Nicholas W Lerche
Biographic Data
| ID | 5206586 |
|---|---|
| NAME | Nicholas W Lerche |
| GIVEN NAMES | Nicholas W |
| FAMILY NAME | Lerche |
| SIGNATURE | LERCHE N W |
| AFFILIATIONS | University of California, Davis |
| VERIFIED | No |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 10 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1989 |
| LATEST PUBLICATION YEAR | 2014 |
| H-INDEX | 0 |
Familial aggregation of chronic diarrhea disease ( CDD ) in rhesus macaques ( M acaca mulatta )
Chronic diarrheal disease (CDD) is a critical problem for breeders of captive rhesus macaque (Macaca mulatta), as it results in significant levels of morbidity and death annually. As with other inflammatory disorders, CDD is thought to be caused by environmental and/or genetic factors. Although correspondence between the characters defined as Mendelian by pedigree or segregation analysis and functional genes is difficult to establish, such analys…
Single‐Nucleotide Polymorphisms Reveal Patterns of Allele Sharing Across the Species Boundary Between Rhesus ( Macaca mulatta ) and Cynomolgus ( M. fascicularis ) Macaques
Both phenotypic and genetic evidence for asymmetric hybridization between rhesus ( Macaca mulatta ) and cynomolgus ( Macaca fascicularis ) macaques has been observed in the region of Indochina where both species are sympatric. The large‐scale sharing of major histocompatibility complex (MHC) class II alleles between the two species in this region supports the hypothesis that genes, and especially genes involved in immune response, are being trans…
Genetic characterization of specific pathogen‐free rhesus macaque ( Macaca mulatta ) populations at the California National Primate Research Center (CNPRC)
A study based on 14 STRs was conducted to understand intergenerational genetic changes that have occurred within the California National Primate Research Center's (CNPRC) regular specific pathogen‐free (SPF) and super‐SPF captive rhesus macaque populations relative to their conventional founders. Intergenerational genetic drift has caused age cohorts of each study population, especially within the conventional population, to become increasingly d…
Microsatellite markers for standardized genetic management of captive colonies of rhesus macaques (Macaca mulatta)
To preserve genetic variability and minimize genetic subdivision among captive Macaca mulatta at each of the U.S. National Institutes of Health (NIH)-sponsored regional research colonies, the genetic structure of each colony must be characterized. To compare population genetic and demographic parameters across colonies and generations, one standard panel of highly informative genetic markers is required. We assembled a core marker set of four mul…
Prevalence of antibodies to selected viruses in a long‐term closed breeding colony of rhesus macaques ( Macaca mulatta ) in Brazil
The rhesus macaque breeding colony of the Oswaldo Cruz Foundation (FIOCRUZ) was established in 1932 from a founding stock of 100 animals. This population has remained closed to new animal introductions for almost 70 years. A serologic survey was performed to determine the prevalence of antibodies to selected viruses as a first approach to identifying viral pathogens endemic in this population. Banked serum samples were tested for antibodies to si…
Major histocompatibility complex class II polymorphisms in Macaca mulatta
In the last 5 years, HLA class II genotyping methods have been adapted for genotyping of class II loci in rhesus macaques. Since previously published typing protocols were used on samples that were collected and stored under ideal conditions, it was of interest to determine if these methods were adequate for genotyping a large collection of archival samples from which DNA had been isolated and stored under various conditions. Established macaque …
Islet cell antibodies in Sulawesi macaques
Older monkeys of the Sulawesian species Macaca nigra spontaneously develop a lesion in the pancreatic islets of Langerhans in which there is deposition of amyloid and gradual degeneration of all cells, which can lead eventually to development of diabetes mellitus. Islet cell antibodies (ICA), formed in response to the release of cellular antigens, can be used to detect the islet lesion and to monitor the progression of each monkey toward diabetes…
Individual differences in peripheral blood immunological and hormonal measures in adult male rhesus macaques (Macaca mulatta)
A growing body of research has indicated that consistent individual differences exist in physiological systems with which the immune system interacts. Few data have been reported that demonstrate stable individual differences in immunological measures, however. In the present study, enumerative measures of immune system activity were examined in 36 adult male rhesus macaques over a 13 month period under baseline conditions as well as under condit…
Social Separation, Housing Relocation, and Survival in Simian Aids
OBJECTIVE: To test the hypothesis that changes in housing, particularly those involving social separations, would have a negative impact on survival in rhesus monkeys experimentally inoculated with the simian immunodeficiency virus (SIV). METHODS: An archival methodology was used. Colony records at four Regional Primate Research Centers were screened, and data pertaining to demographics, contents of the inoculum, medical history before and after …
Population survey of macaques in northern Sulawesi
A field survey of 25 sites in Sulawesi Utara (north Sulawesi) in 1987 and 1988 found macaques in 16 of these sites. The most viable population of Macaca nigra was found in the Tangkoko reserve at an estimated density of 76.2 monkeys/km 2 , which is less than one‐third the abundance reported in the late 1970s by the MacKinnons. The adjacent reserves of Batuangus and Duasudara had only 22 monkeys/km 2 , yielding a population estimate for these thre…
No prominent works on this page.
Population survey of macaques in northern Sulawesi
A field survey of 25 sites in Sulawesi Utara (north Sulawesi) in 1987 and 1988 found macaques in 16 of these sites. The most viable population of Macaca nigra was found in the Tangkoko reserve at an estimated density of 76.2 monkeys/km 2 , which is less than one‐third the abundance reported in the late 1970s by the MacKinnons. The adjacent reserves of Batuangus and Duasudara had only 22 monkeys/km 2 , yielding a population estimate for these thre…
Individual differences in peripheral blood immunological and hormonal measures in adult male rhesus macaques (Macaca mulatta)
A growing body of research has indicated that consistent individual differences exist in physiological systems with which the immune system interacts. Few data have been reported that demonstrate stable individual differences in immunological measures, however. In the present study, enumerative measures of immune system activity were examined in 36 adult male rhesus macaques over a 13 month period under baseline conditions as well as under condit…
Social Separation, Housing Relocation, and Survival in Simian Aids
OBJECTIVE: To test the hypothesis that changes in housing, particularly those involving social separations, would have a negative impact on survival in rhesus monkeys experimentally inoculated with the simian immunodeficiency virus (SIV). METHODS: An archival methodology was used. Colony records at four Regional Primate Research Centers were screened, and data pertaining to demographics, contents of the inoculum, medical history before and after …
Islet cell antibodies in Sulawesi macaques
Older monkeys of the Sulawesian species Macaca nigra spontaneously develop a lesion in the pancreatic islets of Langerhans in which there is deposition of amyloid and gradual degeneration of all cells, which can lead eventually to development of diabetes mellitus. Islet cell antibodies (ICA), formed in response to the release of cellular antigens, can be used to detect the islet lesion and to monitor the progression of each monkey toward diabetes…
Major histocompatibility complex class II polymorphisms in Macaca mulatta
In the last 5 years, HLA class II genotyping methods have been adapted for genotyping of class II loci in rhesus macaques. Since previously published typing protocols were used on samples that were collected and stored under ideal conditions, it was of interest to determine if these methods were adequate for genotyping a large collection of archival samples from which DNA had been isolated and stored under various conditions. Established macaque …
Prevalence of antibodies to selected viruses in a long‐term closed breeding colony of rhesus macaques ( Macaca mulatta ) in Brazil
The rhesus macaque breeding colony of the Oswaldo Cruz Foundation (FIOCRUZ) was established in 1932 from a founding stock of 100 animals. This population has remained closed to new animal introductions for almost 70 years. A serologic survey was performed to determine the prevalence of antibodies to selected viruses as a first approach to identifying viral pathogens endemic in this population. Banked serum samples were tested for antibodies to si…
Microsatellite markers for standardized genetic management of captive colonies of rhesus macaques (Macaca mulatta)
To preserve genetic variability and minimize genetic subdivision among captive Macaca mulatta at each of the U.S. National Institutes of Health (NIH)-sponsored regional research colonies, the genetic structure of each colony must be characterized. To compare population genetic and demographic parameters across colonies and generations, one standard panel of highly informative genetic markers is required. We assembled a core marker set of four mul…
Genetic characterization of specific pathogen‐free rhesus macaque ( Macaca mulatta ) populations at the California National Primate Research Center (CNPRC)
A study based on 14 STRs was conducted to understand intergenerational genetic changes that have occurred within the California National Primate Research Center's (CNPRC) regular specific pathogen‐free (SPF) and super‐SPF captive rhesus macaque populations relative to their conventional founders. Intergenerational genetic drift has caused age cohorts of each study population, especially within the conventional population, to become increasingly d…
Single‐Nucleotide Polymorphisms Reveal Patterns of Allele Sharing Across the Species Boundary Between Rhesus ( Macaca mulatta ) and Cynomolgus ( M. fascicularis ) Macaques
Both phenotypic and genetic evidence for asymmetric hybridization between rhesus ( Macaca mulatta ) and cynomolgus ( Macaca fascicularis ) macaques has been observed in the region of Indochina where both species are sympatric. The large‐scale sharing of major histocompatibility complex (MHC) class II alleles between the two species in this region supports the hypothesis that genes, and especially genes involved in immune response, are being trans…
Familial aggregation of chronic diarrhea disease ( CDD ) in rhesus macaques ( M acaca mulatta )
Chronic diarrheal disease (CDD) is a critical problem for breeders of captive rhesus macaque (Macaca mulatta), as it results in significant levels of morbidity and death annually. As with other inflammatory disorders, CDD is thought to be caused by environmental and/or genetic factors. Although correspondence between the characters defined as Mendelian by pedigree or segregation analysis and functional genes is difficult to establish, such analys…
Biology (10 works) · Primate Behavior and Ecology (6 works) · Gene (5 works) · Genetics (5 works) · HIV Research and Treatment (5 works) · Rhesus macaque (5 works) · Allele (4 works) · Ecology (4 works) · Medicine (4 works) · Demography (3 works)