Chris Gennings
Biographic Data
| ID | 5504457 |
|---|---|
| NAME | Chris Gennings |
| GIVEN NAMES | Chris |
| FAMILY NAME | Gennings |
| SIGNATURE | GENNINGS C |
| AFFILIATIONS | Icahn School of Medicine at Mount Sinai |
| ORCID | 0000-0002-6058-5907 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 6 |
| AUTHOR COUNT | 14 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2010 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: Focus on the RE-Mend project
The number of people seeking help for mental illness is increasing across all ages, creating a major burden for individuals, families, and the society. While personalized medicine is advancing in other fields, diagnosis and treatment of mental disorders remain largely symptom-based and fail to capture individual, sex, and gender differences in risk, manifestation, and treatment response. Early signs of illness often go unnoticed due to the lack o…
A weighted quantile sum regression with penalized weights and two indices
Background: New statistical methodologies were developed in the last decade to face the challenges of estimating the effects of exposure to multiple chemicals. Weighted Quantile Sum (WQS) regression is a recent statistical method that allows estimating a mixture effect associated with a specific health effect and identifying the components that characterize the mixture effect. Objectives: In this study, we propose an extension of WQS regression t…
Predictors of Phthalate Metabolites Exposure among Healthy Pregnant Women in the United States, 2010–2015
Phthalate use and the concentrations of their metabolites in humans vary by geographic region, race, ethnicity, sex, product use and other factors. Exposure during pregnancy may be associated with detrimental reproductive and developmental outcomes. No studies have evaluated the predictors of exposure to a wide range of phthalate metabolites in a large, diverse population. We examined the determinants of phthalate metabolites in a cohort of racia…
Selecting External Controls for Internal Cases Using Stratification Score Matching Methods
Rare-disease registries can be useful for studying the associations between environmental exposures and disease severity, but often require the addition of a healthy comparison control group. Defining a surrogate control group, matched and balanced on potentially confounding variables, would allow for the comparison of exposure distributions with cases from a registry. In the present study, we assess whether controls selected externally, using st…
Human Microbiome Mixture Analysis Using Weighted Quantile Sum Regression
Studies of the health effects of the microbiome often measure overall associations by using diversity metrics, and individual taxa associations in separate analyses, but do not consider the correlated relationships between taxa in the microbiome. In this study, we applied random subset weighted quantile sum regression with repeated holdouts (WQS RSRH ), a mixture method successfully applied to 'omic data to account for relationships between many …
Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
Environmental exposures to a myriad of chemicals are associated with adverse health effects in humans, while good nutrition is associated with improved health. Single chemical in vivo and in vitro studies demonstrate causal links between the chemicals and outcomes, but such studies do not represent human exposure to environmental mixtures. One way of summarizing the effect of the joint action of chemical mixtures is through an empirically weighte…
Nephrotoxic Metal Mixtures and Preadolescent Kidney Function
Exposure to metals including lead (Pb), cadmium (Cd), and arsenic (As), may impair kidney function as individual toxicants or in mixtures. However, no single medium is ideal to study multiple metals simultaneously. We hypothesized that multi-media biomarkers (MMBs), integrated indices combining information across biomarkers, are informative of adverse kidney function. Levels of Pb, Cd, and As were quantified in blood and urine in 4-6-year-old Mex…
Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: The Programming Research in Obesity, Growth Environment and Social Stress Cohort Study
OBJECTIVE: Maternal stress during pregnancy may influence childhood growth and adiposity, possibly through immune/inflammatory programming. We investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in 424 mother-child pairs in Mexico City, Mexico. METHODS: A stress index was created based on four prenatally administered stress-related scales (Exposure to Violence, Cr…
Modeling Pediatric Body Mass Index and Neighborhood Environment at Different Spatial Scales
In public health research, it has been well established that geographic location plays an important role in influencing health outcomes. In recent years, there has been an increased emphasis on the impact of neighborhood or contextual factors as potential risk factors for childhood obesity. Some neighborhood factors relevant to childhood obesity include access to food sources, access to recreational facilities, neighborhood safety, and socioecono…
Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting
Validation of a Food Frequency Questionnaire for Estimating Micronutrient Intakes in an Urban US Sample of Multi-Ethnic Pregnant Women
Childhood abuse is associated with increased hair cortisol levels among urban pregnant women
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis activity is known to be altered following events such as childhood abuse. However, despite potential adverse consequences for the offspring of women who have experienced abuse, very little is known about altered HPA axis activity during pregnancy. METHODS: During pregnancy, 180 women from diverse racial/ethnic backgrounds reported on their exposure to emotional, physical and/or sexual abuse be…
Who's Doing the Math? Are We Really Compensating Research Participants
Although compensation for expenses to participants in research projects is considered important and the primary reason for paying, there is no evidence to support that investigators and IRB members actually calculate participant cost. Payment recommendations for six hypothetical studies were obtained from a national survey of IRB chairpersons (N = 353) and investigators (N = 495). Survey respondents also recommended payment for specific study pro…
Why Do We Pay? A National Survey of Investigators and IRB Chairpersons
The principle that payment to participants should not be undue or coercive is the consensus of international and national guidelines and ethical debates; however, what this means in practice is unclear. This study determined the attitudes and practices of IRB chairpersons and investigators regarding participant payment. One thousand six hundred investigators and 1900 IRB chairpersons received an invitation to participate in a web-based survey. Fo…
Why Do We Pay? A National Survey of Investigators and IRB Chairpersons
The principle that payment to participants should not be undue or coercive is the consensus of international and national guidelines and ethical debates; however, what this means in practice is unclear. This study determined the attitudes and practices of IRB chairpersons and investigators regarding participant payment. One thousand six hundred investigators and 1900 IRB chairpersons received an invitation to participate in a web-based survey. Fo…
Who's Doing the Math? Are We Really Compensating Research Participants
Although compensation for expenses to participants in research projects is considered important and the primary reason for paying, there is no evidence to support that investigators and IRB members actually calculate participant cost. Payment recommendations for six hypothetical studies were obtained from a national survey of IRB chairpersons (N = 353) and investigators (N = 495). Survey respondents also recommended payment for specific study pro…
Who's Doing the Math? Are We Really Compensating Research Participants
Although compensation for expenses to participants in research projects is considered important and the primary reason for paying, there is no evidence to support that investigators and IRB members actually calculate participant cost. Payment recommendations for six hypothetical studies were obtained from a national survey of IRB chairpersons (N = 353) and investigators (N = 495). Survey respondents also recommended payment for specific study pro…
Why Do We Pay? A National Survey of Investigators and IRB Chairpersons
The principle that payment to participants should not be undue or coercive is the consensus of international and national guidelines and ethical debates; however, what this means in practice is unclear. This study determined the attitudes and practices of IRB chairpersons and investigators regarding participant payment. One thousand six hundred investigators and 1900 IRB chairpersons received an invitation to participate in a web-based survey. Fo…
Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting
Validation of a Food Frequency Questionnaire for Estimating Micronutrient Intakes in an Urban US Sample of Multi-Ethnic Pregnant Women
Childhood abuse is associated with increased hair cortisol levels among urban pregnant women
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis activity is known to be altered following events such as childhood abuse. However, despite potential adverse consequences for the offspring of women who have experienced abuse, very little is known about altered HPA axis activity during pregnancy. METHODS: During pregnancy, 180 women from diverse racial/ethnic backgrounds reported on their exposure to emotional, physical and/or sexual abuse be…
Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: The Programming Research in Obesity, Growth Environment and Social Stress Cohort Study
OBJECTIVE: Maternal stress during pregnancy may influence childhood growth and adiposity, possibly through immune/inflammatory programming. We investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in 424 mother-child pairs in Mexico City, Mexico. METHODS: A stress index was created based on four prenatally administered stress-related scales (Exposure to Violence, Cr…
Modeling Pediatric Body Mass Index and Neighborhood Environment at Different Spatial Scales
In public health research, it has been well established that geographic location plays an important role in influencing health outcomes. In recent years, there has been an increased emphasis on the impact of neighborhood or contextual factors as potential risk factors for childhood obesity. Some neighborhood factors relevant to childhood obesity include access to food sources, access to recreational facilities, neighborhood safety, and socioecono…
Nephrotoxic Metal Mixtures and Preadolescent Kidney Function
Exposure to metals including lead (Pb), cadmium (Cd), and arsenic (As), may impair kidney function as individual toxicants or in mixtures. However, no single medium is ideal to study multiple metals simultaneously. We hypothesized that multi-media biomarkers (MMBs), integrated indices combining information across biomarkers, are informative of adverse kidney function. Levels of Pb, Cd, and As were quantified in blood and urine in 4-6-year-old Mex…
Selecting External Controls for Internal Cases Using Stratification Score Matching Methods
Rare-disease registries can be useful for studying the associations between environmental exposures and disease severity, but often require the addition of a healthy comparison control group. Defining a surrogate control group, matched and balanced on potentially confounding variables, would allow for the comparison of exposure distributions with cases from a registry. In the present study, we assess whether controls selected externally, using st…
Human Microbiome Mixture Analysis Using Weighted Quantile Sum Regression
Studies of the health effects of the microbiome often measure overall associations by using diversity metrics, and individual taxa associations in separate analyses, but do not consider the correlated relationships between taxa in the microbiome. In this study, we applied random subset weighted quantile sum regression with repeated holdouts (WQS RSRH ), a mixture method successfully applied to 'omic data to account for relationships between many …
Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference
Environmental exposures to a myriad of chemicals are associated with adverse health effects in humans, while good nutrition is associated with improved health. Single chemical in vivo and in vitro studies demonstrate causal links between the chemicals and outcomes, but such studies do not represent human exposure to environmental mixtures. One way of summarizing the effect of the joint action of chemical mixtures is through an empirically weighte…
A weighted quantile sum regression with penalized weights and two indices
Background: New statistical methodologies were developed in the last decade to face the challenges of estimating the effects of exposure to multiple chemicals. Weighted Quantile Sum (WQS) regression is a recent statistical method that allows estimating a mixture effect associated with a specific health effect and identifying the components that characterize the mixture effect. Objectives: In this study, we propose an extension of WQS regression t…
Predictors of Phthalate Metabolites Exposure among Healthy Pregnant Women in the United States, 2010–2015
Phthalate use and the concentrations of their metabolites in humans vary by geographic region, race, ethnicity, sex, product use and other factors. Exposure during pregnancy may be associated with detrimental reproductive and developmental outcomes. No studies have evaluated the predictors of exposure to a wide range of phthalate metabolites in a large, diverse population. We examined the determinants of phthalate metabolites in a cohort of racia…
The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: Focus on the RE-Mend project
The number of people seeking help for mental illness is increasing across all ages, creating a major burden for individuals, families, and the society. While personalized medicine is advancing in other fields, diagnosis and treatment of mental disorders remain largely symptom-based and fail to capture individual, sex, and gender differences in risk, manifestation, and treatment response. Early signs of illness often go unnoticed due to the lack o…
Medicine (10 works) · Biology (6 works) · Statistics (6 works) · Environmental health (5 works) · Mathematics (5 works) · Internal Medicine (4 works) · Computer Science (3 works) · Econometrics (3 works) · Endocrinology (3 works) · Health, Environment, Cognitive Aging (3 works)