Neal L Benowitz
Biographic Data
| ID | 6059419 |
|---|---|
| NAME | Neal L Benowitz |
| GIVEN NAMES | Neal L |
| FAMILY NAME | Benowitz |
| SIGNATURE | BENOWITZ N L |
| AFFILIATIONS | University of California, San Francisco |
| ORCID | 0000-0003-2041-8124 |
| VERIFIED | Yes |
| TOTAL WORKS | 43 |
| TOTAL CITATIONS | 36 |
| AUTHOR COUNT | 43 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1987 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 4 |
E-Cigarettes in Historical Context—Innovation, Risk, and Regulation
This Viewpoint discusses the potential for e-cigarettes to displace smoking, restrictive regulations, and public misperceptions amid enduring nicotine demand and persistent smoking-related disease
Nicotine levels in flavoured hookah (waterpipe) tobacco products: Discrepancies between labelled and measured levels
Nicotine levels cited by leading hookah tobacco manufacturers are misleading. The advertised levels of nicotine do not reflect the quantified dose of nicotine available to consumers of hookah tobacco products. Findings highlight the need for the development of hookah tobacco product regulations and labelling standards, similar to other tobacco products, to avoid misleading vulnerable consumers, including youth and young adults
Associations of Cannabis Use, High-Risk Alcohol Use, and Depressive Symptomology with Motivation and Attempts to Quit Cigarette Smoking Among Adults: Findings from the 2020 ITC Four Country Smoking an…
The online version contains supplementary material available at 10.1007/s11469-023-01214-8
Policy-relevant differences between secondhand and thirdhand smoke: Strengthening protections from involuntary exposure to tobacco smoke pollutants
Starting in the 1970s, individuals, businesses and the public have increasingly benefited from policies prohibiting smoking indoors, saving thousands of lives and billions of dollars in healthcare expenditures. Smokefree policies to protect against secondhand smoke exposure, however, do not fully protect the public from the persistent and toxic chemical residues from tobacco smoke (also known as thirdhand smoke) that linger in indoor environments…
Effects of dual use of e-cigarette and cannabis during adolescence on cigarette use in young adulthood
Adolescent e-cigarette and cannabis use was associated with more frequent smoking during young adulthood, with larger effects of dual use. Associations were partially mediated through nicotine dependence. Dual use of cannabis and e-cigarettes may contribute to the development of nicotine dependence and increased use of combustible cigarettes
Traditional Heart-Healthy Diet and Medication Adherence in the Norton Sound Region: An 18-Month Telehealth Intervention
In a remote region of Alaska, telemedicine proved feasible and acceptable for engaging Alaska Native men and women in counseling on CVD risk behaviors. The findings indicate that more touchpoints may be necessary to impart comprehensive lasting change in heart-healthy eating patterns. Medication adherence group differences were not significant; however, medication adherence was high overall
Balfour et al. Respond
AffiliationsDavid J. K. Balfour is retired from the Division of Systems Medicine, School of Medicine, University of Dundee, Dundee, UK. Neal L. Benowitz is with the Department of Medicine, School of Medicine, University of California, San Francisco. Suzanne M. Colby is with the Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI. Dorothy K. Hatsukami is with the Department of Psychiatry and Behavio…
Balfour et al. Respond
Balancing Consideration of the Risks and Benefits of E-Cigarettes
The topic of e-cigarettes is controversial. Opponents focus on e-cigarettes’ risks for young people, while supporters emphasize the potential for e-cigarettes to assist smokers in quitting smoking. Most US health organizations, media coverage, and policymakers have focused primarily on risks to youths. Because of their messaging, much of the public—including most smokers—now consider e-cigarette use as dangerous as or more dangerous than smoking.…
Biochemical Verification of Tobacco Use and Abstinence: 2019 Update
BACKGROUND: The changing prevalence and patterns of tobacco use, the advent of novel nicotine delivery devices, and the development of new biomarkers prompted an update of the 2002 Society for Research on Nicotine and Tobacco (SRNT) report on whether and how to apply biomarker verification for tobacco use and abstinence. METHODS: The SRNT Treatment Research Network convened a group of investigators with expertise in tobacco biomarkers to update t…
Australian smokers’ experiences and perceptions of recessed and firm filter cigarettes
RFCs and FFCs undermine plain packaging legislation, which aims to reduce appeal and minimise misperceptions about the relative harms of different tobacco products. Like other filter modifications, these filter variants should be disallowed
Reducing nicotine exposure results in weight gain in smokers randomised to very low nicotine content cigarettes
NCT01681875, Post-results
Perceived risks and reasons to smoke cigarettes during pregnancy among Alaska native women
Results from this work may be helpful in advancing research by identifying targets for intervention specific to Alaska Native women receiving prenatal care in Anchorage, Alaska
Thirdhand smoke contamination in hospital settings: Assessing exposure risk for vulnerable paediatric patients: Table 1
THS appears to be ubiquitous, even in closely guarded healthcare settings. Future research will address potential health consequences and THS-reduction policies. Ultimately, hospital policies and interventions to reduce THS transport and exposure may prove necessary, especially for immunocompromised children
E-Cigarettes: A Scientific Review
chemicals delivered to users and the air pollution generated by the exhaled aerosol. -liquids are flavored, including tobacco, menthol, coffee, fruit, candy, and alcohol flavors, as well as unusual flavors such as cola and Belgian waffle. 3 Flavored (conventional) tobacco products are used disproportionately by youth and initiators
Electronic cigarettes: Review of use, content, safety, effects on smokers and potential for harm and benefit
Different profiles of carcinogen exposure in Chinese compared with US cigarette smokers
NCT00264342
Biomarkers of secondhand smoke exposure in automobiles
Brief SHS exposure in cars resulted in substantial increases in levels of tobacco biomarkers in non-smokers. For optimal characterisation of SHS exposure, tobacco biomarkers should be measured within 4-8 h post-exposure. Additional studies are needed to better describe the relationship between tobacco biomarkers and environmental markers of SHS
Validity of self-reported adult secondhand smoke exposure
The single item ASHES-7d Home screener is brief, assesses recent SHS exposure over a week's time, and yielded the optimal balance of sensitivity and specificity. The current findings support use of the ASHES-7d Home screener to detect SHS exposure and can be easily incorporated into assessment of other major vital signs in cardiology
Population Approaches to Improve Diet, Physical Activity, and Smoking Habits: A Scientific Statement From the American Heart Association
BACKGROUND: Poor lifestyle behaviors, including suboptimal diet, physical inactivity, and tobacco use, are leading causes of preventable diseases globally. Although even modest population shifts in risk substantially alter health outcomes, the optimal population-level approaches to improve lifestyle are not well established. METHODS AND RESULTS: For this American Heart Association scientific statement, the writing group systematically reviewed an…
Thirdhand Tobacco Smoke: Emerging Evidence and Arguments for a Multidisciplinary Research Agenda
BACKGROUND: There is broad consensus regarding the health impact of tobacco use and secondhand smoke exposure, yet considerable ambiguity exists about the nature and consequences of thirdhand smoke (THS). OBJECTIVES: We introduce definitions of THS and THS exposure and review recent findings about constituents, indoor sorption-desorption dynamics, and transformations of THS; distribution and persistence of THS in residential settings; implication…
Attitudes and Practices of Hookah Smokers in the San Francisco Bay Area
As many as 10 million people will die annually by the year 2030 due to tobacco-related causes. While much research has focused on cigarettes, the increasing popularity of smoking hookah (water pipe) has received much less attention. Epidemiological studies have been carried out in India, Pakistan, Syria, Kuwait, and Lebanon, but there are few in the United States. Hookah smoking is typically a social activity and there are many myths and rumors a…
Nicotine Addiction
This review gives an account of the cigarette as a highly efficient nicotine delivery system. It explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction to tobacco smoking. The basis of nicotine addiction rests on its effects on the brain, but addiction is also influenced by learned or conditioned factors, genetics, and social and environmental conditions.
Nicotine Chemistry, Metabolism, Kinetics and Biomarkers
Calibrating Self-Reported Measures of Maternal Smoking in Pregnancy via Bioassays Using a Monte Carlo Approach
Maternal smoking during pregnancy is a major public health problem that has been associated with numerous short- and long-term adverse health outcomes in offspring. However, characterizing smoking exposure during pregnancy precisely has been rather difficult: self-reported measures of smoking often suffer from recall bias, deliberate misreporting, and selective non-disclosure, while single bioassay measures of nicotine metabolites only reflect re…
Apparent underreporting of cigarette consumption among Mexican American smokers
To determine the accuracy of self-report of cigarette consumption among Mexican American smokers, we compared self-reported cigarette use and serum cotinine concentrations in a sample of 547 participants in the Hispanic Health and Nutrition Examination Survey (HHANES). We defined underreporting of cigarette use as a cotinine to cigarette-per-day ratio of greater than 0.142 microM/l which represented a substantial discrepancy between self-reported…
Balancing Consideration of the Risks and Benefits of E-Cigarettes
The topic of e-cigarettes is controversial. Opponents focus on e-cigarettes’ risks for young people, while supporters emphasize the potential for e-cigarettes to assist smokers in quitting smoking. Most US health organizations, media coverage, and policymakers have focused primarily on risks to youths. Because of their messaging, much of the public—including most smokers—now consider e-cigarette use as dangerous as or more dangerous than smoking.…
Elimination of cotinine from body fluids: Implications for noninvasive measurement of tobacco smoke exposure
Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two occasional smokers). Half-lives for cotinine averaged 16-19 hours in the different body fluids (range 10 to 27 hours between subjects). There was no tendency for the half-life in saliva to be longer than in plasma or urine. We conclude that choice of body fluid for cotinine assay in smoking studies should depend on practical rat…
Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers
Cotinine was measured in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers. Serum and saliva could not discriminate between nonsmokers and passive smokers. Mean urine cotinine was higher in passive smokers than nonsmokers but there was a great deal of intersubject overlap. Cotinine in all body fluids could separate active smokers from the other two groups. Among smokers, light smokers had lower levels than heavier sm…
Smokeless tobacco, cardiovascular risk factors, and nicotine and cotinine levels in professional baseball players
BACKGROUND. The use of smokeless tobacco (ST), which has increased in popularity over the past 2 decades, results in considerable systemic exposure to nicotine. Nicotine might contribute to atherosclerosis by an effect on cardiovascular risk factors. METHODS. The effects of ST use on cardiovascular risk factors and cotinine and nicotine levels were studied in 1061 professional baseball players during spring training in 1988 and 1989. RESULTS. Of …
Determinants of salivary cotinine level: A population-based study in Brazil
OBJECTIVE: A cross-sectional population-based study was conducted to assess, in active smokers, the relationship of number of cigarettes smoked and other characteristics to salivary cotinine concentrations. METHODS: A random sample of active smokers aged 15 years or older was selected using a stepwise cluster sample strategy, in the year 2000 in Rio de Janeiro, Brazil. The study included 401 subjects. Salivary cotinine concentration was determine…
Spontaneous cigarette brand switching: Consequences for nicotine and carbon monoxide exposure
A group of smokers who had participated in smoking-related studies three to six years earlier were re-studied to assess changes in their smoking practices. Individuals who smoked the same brands of cigarettes showed no change in plasma cotinine (reflecting exposure to nicotine) or expired carbon monoxide (CO) concentration. Those who switched to cigarettes of lower nicotine yield (average decrease 38 per cent) showed reduced plasma cotinine conce…
Influence of tobacco abstinence on the disposition kinetics and effects of nicotine
Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers
Cotinine was measured in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers. Serum and saliva could not discriminate between nonsmokers and passive smokers. Mean urine cotinine was higher in passive smokers than nonsmokers but there was a great deal of intersubject overlap. Cotinine in all body fluids could separate active smokers from the other two groups. Among smokers, light smokers had lower levels than heavier sm…
Response from Jarvis, et al
Response from Jarvis, et al. Martin J. Jarvis, Michael A. H. Russell, Colin Feyerabend, and Neal L. Benowitz CopyRight https://doi.org/10.2105/AJPH.78.6.718-a Published Online: October 07, 2011
Elimination of cotinine from body fluids: Implications for noninvasive measurement of tobacco smoke exposure
Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two occasional smokers). Half-lives for cotinine averaged 16-19 hours in the different body fluids (range 10 to 27 hours between subjects). There was no tendency for the half-life in saliva to be longer than in plasma or urine. We conclude that choice of body fluid for cotinine assay in smoking studies should depend on practical rat…
Apparent underreporting of cigarette consumption among Mexican American smokers
To determine the accuracy of self-report of cigarette consumption among Mexican American smokers, we compared self-reported cigarette use and serum cotinine concentrations in a sample of 547 participants in the Hispanic Health and Nutrition Examination Survey (HHANES). We defined underreporting of cigarette use as a cotinine to cigarette-per-day ratio of greater than 0.142 microM/l which represented a substantial discrepancy between self-reported…
Elevated nicotine levels in cervical lavages from passive smokers
One hundred forty-five nonsmokers found to have normal cytologic diagnoses on routine Pap smears were interviewed regarding environmental exposure to tobacco smoke, and a 3 ml saline lavage of the cervix was collected for measurement of cervical nicotine levels by gas chromatography-mass spectroscopy. Nicotine levels tended to be highest among women exposed to tobacco smoke in the home, intermediate in women exposed only outside the home, and low…
Smokeless tobacco, cardiovascular risk factors, and nicotine and cotinine levels in professional baseball players
BACKGROUND. The use of smokeless tobacco (ST), which has increased in popularity over the past 2 decades, results in considerable systemic exposure to nicotine. Nicotine might contribute to atherosclerosis by an effect on cardiovascular risk factors. METHODS. The effects of ST use on cardiovascular risk factors and cotinine and nicotine levels were studied in 1061 professional baseball players during spring training in 1988 and 1989. RESULTS. Of …
Pérez-Stable and Colleagues Respond
Pérez-Stable and Colleagues Respond Eliseo J. Pérez-Stable, Barbara Marín, Gerardo Marín, and Neal Benowitz W J McCarthy, N H Caskey, and M E JarvikCopyRight https://doi.org/10.2105/AJPH.82.8.1172 Published Online: October 07, 2011
Medical implications
Cotinine as a Biomarker of Environmental Tobacco Smoke Exposure
Neal L. Benowitz; Cotinine as a Biomarker of Environmental Tobacco Smoke Exposure, Epidemiologic Reviews, Volume 18, Issue 2, 1 January 1996, Pages 188–204, htt
Nicotine content of the eclipse nicotine delivery device
Nicotine content of the eclipse nicotine delivery device. N L Benowitz, P Jacob, 3rd, J Slade, and L YuCopyRight https://doi.org/10.2105/AJPH.87.11.1865 Published Online: October 07, 2011
Occasional smoking in a study of premenopausal women
Occasional smoking in a study of premenopausal women. E P Elkin, G C Windham, N L Benowitz, and S H Swan Corinne G. Husten, and Gary Giovino CopyRight https://doi.org/10.2105/AJPH.89.3.420 Published Online: October 07, 2011
The use of pharmacotherapies for smoking cessation during pregnancy
1) to determine the current state of knowledge related to the use of pharmacotherapies for smoking cessation during pregnancy; and (2) to outline a research agenda to determine the eVectiveness and safety of these pharmacotherapies
Biochemical verification of tobacco use and cessation
SRNT Subcommittee on Biochemical Verification; Biochemical verification of tobacco use and cessation, Nicotine & Tobacco Research, Volume 4, Issue 2, 1 May
Maternal Smoking During Pregnancy and Severe Antisocial Behavior in Offspring: A Review
Objectives. Recent research suggests that in utero exposure to maternal smoking is a risk factor for conduct disorder and delinquency. We review evidence of causality, a controversial but important public health question. Methods. We analyzed studies of maternal prenatal smoking and offspring antisocial behavior within a causal framework. Results. The association is (1) independent of confounders, (2) present across diverse contexts, and (3) cons…
Bupropion in breast milk: An exposure assessment for potential treatment to prevent post-partum tobacco use
Bupropion and its active metabolites are present in the breast milk of lactating women. The concentrations of bupropion in breast milk and urine were highly correlated. These results indicate that the daily dose of bupropion and metabolites that would be delivered to an infant of a woman taking a therapeutic dose of bupropion is small. These results suggest that the effectiveness of bupropion to prevent post-partum relapse to tobacco use should b…
Determinants of salivary cotinine level: A population-based study in Brazil
OBJECTIVE: A cross-sectional population-based study was conducted to assess, in active smokers, the relationship of number of cigarettes smoked and other characteristics to salivary cotinine concentrations. METHODS: A random sample of active smokers aged 15 years or older was selected using a stepwise cluster sample strategy, in the year 2000 in Rio de Janeiro, Brazil. The study included 401 subjects. Salivary cotinine concentration was determine…
Nicotine Chemistry, Metabolism, Kinetics and Biomarkers
Calibrating Self-Reported Measures of Maternal Smoking in Pregnancy via Bioassays Using a Monte Carlo Approach
Maternal smoking during pregnancy is a major public health problem that has been associated with numerous short- and long-term adverse health outcomes in offspring. However, characterizing smoking exposure during pregnancy precisely has been rather difficult: self-reported measures of smoking often suffer from recall bias, deliberate misreporting, and selective non-disclosure, while single bioassay measures of nicotine metabolites only reflect re…
Nicotine Addiction
This review gives an account of the cigarette as a highly efficient nicotine delivery system. It explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction to tobacco smoking. The basis of nicotine addiction rests on its effects on the brain, but addiction is also influenced by learned or conditioned factors, genetics, and social and environmental conditions.
Thirdhand Tobacco Smoke: Emerging Evidence and Arguments for a Multidisciplinary Research Agenda
BACKGROUND: There is broad consensus regarding the health impact of tobacco use and secondhand smoke exposure, yet considerable ambiguity exists about the nature and consequences of thirdhand smoke (THS). OBJECTIVES: We introduce definitions of THS and THS exposure and review recent findings about constituents, indoor sorption-desorption dynamics, and transformations of THS; distribution and persistence of THS in residential settings; implication…
Attitudes and Practices of Hookah Smokers in the San Francisco Bay Area
As many as 10 million people will die annually by the year 2030 due to tobacco-related causes. While much research has focused on cigarettes, the increasing popularity of smoking hookah (water pipe) has received much less attention. Epidemiological studies have been carried out in India, Pakistan, Syria, Kuwait, and Lebanon, but there are few in the United States. Hookah smoking is typically a social activity and there are many myths and rumors a…
Population Approaches to Improve Diet, Physical Activity, and Smoking Habits: A Scientific Statement From the American Heart Association
BACKGROUND: Poor lifestyle behaviors, including suboptimal diet, physical inactivity, and tobacco use, are leading causes of preventable diseases globally. Although even modest population shifts in risk substantially alter health outcomes, the optimal population-level approaches to improve lifestyle are not well established. METHODS AND RESULTS: For this American Heart Association scientific statement, the writing group systematically reviewed an…
Biomarkers of secondhand smoke exposure in automobiles
Brief SHS exposure in cars resulted in substantial increases in levels of tobacco biomarkers in non-smokers. For optimal characterisation of SHS exposure, tobacco biomarkers should be measured within 4-8 h post-exposure. Additional studies are needed to better describe the relationship between tobacco biomarkers and environmental markers of SHS
Medicine (41 works) · Smoking Behavior and Cessation (36 works) · Environmental health (29 works) · Nicotine (22 works) · Internal Medicine (15 works) · Psychiatry (14 works) · Cotinine (13 works) · Air Quality and Health Impacts (11 works) · Psychology (11 works) · Smoking cessation (10 works)