Thomas C Register
Biographic Data
| ID | 5470969 |
|---|---|
| NAME | Thomas C Register |
| GIVEN NAMES | Thomas C |
| FAMILY NAME | Register |
| SIGNATURE | REGISTER T C |
| AFFILIATIONS | Wake Forest University |
| ORCID | 0000-0002-4078-0166 |
| VERIFIED | Yes |
| TOTAL WORKS | 7 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 7 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2008 |
| LATEST PUBLICATION YEAR | 2021 |
| H-INDEX | 0 |
Aging‐related Alzheimer's disease‐like neuropathology and functional decline in captive vervet monkeys ( Chlorocebus aethiops sabaeus )
Age‐related neurodegeneration characteristic of late‐onset Alzheimer's disease (LOAD) begins in middle age, well before symptoms. Translational models to identify modifiable risk factors are needed to understand etiology and identify therapeutic targets. Here, we outline the evidence supporting the vervet monkey ( Chlorocebus aethiops sabaeus ) as a model of aging‐related AD‐like neuropathology and associated phenotypes including cognitive functi…
Preclinical laboratory assessments of predictors of social rank in female cynomolgus monkeys
Physiological and behavioral differences between dominant and subordinate monkeys have been useful in preclinical models investigating numerous disease states. In captivity, it has been inferred that subordinate monkeys live in a context of chronic social stress and may be at risk for a variety of dysfunctions; however, the factors that influence eventual rank are not entirely known. The goal of the present study was to first evaluate several phe…
Effects of Long-Term Sertraline Treatment and Depression on Coronary Artery Atherosclerosis in Premenopausal Female Primates
OBJECTIVES: Major depressive disorder and coronary heart disease often co-occur in the same individuals. Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for depression and other disorders, but their effects on coronary heart disease risk remain unclear. We determined the effects of an SSRI on coronary artery atherosclerosis (CAA) in an established nonhuman primate model used to clarify the association between depression and …
Effect of Depression and Sertraline Treatment on Cardiac Function in Female Nonhuman Primates
Social stress, visceral obesity, and coronary artery atherosclerosis
Abdominal obesity is prevalent and often accompanied by an array of metabolic perturbations including elevated blood pressure, dyslipidemia, impaired glucose tolerance or insulin resistance, a prothrombotic state, and a proinflammatory state, together referred to as the metabolic syndrome. The metabolic syndrome greatly increases coronary heart disease (CHD) risk. Social stress also increases CHD although the mechanisms through which this occurs …
Primate models in women's health
Female cynomolgus monkeys are excellent models for understanding cardiovascular disease and the relationships between inflammatory processes and conditions such as atherogenesis. This review summarizes published research findings obtained through comprehensive, multidisciplinary, multi‐investigator studies in nonhuman primates over the past two decades. These studies examined the effects of exogenous estrogens and dietary soy protein/isoflavones …
Depressive Behavior and Coronary Artery Atherogenesis in Adult Female Cynomolgus Monkeys
Objective: To examine depressive behavior and early coronary artery atherogenesis in 36 socially housed female cynomolgus monkeys, an established model of atherogenesis and depression. Coronary heart disease (CHD) is caused by coronary artery atherosclerosis (CAA) and its sequelae which develop over a period of decades. Thus, in prospective studies of depression and CHD, CAA was likely present at baseline in most subjects who experienced cardiac …
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Depressive Behavior and Coronary Artery Atherogenesis in Adult Female Cynomolgus Monkeys
Objective: To examine depressive behavior and early coronary artery atherogenesis in 36 socially housed female cynomolgus monkeys, an established model of atherogenesis and depression. Coronary heart disease (CHD) is caused by coronary artery atherosclerosis (CAA) and its sequelae which develop over a period of decades. Thus, in prospective studies of depression and CHD, CAA was likely present at baseline in most subjects who experienced cardiac …
Social stress, visceral obesity, and coronary artery atherosclerosis
Abdominal obesity is prevalent and often accompanied by an array of metabolic perturbations including elevated blood pressure, dyslipidemia, impaired glucose tolerance or insulin resistance, a prothrombotic state, and a proinflammatory state, together referred to as the metabolic syndrome. The metabolic syndrome greatly increases coronary heart disease (CHD) risk. Social stress also increases CHD although the mechanisms through which this occurs …
Primate models in women's health
Female cynomolgus monkeys are excellent models for understanding cardiovascular disease and the relationships between inflammatory processes and conditions such as atherogenesis. This review summarizes published research findings obtained through comprehensive, multidisciplinary, multi‐investigator studies in nonhuman primates over the past two decades. These studies examined the effects of exogenous estrogens and dietary soy protein/isoflavones …
Effect of Depression and Sertraline Treatment on Cardiac Function in Female Nonhuman Primates
Effects of Long-Term Sertraline Treatment and Depression on Coronary Artery Atherosclerosis in Premenopausal Female Primates
OBJECTIVES: Major depressive disorder and coronary heart disease often co-occur in the same individuals. Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for depression and other disorders, but their effects on coronary heart disease risk remain unclear. We determined the effects of an SSRI on coronary artery atherosclerosis (CAA) in an established nonhuman primate model used to clarify the association between depression and …
Preclinical laboratory assessments of predictors of social rank in female cynomolgus monkeys
Physiological and behavioral differences between dominant and subordinate monkeys have been useful in preclinical models investigating numerous disease states. In captivity, it has been inferred that subordinate monkeys live in a context of chronic social stress and may be at risk for a variety of dysfunctions; however, the factors that influence eventual rank are not entirely known. The goal of the present study was to first evaluate several phe…
Aging‐related Alzheimer's disease‐like neuropathology and functional decline in captive vervet monkeys ( Chlorocebus aethiops sabaeus )
Age‐related neurodegeneration characteristic of late‐onset Alzheimer's disease (LOAD) begins in middle age, well before symptoms. Translational models to identify modifiable risk factors are needed to understand etiology and identify therapeutic targets. Here, we outline the evidence supporting the vervet monkey ( Chlorocebus aethiops sabaeus ) as a model of aging‐related AD‐like neuropathology and associated phenotypes including cognitive functi…
Medicine (6 works) · Internal Medicine (5 works) · Biology (4 works) · Endocrinology (4 works) · Stress Responses and Cortisol (4 works) · Coronary artery disease (3 works) · Physiology (3 works) · Psychology (3 works) · Adipokines, Inflammation, and Metabolic Diseases (2 works) · Artery (2 works)