Matthew J Jorgensen
Biographic Data
| ID | 5207627 |
|---|---|
| NAME | Matthew J Jorgensen |
| GIVEN NAMES | Matthew J |
| FAMILY NAME | Jorgensen |
| SIGNATURE | JØRGENSEN M J |
| AFFILIATIONS | Wake Forest University |
| ORCID | 0000-0002-0977-6425 |
| VERIFIED | Yes |
| TOTAL WORKS | 12 |
| TOTAL CITATIONS | 12 |
| AUTHOR COUNT | 12 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1993 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 1 |
Development and assessment of a stair ascension challenge as a measure of aging and physical function in nonhuman primates
Nonhuman primates (NHPs) are valuable models for studying healthspan, including frailty development. Frailty metrics in people centers on functional measures, including usual gait speed which can be predictive of all‐cause mortality. This concept that physical competencies are able to prognosticate an individual's health trajectory over chronologic aging is well‐accepted and has led to refinements in how physical function is evaluated, and includ…
Modeling variation in the growth of wild and captive juvenile vervet monkeys in relation to diet and resource availability
OBJECTIVES: To compare longitudinal weight gain in captive and wild juvenile vervet monkeys and conduct an empirical assessment of different mechanistic growth models. METHODS: Weights were collected from two groups of captive monkeys and two consecutive cohorts of wild monkeys until the end of the juvenile period (~800 days). The captive groups were each fed different diets, while the wild groups experienced different ecological conditions. Thre…
Composition and stability of the vervet monkey milk microbiome
The human milk microbiome is vertically transmitted to offspring during the postnatal period and has emerged as a critical driver of infant immune and metabolic development. Despite this importance in humans, the milk microbiome of nonhuman primates remains largely unexplored. This dearth of comparative work precludes our ability to understand how species‐specific differences in the milk microbiome may differentially drive maternal effects and li…
Pair housing of Vervets/African Green Monkeys for biomedical research
Vervets, also known as African green monkeys, are a nonhuman primate species widely used in biomedical research. However, there are currently few references available describing techniques and rates of success for pair-housing this species. We present data from four cohorts of vervets from three different facilities: (i) the Wake Forest Vervet Research Colony (VRC; n = 72 female pairs, n= 52 male pairs), (ii) the University of Louisiana at Lafaye…
Vitamin D heritability and effect of pregnancy status in Vervet monkeys ( Chlorocebus aethiops sabaeus ) under conditions of modest and high dietary supplementation
OBJECTIVES: The two objectives of the current study were to: 1) investigate the genetic contributions to variations in serum vitamin D concentrations under two dietary conditions (a standard monkey biscuit diet vs. a diet designed to model typical American consumption); and 2) explore the interaction of vitamin D with pregnancy status using a cohort of pedigreed female vervet/African green monkeys. METHODS: This study includes 185 female (≥3.5 ye…
Significant Genotype by Diet (G × D) Interaction Effects on Cardiometabolic Responses to a Pedigree‐Wide, Dietary Challenge in Vervet Monkeys ( Chlorocebus aethiops sabaeus )
Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys ( Chlorocebus aethiops sabaeus ; n = 309) from a multigenerational pedigreed colony initially fed with a pla…
Hydrogen and Oxygen Isotope Ratios in Body Water and Hair: Modeling Isotope Dynamics in Nonhuman Primates
The stable isotopic composition of drinking water, diet, and atmospheric oxygen influence the isotopic composition of body water ( 2 H / 1 H , 18 O / 16 O expressed as δ 2 H and δ 18 O ). In turn, body water influences the isotopic composition of organic matter in tissues, such as hair and teeth, which are often used to reconstruct historical dietary and movement patterns of animals and humans. Here, we used a nonhuman primate system ( M acaca fa…
High‐fiber diet promotes weight loss and affects maternal behavior in vervet monkeys
The dramatic increase in obesity in western societies has shifted the emphasis in nutrition research from the problems of undernutrition to the adverse consequences of being overweight. As with humans, Old World monkeys are at increased risk for type II diabetes and other chronic diseases when they gain excessive weight. To prevent overweight and obesity, promote animal health, and provide a more natural level of fiber in the diet, the standard c…
Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring
Nutritional interventions are important for reducing obesity and related conditions. Soy is a good source of protein and also contains isoflavones that may affect plasma lipids, body weight, and insulin action. Described here are data from a monkey breeding colony in which monkeys were initially fed a standard chow diet that is low fat with protein derived from soy. Monkeys were then randomized to a defined diet with a fat content similar to the …
Adolescent impulsivity predicts adult dominance attainment in male vervet monkeys
Adolescence is characterized by behavioral and physiological changes that prepare individuals for the transition to adulthood. The purpose of this study was to evaluate the effects of behavioral, morphological, neurobiological, and developmental characteristics of adolescent male vervets in predicting later dominance attainment. Thirty‐six adolescent male vervets were tested for social impulsivity by means of the Intruder Challenge test while the…
Effects of puzzle feeders on pathological behavior in individually housed rhesus monkeys
Self-injurious behavior (SIB) occurs in about 10% of individually housed monkeys. Monkeys with SIB bite their own bodies frequently, occasionally inflicting wounds as a result. At present, there is no standard treatment for this phenomenon. We examined the effectiveness of puzzle feeders in alleviating SIB in monkeys with a veterinary record of self-inflicted wounding. Two groups of monkeys (SIB and controls) were exposed to puzzle feeders for a …
An empirical study of moral intuitions: Toward an evolutionary ethics
This study of moral intuitions used a questionnaire containing 2 moral dilemmas that were administered to university students. The dilemmas probed the underlying dimensions involved in moral intuitions. The results of both group- and individual-level analyses suggested that the most important dimensions were Speciesism, Abhorrent Political Philosophy (Nazism), and Inclusive Fitness, followed by Social Contract and Number of Individuals. The dimen…
An empirical study of moral intuitions: Toward an evolutionary ethics
This study of moral intuitions used a questionnaire containing 2 moral dilemmas that were administered to university students. The dilemmas probed the underlying dimensions involved in moral intuitions. The results of both group- and individual-level analyses suggested that the most important dimensions were Speciesism, Abhorrent Political Philosophy (Nazism), and Inclusive Fitness, followed by Social Contract and Number of Individuals. The dimen…
Vitamin D heritability and effect of pregnancy status in Vervet monkeys ( Chlorocebus aethiops sabaeus ) under conditions of modest and high dietary supplementation
OBJECTIVES: The two objectives of the current study were to: 1) investigate the genetic contributions to variations in serum vitamin D concentrations under two dietary conditions (a standard monkey biscuit diet vs. a diet designed to model typical American consumption); and 2) explore the interaction of vitamin D with pregnancy status using a cohort of pedigreed female vervet/African green monkeys. METHODS: This study includes 185 female (≥3.5 ye…
An empirical study of moral intuitions: Toward an evolutionary ethics
This study of moral intuitions used a questionnaire containing 2 moral dilemmas that were administered to university students. The dilemmas probed the underlying dimensions involved in moral intuitions. The results of both group- and individual-level analyses suggested that the most important dimensions were Speciesism, Abhorrent Political Philosophy (Nazism), and Inclusive Fitness, followed by Social Contract and Number of Individuals. The dimen…
Effects of puzzle feeders on pathological behavior in individually housed rhesus monkeys
Self-injurious behavior (SIB) occurs in about 10% of individually housed monkeys. Monkeys with SIB bite their own bodies frequently, occasionally inflicting wounds as a result. At present, there is no standard treatment for this phenomenon. We examined the effectiveness of puzzle feeders in alleviating SIB in monkeys with a veterinary record of self-inflicted wounding. Two groups of monkeys (SIB and controls) were exposed to puzzle feeders for a …
Adolescent impulsivity predicts adult dominance attainment in male vervet monkeys
Adolescence is characterized by behavioral and physiological changes that prepare individuals for the transition to adulthood. The purpose of this study was to evaluate the effects of behavioral, morphological, neurobiological, and developmental characteristics of adolescent male vervets in predicting later dominance attainment. Thirty‐six adolescent male vervets were tested for social impulsivity by means of the Intruder Challenge test while the…
Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring
Nutritional interventions are important for reducing obesity and related conditions. Soy is a good source of protein and also contains isoflavones that may affect plasma lipids, body weight, and insulin action. Described here are data from a monkey breeding colony in which monkeys were initially fed a standard chow diet that is low fat with protein derived from soy. Monkeys were then randomized to a defined diet with a fat content similar to the …
High‐fiber diet promotes weight loss and affects maternal behavior in vervet monkeys
The dramatic increase in obesity in western societies has shifted the emphasis in nutrition research from the problems of undernutrition to the adverse consequences of being overweight. As with humans, Old World monkeys are at increased risk for type II diabetes and other chronic diseases when they gain excessive weight. To prevent overweight and obesity, promote animal health, and provide a more natural level of fiber in the diet, the standard c…
Hydrogen and Oxygen Isotope Ratios in Body Water and Hair: Modeling Isotope Dynamics in Nonhuman Primates
The stable isotopic composition of drinking water, diet, and atmospheric oxygen influence the isotopic composition of body water ( 2 H / 1 H , 18 O / 16 O expressed as δ 2 H and δ 18 O ). In turn, body water influences the isotopic composition of organic matter in tissues, such as hair and teeth, which are often used to reconstruct historical dietary and movement patterns of animals and humans. Here, we used a nonhuman primate system ( M acaca fa…
Significant Genotype by Diet (G × D) Interaction Effects on Cardiometabolic Responses to a Pedigree‐Wide, Dietary Challenge in Vervet Monkeys ( Chlorocebus aethiops sabaeus )
Nutrient composition of a diet (D) has been shown to interact with genetic predispositions (G) to affect various lipid phenotypes. Our aim in this study was to confirm G × D interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. Subjects were vervet monkeys ( Chlorocebus aethiops sabaeus ; n = 309) from a multigenerational pedigreed colony initially fed with a pla…
Vitamin D heritability and effect of pregnancy status in Vervet monkeys ( Chlorocebus aethiops sabaeus ) under conditions of modest and high dietary supplementation
OBJECTIVES: The two objectives of the current study were to: 1) investigate the genetic contributions to variations in serum vitamin D concentrations under two dietary conditions (a standard monkey biscuit diet vs. a diet designed to model typical American consumption); and 2) explore the interaction of vitamin D with pregnancy status using a cohort of pedigreed female vervet/African green monkeys. METHODS: This study includes 185 female (≥3.5 ye…
Pair housing of Vervets/African Green Monkeys for biomedical research
Vervets, also known as African green monkeys, are a nonhuman primate species widely used in biomedical research. However, there are currently few references available describing techniques and rates of success for pair-housing this species. We present data from four cohorts of vervets from three different facilities: (i) the Wake Forest Vervet Research Colony (VRC; n = 72 female pairs, n= 52 male pairs), (ii) the University of Louisiana at Lafaye…
Composition and stability of the vervet monkey milk microbiome
The human milk microbiome is vertically transmitted to offspring during the postnatal period and has emerged as a critical driver of infant immune and metabolic development. Despite this importance in humans, the milk microbiome of nonhuman primates remains largely unexplored. This dearth of comparative work precludes our ability to understand how species‐specific differences in the milk microbiome may differentially drive maternal effects and li…
Modeling variation in the growth of wild and captive juvenile vervet monkeys in relation to diet and resource availability
OBJECTIVES: To compare longitudinal weight gain in captive and wild juvenile vervet monkeys and conduct an empirical assessment of different mechanistic growth models. METHODS: Weights were collected from two groups of captive monkeys and two consecutive cohorts of wild monkeys until the end of the juvenile period (~800 days). The captive groups were each fed different diets, while the wild groups experienced different ecological conditions. Thre…
Development and assessment of a stair ascension challenge as a measure of aging and physical function in nonhuman primates
Nonhuman primates (NHPs) are valuable models for studying healthspan, including frailty development. Frailty metrics in people centers on functional measures, including usual gait speed which can be predictive of all‐cause mortality. This concept that physical competencies are able to prognosticate an individual's health trajectory over chronologic aging is well‐accepted and has led to refinements in how physical function is evaluated, and includ…
Biology (9 works) · Medicine (5 works) · Primate Behavior and Ecology (5 works) · Diet and metabolism studies (4 works) · Psychology (4 works) · Vervet monkey (4 works) · Zoology (4 works) · Animal science (3 works) · Ecology (3 works) · Endocrinology (3 works)