Brendan Parent
Biographic Data
| ID | 5502092 |
|---|---|
| NAME | Brendan Parent |
| GIVEN NAMES | Brendan |
| FAMILY NAME | Parent |
| SIGNATURE | PARENT B |
| AFFILIATIONS | New York University |
| ORCID | 0000-0003-3057-5684 |
| VERIFIED | Yes |
| TOTAL WORKS | 16 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 16 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2014 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
The Dead Donor Rule and Normothermic Regional Perfusion
Normothermic regional perfusion (NRP) can be used after the circulatory determination of death to prevent or minimize organ damage before the donor's organs are retrieved. It involves restarting circulation within the donor's body to reperfuse abdominal and thoracic organs while occluding the arteries that supply oxygenated blood to the brain to prevent brain recirculation and the possible restoration of brain function. Yet there are many who obj…
Does normothermic regional perfusion harm donors after circulatory death
Normothermic regional perfusion during controlled donation after circulatory death has emerged as a means to increase the number and viability of organs available for transplant. Because normothermic regional perfusion uses extracorporeal membrane oxygenation, an intervention used for resuscitation under other circumstances, critics have concluded that organ donation using normothermic regional perfusion violates the dead donor rule. As such, the…
Research involving the recently deceased
Research involving recently deceased humans that are physiologically maintained following declaration of death by neurologic criteria—or ‘research involving the recently deceased’—can fill a translational research gap while reducing harm to animals and living human subjects. It also creates new challenges for honouring the donor’s legacy, respecting the rights of donor loved ones, resource allocation and public health. As this research model gain…
Update on the ethical, legal and technical challenges of translating xenotransplantation
This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King’s College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotran…
Examining the Ethics and Impacts of Laws Restricting Transgender Youth‐Athlete Participation
As of this writing, twenty‐one states have passed laws barring transgender youth‐athletes from competing on public‐school sports teams in accordance with their gender identity. Proponents of these regulations claim that transgender females in particular have inherent physiological advantages that threaten a “level playing field” for their cisgender competitors. Existing evidence is limited but does not support these restrictions. Gathering more r…
Challenges Unique to Transgender Persons in US Correctional Settings
Human, Nonhuman, and Chimeric Research
Human‐nonhuman chimeric research—research on nonhuman animals who contain human cells—is being used to understand human disease and development and to create potential human treatments such as transplantable organs. A proposed advantage of chimeric models is that they can approximate human biology and therefore allow scientists to learn about and improve human health without risking harms to humans. Among the emerging ethical issues being explore…
Clarifying the Ethics and Oversight of Chimeric Research
This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethi…
Mistrust and inconsistency during Covid-19
As the USA contends with another surge in COVID-19 cases, hospitals may soon need to answer the unresolved question of who lives and dies when ventilator demand exceeds supply. Although most triage policies in the USA have seemingly converged on the use of clinical need and benefit as primary criteria for prioritisation, significant differences exist between institutions in how to assign priority to patients with identical medical prognoses: the …
Death's Troubled Relationship With the Law
Death's legal definition must be responsive to advances in technology, and it must delineate between life and death. But where to draw the line is difficult to determine. Death's current legal definition requires irreversible cessation of cardiorespiratory function or irreversible cessation of all brain function. But technology can often restore some brain functions without restoring consciousness, so brain death is often diagnosed without the ir…
Bigger, Faster, Stronger, More Ethical
Consider four elite female runners who trained hard for a 1500‐meter race. Runner 1 took extra‐strength aspirin before the race. Runner 2 has a genetic condition that results in greater levels of testosterone in her body than the typical range for a woman. Runner 3 has been on a carefully scheduled regimen of the hormone erythropoietin (EPO), which has increased her red blood cell count. Runner 4 has a team of diet, sleep, and exercise experts wh…
Military Genitourinary Trauma
The men and women who serve in the armed forces, in the words of Major General Joseph Caravalho, “sign a blank check, co‐signed by their families, payable to the Army, Navy, Air Force, or Marines, up to and including their lives.” It is human nature to consider such a pact in polarized terms; the pact concludes in either a celebratory homecoming or funereal mourning. But in reality, surviving catastrophic injury may incur the greatest debt. The s…
Players’ Doctors
Years ago, one of us had the opportunity to talk with a starting guard in the National Basketball Association about his health care. The player, then a rookie, did not have his own personal doctor. Instead, he received his health care from the team doctor. This athlete was very well paid and could have received care anywhere he wished in the area. But he came from a very poor neighborhood. Growing up, he said, he had no health care other than hea…
Undocumented Immigrants Face a Unique Set of Risks from Tuberculosis Treatment
Undocumented immigrants treated with isoniazid (INH) for latent tuberculosis infection should be covered for transplant for INH-related liver failure
Pig Hearts and Machine-Lathed Kidneys
To most people outside the relevant laboratories and operating rooms, xenotransplants and artificial organ transplants are bizarre. While the bizarre scares many away and angers others, Lesley A. Sharp approached it and asked, What behooves medical research to take organs out of pigs and primates and design organs out of metal and plastic and use them to replace failing organs in humans? Sharp attended years of conferences, visited countless hosp…
Faces as Organ Donations
Recent policy changes enacted by the Organ Procurement and Transplantation Network designate faces as organs for the purposes of donation and transplantation. The OPTN policy includes no requirement that donors be made aware that faces are among donatable parts, but it does require specific consent to face donation (not just organ donation in general) from either the donor or donor's family before a face can be transplanted. If you are a register…
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Pig Hearts and Machine-Lathed Kidneys
To most people outside the relevant laboratories and operating rooms, xenotransplants and artificial organ transplants are bizarre. While the bizarre scares many away and angers others, Lesley A. Sharp approached it and asked, What behooves medical research to take organs out of pigs and primates and design organs out of metal and plastic and use them to replace failing organs in humans? Sharp attended years of conferences, visited countless hosp…
Faces as Organ Donations
Recent policy changes enacted by the Organ Procurement and Transplantation Network designate faces as organs for the purposes of donation and transplantation. The OPTN policy includes no requirement that donors be made aware that faces are among donatable parts, but it does require specific consent to face donation (not just organ donation in general) from either the donor or donor's family before a face can be transplanted. If you are a register…
Military Genitourinary Trauma
The men and women who serve in the armed forces, in the words of Major General Joseph Caravalho, “sign a blank check, co‐signed by their families, payable to the Army, Navy, Air Force, or Marines, up to and including their lives.” It is human nature to consider such a pact in polarized terms; the pact concludes in either a celebratory homecoming or funereal mourning. But in reality, surviving catastrophic injury may incur the greatest debt. The s…
Players’ Doctors
Years ago, one of us had the opportunity to talk with a starting guard in the National Basketball Association about his health care. The player, then a rookie, did not have his own personal doctor. Instead, he received his health care from the team doctor. This athlete was very well paid and could have received care anywhere he wished in the area. But he came from a very poor neighborhood. Growing up, he said, he had no health care other than hea…
Undocumented Immigrants Face a Unique Set of Risks from Tuberculosis Treatment
Undocumented immigrants treated with isoniazid (INH) for latent tuberculosis infection should be covered for transplant for INH-related liver failure
Bigger, Faster, Stronger, More Ethical
Consider four elite female runners who trained hard for a 1500‐meter race. Runner 1 took extra‐strength aspirin before the race. Runner 2 has a genetic condition that results in greater levels of testosterone in her body than the typical range for a woman. Runner 3 has been on a carefully scheduled regimen of the hormone erythropoietin (EPO), which has increased her red blood cell count. Runner 4 has a team of diet, sleep, and exercise experts wh…
Death's Troubled Relationship With the Law
Death's legal definition must be responsive to advances in technology, and it must delineate between life and death. But where to draw the line is difficult to determine. Death's current legal definition requires irreversible cessation of cardiorespiratory function or irreversible cessation of all brain function. But technology can often restore some brain functions without restoring consciousness, so brain death is often diagnosed without the ir…
Mistrust and inconsistency during Covid-19
As the USA contends with another surge in COVID-19 cases, hospitals may soon need to answer the unresolved question of who lives and dies when ventilator demand exceeds supply. Although most triage policies in the USA have seemingly converged on the use of clinical need and benefit as primary criteria for prioritisation, significant differences exist between institutions in how to assign priority to patients with identical medical prognoses: the …
Human, Nonhuman, and Chimeric Research
Human‐nonhuman chimeric research—research on nonhuman animals who contain human cells—is being used to understand human disease and development and to create potential human treatments such as transplantable organs. A proposed advantage of chimeric models is that they can approximate human biology and therefore allow scientists to learn about and improve human health without risking harms to humans. Among the emerging ethical issues being explore…
Clarifying the Ethics and Oversight of Chimeric Research
This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethi…
Examining the Ethics and Impacts of Laws Restricting Transgender Youth‐Athlete Participation
As of this writing, twenty‐one states have passed laws barring transgender youth‐athletes from competing on public‐school sports teams in accordance with their gender identity. Proponents of these regulations claim that transgender females in particular have inherent physiological advantages that threaten a “level playing field” for their cisgender competitors. Existing evidence is limited but does not support these restrictions. Gathering more r…
Challenges Unique to Transgender Persons in US Correctional Settings
Research involving the recently deceased
Research involving recently deceased humans that are physiologically maintained following declaration of death by neurologic criteria—or ‘research involving the recently deceased’—can fill a translational research gap while reducing harm to animals and living human subjects. It also creates new challenges for honouring the donor’s legacy, respecting the rights of donor loved ones, resource allocation and public health. As this research model gain…
Update on the ethical, legal and technical challenges of translating xenotransplantation
This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King’s College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotran…
Does normothermic regional perfusion harm donors after circulatory death
Normothermic regional perfusion during controlled donation after circulatory death has emerged as a means to increase the number and viability of organs available for transplant. Because normothermic regional perfusion uses extracorporeal membrane oxygenation, an intervention used for resuscitation under other circumstances, critics have concluded that organ donation using normothermic regional perfusion violates the dead donor rule. As such, the…
The Dead Donor Rule and Normothermic Regional Perfusion
Normothermic regional perfusion (NRP) can be used after the circulatory determination of death to prevent or minimize organ damage before the donor's organs are retrieved. It involves restarting circulation within the donor's body to reperfuse abdominal and thoracic organs while occluding the arteries that supply oxygenated blood to the brain to prevent brain recirculation and the possible restoration of brain function. Yet there are many who obj…
Political science (13 works) · Law (12 works) · Medicine (11 works) · Psychology (8 works) · Sociology (8 works) · Organ Donation and Transplantation (6 works) · Computer Science (5 works) · Engineering ethics (5 works) · Transplantation (5 works) · Neuroethics, Human Enhancement, Biomedical Innovations (4 works)