600 000 women annually worldwide with over 300 000 deaths [1]. Over 70% of these cases are in sub-Saharan Africa with correspondingly high mortality due to late presentation of cases and poor infrastructure for treatment of invasive cancer. Yet, this is one cancer that the natural history is [...]
Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men
OBJECTIVE: Higher optimism is associated with reduced mortality and a lower risk of age-related chronic diseases. DNA methylation (DNAm) may provide insight into mechanisms underlying these relationships. We hypothesized that DNAm would differ among older individuals who are more versus less optimistic. METHODS: Using cross-sectional data from two population-based cohorts of women with diverse races/ethnicities ( n = 3816) and men (only White, n …
Community cervical cancer screening and precancer risk in women living with HIV in Jos Nigeria
The majority of indigent women receiving care at HIV clinics had their first Pap test screening, and lack of organized screening among older and post-menopausal women with HIV, puts women at a higher risk of developing severe cervical precancer lesions
Developing a Novel Index for Individual-Level Social Determinants and Cardiovascular Diseases in the Coronary Artery Risk Development in Young Adults (Cardia) Study
Higher iSDH indices in early adulthood were associated with increased LVMI values in midlife. The association between the iSDH index and CVD was stronger among Black adults than with White adults
Assessing differences in epigenetic aging markers between sexual or gender minority and straight cisgender adults using the Coronary Artery Risk Development in Young Adults cohort
Medicine (12 obras) · Biology (6 obras) · Epigenetics and DNA Methylation (6 obras) · Internal Medicine (6 obras) · DNA methylation (5 obras) · Environmental health (5 obras) · Epigenetics (5 obras) · Gene (5 obras) · Genetics (4 obras) · Bioinformatics (3 obras)