Victor Akelo
Datos Biográficos
| ID | 5472018 |
|---|---|
| NOMBRE | Victor Akelo |
| NOMBRES | Victor |
| APELLIDO | Akelo |
| FIRMA | AKELO V |
| AFILIACIONES | Centers for Disease Control and Prevention |
| ORCID | 0000-0001-7518-2855 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 14 |
| TOTAL DE CITAS | 0 |
| TOTAL COMO AUTOR | 14 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2020 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 0 |
Country-specific estimates of misclassification rates of computer-coded verbal autopsy algorithms
INTRODUCTION: Computer-coded verbal autopsy (CCVA) algorithms are routinely used to determine individual cause of death (COD) and derive population-level estimates of cause-specific mortality fractions (CSMFs). But frequent COD misclassification leads to biased CSMF estimates. The VA-calibration framework reduces the bias by estimating misclassification rates; but it overlooks systematic patterns and cross-country variation, reducing the accuracy…
How maternal morbidities impact women’s quality of life during pregnancy and postpartum in sub-Saharan Africa and South Asia
Maternal morbidities present a major burden to the health and well-being of childbearing women. However, their impacts on women’s functional health are not well understood. This work aims to describe how maternal morbidities affect women’s quality of life (QoL) in pregnancy and the postpartum period . This qualitative study involved 118 pregnant and 135 postpartum women at six study sites in Kenya, Ghana, Zambia, Pakistan, and India. Data were co…
Systematic review of risk assessment tools for post-discharge mortality among children in sub-Saharan Africa
Post-discharge mortality is increasingly recognized as a major contributor to the high burden of childhood mortality in sub-Saharan Africa. Accurate identification of children at risk for post-discharge mortality is critically important to inform interventions to reduce deaths following hospital discharge. Our objective was to describe the current state of development, validation, or implementation for risk assessment tools for post-hospital disc…
Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal d…
Achieving the Sustainable Development Goal of reducing child mortality to Shigella /EIEC (14.0%), ST-ETEC (12.4%), rotavirus (26.4%), and adenovirus (non-40/41: 19.0%; 40/41: 5.0%). These pathogens were frequently identified as co-infections. Diarrheal disease accounted for a substantial share of child deaths across CHAMPS sites. Reducing mortality will require preventing diarrhea and addressing key contributors such as malnutrition and HIV
A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during Covid-19 in Kenya, 2018–2022
The impact of the COVID-19 pandemic on pediatric mortality, including measures to ensure continuity of HIV care, is not well described in Kenya. We evaluated causes of death (COD) among decedents under 5 years of age both before and during the COVID-19 pandemic in Kenya. We analyzed Child Health and Mortality Prevention Surveillance (CHAMPS) data collected in February 2018–March 2022. We describe the proportional contribution of specific conditio…
Survival probability and under-five mortality predictors in Western Kenya between 2015 and 2020
Under-five mortality in Siaya was 63/1000 live births, which is higher than the national average of 41.6/1000 live births. Gender, maternal education, number of ANC visits, maternal age, delivery in hospital, and availability of toilets at home were the main predictors of under-five mortality. These observations reinforce the need to target multiple components at the community and institutional levels to reduce childhood mortality. Such intervent…
Contribution of malnutrition to infant and child deaths in Sub-Saharan Africa and South Asia
Introduction Malnutrition contributes to 45% of all childhood deaths globally, but these modelled estimates lack direct measurements in countries with high malnutrition and under-5 mortality rates. We investigated malnutrition’s role in infant and child deaths in the Child Health and Mortality Prevention Surveillance (CHAMPS) network. Methods We analysed CHAMPS data from seven sites (Bangladesh, Ethiopia, Kenya, Mali, Mozambique, Sierra Leone and…
Identifying delays in healthcare seeking and provision
Delays in illness recognition, healthcare seeking, and in the provision of appropriate clinical care are common in resource-limited settings. Our objective was to determine the frequency of delays in the “Three Delays-in-Healthcare”, and factors associated with delays, among deceased infants and children in seven countries with high childhood mortality. We conducted a retrospective, descriptive study using data from verbal autopsies and medical r…
Adverse maternal, fetal, and newborn outcomes among pregnant women with Sars-CoV-2 infection
Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 and December 2021 were investigated with MITS within 24–72 hours of death. Testing included blood, cerebrospinal fluid and lung cultures, multi-pathoge…
Acceptability of minimally invasive autopsy by community members and healthcare workers in Siaya and Kisumu counties, western Kenya, 2017–2018
Worldwide, nearly six million children under the age of five (
Causes of death in HIV-infected and HIV-uninfected children aged under-five years in western Kenya
Nearly all HIV-infected decedents' underlying cause of death was HIV disease, which was associated with malnutrition. Our findings underscore the need for strengthening early identification and management of HIV-infected children. Prevention, early diagnosis and treatment of malnutrition could be instrumental in improving the survival of HIV-infected and HIV-uninfected children.
First cases of Sars-CoV-2 infection and secondary transmission in Kisumu, Kenya
We investigated the first 152 laboratory-confirmed SARS-CoV-2 cases (125 primary and 27 secondary) and their 248 close contacts in Kisumu County, Kenya. Conducted June 10–October 8, 2020, this study included interviews and sample collection at enrolment and 14–21 days later. Median age was 35 years (IQR 28–44); 69.0% reported COVID-19 related symptoms, most commonly cough (60.0%), headache (55.2%), fever (53.3%) and loss of taste or smell (43.8%)…
Healthcare-related stigma among men who have sex with men and transgender women in sub-Saharan Africa participating in HIV Prevention Trials Network (HPTN) 075 study
The inability to access health services when needed is a critical barrier to HIV prevention, treatment and care among men who have sex with men (MSM) and transgender women (TGW). Using data collected in HPTN 075, we explored factors associated with any experienced healthcare-related stigma. HPTN 075 was a cohort study to assess the feasibility of recruiting and retaining MSM and TGW in clinical trials in sub-Saharan Africa. Of 401 MSM and TGW enr…
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Healthcare-related stigma among men who have sex with men and transgender women in sub-Saharan Africa participating in HIV Prevention Trials Network (HPTN) 075 study
The inability to access health services when needed is a critical barrier to HIV prevention, treatment and care among men who have sex with men (MSM) and transgender women (TGW). Using data collected in HPTN 075, we explored factors associated with any experienced healthcare-related stigma. HPTN 075 was a cohort study to assess the feasibility of recruiting and retaining MSM and TGW in clinical trials in sub-Saharan Africa. Of 401 MSM and TGW enr…
Causes of death in HIV-infected and HIV-uninfected children aged under-five years in western Kenya
Nearly all HIV-infected decedents' underlying cause of death was HIV disease, which was associated with malnutrition. Our findings underscore the need for strengthening early identification and management of HIV-infected children. Prevention, early diagnosis and treatment of malnutrition could be instrumental in improving the survival of HIV-infected and HIV-uninfected children.
First cases of Sars-CoV-2 infection and secondary transmission in Kisumu, Kenya
We investigated the first 152 laboratory-confirmed SARS-CoV-2 cases (125 primary and 27 secondary) and their 248 close contacts in Kisumu County, Kenya. Conducted June 10–October 8, 2020, this study included interviews and sample collection at enrolment and 14–21 days later. Median age was 35 years (IQR 28–44); 69.0% reported COVID-19 related symptoms, most commonly cough (60.0%), headache (55.2%), fever (53.3%) and loss of taste or smell (43.8%)…
Adverse maternal, fetal, and newborn outcomes among pregnant women with Sars-CoV-2 infection
Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021
Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 and December 2021 were investigated with MITS within 24–72 hours of death. Testing included blood, cerebrospinal fluid and lung cultures, multi-pathoge…
Acceptability of minimally invasive autopsy by community members and healthcare workers in Siaya and Kisumu counties, western Kenya, 2017–2018
Worldwide, nearly six million children under the age of five (
Contribution of malnutrition to infant and child deaths in Sub-Saharan Africa and South Asia
Introduction Malnutrition contributes to 45% of all childhood deaths globally, but these modelled estimates lack direct measurements in countries with high malnutrition and under-5 mortality rates. We investigated malnutrition’s role in infant and child deaths in the Child Health and Mortality Prevention Surveillance (CHAMPS) network. Methods We analysed CHAMPS data from seven sites (Bangladesh, Ethiopia, Kenya, Mali, Mozambique, Sierra Leone and…
Identifying delays in healthcare seeking and provision
Delays in illness recognition, healthcare seeking, and in the provision of appropriate clinical care are common in resource-limited settings. Our objective was to determine the frequency of delays in the “Three Delays-in-Healthcare”, and factors associated with delays, among deceased infants and children in seven countries with high childhood mortality. We conducted a retrospective, descriptive study using data from verbal autopsies and medical r…
How maternal morbidities impact women’s quality of life during pregnancy and postpartum in sub-Saharan Africa and South Asia
Maternal morbidities present a major burden to the health and well-being of childbearing women. However, their impacts on women’s functional health are not well understood. This work aims to describe how maternal morbidities affect women’s quality of life (QoL) in pregnancy and the postpartum period . This qualitative study involved 118 pregnant and 135 postpartum women at six study sites in Kenya, Ghana, Zambia, Pakistan, and India. Data were co…
Systematic review of risk assessment tools for post-discharge mortality among children in sub-Saharan Africa
Post-discharge mortality is increasingly recognized as a major contributor to the high burden of childhood mortality in sub-Saharan Africa. Accurate identification of children at risk for post-discharge mortality is critically important to inform interventions to reduce deaths following hospital discharge. Our objective was to describe the current state of development, validation, or implementation for risk assessment tools for post-hospital disc…
Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal d…
Achieving the Sustainable Development Goal of reducing child mortality to Shigella /EIEC (14.0%), ST-ETEC (12.4%), rotavirus (26.4%), and adenovirus (non-40/41: 19.0%; 40/41: 5.0%). These pathogens were frequently identified as co-infections. Diarrheal disease accounted for a substantial share of child deaths across CHAMPS sites. Reducing mortality will require preventing diarrhea and addressing key contributors such as malnutrition and HIV
A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during Covid-19 in Kenya, 2018–2022
The impact of the COVID-19 pandemic on pediatric mortality, including measures to ensure continuity of HIV care, is not well described in Kenya. We evaluated causes of death (COD) among decedents under 5 years of age both before and during the COVID-19 pandemic in Kenya. We analyzed Child Health and Mortality Prevention Surveillance (CHAMPS) data collected in February 2018–March 2022. We describe the proportional contribution of specific conditio…
Survival probability and under-five mortality predictors in Western Kenya between 2015 and 2020
Under-five mortality in Siaya was 63/1000 live births, which is higher than the national average of 41.6/1000 live births. Gender, maternal education, number of ANC visits, maternal age, delivery in hospital, and availability of toilets at home were the main predictors of under-five mortality. These observations reinforce the need to target multiple components at the community and institutional levels to reduce childhood mortality. Such intervent…
Country-specific estimates of misclassification rates of computer-coded verbal autopsy algorithms
INTRODUCTION: Computer-coded verbal autopsy (CCVA) algorithms are routinely used to determine individual cause of death (COD) and derive population-level estimates of cause-specific mortality fractions (CSMFs). But frequent COD misclassification leads to biased CSMF estimates. The VA-calibration framework reduces the bias by estimating misclassification rates; but it overlooks systematic patterns and cross-country variation, reducing the accuracy…
Medicine (9 obras) · Global Maternal and Child Health (8 obras) · Internal Medicine (6 obras) · Pediatrics (6 obras) · Cause of death (5 obras) · Child Nutrition and Water Access (5 obras) · Disease (5 obras) · Child mortality (4 obras) · Environmental health (4 obras) · Health care (4 obras)