Pietro Ferrari
Biographic Data
| ID | 5458736 |
|---|---|
| NAME | Pietro Ferrari |
| GIVEN NAMES | Pietro |
| FAMILY NAME | Ferrari |
| SIGNATURE | FERRARI P |
| AFFILIATIONS | Centre international de recherche sur le cancer |
| ORCID | 0000-0001-9358-7338 |
| VERIFIED | Yes |
| TOTAL WORKS | 22 |
| TOTAL CITATIONS | 3 |
| WORKS AS AUTHOR | 22 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2002 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Does lifestyle explain the relationship between socioeconomic position and multimorbidity of cancer and cardiometabolic diseases? A mediation analysis applied to the European Prospective Investigation…
BACKGROUND: Multimorbidity is socially patterned, with lower socioeconomic position (SEP) linked to higher risk. We examined whether a Healthy Lifestyle Index (HLI) mediates the SEP-multimorbidity association and whether pathways differ by sex. METHODS: We used data from 244 886 participants in the European Prospective Investigation into Cancer and Nutrition study. HLI was derived from smoking, alcohol consumption, physical activity, body mass in…
Dietary patterns among Afghan adults and their associations with overweight and obesity
Three distinct dietary patterns were identified among Afghan adults from Kandahar. Weak positive associations were found between the Western dietary pattern and general and central obesity. Associations of fruits and vegetables and traditional dietary patterns with obesity deserve further evaluation in a larger sample and with more detailed dietary intake assessment methods that also consider preparation methods and food processing
Quantifying the environmental and food biodiversity impacts of ultra-processed foods
Objective: While associations of ultra-processed food (UPF) consumption with adverse health outcomes are accruing, its environmental and food biodiversity impacts remain underexplored. This study examines associations between UPF consumption and dietary greenhouse gas emissions (GHGe), land use and food biodiversity. Design: Prospective cohort study. Linear mixed models estimated associations between UPF intake (g/d and kcal/d) and GHGe (kg CO 2 …
Overall lifestyle changes in adulthood are associated with cancer incidence in the Norwegian Women and Cancer Study (Nowac) – a prospective cohort study
This study provides evidence that overall lifestyle changes among cancer-free women between the ages of 41 and 76 impact the incidence of many cancer types. Regardless of baseline lifestyle, there was a negative dose-response relationship between magnitude of positive lifestyle change and the incidence of overall lifestyle-related cancers. We observed that underlying this trend was an especially clear association between lifestyle worsening and i…
Global burden of cancer in 2020 attributable to alcohol consumption
BACKGROUND: Alcohol use is causally linked to multiple cancers. We present global, regional, and national estimates of alcohol-attributable cancer burden in 2020 to inform alcohol policy and cancer control across different settings globally. METHODS: In this population-based study, population attributable fractions (PAFs) calculated using a theoretical minimum-risk exposure of lifetime abstention and 2010 alcohol consumption estimates from the Gl…
Temporal trends in food group availability and cancer incidence in Africa
Objective: We evaluated the relationship between food availability, as the only dietary exposure data available across Africa, and age-standardised cancer incidence rates (ASR) in eighteen countries. Design: Ecological study. Setting: Availability of food groups and dietary energy was considered for five hypothetical time points: years of collection of ASR ( T 0 ) and 5, 10, 15 and 20 preceding years ( T –5 , T –10 , T –15 , T –20 ). Ecological c…
Risk thresholds for alcohol consumption
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-inco…
A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (Epic)
Objective Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confide…
Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and breast cancer risk in the Cancer de Màma (Cama) study
Objective We investigated the association between adherence to the recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and breast cancer (BC) risk in the Cancer de Màma (CAMA) study in a Mexican population. Design Population-based case–control study. Subjects Incident BC cases ( n 1000) and controls ( n 1074) matched on age, region and health-care system were recruited. Setting In-person interviews…
Identifying dietary patterns using a normal mixture model
BACKGROUND: Finite mixture models posit the existence of a latent categorical variable and can be used for probabilistic classification. The authors illustrate the use of mixture models for dietary pattern analysis. An advantage of this approach is taking classification uncertainty into account. METHODS: Participants were a random sample of women from the European Prospective Investigation into Cancer. Food consumption was measured using dietary …
P2-307 Latent model for DNA methylation, nucleotide synthesis and immune activation for lung cancer risk
Introduction Lung cancer (LC) remains the leading cause of cancer mortality worldwide. In addition to tobacco exposure, low intake of specific micronutrient has been linked to LC. The diet is the main source of vitamins and amino acids involved in the one-carbon metabolism, which is considered key mechanism in maintaining DNA integrity, regulating gene expression, and may thus affect carcinogenesis. Two important branches of the one-carbon metabo…
General and Abdominal Adiposity and Risk of Death in Europe
BACKGROUND: Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death. METHODS: We examined the association of BMI, waist circumference, and waist-to-hip ratio with the risk of death among 359,387 partici…
Dietary patterns and survival of older Europeans
Objective To investigate the association of a posteriori dietary patterns with overall survival of older Europeans. Design and setting This is a multi-centre cohort study. Cox regression analysis was used to investigate the association of the prevailing, a posteriori -derived, plant-based dietary pattern with all-cause mortality in a population of subjects who were 60 years or older at recruitment to the European Prospective Investigation into Ca…
Plasma levels of six carotenoids in nine European countries
Background: In addition to their possible direct biological effects, plasma carotenoids can be used as biochemical markers of fruit and vegetable consumption for identifying diet–disease associations in epidemiological studies. Few studies have compared levels of these carotenoids between countries in Europe. Objective: Our aim was to assess the variability of plasma carotenoid levels within the cohort of the European Prospective Investigation in…
Trends in self-reported past alcoholic beverage consumption and ethanol intake from 1950 to 1995 observed in eight European countries participating in the European Investigation into Cancer and Nutrit…
Objective: To describe the trends of self-reported past consumption of alcoholic beverages and ethanol intake from 1950 to 1995 within the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Data on consumption of beer/cider, wine and liqueur/spirits were obtained retrospectively at age 20, 30 and 40 years to calculate average consumption and ethanol intake for the time periods 1950–1975 (at age 20), 1960–1985 (at age 30)…
European Prospective Investigation into Cancer and Nutrition (Epic)
The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35–70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and caus…
European Prospective Investigation into Cancer and Nutrition (Epic) calibration study
The European Prospective Investigation into Cancer and Nutrition (EPIC), which covers a large cohort of half a million men and women from 23 European centres in 10 Western European countries, was designed to study the relationship between diet and the risk of chronic diseases, particularly cancer. Information on usual individual dietary intake was assessed using different validated dietary assessment methods across participating countries. In ord…
Uses and limitations of statistical accounting for random error correlations, in the validation of dietary questionnaire assessments
Objective: To examine statistical models that account for correlation between random errors of different dietary assessment methods, in dietary validation studies. Setting: In nutritional epidemiology, sub-studies on the accuracy of the dietary questionnaire measurements are used to correct for biases in relative risk estimates induced by dietary assessment errors. Generally, such validation studies are based on the comparison of questionnaire me…
Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (Epic) project
Objective: To describe the diversity in dietary patterns existing across centres/regions participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design and setting: Single 24-hour dietary recall measurements were obtained by means of standardised face-to-face interviews using the EPIC-SOFT software. These have been used to present a graphic multi-dimensional comparison of the adjusted mean consumption of 22 food …
Physical activity of subjects aged 50–64 years involved in the European Prospective Investigation into Cancer and Nutrition (Epic)
Objective: To describe physical activity of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis was restricted to participants in the age group 50–64 years, which was represented in all EPIC centres. It involved 236 386 participants from 25 centres in nine countries. In each EPIC centre, physical…
Bias in dietary-report instruments and its implications for nutritional epidemiology
Objective: To evaluate measurement error structure in dietary assessment instruments and to investigate its implications for nutritional studies, using urinary nitrogen excretion as a reference biomarker for protein intake. Design: The dietary assessment methods included different food-frequency questionnaires (FFQs) and such conventional dietary-report reference instruments as a series of 24-hour recalls, 4-day weighed food records or 7-day diar…
Evaluation of under- and overreporting of energy intake in the 24-hour diet recalls in the European Prospective Investigation into Cancer and Nutrition (Epic)
EI tends to be underestimated in the vast majority of the EPIC centres, although to varying degrees; at the aggregate level most centres were below the expected reference value of 1.55. Underreporting seems to be more prevalent among women than men in the EPIC calibration sample. The hypothesis that BMI (or weight) and age are causally related to underreporting seems to be confirmed in the present work. This introduces further complexity in the w…
Identifying dietary patterns using a normal mixture model
BACKGROUND: Finite mixture models posit the existence of a latent categorical variable and can be used for probabilistic classification. The authors illustrate the use of mixture models for dietary pattern analysis. An advantage of this approach is taking classification uncertainty into account. METHODS: Participants were a random sample of women from the European Prospective Investigation into Cancer. Food consumption was measured using dietary …
Trends in self-reported past alcoholic beverage consumption and ethanol intake from 1950 to 1995 observed in eight European countries participating in the European Investigation into Cancer and Nutrit…
Objective: To describe the trends of self-reported past consumption of alcoholic beverages and ethanol intake from 1950 to 1995 within the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Data on consumption of beer/cider, wine and liqueur/spirits were obtained retrospectively at age 20, 30 and 40 years to calculate average consumption and ethanol intake for the time periods 1950–1975 (at age 20), 1960–1985 (at age 30)…
European Prospective Investigation into Cancer and Nutrition (Epic)
The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35–70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and caus…
European Prospective Investigation into Cancer and Nutrition (Epic) calibration study
The European Prospective Investigation into Cancer and Nutrition (EPIC), which covers a large cohort of half a million men and women from 23 European centres in 10 Western European countries, was designed to study the relationship between diet and the risk of chronic diseases, particularly cancer. Information on usual individual dietary intake was assessed using different validated dietary assessment methods across participating countries. In ord…
Uses and limitations of statistical accounting for random error correlations, in the validation of dietary questionnaire assessments
Objective: To examine statistical models that account for correlation between random errors of different dietary assessment methods, in dietary validation studies. Setting: In nutritional epidemiology, sub-studies on the accuracy of the dietary questionnaire measurements are used to correct for biases in relative risk estimates induced by dietary assessment errors. Generally, such validation studies are based on the comparison of questionnaire me…
Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (Epic) project
Objective: To describe the diversity in dietary patterns existing across centres/regions participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design and setting: Single 24-hour dietary recall measurements were obtained by means of standardised face-to-face interviews using the EPIC-SOFT software. These have been used to present a graphic multi-dimensional comparison of the adjusted mean consumption of 22 food …
Physical activity of subjects aged 50–64 years involved in the European Prospective Investigation into Cancer and Nutrition (Epic)
Objective: To describe physical activity of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis was restricted to participants in the age group 50–64 years, which was represented in all EPIC centres. It involved 236 386 participants from 25 centres in nine countries. In each EPIC centre, physical…
Bias in dietary-report instruments and its implications for nutritional epidemiology
Objective: To evaluate measurement error structure in dietary assessment instruments and to investigate its implications for nutritional studies, using urinary nitrogen excretion as a reference biomarker for protein intake. Design: The dietary assessment methods included different food-frequency questionnaires (FFQs) and such conventional dietary-report reference instruments as a series of 24-hour recalls, 4-day weighed food records or 7-day diar…
Evaluation of under- and overreporting of energy intake in the 24-hour diet recalls in the European Prospective Investigation into Cancer and Nutrition (Epic)
EI tends to be underestimated in the vast majority of the EPIC centres, although to varying degrees; at the aggregate level most centres were below the expected reference value of 1.55. Underreporting seems to be more prevalent among women than men in the EPIC calibration sample. The hypothesis that BMI (or weight) and age are causally related to underreporting seems to be confirmed in the present work. This introduces further complexity in the w…
Plasma levels of six carotenoids in nine European countries
Background: In addition to their possible direct biological effects, plasma carotenoids can be used as biochemical markers of fruit and vegetable consumption for identifying diet–disease associations in epidemiological studies. Few studies have compared levels of these carotenoids between countries in Europe. Objective: Our aim was to assess the variability of plasma carotenoid levels within the cohort of the European Prospective Investigation in…
Dietary patterns and survival of older Europeans
Objective To investigate the association of a posteriori dietary patterns with overall survival of older Europeans. Design and setting This is a multi-centre cohort study. Cox regression analysis was used to investigate the association of the prevailing, a posteriori -derived, plant-based dietary pattern with all-cause mortality in a population of subjects who were 60 years or older at recruitment to the European Prospective Investigation into Ca…
General and Abdominal Adiposity and Risk of Death in Europe
BACKGROUND: Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death. METHODS: We examined the association of BMI, waist circumference, and waist-to-hip ratio with the risk of death among 359,387 partici…
P2-307 Latent model for DNA methylation, nucleotide synthesis and immune activation for lung cancer risk
Introduction Lung cancer (LC) remains the leading cause of cancer mortality worldwide. In addition to tobacco exposure, low intake of specific micronutrient has been linked to LC. The diet is the main source of vitamins and amino acids involved in the one-carbon metabolism, which is considered key mechanism in maintaining DNA integrity, regulating gene expression, and may thus affect carcinogenesis. Two important branches of the one-carbon metabo…
Identifying dietary patterns using a normal mixture model
BACKGROUND: Finite mixture models posit the existence of a latent categorical variable and can be used for probabilistic classification. The authors illustrate the use of mixture models for dietary pattern analysis. An advantage of this approach is taking classification uncertainty into account. METHODS: Participants were a random sample of women from the European Prospective Investigation into Cancer. Food consumption was measured using dietary …
Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and breast cancer risk in the Cancer de Màma (Cama) study
Objective We investigated the association between adherence to the recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and breast cancer (BC) risk in the Cancer de Màma (CAMA) study in a Mexican population. Design Population-based case–control study. Subjects Incident BC cases ( n 1000) and controls ( n 1074) matched on age, region and health-care system were recruited. Setting In-person interviews…
A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (Epic)
Objective Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confide…
Risk thresholds for alcohol consumption
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-inco…
Temporal trends in food group availability and cancer incidence in Africa
Objective: We evaluated the relationship between food availability, as the only dietary exposure data available across Africa, and age-standardised cancer incidence rates (ASR) in eighteen countries. Design: Ecological study. Setting: Availability of food groups and dietary energy was considered for five hypothetical time points: years of collection of ASR ( T 0 ) and 5, 10, 15 and 20 preceding years ( T –5 , T –10 , T –15 , T –20 ). Ecological c…
Global burden of cancer in 2020 attributable to alcohol consumption
BACKGROUND: Alcohol use is causally linked to multiple cancers. We present global, regional, and national estimates of alcohol-attributable cancer burden in 2020 to inform alcohol policy and cancer control across different settings globally. METHODS: In this population-based study, population attributable fractions (PAFs) calculated using a theoretical minimum-risk exposure of lifetime abstention and 2010 alcohol consumption estimates from the Gl…
Overall lifestyle changes in adulthood are associated with cancer incidence in the Norwegian Women and Cancer Study (Nowac) – a prospective cohort study
This study provides evidence that overall lifestyle changes among cancer-free women between the ages of 41 and 76 impact the incidence of many cancer types. Regardless of baseline lifestyle, there was a negative dose-response relationship between magnitude of positive lifestyle change and the incidence of overall lifestyle-related cancers. We observed that underlying this trend was an especially clear association between lifestyle worsening and i…
Dietary patterns among Afghan adults and their associations with overweight and obesity
Three distinct dietary patterns were identified among Afghan adults from Kandahar. Weak positive associations were found between the Western dietary pattern and general and central obesity. Associations of fruits and vegetables and traditional dietary patterns with obesity deserve further evaluation in a larger sample and with more detailed dietary intake assessment methods that also consider preparation methods and food processing
Quantifying the environmental and food biodiversity impacts of ultra-processed foods
Objective: While associations of ultra-processed food (UPF) consumption with adverse health outcomes are accruing, its environmental and food biodiversity impacts remain underexplored. This study examines associations between UPF consumption and dietary greenhouse gas emissions (GHGe), land use and food biodiversity. Design: Prospective cohort study. Linear mixed models estimated associations between UPF intake (g/d and kcal/d) and GHGe (kg CO 2 …
Does lifestyle explain the relationship between socioeconomic position and multimorbidity of cancer and cardiometabolic diseases? A mediation analysis applied to the European Prospective Investigation…
BACKGROUND: Multimorbidity is socially patterned, with lower socioeconomic position (SEP) linked to higher risk. We examined whether a Healthy Lifestyle Index (HLI) mediates the SEP-multimorbidity association and whether pathways differ by sex. METHODS: We used data from 244 886 participants in the European Prospective Investigation into Cancer and Nutrition study. HLI was derived from smoking, alcohol consumption, physical activity, body mass in…
Medicine (18 works) · Nutritional Studies and Diet (15 works) · Demography (14 works) · Internal Medicine (13 works) · Demography (12 works) · Environmental health (12 works) · European Prospective Investigation into Cancer and Nutrition (12 works) · Cancer (11 works) · Prospective cohort study (10 works) · EPIC (9 works)