Andres Ruiz‐Linares
Biographic Data
| ID | 5204891 |
|---|---|
| NAME | Andres Ruiz‐Linares |
| GIVEN NAMES | Andres |
| FAMILY NAME | Ruiz‐Linares |
| SIGNATURE | LINARES A R |
| AFFILIATIONS | Department of Genetics Evolution and Environment and UCL Genetics Institute University College London London UK |
| VERIFIED | No |
| TOTAL WORKS | 13 |
| TOTAL CITATIONS | 59 |
| AUTHOR COUNT | 13 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2006 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 3 |
Distribution of Polymorphisms Associated With Obesity in a Sample of Admixed Mexican Adults
Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos
The proportion of obesity was heavily dependent on the index and the population. Genomic ancestry has a significant influence on the anthropometric measurements, especially on central adiposity. As a whole, we detected a large interpopulation variation that suggests that better approaches to overweight and obesity phenotypes are needed in order to obtain more precise reference values
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
Objectives To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods We characterized a sample from Colombia ( N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome‐wide SNP data. We tested for correlation between dental traits…
A geometric morphometric approach to the study of variation of shovel‐shaped incisors
OBJECTIVES: The scoring and analysis of dental nonmetric traits are predominantly accomplished by using the Arizona State University Dental Anthropology System (ASUDAS), a standard protocol based on strict definitions and three-dimensional dental plaques. However, visual scoring, even when controlled by strict definitions of features, visual reference, and the experience of the observer, includes an unavoidable part of subjectivity. In this metho…
Facial asymmetry and genetic ancestry in L atin A merican admixed populations
Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctua…
Fibroblast growth factor receptor 1 ( FGFR1 ) variants and craniofacial variation in Amerindians and related populations
FGFR1 polymorphisms, especially rs4647905, can have an important role in the normal human skull variation, primarily due to their influence in head length, which would affect other cephalometric absolute/linear measures as well as indices like CI as a result of the pervasive nature of the morphological integration that characterizes the human skull
X‐chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non‐Amerindian populations
Objectives: We report X‐chromosomal linkage disequilibrium (LD) patterns in Amerindian (Kogi, Wayuu, and Zenu) and admixed Latin American (Central Valley of Costa Rica and Southern Brazilian Gaucho) populations. Methods: Short tandem repeats (STRs) widespread along the X‐chromosome were investigated in 132 and 124 chromosomes sampled from the Amerindian tribes and the admixed Latin American populations, respectively. Diversity indexes (gene diver…
Brief communication: Population data support the adaptive nature of HACNS1 sapiens/neandertal‐chimpanzee differences in a limb expression domain
The 546‐base pair enhancer of limb expression HACNS1 , which is highly constrained in all terrestrial vertebrates, has accumulated 16 human‐specific changes after the human‐chimpanzee split. There has been discussion whether this process was driven by positive selection or biased gene conversion, without considering population data. We studied 83 South Amerindian, 11 Eskimo, 35 Europeans, 37 Bantu, and non‐Bantu Sub‐Saharan speakers, and 28 Brazi…
Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers
Colombia is a country with great geographic heterogeneity and marked regional differences in pre‐Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X‐Chromosome), maternal (mtDNA), and paternal (Y‐chromosome) m…
Brief communication: Patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations
Comparative studies of linkage disequilibrium (LD) can provide insights into human demographic history. Here, we characterize LD in six Native American populations using seven microsatellite markers in Xq13, a region of the genome extensively studied in populations around the world. Native Americans show relatively low diversity and high LD, in agreement with recent genome‐wide survey and a scenario of sequential founder effects accompanying huma…
X‐chromosome lineages and the settlement of the Americas
Most genetic studies on the origins of Native Americans have examined data from mtDNA and Y‐chromosome DNA. To complement these studies and to broaden our understanding of the origin of Native American populations, we present an analysis of 1,873 X‐chromosomes representing Native American ( n = 438) and other continental populations ( n = 1,435). We genotyped 36 polymorphic sites, forming an informative haplotype within an 8‐kb DNA segment spanni…
A revertant of the major founder Native American haplogroup C common in populations from northern South America
We examined the mtDNA RFLP diversity of 17 Native American populations from Colombia. Five of the populations studied were found to have variable frequencies of a mtDNA type lacking the characteristic changes of haplogroups A‐D. Sequencing of mtDNA HVS‐I and II showed that this “null” RFLP type carries all the substitutions characteristic of Native American founder lineage C. A back mutation has therefore recreated the +13,259 Hin cII/−13,262 Alu…
Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil
A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS-I), and a fraction of them was also studied for seven biallelic Y-chromosome polymorphisms. Nineteen HVS-I lineages were detected, which showed distinct distributions in the two tribes. The G ST value obtained with the mtDNA data is about 5 times highe…
Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil
A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS-I), and a fraction of them was also studied for seven biallelic Y-chromosome polymorphisms. Nineteen HVS-I lineages were detected, which showed distinct distributions in the two tribes. The G ST value obtained with the mtDNA data is about 5 times highe…
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
Objectives To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods We characterized a sample from Colombia ( N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome‐wide SNP data. We tested for correlation between dental traits…
Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers
Colombia is a country with great geographic heterogeneity and marked regional differences in pre‐Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X‐Chromosome), maternal (mtDNA), and paternal (Y‐chromosome) m…
A geometric morphometric approach to the study of variation of shovel‐shaped incisors
OBJECTIVES: The scoring and analysis of dental nonmetric traits are predominantly accomplished by using the Arizona State University Dental Anthropology System (ASUDAS), a standard protocol based on strict definitions and three-dimensional dental plaques. However, visual scoring, even when controlled by strict definitions of features, visual reference, and the experience of the observer, includes an unavoidable part of subjectivity. In this metho…
Facial asymmetry and genetic ancestry in L atin A merican admixed populations
Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctua…
Brief communication: Population data support the adaptive nature of HACNS1 sapiens/neandertal‐chimpanzee differences in a limb expression domain
The 546‐base pair enhancer of limb expression HACNS1 , which is highly constrained in all terrestrial vertebrates, has accumulated 16 human‐specific changes after the human‐chimpanzee split. There has been discussion whether this process was driven by positive selection or biased gene conversion, without considering population data. We studied 83 South Amerindian, 11 Eskimo, 35 Europeans, 37 Bantu, and non‐Bantu Sub‐Saharan speakers, and 28 Brazi…
Brief communication: Patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations
Comparative studies of linkage disequilibrium (LD) can provide insights into human demographic history. Here, we characterize LD in six Native American populations using seven microsatellite markers in Xq13, a region of the genome extensively studied in populations around the world. Native Americans show relatively low diversity and high LD, in agreement with recent genome‐wide survey and a scenario of sequential founder effects accompanying huma…
X‐chromosome lineages and the settlement of the Americas
Most genetic studies on the origins of Native Americans have examined data from mtDNA and Y‐chromosome DNA. To complement these studies and to broaden our understanding of the origin of Native American populations, we present an analysis of 1,873 X‐chromosomes representing Native American ( n = 438) and other continental populations ( n = 1,435). We genotyped 36 polymorphic sites, forming an informative haplotype within an 8‐kb DNA segment spanni…
A revertant of the major founder Native American haplogroup C common in populations from northern South America
We examined the mtDNA RFLP diversity of 17 Native American populations from Colombia. Five of the populations studied were found to have variable frequencies of a mtDNA type lacking the characteristic changes of haplogroups A‐D. Sequencing of mtDNA HVS‐I and II showed that this “null” RFLP type carries all the substitutions characteristic of Native American founder lineage C. A back mutation has therefore recreated the +13,259 Hin cII/−13,262 Alu…
Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil
A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS-I), and a fraction of them was also studied for seven biallelic Y-chromosome polymorphisms. Nineteen HVS-I lineages were detected, which showed distinct distributions in the two tribes. The G ST value obtained with the mtDNA data is about 5 times highe…
X‐chromosome lineages and the settlement of the Americas
Most genetic studies on the origins of Native Americans have examined data from mtDNA and Y‐chromosome DNA. To complement these studies and to broaden our understanding of the origin of Native American populations, we present an analysis of 1,873 X‐chromosomes representing Native American ( n = 438) and other continental populations ( n = 1,435). We genotyped 36 polymorphic sites, forming an informative haplotype within an 8‐kb DNA segment spanni…
Brief communication: Population data support the adaptive nature of HACNS1 sapiens/neandertal‐chimpanzee differences in a limb expression domain
The 546‐base pair enhancer of limb expression HACNS1 , which is highly constrained in all terrestrial vertebrates, has accumulated 16 human‐specific changes after the human‐chimpanzee split. There has been discussion whether this process was driven by positive selection or biased gene conversion, without considering population data. We studied 83 South Amerindian, 11 Eskimo, 35 Europeans, 37 Bantu, and non‐Bantu Sub‐Saharan speakers, and 28 Brazi…
Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers
Colombia is a country with great geographic heterogeneity and marked regional differences in pre‐Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X‐Chromosome), maternal (mtDNA), and paternal (Y‐chromosome) m…
Brief communication: Patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations
Comparative studies of linkage disequilibrium (LD) can provide insights into human demographic history. Here, we characterize LD in six Native American populations using seven microsatellite markers in Xq13, a region of the genome extensively studied in populations around the world. Native Americans show relatively low diversity and high LD, in agreement with recent genome‐wide survey and a scenario of sequential founder effects accompanying huma…
X‐chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non‐Amerindian populations
Objectives: We report X‐chromosomal linkage disequilibrium (LD) patterns in Amerindian (Kogi, Wayuu, and Zenu) and admixed Latin American (Central Valley of Costa Rica and Southern Brazilian Gaucho) populations. Methods: Short tandem repeats (STRs) widespread along the X‐chromosome were investigated in 132 and 124 chromosomes sampled from the Amerindian tribes and the admixed Latin American populations, respectively. Diversity indexes (gene diver…
Fibroblast growth factor receptor 1 ( FGFR1 ) variants and craniofacial variation in Amerindians and related populations
FGFR1 polymorphisms, especially rs4647905, can have an important role in the normal human skull variation, primarily due to their influence in head length, which would affect other cephalometric absolute/linear measures as well as indices like CI as a result of the pervasive nature of the morphological integration that characterizes the human skull
Facial asymmetry and genetic ancestry in L atin A merican admixed populations
Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctua…
Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos
The proportion of obesity was heavily dependent on the index and the population. Genomic ancestry has a significant influence on the anthropometric measurements, especially on central adiposity. As a whole, we detected a large interpopulation variation that suggests that better approaches to overweight and obesity phenotypes are needed in order to obtain more precise reference values
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
Objectives To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods We characterized a sample from Colombia ( N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome‐wide SNP data. We tested for correlation between dental traits…
A geometric morphometric approach to the study of variation of shovel‐shaped incisors
OBJECTIVES: The scoring and analysis of dental nonmetric traits are predominantly accomplished by using the Arizona State University Dental Anthropology System (ASUDAS), a standard protocol based on strict definitions and three-dimensional dental plaques. However, visual scoring, even when controlled by strict definitions of features, visual reference, and the experience of the observer, includes an unavoidable part of subjectivity. In this metho…
Distribution of Polymorphisms Associated With Obesity in a Sample of Admixed Mexican Adults
Biology (10 works) · Evolutionary biology (9 works) · Gene (9 works) · Genetics (9 works) · Population (9 works) · Demography (8 works) · Allele (6 works) · Forensic and Genetic Research (6 works) · Genetics (6 works) · Genetic variation (5 works)