Nora D Volkow
Biographic Data
| ID | 5686517 |
|---|---|
| NAME | Nora D Volkow |
| GIVEN NAMES | Nora D |
| FAMILY NAME | Volkow |
| SIGNATURE | VOLKOW N D |
| AFFILIATIONS | National Institutes of Health |
| ORCID | 0000-0001-6668-0908 |
| VERIFIED | Yes |
| TOTAL WORKS | 27 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 27 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2001 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 0 |
Associations of cannabis use, use frequency, and cannabis use disorder with violent behavior among young adults in the United States
Disparities in Overdose Deaths: Looking Back at Larochelle and Colleagues’ 2021 Paper
Disparities in Overdose Deaths: Looking Back at Larochelle and Colleagues' 2021 Paper Nora D. Volkow MD, Beth Han PhD, MD, MPH, and Redonna K. Chandler PhD Affiliation All authors are with the National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD. CopyRightCorrespondence should be sent to Nora D. Volkow, 3WFN Room 09D20, MSC 6025, 301 North Stonestreet Ave, Bethesda, MD 20892 (e-mail: [email protected]). Reprints can be…
How Academic Medicine Can Help Confront the Opioid Crisis
The United States is in the midst of a devastating overdose and addiction crisis involving opioids as well as other drugs. Yet, despite the existence of effective treatments for opioid use disorder, only a minority of people who need treatment for this or other substance use disorders receive it. Besides the terrible human and economic costs of overdose deaths and the other health consequences of addiction, untreated substance use has wide-rangin…
Prenatal caffeine exposure: Association with neurodevelopmental outcomes in 9‐ to 11‐year‐old children
BACKGROUND: Despite the widespread use of caffeine including consumption during pregnancy, the effect of prenatal caffeine exposure on child brain development and behavior is unclear. METHODS: To address this, we used data from the Adolescent Brain and Cognitive Development Study (n = 11,875 children aged 9-11 years from 22 sites across the United States). We explored the associations between prenatal caffeine exposure and various developmental o…
Increased risk of Covid ‐19 infection and mortality in people with mental disorders: Analysis from electronic health records in the United States
Concerns have been expressed that persons with a pre‐existing mental disorder may represent a population at increased risk for COVID‐19 infection and with a higher likelihood of adverse outcomes of the infection, but there is no systematic research evidence in this respect. This study assessed the impact of a recent (within past year) diagnosis of a mental disorder – including attention‐deficit/hyperactivity disorder (ADHD), bipolar disorder, de…
Covid-19 risk and outcomes in patients with substance use disorders: Analyses from electronic health records in the United States
The global pandemic of COVID-19 is colliding with the epidemic of opioid use disorders (OUD) and other substance use disorders (SUD) in the United States (US). Currently, there is limited data on risks, disparity, and outcomes for COVID-19 in individuals suffering from SUD. This is a retrospective case-control study of electronic health records (EHRs) data of 73,099,850 unique patients, of whom 12,030 had a diagnosis of COVID-19. Patients with a …
LRRK2 Gene Variants Associated With a Higher Risk for Alcohol Dependence in Multiethnic Populations
Background: Genetics influence the vulnerability to alcohol use disorders, and among the implicated genes, three previous studies have provided evidences for the involvement of LRRK2 in alcohol dependence (AD). LRRK2 expression is broadly dysregulated in postmortem brain from AD humans, as well as in the brain of mice with alcohol dependent-like behaviors and in a zebrafish model of alcohol preference. The aim of the present study was to evaluate…
Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women
Background: There are known sex differences in behavioral and clinical outcomes associated with drugs of abuse, including cannabis. However, little is known about how chronic cannabis use and sex interact to affect brain structure, particularly in regions with high cannabinoid receptor expression, such as the cerebellum, amygdala, and hippocampus. Based on behavioral data suggesting that females may be particularly vulnerable to the effects of ch…
Collision of the Covid-19 and Addiction Epidemics
Ideas and Opinions2 April 2020Collision of the COVID-19 and Addiction EpidemicsFREENora D. Volkow, MDNora D. Volkow, MDNational Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland (N.D.V.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-1212 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedIn…
Ethical Imperatives to Overcome Stigma Against People With Substance Use Disorders
Responding to the public health crisis in the United States resulting from untreated opioid use disorder (OUD) requires expanding delivery of effective treatments, including medications, and eliminating stigma against people with OUD and people seeking OUD treatment. Stigma discourages people with substance use disorders from seeking care and compromises the care they receive when they do seek it. Stigma against both medication treatments for OUD…
Neurobiologic Advances from the Brain Disease Model of Addiction
This article reviews scientific advances in the prevention and treatment of substance-use disorder and related developments in public policy. In the past two decades, research has increasingly supported the view that addiction is a disease of the brain. Although the brain disease model of addiction has yielded effective preventive measures, treatment interventions, and public health policies to address substance-use disorders, the underlying conc…
Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review
Neurobiology of addiction: A neurocircuitry analysis
Medication-Assisted Therapies — Tackling the Opioid-Overdose Epidemic
T he rate of death from over- doses of prescription opioids in the United States more than quadrupled between 1999 and 2010 (see graph), far exceeding the combined death toll from cocaine and heroin overdoses. 1 In 2010 alone, prescription opioids were involved in 16,651 overdose deaths, whereas heroin was implicated in 3036. Some 82% of the deaths due to prescription An audio interview with Dr.
Adverse Health Effects of Marijuana Use
As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration. Although the harms associated with marijuana use have not been well studied, enough information is available to cause concern.
Obesity and addiction: Neurobiological overlaps
Drug addiction and obesity appear to share several properties. Both can be defined as disorders in which the saliency of a specific type of reward (food or drug) becomes exaggerated relative to, and at the expense of others rewards. Both drugs and food have powerful reinforcing effects, which are in part mediated by abrupt dopamine increases in the brain reward centres. The abrupt dopamine increases, in vulnerable individuals, can override the br…
Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications
Reward, dopamine and the control of food intake: Implications for obesity
Contrast of medical and nonmedical use of stimulant drugs, basis for the distinction, and risk of addiction: Comment on Smith and Farah (2011)
Smith and Farah (2011) presented a scholarly review of critical areas related to their intriguing title "Are Prescription Stimulants 'Smart Pills'?" We contend that they accomplished the main goal of the article, to get the facts straight about possible cognitive enhancement via the nonmedical use of stimulant drugs by individuals without a diagnosis of attention-deficit/hyperactivity disorder (ADHD). At the same time, they justified their main c…
Treating Drug Abuse and Addiction in the Criminal Justice System: Improving Public Health and Safety
Despite increasing evidence that addiction is a treatable disease of the brain, most individuals do not receive treatment. Involvement in the criminal justice system often results from illegal drug-seeking behavior and participation in illegal activities that reflect, in part, disrupted behavior ensuing from brain changes triggered by repeated drug use. Treating drug-involved offenders provides a unique opportunity to decrease substance abuse and…
Neural mechanisms of anger regulation as a function of genetic risk for violence
Genetic risk may predispose individuals to compromised anger regulation, potentially through modulation of brain responses to emotionally evocative stimuli. Emphatically expressed, the emotional word No can prohibit behavior through conditioning. In a recent functional magnetic resonance imaging study, the authors showed that healthy males attribute negative valence to No while showing a lateral orbitofrontal response that correlated with their s…
What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
The words "No" and "Yes" are involved in conditioning to prohibit or encourage behavior, respectively. The authors, therefore, hypothesized that these words would be attributed to endogenous valence, activating neuronal circuits involved with valence and emotional control. Functional MRI (fMRI) at 4 Tesla was used to record regional brain activity while participants were exposed to emphatic vocalizations of the words. Results showed that No and Y…
Withdrawn: Common brain mechanisms in addiction and obesity
How can drug addiction help us understand obesity?
The Neural Basis of Addiction: A Pathology of Motivation and Choice
OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering motivational strength and decreased ability to control the desire to obtain drugs. In this review the authors explore how advances in neurobiology are approaching an understanding of the cellular and circuitry underpinnings of addiction, and they describe the novel pharmacotherapeutic targets emerging from this understanding. METHOD: Findings from neuroimaging of addi…
No prominent works on this page.
Brain dopamine and obesity
Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
OBJECTIVE: Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction. METHOD: An integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed. This model and findings from neuroimaging studies on the behavioral, cognitive, and emotional processes t…
How can drug addiction help us understand obesity?
The Neural Basis of Addiction: A Pathology of Motivation and Choice
OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering motivational strength and decreased ability to control the desire to obtain drugs. In this review the authors explore how advances in neurobiology are approaching an understanding of the cellular and circuitry underpinnings of addiction, and they describe the novel pharmacotherapeutic targets emerging from this understanding. METHOD: Findings from neuroimaging of addi…
Withdrawn: Common brain mechanisms in addiction and obesity
What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
The words "No" and "Yes" are involved in conditioning to prohibit or encourage behavior, respectively. The authors, therefore, hypothesized that these words would be attributed to endogenous valence, activating neuronal circuits involved with valence and emotional control. Functional MRI (fMRI) at 4 Tesla was used to record regional brain activity while participants were exposed to emphatic vocalizations of the words. Results showed that No and Y…
Treating Drug Abuse and Addiction in the Criminal Justice System: Improving Public Health and Safety
Despite increasing evidence that addiction is a treatable disease of the brain, most individuals do not receive treatment. Involvement in the criminal justice system often results from illegal drug-seeking behavior and participation in illegal activities that reflect, in part, disrupted behavior ensuing from brain changes triggered by repeated drug use. Treating drug-involved offenders provides a unique opportunity to decrease substance abuse and…
Neural mechanisms of anger regulation as a function of genetic risk for violence
Genetic risk may predispose individuals to compromised anger regulation, potentially through modulation of brain responses to emotionally evocative stimuli. Emphatically expressed, the emotional word No can prohibit behavior through conditioning. In a recent functional magnetic resonance imaging study, the authors showed that healthy males attribute negative valence to No while showing a lateral orbitofrontal response that correlated with their s…
Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications
Reward, dopamine and the control of food intake: Implications for obesity
Contrast of medical and nonmedical use of stimulant drugs, basis for the distinction, and risk of addiction: Comment on Smith and Farah (2011)
Smith and Farah (2011) presented a scholarly review of critical areas related to their intriguing title "Are Prescription Stimulants 'Smart Pills'?" We contend that they accomplished the main goal of the article, to get the facts straight about possible cognitive enhancement via the nonmedical use of stimulant drugs by individuals without a diagnosis of attention-deficit/hyperactivity disorder (ADHD). At the same time, they justified their main c…
Obesity and addiction: Neurobiological overlaps
Drug addiction and obesity appear to share several properties. Both can be defined as disorders in which the saliency of a specific type of reward (food or drug) becomes exaggerated relative to, and at the expense of others rewards. Both drugs and food have powerful reinforcing effects, which are in part mediated by abrupt dopamine increases in the brain reward centres. The abrupt dopamine increases, in vulnerable individuals, can override the br…
Medication-Assisted Therapies — Tackling the Opioid-Overdose Epidemic
T he rate of death from over- doses of prescription opioids in the United States more than quadrupled between 1999 and 2010 (see graph), far exceeding the combined death toll from cocaine and heroin overdoses. 1 In 2010 alone, prescription opioids were involved in 16,651 overdose deaths, whereas heroin was implicated in 3036. Some 82% of the deaths due to prescription An audio interview with Dr.
Adverse Health Effects of Marijuana Use
As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration. Although the harms associated with marijuana use have not been well studied, enough information is available to cause concern.
Neurobiologic Advances from the Brain Disease Model of Addiction
This article reviews scientific advances in the prevention and treatment of substance-use disorder and related developments in public policy. In the past two decades, research has increasingly supported the view that addiction is a disease of the brain. Although the brain disease model of addiction has yielded effective preventive measures, treatment interventions, and public health policies to address substance-use disorders, the underlying conc…
Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review
Neurobiology of addiction: A neurocircuitry analysis
Collision of the Covid-19 and Addiction Epidemics
Ideas and Opinions2 April 2020Collision of the COVID-19 and Addiction EpidemicsFREENora D. Volkow, MDNora D. Volkow, MDNational Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland (N.D.V.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-1212 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedIn…
Ethical Imperatives to Overcome Stigma Against People With Substance Use Disorders
Responding to the public health crisis in the United States resulting from untreated opioid use disorder (OUD) requires expanding delivery of effective treatments, including medications, and eliminating stigma against people with OUD and people seeking OUD treatment. Stigma discourages people with substance use disorders from seeking care and compromises the care they receive when they do seek it. Stigma against both medication treatments for OUD…
Increased risk of Covid ‐19 infection and mortality in people with mental disorders: Analysis from electronic health records in the United States
Concerns have been expressed that persons with a pre‐existing mental disorder may represent a population at increased risk for COVID‐19 infection and with a higher likelihood of adverse outcomes of the infection, but there is no systematic research evidence in this respect. This study assessed the impact of a recent (within past year) diagnosis of a mental disorder – including attention‐deficit/hyperactivity disorder (ADHD), bipolar disorder, de…
Covid-19 risk and outcomes in patients with substance use disorders: Analyses from electronic health records in the United States
The global pandemic of COVID-19 is colliding with the epidemic of opioid use disorders (OUD) and other substance use disorders (SUD) in the United States (US). Currently, there is limited data on risks, disparity, and outcomes for COVID-19 in individuals suffering from SUD. This is a retrospective case-control study of electronic health records (EHRs) data of 73,099,850 unique patients, of whom 12,030 had a diagnosis of COVID-19. Patients with a …
LRRK2 Gene Variants Associated With a Higher Risk for Alcohol Dependence in Multiethnic Populations
Background: Genetics influence the vulnerability to alcohol use disorders, and among the implicated genes, three previous studies have provided evidences for the involvement of LRRK2 in alcohol dependence (AD). LRRK2 expression is broadly dysregulated in postmortem brain from AD humans, as well as in the brain of mice with alcohol dependent-like behaviors and in a zebrafish model of alcohol preference. The aim of the present study was to evaluate…
Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women
Background: There are known sex differences in behavioral and clinical outcomes associated with drugs of abuse, including cannabis. However, little is known about how chronic cannabis use and sex interact to affect brain structure, particularly in regions with high cannabinoid receptor expression, such as the cerebellum, amygdala, and hippocampus. Based on behavioral data suggesting that females may be particularly vulnerable to the effects of ch…
How Academic Medicine Can Help Confront the Opioid Crisis
The United States is in the midst of a devastating overdose and addiction crisis involving opioids as well as other drugs. Yet, despite the existence of effective treatments for opioid use disorder, only a minority of people who need treatment for this or other substance use disorders receive it. Besides the terrible human and economic costs of overdose deaths and the other health consequences of addiction, untreated substance use has wide-rangin…
Prenatal caffeine exposure: Association with neurodevelopmental outcomes in 9‐ to 11‐year‐old children
BACKGROUND: Despite the widespread use of caffeine including consumption during pregnancy, the effect of prenatal caffeine exposure on child brain development and behavior is unclear. METHODS: To address this, we used data from the Adolescent Brain and Cognitive Development Study (n = 11,875 children aged 9-11 years from 22 sites across the United States). We explored the associations between prenatal caffeine exposure and various developmental o…
Medicine (18 works) · Psychology (17 works) · Addiction (11 works) · Neuroscience (11 works) · Neurotransmitter Receptor Influence on Behavior (11 works) · Psychiatry (10 works) · Cognition (9 works) · Dopamine (6 works) · Internal Medicine (6 works) · Prefrontal cortex (6 works)