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Zhening Liu

Biographic Data

ID5496643
NAMEZhening Liu
GIVEN NAMESZhening
FAMILY NAMELiu
SIGNATURELIU Z
AFFILIATIONSCentral South University
ORCID0000-0001-6893-2427
VERIFIEDYes
TOTAL WORKS23
TOTAL CITATIONS0
AUTHOR COUNT23
EDITOR COUNT0
FIRST PUBLICATION YEAR2017
LATEST PUBLICATION YEAR2026
H-INDEX0
  • Parental Overprotection and Adolescent Mental Health: The Mediating Roles of Psychological Resilience and Bullying Victimization

    Open Access•Guanyu Chen, Xiawei Liu et al.•ARTICLE•Child & Family Social Work•2026

    Parental overprotection—marked by excessive control and restricted autonomy—can hinder adolescents' emotional growth and social competence. This study examined how psychological resilience and bullying victimization explain the link between overprotective parenting and adolescent mental health in a clinical sample. Data were collected from 219 adolescents and young adults (aged 12–25 years) attending a psychiatric outpatient clinic in China, usin…

  • Taohong siwu decoction alleviates hand-foot skin reaction by regulating Rage-mediated keratinocyte apoptosis and autophagy

    Open Access•Huijing Dong, Zhening Liu et al.•ARTICLE•Journal of Ethnopharmacology•2026

  • The relationship between gender identity and depressive symptoms in adolescents: A moderated mediation model of self-efficacy and family functioning

    Open Access•Chenyu Hou, Chia-Hui Hou et al.•ARTICLE•BMC Public Health•2025

    Transgender adolescents showed significantly poorer mental health than cisgender adolescents. There was a partial mediating effect of self-efficacy between gender identity and adolescent depression, with family functioning moderating the latter half of this mediation effect. This study advances our understanding of the relationship between depression and self-efficacy or family functioning in adolescents of different gender identities

  • Improvement of social functioning in patients with first-episode schizophrenia using blonanserin treatment: A prospective, multi-centre, single-arm clinical trial

    Open Access•Tian-Qi Gao, Hong Deng et al.•ARTICLE•Frontiers in Psychiatry•2024

    Blonanserin treatment exhibited favourable effects on social functioning in individuals with first-episode schizophrenia. The results suggest that blonanserin was effective treatment options for patients with schizophrenia encountering functional impairments

  • Profile and mental health characterization of childhood overprotection/overcontrol experiences among Chinese university students: A nationwide survey

    Open Access•Jiamei Zhang, Zhipeng Wu et al.•ARTICLE•Frontiers in Psychiatry•2023

    Our results may provide initial evidence that childhood OP/OC experiences would have negative effects on young people's mental health which merits further investigations, especially in clinical populations

  • Profiles of depressive symptoms and influential factors among people living with HIV in China

    Open Access•Dongfang Wang, Qijian Deng et al.•ARTICLE•BMC Public Health•2023

    Identifying profiles of depressive symptoms among PLWHs using the PHQ-9 items allows for understanding of the distinct paths of development of depressive symptoms and for developing tailored prevention and intervention programs for PLWHs

  • Association between night shift work and NAFLD: A prospective analysis of 281,280 UK Biobank participants

    Open Access•Hangkai Huang, Zhening Liu et al.•ARTICLE•BMC Public Health•2023

    Night shift work was associated with increased risks of incident NAFLD

  • Increasing Trends in Mental Health Problems Among Urban Chinese Adolescents: Results From Repeated Cross-Sectional Data in Changsha 2016–2020

    Open Access•Zhipeng Wu, Biao Wang et al.•ARTICLE•Frontiers in Public Health•2022

    This study performed a repeated cross-sectional analysis to explore possible trends in mental health problems among Chinese adolescents over the years of 2016–2020. A total of 2,837 different seventh-grade students were surveyed in three waves from a junior high school in Changsha city, Hunan province in China (978 in 2016, 949 in 2019, and 910 in 2020) using the Mental Health Inventory of Middle School Students (MMHI-60). The results showed that…

  • Shared and distinct patterns of dynamical degree centrality in bipolar disorder across different mood states

    Open Access•Fuping Sun, Zhening Liu et al.•ARTICLE•Frontiers in Psychiatry•2022

    This study demonstrated the distinct and shared brain dynamical pattern of the depressive, manic, and euthymia states. Our findings provide new insights into the pathophysiology of bipolar disorder across different mood states from the dynamical brain network pattern perspective

  • Association Between Wisdom and Psychotic-Like Experiences in the General Population: A Cross-Sectional Study

    Open Access•Zhipeng Wu, Zhengqian Jiang et al.•ARTICLE•Frontiers in Psychiatry•2022

    Our results implicated that wisdom could protect individuals from distressful subclinical psychotic symptoms and wiser individuals have better general mental health

  • Differential Dynamical Pattern of Regional Homogeneity in Bipolar and Unipolar Depression: A Preliminary Resting-State fMRI Study

    Open Access•Fuping Sun, Zhening Liu et al.•ARTICLE•Frontiers in Psychiatry•2021

    Background: Bipolar depression (BD) and unipolar depression (UD) are both characterized by depressive moods, which are difficult to distinguish in clinical practice. Human brain activity is time-varying and dynamic. Investigating dynamical pattern alterations of depressed brains can provide deep insights into the pathophysiological features of depression. This study aimed to explore similar and different abnormal dynamic patterns between BD and U…

  • Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study

    Open Access•Xiaojun Huang, Zhipeng Wu et al.•ARTICLE•Frontiers in Psychiatry•2021

    Betel quid (BQ) is one of the most popular addictive substances in the world. However, the neurophysiological mechanism underlying BQ addiction remains unclear. This study aimed to investigate whether and how BQ chewing would affect brain function in the framework of a dynamic brain network model. Resting-state functional magnetic resonance imaging scans were collected from 24 male BQ-dependent individuals and 26 male non-addictive healthy indivi…

  • Abnormal Large-Scale Network Activation Present in Bipolar Mania and Bipolar Depression Under Resting State

    Open Access•Can Zeng, Brendan Ross et al.•ARTICLE•Frontiers in Psychiatry•2021

    Introduction: Previous studies have primarily focused on the neuropathological mechanisms of the emotional circuit present in bipolar mania and bipolar depression. Recent studies applying resting-state functional magnetic resonance imaging (fMRI) have raise the possibility of examining brain-wide networks abnormality between the two oppositional emotion states, thus this study aimed to characterize the different functional architecture represente…

  • The Role of Military Training in Improving Psychological Resilience and Reducing Depression Among College Freshmen

    Open Access•Rui Guo, Meng Sun et al.•ARTICLE•Frontiers in Psychiatry•2021

    Background: Military training plays an important protective role in enhancing mental health. However, the effects of military training on psychological resilience and depression among college freshmen in China remain unclear. The present study aimed to evaluate changes in psychological resilience and depression through military training among college freshmen, and to investigate associated psychosocial factors including childhood trauma that may …

  • Acute and Chronic Effects of Betel Quid Chewing on Brain Functional Connectivity

    Open Access•Adellah Sariah, Shuixia Guo et al.•ARTICLE•Frontiers in Psychiatry•2020

    These findings show that individuals who chronically use betel quid have higher functional connectivity than controls of the orbitofrontal cortex, and inferior temporal and angular gyri. Acute effects of betel quid are to increase the functional connectivity of some visual cortical areas (which may relate to the acute symptoms) and the basal ganglia and thalamus

  • Altered Temporal Variability of Local and Large-Scale Resting-State Brain Functional Connectivity Patterns in Schizophrenia and Bipolar Disorder

    Open Access•Yicheng Long, Zhening Liu et al.•ARTICLE•Frontiers in Psychiatry•2020

    Schizophrenia and bipolar disorder share some common clinical features and are both characterized by aberrant resting-state functional connectivity (FC). However, little is known about the common and specific aberrant features of the dynamic FC patterns in these two disorders. In this study, we explored the differences in dynamic FC among schizophrenia patients ( n = 66), type I bipolar disorder patients ( n = 53), and healthy controls ( n = 66),…

  • Reduced Cortical Thickness in the Right Caudal Middle Frontal Is Associated With Symptom Severity in Betel Quid-Dependent Chewers

    Open Access•Adellah Sariah, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2020

    The findings provide evidence for cortical thickness abnormality in betel dependent chewers and further propose that the severity of betel quid symptoms may be a critical aspect associated with the cortical alterations. The observed alterations may serve as potential mechanisms to explain why BQ chewing behavior is persistent among individuals with betel quid dependence

  • Bipolar Mood State Reflected in Functional Connectivity of the Hate Circuit: A Resting-State Functional Magnetic Resonance Imaging Study

    Open Access•Zebin Fan, Jie Yang et al.•ARTICLE•Frontiers in Psychiatry•2020

    Our preliminary findings suggest that altered functional connectivity of the hate circuit in different mood phases may be related to state markers and underpin the neuropathological basis of bipolar disorder

  • Abnormal Connectivity Within Anterior Cortical Midline Structures in Bipolar Disorder: Evidence From Integrated MRI and Functional MRI

    Open Access•Jie Yang, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2019

    Background: Aberrant functional and structural connectivity across multiple brain networks have been reported in bipolar disorder (BD). However, most previous studies consider the functional and structural alterations in isolation regardless of their possible integrative relationship. The present study aimed to identify the brain connectivity alterations in BD by capturing the latent nexus in multimodal neuroimaging data. Methods: Structural and …

  • Resilience and Cognitive Function in Patients With Schizophrenia and Bipolar Disorder, and Healthy Controls

    Open Access•Mengjie Deng, Yunzhi Pan et al.•ARTICLE•Frontiers in Psychiatry•2018

    Background: This study compared adaptive resilience among patients with schizophrenia, bipolar disorder, and healthy controls, and examined the relationship of resilience to cognitive function. Methods: A sample of 81 patients diagnosed with schizophrenia, 34 with bipolar disorder, and 52 healthy controls completed the Connor-Davidson Resilience Scale (CD-RISC) and cognitive tests of verbal comprehension, executive functioning, and working memory…

  • Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia

    Open Access•Yicheng Long, Xuan Ouyang et al.•ARTICLE•Frontiers in Psychiatry•2018

    Objective: The study was aimed to investigate the possible associations among suicidal ideation, brain white matter (WM) integrity and cognitive deficit in first-episode schizophrenia (FES) using diffusion tensor imaging. Methods: The sample contained 18 FES patients with suicidal ideation (SI+), 45 FES patients without suicidal ideation (SI-) and 44 healthy controls. The Calgary Depression Scale for Schizophrenia was used to measure the suicidal…

  • Altered Brain Functional Connectivity in Betel Quid-Dependent Chewers

    Open Access•Xiaojun Huang, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2017

    Our findings provide further evidence that BQ chewing may lead to brain functional connectivity changes, which may play a key role in the psychological and physiological effects of BQ

  • Decreased Left Putamen and Thalamus Volume Correlates with Delusions in First-Episode Schizophrenia Patients

    Open Access•Xiaojun Huang, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2017

    Left putamen and thalamus volume loss may be biological correlates of delusions in schizophrenia

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  • Altered Brain Functional Connectivity in Betel Quid-Dependent Chewers

    Open Access•Xiaojun Huang, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2017

    Our findings provide further evidence that BQ chewing may lead to brain functional connectivity changes, which may play a key role in the psychological and physiological effects of BQ

  • Decreased Left Putamen and Thalamus Volume Correlates with Delusions in First-Episode Schizophrenia Patients

    Open Access•Xiaojun Huang, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2017

    Left putamen and thalamus volume loss may be biological correlates of delusions in schizophrenia

  • Resilience and Cognitive Function in Patients With Schizophrenia and Bipolar Disorder, and Healthy Controls

    Open Access•Mengjie Deng, Yunzhi Pan et al.•ARTICLE•Frontiers in Psychiatry•2018

    Background: This study compared adaptive resilience among patients with schizophrenia, bipolar disorder, and healthy controls, and examined the relationship of resilience to cognitive function. Methods: A sample of 81 patients diagnosed with schizophrenia, 34 with bipolar disorder, and 52 healthy controls completed the Connor-Davidson Resilience Scale (CD-RISC) and cognitive tests of verbal comprehension, executive functioning, and working memory…

  • Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia

    Open Access•Yicheng Long, Xuan Ouyang et al.•ARTICLE•Frontiers in Psychiatry•2018

    Objective: The study was aimed to investigate the possible associations among suicidal ideation, brain white matter (WM) integrity and cognitive deficit in first-episode schizophrenia (FES) using diffusion tensor imaging. Methods: The sample contained 18 FES patients with suicidal ideation (SI+), 45 FES patients without suicidal ideation (SI-) and 44 healthy controls. The Calgary Depression Scale for Schizophrenia was used to measure the suicidal…

  • Abnormal Connectivity Within Anterior Cortical Midline Structures in Bipolar Disorder: Evidence From Integrated MRI and Functional MRI

    Open Access•Jie Yang, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2019

    Background: Aberrant functional and structural connectivity across multiple brain networks have been reported in bipolar disorder (BD). However, most previous studies consider the functional and structural alterations in isolation regardless of their possible integrative relationship. The present study aimed to identify the brain connectivity alterations in BD by capturing the latent nexus in multimodal neuroimaging data. Methods: Structural and …

  • Acute and Chronic Effects of Betel Quid Chewing on Brain Functional Connectivity

    Open Access•Adellah Sariah, Shuixia Guo et al.•ARTICLE•Frontiers in Psychiatry•2020

    These findings show that individuals who chronically use betel quid have higher functional connectivity than controls of the orbitofrontal cortex, and inferior temporal and angular gyri. Acute effects of betel quid are to increase the functional connectivity of some visual cortical areas (which may relate to the acute symptoms) and the basal ganglia and thalamus

  • Altered Temporal Variability of Local and Large-Scale Resting-State Brain Functional Connectivity Patterns in Schizophrenia and Bipolar Disorder

    Open Access•Yicheng Long, Zhening Liu et al.•ARTICLE•Frontiers in Psychiatry•2020

    Schizophrenia and bipolar disorder share some common clinical features and are both characterized by aberrant resting-state functional connectivity (FC). However, little is known about the common and specific aberrant features of the dynamic FC patterns in these two disorders. In this study, we explored the differences in dynamic FC among schizophrenia patients ( n = 66), type I bipolar disorder patients ( n = 53), and healthy controls ( n = 66),…

  • Reduced Cortical Thickness in the Right Caudal Middle Frontal Is Associated With Symptom Severity in Betel Quid-Dependent Chewers

    Open Access•Adellah Sariah, Weidan Pu et al.•ARTICLE•Frontiers in Psychiatry•2020

    The findings provide evidence for cortical thickness abnormality in betel dependent chewers and further propose that the severity of betel quid symptoms may be a critical aspect associated with the cortical alterations. The observed alterations may serve as potential mechanisms to explain why BQ chewing behavior is persistent among individuals with betel quid dependence

  • Bipolar Mood State Reflected in Functional Connectivity of the Hate Circuit: A Resting-State Functional Magnetic Resonance Imaging Study

    Open Access•Zebin Fan, Jie Yang et al.•ARTICLE•Frontiers in Psychiatry•2020

    Our preliminary findings suggest that altered functional connectivity of the hate circuit in different mood phases may be related to state markers and underpin the neuropathological basis of bipolar disorder

  • Differential Dynamical Pattern of Regional Homogeneity in Bipolar and Unipolar Depression: A Preliminary Resting-State fMRI Study

    Open Access•Fuping Sun, Zhening Liu et al.•ARTICLE•Frontiers in Psychiatry•2021

    Background: Bipolar depression (BD) and unipolar depression (UD) are both characterized by depressive moods, which are difficult to distinguish in clinical practice. Human brain activity is time-varying and dynamic. Investigating dynamical pattern alterations of depressed brains can provide deep insights into the pathophysiological features of depression. This study aimed to explore similar and different abnormal dynamic patterns between BD and U…

  • Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study

    Open Access•Xiaojun Huang, Zhipeng Wu et al.•ARTICLE•Frontiers in Psychiatry•2021

    Betel quid (BQ) is one of the most popular addictive substances in the world. However, the neurophysiological mechanism underlying BQ addiction remains unclear. This study aimed to investigate whether and how BQ chewing would affect brain function in the framework of a dynamic brain network model. Resting-state functional magnetic resonance imaging scans were collected from 24 male BQ-dependent individuals and 26 male non-addictive healthy indivi…

  • Abnormal Large-Scale Network Activation Present in Bipolar Mania and Bipolar Depression Under Resting State

    Open Access•Can Zeng, Brendan Ross et al.•ARTICLE•Frontiers in Psychiatry•2021

    Introduction: Previous studies have primarily focused on the neuropathological mechanisms of the emotional circuit present in bipolar mania and bipolar depression. Recent studies applying resting-state functional magnetic resonance imaging (fMRI) have raise the possibility of examining brain-wide networks abnormality between the two oppositional emotion states, thus this study aimed to characterize the different functional architecture represente…

  • The Role of Military Training in Improving Psychological Resilience and Reducing Depression Among College Freshmen

    Open Access•Rui Guo, Meng Sun et al.•ARTICLE•Frontiers in Psychiatry•2021

    Background: Military training plays an important protective role in enhancing mental health. However, the effects of military training on psychological resilience and depression among college freshmen in China remain unclear. The present study aimed to evaluate changes in psychological resilience and depression through military training among college freshmen, and to investigate associated psychosocial factors including childhood trauma that may …

  • Increasing Trends in Mental Health Problems Among Urban Chinese Adolescents: Results From Repeated Cross-Sectional Data in Changsha 2016–2020

    Open Access•Zhipeng Wu, Biao Wang et al.•ARTICLE•Frontiers in Public Health•2022

    This study performed a repeated cross-sectional analysis to explore possible trends in mental health problems among Chinese adolescents over the years of 2016–2020. A total of 2,837 different seventh-grade students were surveyed in three waves from a junior high school in Changsha city, Hunan province in China (978 in 2016, 949 in 2019, and 910 in 2020) using the Mental Health Inventory of Middle School Students (MMHI-60). The results showed that…

  • Shared and distinct patterns of dynamical degree centrality in bipolar disorder across different mood states

    Open Access•Fuping Sun, Zhening Liu et al.•ARTICLE•Frontiers in Psychiatry•2022

    This study demonstrated the distinct and shared brain dynamical pattern of the depressive, manic, and euthymia states. Our findings provide new insights into the pathophysiology of bipolar disorder across different mood states from the dynamical brain network pattern perspective

  • Association Between Wisdom and Psychotic-Like Experiences in the General Population: A Cross-Sectional Study

    Open Access•Zhipeng Wu, Zhengqian Jiang et al.•ARTICLE•Frontiers in Psychiatry•2022

    Our results implicated that wisdom could protect individuals from distressful subclinical psychotic symptoms and wiser individuals have better general mental health

  • Profile and mental health characterization of childhood overprotection/overcontrol experiences among Chinese university students: A nationwide survey

    Open Access•Jiamei Zhang, Zhipeng Wu et al.•ARTICLE•Frontiers in Psychiatry•2023

    Our results may provide initial evidence that childhood OP/OC experiences would have negative effects on young people's mental health which merits further investigations, especially in clinical populations

  • Profiles of depressive symptoms and influential factors among people living with HIV in China

    Open Access•Dongfang Wang, Qijian Deng et al.•ARTICLE•BMC Public Health•2023

    Identifying profiles of depressive symptoms among PLWHs using the PHQ-9 items allows for understanding of the distinct paths of development of depressive symptoms and for developing tailored prevention and intervention programs for PLWHs

  • Association between night shift work and NAFLD: A prospective analysis of 281,280 UK Biobank participants

    Open Access•Hangkai Huang, Zhening Liu et al.•ARTICLE•BMC Public Health•2023

    Night shift work was associated with increased risks of incident NAFLD

  • Improvement of social functioning in patients with first-episode schizophrenia using blonanserin treatment: A prospective, multi-centre, single-arm clinical trial

    Open Access•Tian-Qi Gao, Hong Deng et al.•ARTICLE•Frontiers in Psychiatry•2024

    Blonanserin treatment exhibited favourable effects on social functioning in individuals with first-episode schizophrenia. The results suggest that blonanserin was effective treatment options for patients with schizophrenia encountering functional impairments

  • The relationship between gender identity and depressive symptoms in adolescents: A moderated mediation model of self-efficacy and family functioning

    Open Access•Chenyu Hou, Chia-Hui Hou et al.•ARTICLE•BMC Public Health•2025

    Transgender adolescents showed significantly poorer mental health than cisgender adolescents. There was a partial mediating effect of self-efficacy between gender identity and adolescent depression, with family functioning moderating the latter half of this mediation effect. This study advances our understanding of the relationship between depression and self-efficacy or family functioning in adolescents of different gender identities

  • Parental Overprotection and Adolescent Mental Health: The Mediating Roles of Psychological Resilience and Bullying Victimization

    Open Access•Guanyu Chen, Xiawei Liu et al.•ARTICLE•Child & Family Social Work•2026

    Parental overprotection—marked by excessive control and restricted autonomy—can hinder adolescents' emotional growth and social competence. This study examined how psychological resilience and bullying victimization explain the link between overprotective parenting and adolescent mental health in a clinical sample. Data were collected from 219 adolescents and young adults (aged 12–25 years) attending a psychiatric outpatient clinic in China, usin…

  • Taohong siwu decoction alleviates hand-foot skin reaction by regulating Rage-mediated keratinocyte apoptosis and autophagy

    Open Access•Huijing Dong, Zhening Liu et al.•ARTICLE•Journal of Ethnopharmacology•2026

Medicine (18 works) · Psychology (18 works) · Psychiatry (15 works) · Cognition (11 works) · Clinical Psychology (10 works) · Functional Brain Connectivity Studies (10 works) · Neuroscience (10 works) · Clinical Psychology (9 works) · Bipolar disorder (7 works) · Resting state fMRI (7 works)

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