Donald S Burke
Biographic Data
| ID | 5232950 |
|---|---|
| NAME | Donald S Burke |
| GIVEN NAMES | Donald S |
| FAMILY NAME | Burke |
| SIGNATURE | BURKE D S |
| AFFILIATIONS | University of Pittsburgh |
| ORCID | 0000-0002-5704-8094 |
| VERIFIED | Yes |
| TOTAL WORKS | 22 |
| TOTAL CITATIONS | 36 |
| AUTHOR COUNT | 22 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1989 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 4 |
Dynamics of drug overdose deaths in the United States during Covid-19
Pandemic era overdose deaths comprise continuing exponential growth, a COVID-19 related sustained rise tied to social disruption, and EIP linked spikes. Future relief payments should consider staggered disbursement and concurrent harm reduction measures to mitigate overdose risk
Reply commentary by Jalal and Burke
Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016
Analyzing the drug abuse epidemic There is a developing drug epidemic in the United States. Jalal et al. analyzed nearly 600,000 unintentional drug overdoses over a 38-year period. Although the overall mortality rate closely followed an exponential growth curve, the pattern itself is a composite of several underlying subepidemics of different drugs. Geographic hotspots have developed over time, as well as drug-specific demographic differences. Sc…
A large-scale immuno-epidemiological simulation of influenza A epidemics
We present a framework for multi-scale simulations of influenza epidemics that enables the study of population-level effects of individual differences in infections and symptoms, with minimal additional computational cost compared to the existing population-level simulations
Kumar et al. Respond
AffiliationsSupriya Kumar and Donald S. Burke are with the Department of Epidemiology Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. John J. Grefenstette and David Galloway are with the Public Health Dynamics Laboratory, Graduate School of Public Health, University of Pittsburgh. Steven M. Albert is with the Department of Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsbu…
FRED (A Framework for Reconstructing Epidemic Dynamics): An open-source software system for modeling infectious diseases and control strategies using census-based populations
State and county public health planners can use FRED to explore the effects of possible influenza epidemics in specific geographic regions of interest and to help evaluate the effect of interventions such as vaccination programs and school closure policies. FRED is available under a free open source license in order to contribute to the development of better modeling tools and to encourage open discussion of modeling tools being used to evaluate …
Policies to Reduce Influenza in the Workplace: Impact Assessments Using an Agent-Based Model
Objectives. We examined the impact of access to paid sick days (PSDs) and stay-at-home behavior on the influenza attack rate in workplaces. Methods. We used an agent-based model of Allegheny County, Pennsylvania, with PSD data from the US Bureau of Labor Statistics, standard influenza epidemic parameters, and the probability of staying home when ill. We compared the influenza attack rate among employees resulting from workplace transmission, focu…
Chapter 12. Toward a Containment Strategy for Smallpox Bioterror: An Individual-Based Computational Approach
Failure to Detect Simian Immunodeficiency Virus Infection in a Large Cameroonian Cohort with High Non-human Primate Exposure
School closure as an influenza mitigation strategy: How variations in legal authority and plan criteria can alter the impact
This agent-based simulation suggests several ways to improve statutes and influenza plans. First, school closure should remain available to state and local authorities as an influenza mitigation strategy. Second, influenza plans need not necessarily specify the threshold for school closures but should clearly define provisions for early and ongoing local monitoring. Finally, school closure authority may be exercised at the statewide or local leve…
Impact of Introducing the Pneumococcal and Rotavirus Vaccines Into the Routine Immunization Program in Niger
Objectives. We investigated whether introducing the rotavirus and pneumococcal vaccines, which are greatly needed in West Africa, would overwhelm existing supply chains (i.e., the series of steps required to get a vaccine from the manufacturers to the target population) in Niger. Methods. As part of the Bill and Melinda Gates Foundation–funded Vaccine Modeling Initiative, we developed a computational model to determine the impact of introducing t…
Would school closure for the 2009 H1N1 influenza epidemic have been worth the cost: A computational simulation of Pennsylvania
Our study suggests that closing schools during the 2009 H1N1 epidemic could have resulted in substantial costs to society as the potential costs of lost productivity and childcare could have far outweighed the cost savings in preventing influenza cases
Impact of changing the measles vaccine vial size on Niger's vaccine supply chain: A computational model
The switch from the 10-dose measles vaccines to smaller vial sizes could overwhelm the capacities of many storage facilities and transport vehicles as well as increase the cost per vaccinated child
Social Network Analysis of Patient Sharing Among Hospitals in Orange County, California
Objectives. We applied social network analyses to determine how hospitals within Orange County, California, are interconnected by patient sharing, a system which may have numerous public health implications. Methods. Our analyses considered 2 general patient-sharing networks: uninterrupted patient sharing (UPS; i.e., direct interhospital transfers) and total patient sharing (TPS; i.e., all interhospital patient sharing, including patients with in…
Strategies for mitigating an influenza pandemic
Strategies for containing an emerging influenza pandemic in Southeast Asia
Bushmeat Hunting, Deforestation, and Prediction of Zoonotic Disease
Understanding the emergence of new zoonotic agents requires knowledge of pathogen biodiversity in wildlife, human-wildlife interactions, anthropogenic pressures on wildlife populations, and changes in society and human behavior. We discuss an interdisciplinary approach combining virology, wildlife biology, disease ecology, and anthropology that enables better understanding of how deforestation and associated hunting leads to the emergence of nove…
The Politics of International Health: The Children's Vaccine Initiative and the Struggle to Develop Vaccines for the Third World (review)
At a sushi bar in Hokkaido I once feasted on "dancing shrimp," scooped live from the tank, dressed, and served still twitching. The taste was exquisite and the sensation unique, but my enjoyment was vaguely uncivilized and discomfiting. So it is with this marvelous but unsettling new book, in which William Muraskin, a sociologist/historian, vivisects and serves up to the reader the living story of a noble experiment called the Children's Vaccine …
James Madison's Dystopian Vision: The Failure of Equilibrium
Journal Article James Madison's Dystopian Vision: The Failure of Equilibrium Get access Donald Burke Donald Burke Ph.D. candidate in history *Wayne State University, Detroit, Michigan. I would like to thank James M. Banner, Jr. and the James Madison Foundation for the opportunity to study the creation of the Constitution, Sandra VanBurkleo for guidance, and Jack N. Rakove for a critical reading of my essay. Search for other works by this author o…
Prevalence of human T-lymphotropic virus in civilian applicants for the United States Armed Forces
BACKGROUND. The wide range in human T-lymphotropic virus (HTLV) seroprevalences reported worldwide has made estimates of seroprevalence difficult in unique populations. In this study, the seropositivity of young adult civilian applicants for the US Armed Forces was determined. METHODS. Serum samples from nine geographic regions were screened by an Enzyme-Linked Immunosorbent Assay (ELISA), and repeatedly reactive samples were further tested by We…
Human immunodeficiency virus seropositivity among members of the active duty US Army 1985-89
Between October 1985 and June 1989, most active duty US Army soldiers were screened for human immunodeficiency virus (HIV) antibody. Of 648,032 screened soldiers in this analysis, 1,588 were HIV-antibody positive. In a multivariate analysis, correlates of positivity included: age [Adjusted Odds Ratios (ref less than 20 years) = 20-24 years, 3.7; 25-29, 9.3; 30-34, 15.7; greater than or equal to 35, 15.9]; being male, [4.2]; being Black or Hispani…
Spatial Diffusion of the Human Immunodeficiency Virus Infection Epidemic in the United States, 1985–87
We present a geographical analysis of the first 22 months of the Department of Defense's human immunodeficiency virus (HIV) screening program for military applicants. This analysis concerns four HIV epidemic foci in the United States: New York City; Miami, Florida: Houston, Texas; and San Francisco, California. The cartographic analysis, using a novel smoothing algorithm to stabilize county-based rates, highlights the diffusion of the HIV epidemi…
Spatial Diffusion of the Human Immunodeficiency Virus Infection Epidemic in the United States, 1985–87
We present a geographical analysis of the first 22 months of the Department of Defense's human immunodeficiency virus (HIV) screening program for military applicants. This analysis concerns four HIV epidemic foci in the United States: New York City; Miami, Florida: Houston, Texas; and San Francisco, California. The cartographic analysis, using a novel smoothing algorithm to stabilize county-based rates, highlights the diffusion of the HIV epidemi…
Social Network Analysis of Patient Sharing Among Hospitals in Orange County, California
Objectives. We applied social network analyses to determine how hospitals within Orange County, California, are interconnected by patient sharing, a system which may have numerous public health implications. Methods. Our analyses considered 2 general patient-sharing networks: uninterrupted patient sharing (UPS; i.e., direct interhospital transfers) and total patient sharing (TPS; i.e., all interhospital patient sharing, including patients with in…
Policies to Reduce Influenza in the Workplace: Impact Assessments Using an Agent-Based Model
Objectives. We examined the impact of access to paid sick days (PSDs) and stay-at-home behavior on the influenza attack rate in workplaces. Methods. We used an agent-based model of Allegheny County, Pennsylvania, with PSD data from the US Bureau of Labor Statistics, standard influenza epidemic parameters, and the probability of staying home when ill. We compared the influenza attack rate among employees resulting from workplace transmission, focu…
Human immunodeficiency virus seropositivity among members of the active duty US Army 1985-89
Between October 1985 and June 1989, most active duty US Army soldiers were screened for human immunodeficiency virus (HIV) antibody. Of 648,032 screened soldiers in this analysis, 1,588 were HIV-antibody positive. In a multivariate analysis, correlates of positivity included: age [Adjusted Odds Ratios (ref less than 20 years) = 20-24 years, 3.7; 25-29, 9.3; 30-34, 15.7; greater than or equal to 35, 15.9]; being male, [4.2]; being Black or Hispani…
Impact of Introducing the Pneumococcal and Rotavirus Vaccines Into the Routine Immunization Program in Niger
Objectives. We investigated whether introducing the rotavirus and pneumococcal vaccines, which are greatly needed in West Africa, would overwhelm existing supply chains (i.e., the series of steps required to get a vaccine from the manufacturers to the target population) in Niger. Methods. As part of the Bill and Melinda Gates Foundation–funded Vaccine Modeling Initiative, we developed a computational model to determine the impact of introducing t…
Spatial Diffusion of the Human Immunodeficiency Virus Infection Epidemic in the United States, 1985–87
We present a geographical analysis of the first 22 months of the Department of Defense's human immunodeficiency virus (HIV) screening program for military applicants. This analysis concerns four HIV epidemic foci in the United States: New York City; Miami, Florida: Houston, Texas; and San Francisco, California. The cartographic analysis, using a novel smoothing algorithm to stabilize county-based rates, highlights the diffusion of the HIV epidemi…
Human immunodeficiency virus seropositivity among members of the active duty US Army 1985-89
Between October 1985 and June 1989, most active duty US Army soldiers were screened for human immunodeficiency virus (HIV) antibody. Of 648,032 screened soldiers in this analysis, 1,588 were HIV-antibody positive. In a multivariate analysis, correlates of positivity included: age [Adjusted Odds Ratios (ref less than 20 years) = 20-24 years, 3.7; 25-29, 9.3; 30-34, 15.7; greater than or equal to 35, 15.9]; being male, [4.2]; being Black or Hispani…
Prevalence of human T-lymphotropic virus in civilian applicants for the United States Armed Forces
BACKGROUND. The wide range in human T-lymphotropic virus (HTLV) seroprevalences reported worldwide has made estimates of seroprevalence difficult in unique populations. In this study, the seropositivity of young adult civilian applicants for the US Armed Forces was determined. METHODS. Serum samples from nine geographic regions were screened by an Enzyme-Linked Immunosorbent Assay (ELISA), and repeatedly reactive samples were further tested by We…
James Madison's Dystopian Vision: The Failure of Equilibrium
Journal Article James Madison's Dystopian Vision: The Failure of Equilibrium Get access Donald Burke Donald Burke Ph.D. candidate in history *Wayne State University, Detroit, Michigan. I would like to thank James M. Banner, Jr. and the James Madison Foundation for the opportunity to study the creation of the Constitution, Sandra VanBurkleo for guidance, and Jack N. Rakove for a critical reading of my essay. Search for other works by this author o…
The Politics of International Health: The Children's Vaccine Initiative and the Struggle to Develop Vaccines for the Third World (review)
At a sushi bar in Hokkaido I once feasted on "dancing shrimp," scooped live from the tank, dressed, and served still twitching. The taste was exquisite and the sensation unique, but my enjoyment was vaguely uncivilized and discomfiting. So it is with this marvelous but unsettling new book, in which William Muraskin, a sociologist/historian, vivisects and serves up to the reader the living story of a noble experiment called the Children's Vaccine …
Strategies for containing an emerging influenza pandemic in Southeast Asia
Bushmeat Hunting, Deforestation, and Prediction of Zoonotic Disease
Understanding the emergence of new zoonotic agents requires knowledge of pathogen biodiversity in wildlife, human-wildlife interactions, anthropogenic pressures on wildlife populations, and changes in society and human behavior. We discuss an interdisciplinary approach combining virology, wildlife biology, disease ecology, and anthropology that enables better understanding of how deforestation and associated hunting leads to the emergence of nove…
Strategies for mitigating an influenza pandemic
Would school closure for the 2009 H1N1 influenza epidemic have been worth the cost: A computational simulation of Pennsylvania
Our study suggests that closing schools during the 2009 H1N1 epidemic could have resulted in substantial costs to society as the potential costs of lost productivity and childcare could have far outweighed the cost savings in preventing influenza cases
Impact of changing the measles vaccine vial size on Niger's vaccine supply chain: A computational model
The switch from the 10-dose measles vaccines to smaller vial sizes could overwhelm the capacities of many storage facilities and transport vehicles as well as increase the cost per vaccinated child
Social Network Analysis of Patient Sharing Among Hospitals in Orange County, California
Objectives. We applied social network analyses to determine how hospitals within Orange County, California, are interconnected by patient sharing, a system which may have numerous public health implications. Methods. Our analyses considered 2 general patient-sharing networks: uninterrupted patient sharing (UPS; i.e., direct interhospital transfers) and total patient sharing (TPS; i.e., all interhospital patient sharing, including patients with in…
Chapter 12. Toward a Containment Strategy for Smallpox Bioterror: An Individual-Based Computational Approach
Failure to Detect Simian Immunodeficiency Virus Infection in a Large Cameroonian Cohort with High Non-human Primate Exposure
School closure as an influenza mitigation strategy: How variations in legal authority and plan criteria can alter the impact
This agent-based simulation suggests several ways to improve statutes and influenza plans. First, school closure should remain available to state and local authorities as an influenza mitigation strategy. Second, influenza plans need not necessarily specify the threshold for school closures but should clearly define provisions for early and ongoing local monitoring. Finally, school closure authority may be exercised at the statewide or local leve…
Impact of Introducing the Pneumococcal and Rotavirus Vaccines Into the Routine Immunization Program in Niger
Objectives. We investigated whether introducing the rotavirus and pneumococcal vaccines, which are greatly needed in West Africa, would overwhelm existing supply chains (i.e., the series of steps required to get a vaccine from the manufacturers to the target population) in Niger. Methods. As part of the Bill and Melinda Gates Foundation–funded Vaccine Modeling Initiative, we developed a computational model to determine the impact of introducing t…
FRED (A Framework for Reconstructing Epidemic Dynamics): An open-source software system for modeling infectious diseases and control strategies using census-based populations
State and county public health planners can use FRED to explore the effects of possible influenza epidemics in specific geographic regions of interest and to help evaluate the effect of interventions such as vaccination programs and school closure policies. FRED is available under a free open source license in order to contribute to the development of better modeling tools and to encourage open discussion of modeling tools being used to evaluate …
Policies to Reduce Influenza in the Workplace: Impact Assessments Using an Agent-Based Model
Objectives. We examined the impact of access to paid sick days (PSDs) and stay-at-home behavior on the influenza attack rate in workplaces. Methods. We used an agent-based model of Allegheny County, Pennsylvania, with PSD data from the US Bureau of Labor Statistics, standard influenza epidemic parameters, and the probability of staying home when ill. We compared the influenza attack rate among employees resulting from workplace transmission, focu…
A large-scale immuno-epidemiological simulation of influenza A epidemics
We present a framework for multi-scale simulations of influenza epidemics that enables the study of population-level effects of individual differences in infections and symptoms, with minimal additional computational cost compared to the existing population-level simulations
Kumar et al. Respond
AffiliationsSupriya Kumar and Donald S. Burke are with the Department of Epidemiology Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. John J. Grefenstette and David Galloway are with the Public Health Dynamics Laboratory, Graduate School of Public Health, University of Pittsburgh. Steven M. Albert is with the Department of Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsbu…
Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016
Analyzing the drug abuse epidemic There is a developing drug epidemic in the United States. Jalal et al. analyzed nearly 600,000 unintentional drug overdoses over a 38-year period. Although the overall mortality rate closely followed an exponential growth curve, the pattern itself is a composite of several underlying subepidemics of different drugs. Geographic hotspots have developed over time, as well as drug-specific demographic differences. Sc…
Reply commentary by Jalal and Burke
Dynamics of drug overdose deaths in the United States during Covid-19
Pandemic era overdose deaths comprise continuing exponential growth, a COVID-19 related sustained rise tied to social disruption, and EIP linked spikes. Future relief payments should consider staggered disbursement and concurrent harm reduction measures to mitigate overdose risk
Medicine (19 works) · Environmental health (11 works) · COVID-19 epidemiological studies (8 works) · Public health (8 works) · Virology (8 works) · Influenza Virus Research Studies (7 works) · Population (7 works) · Virology (7 works) · Computer Science (5 works) · Demography (5 works)