Bruce S Rabin
Biographic Data
| ID | 6070007 |
|---|---|
| NAME | Bruce S Rabin |
| GIVEN NAMES | Bruce S |
| FAMILY NAME | Rabin |
| SIGNATURE | RABIN B S |
| AFFILIATIONS | University of Pittsburgh |
| VERIFIED | No |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1991 |
| LATEST PUBLICATION YEAR | 2012 |
| H-INDEX | 0 |
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studies. In study 1, we assessed stressful life events, GCR, and control variables including baseline antibody to the challenge virus, age, body mass index (BMI), season, race, sex, education, and virus type in 276 healthy adult volunte…
Loneliness, Social Network Size, and Immune Response to Influenza Vaccination in College Freshmen.
Antibody response to the influenza immunization was investigated in 83 1st-semester healthy university freshmen. Elevated levels of loneliness throughout the semester and small social networks were independently associated with poorer antibody response to 1 component of the vaccine. Those with both high levels of loneliness and a small social network had the lowest antibody response. Loneliness was also associated with greater psychological stres…
The Effect of Sunlight on Postoperative Analgesic Medication Use
Objective: Exposure to natural sunlight has been associated with improvement in mood, reduced mortality among patients with cancer, and reduced length of hospitalization for patients who have experienced myocardial infarction. Our aim was to evaluate whether the amount of sunlight in a hospital room modifies a patient’s psychosocial health, the quantity of analgesic medication used, and the pain medication cost. Methods: A prospective study of pa…
Psychological Stress and Antibody Response to Influenza Vaccination
OBJECTIVES: This study attempted to determine whether stress of moderate intensity could modulate the antibody response to an influenza vaccination in healthy young adults, identify critical periods during which stress could influence antibody response, and delineate behavioral and biological pathways that might explain relations between stress and antibody. METHODS: A cohort of 83 healthy young adults underwent 13 days of ambulatory monitoring b…
Healthy Aging Begins With the Fetus
The April editorial of McLeroy et al.1 emphasizes the importance of proper development and implementation of modalities that will be accepted by adult residents of communities for the enhancement of the quality of health and therefore life. The experience of the University of Pittsburgh Healthy Lifestyle Program has been that few adults will participate in wellness programs and those who do are not representative of the total socioeconomic spectr…
Stressful Life Events Precede Exacerbations of Multiple Sclerosis
Objective We longitudinally monitored life events and health changes in patients with multiple sclerosis (MS) to determine whether stressful events may trigger exacerbation of MS. Methods Twenty-three women with MS were followed for 1 year. Each subject completed the Psychiatric Epidemiologic Research Interview on a weekly basis. Further information on potentially stressful events was acquired using the Life Events and Difficulties Schedule. Neur…
Reactivity and Vulnerability to Stress-Associated Risk for Upper Respiratory Illness
OBJECTIVE: We tested the hypothesis that the greater a person's laboratory stress-elicited elevation in cortisol, the greater the life stress-related risk for upper respiratory infection (URI). We also tested the prediction that the greater the laboratory stress-elicited rise in natural killer cell (NK) cytotoxicity, the smaller the life stress-related URI risk. Finally, we explored whether sympathetic nervous system (SNS) and enumerative immune …
Psychological Stress and Antibody Response to Immunization
OBJECTIVE: The objective of this review was to evaluate the evidence for the hypothesis that psychological stress influences antibody response to immunization in humans. METHODS: A critical review of the literature was conducted. RESULTS: The evidence supports an association between psychological stress and suppression of humoral immune (antibody) response to immunization. This association is convincing in the case of secondary immune response bu…
Types of stressors that increase susceptibility to the common cold in healthy adults.
Two-hundred seventy-six volunteers completed a life stressor interview and psychological questionnaires and provided blood and urine samples. They were then inoculated with common cold viruses and monitored for the onset of disease. Although severe acute stressful life events (less than 1 month long) were not associated with developing colds, severe chronic stressors (1 month or longer) were associated with a substantial increase in risk of disea…
Stability and Intercorrelations of Immune, Cardiovascular, Endocrine, and Psychological Responses to an Acute Laboratory Stressor
Hamrick, Natalie A.; Cohen, Sheldon A.; Rodriguez, Mario; Manuck, Stephen; Rabin, Bruce Author Information
Stressor-Induced Alteration of Cytokine Production in Multiple Sclerosis Patients and Controls
OBJECTIVE: We administered an acute psychological stressor to multiple sclerosis (MS) patients and normal controls to determine whether differences in subjective and physiological responses to stress may underlie the susceptibility of MS patients to stress-related exacerbations. METHOD: Twenty-five MS patients (18 female, 7 male) and 25 age- and gender-matched controls participated in the study. They were asked to give a 5-minute videotaped speec…
Chronic Social Stress, Social Status, and Susceptibility to Upper Respiratory Infections in Nonhuman Primates
OBJECTIVE: The objective of the study was to assess the roles of social stress and social status in susceptibility to upper respiratory infection. METHOD: Sixty male cynomolgus monkeys were randomly assigned to stable or unstable social conditions for 15 months. Two markers of social status, social rank and percent of behaviors that were submissive, were assessed at independent observation periods. Endocrine, immune, and behavioral responses were…
Effects of social reorganization on cellular immunity in male cynomolgus monkeys
Adrenergic Blockade Ameliorates Cellular Immune Responses to Mental Stress in Humans
This study evaluated the sympathoadrenal modulation of behaviorally evoked immune responses by administration of a nonselective adrenoceptor antagonist (labetalol) to subjects exposed to mental stress. In a 2 x 2 factorial design, subjects were assigned to a labetalol or saline condition and, within each condition, were exposed either to acute laboratory stress or no stress (control). Lymphocyte subsets, natural killer (NK) cell cytotoxicity, and…
Stability of Individual Differences in Cellular Immune Responses to Acute Psychological Stress
To determine the stability of individual differences in cellular immune reactions to acute mental stress, we correlated enumerative and functional lymphocyte responses to an evaluative speech task across two experimental sessions scheduled 2 weeks apart in 30 young men. Relative to pretask baseline measurements, the speech stressor elicited a diminished proliferative response to phytohemagglutinin and concanavalin A, a decrease in circulating CD1…
Cardiovascular reactivity and the course of immune response to an acute psychological stressor
This study evaluated the temporal nature of cellular immune responses, as well as the effects of cardiovascular reactivity on immune responses after exposure to an acute psychological stressor. Lymphocyte subsets and lymphocyte proliferative response to phytohemagglutinin were assessed at baseline and at 5 and 21 minutes after stressor onset in the experimental group and at the same time points in a nonstressor control group. By 5 minutes after s…
Lymphocyte subset and cellular immune responses to a brief experimental stressor
To evaluate effects of acute mental stress on aspects of cellular immunity, lymphocyte populations and phytohemagglutinin (PHA)-stimulated T-cell mitogenesis were measured in 33 healthy young men, both before and immediately following subjects' performance of a frustrating, 21-minute laboratory task (Stroop test). Relative to baseline evaluations, post-task measurements showed a significant reduction in mitogenesis and alterations in various circ…
The relationship of agonistic and affiliative behavior patterns to cellular immune function among cynomolgus monkeys ( Macaca fascicularis ) living in unstable social groups
Considerable recent interest has focused on the possibility that behavioral factors may influence immune competence, and hence, potentially, patterns of disease. We report here the relationship between the aggressive and affiliative behavior and the cellular immune responses of 30 adult male cynomolgus monkeys ( Macaca fascicularis ) living in small (n = 5) social groups whose members were periodically redistributed over 26 months. Animals also w…
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The relationship of agonistic and affiliative behavior patterns to cellular immune function among cynomolgus monkeys ( Macaca fascicularis ) living in unstable social groups
Considerable recent interest has focused on the possibility that behavioral factors may influence immune competence, and hence, potentially, patterns of disease. We report here the relationship between the aggressive and affiliative behavior and the cellular immune responses of 30 adult male cynomolgus monkeys ( Macaca fascicularis ) living in small (n = 5) social groups whose members were periodically redistributed over 26 months. Animals also w…
Lymphocyte subset and cellular immune responses to a brief experimental stressor
To evaluate effects of acute mental stress on aspects of cellular immunity, lymphocyte populations and phytohemagglutinin (PHA)-stimulated T-cell mitogenesis were measured in 33 healthy young men, both before and immediately following subjects' performance of a frustrating, 21-minute laboratory task (Stroop test). Relative to baseline evaluations, post-task measurements showed a significant reduction in mitogenesis and alterations in various circ…
Cardiovascular reactivity and the course of immune response to an acute psychological stressor
This study evaluated the temporal nature of cellular immune responses, as well as the effects of cardiovascular reactivity on immune responses after exposure to an acute psychological stressor. Lymphocyte subsets and lymphocyte proliferative response to phytohemagglutinin were assessed at baseline and at 5 and 21 minutes after stressor onset in the experimental group and at the same time points in a nonstressor control group. By 5 minutes after s…
Adrenergic Blockade Ameliorates Cellular Immune Responses to Mental Stress in Humans
This study evaluated the sympathoadrenal modulation of behaviorally evoked immune responses by administration of a nonselective adrenoceptor antagonist (labetalol) to subjects exposed to mental stress. In a 2 x 2 factorial design, subjects were assigned to a labetalol or saline condition and, within each condition, were exposed either to acute laboratory stress or no stress (control). Lymphocyte subsets, natural killer (NK) cell cytotoxicity, and…
Stability of Individual Differences in Cellular Immune Responses to Acute Psychological Stress
To determine the stability of individual differences in cellular immune reactions to acute mental stress, we correlated enumerative and functional lymphocyte responses to an evaluative speech task across two experimental sessions scheduled 2 weeks apart in 30 young men. Relative to pretask baseline measurements, the speech stressor elicited a diminished proliferative response to phytohemagglutinin and concanavalin A, a decrease in circulating CD1…
Effects of social reorganization on cellular immunity in male cynomolgus monkeys
Chronic Social Stress, Social Status, and Susceptibility to Upper Respiratory Infections in Nonhuman Primates
OBJECTIVE: The objective of the study was to assess the roles of social stress and social status in susceptibility to upper respiratory infection. METHOD: Sixty male cynomolgus monkeys were randomly assigned to stable or unstable social conditions for 15 months. Two markers of social status, social rank and percent of behaviors that were submissive, were assessed at independent observation periods. Endocrine, immune, and behavioral responses were…
Types of stressors that increase susceptibility to the common cold in healthy adults.
Two-hundred seventy-six volunteers completed a life stressor interview and psychological questionnaires and provided blood and urine samples. They were then inoculated with common cold viruses and monitored for the onset of disease. Although severe acute stressful life events (less than 1 month long) were not associated with developing colds, severe chronic stressors (1 month or longer) were associated with a substantial increase in risk of disea…
Stability and Intercorrelations of Immune, Cardiovascular, Endocrine, and Psychological Responses to an Acute Laboratory Stressor
Hamrick, Natalie A.; Cohen, Sheldon A.; Rodriguez, Mario; Manuck, Stephen; Rabin, Bruce Author Information
Stressor-Induced Alteration of Cytokine Production in Multiple Sclerosis Patients and Controls
OBJECTIVE: We administered an acute psychological stressor to multiple sclerosis (MS) patients and normal controls to determine whether differences in subjective and physiological responses to stress may underlie the susceptibility of MS patients to stress-related exacerbations. METHOD: Twenty-five MS patients (18 female, 7 male) and 25 age- and gender-matched controls participated in the study. They were asked to give a 5-minute videotaped speec…
Psychological Stress and Antibody Response to Immunization
OBJECTIVE: The objective of this review was to evaluate the evidence for the hypothesis that psychological stress influences antibody response to immunization in humans. METHODS: A critical review of the literature was conducted. RESULTS: The evidence supports an association between psychological stress and suppression of humoral immune (antibody) response to immunization. This association is convincing in the case of secondary immune response bu…
Stressful Life Events Precede Exacerbations of Multiple Sclerosis
Objective We longitudinally monitored life events and health changes in patients with multiple sclerosis (MS) to determine whether stressful events may trigger exacerbation of MS. Methods Twenty-three women with MS were followed for 1 year. Each subject completed the Psychiatric Epidemiologic Research Interview on a weekly basis. Further information on potentially stressful events was acquired using the Life Events and Difficulties Schedule. Neur…
Reactivity and Vulnerability to Stress-Associated Risk for Upper Respiratory Illness
OBJECTIVE: We tested the hypothesis that the greater a person's laboratory stress-elicited elevation in cortisol, the greater the life stress-related risk for upper respiratory infection (URI). We also tested the prediction that the greater the laboratory stress-elicited rise in natural killer cell (NK) cytotoxicity, the smaller the life stress-related URI risk. Finally, we explored whether sympathetic nervous system (SNS) and enumerative immune …
Healthy Aging Begins With the Fetus
The April editorial of McLeroy et al.1 emphasizes the importance of proper development and implementation of modalities that will be accepted by adult residents of communities for the enhancement of the quality of health and therefore life. The experience of the University of Pittsburgh Healthy Lifestyle Program has been that few adults will participate in wellness programs and those who do are not representative of the total socioeconomic spectr…
Psychological Stress and Antibody Response to Influenza Vaccination
OBJECTIVES: This study attempted to determine whether stress of moderate intensity could modulate the antibody response to an influenza vaccination in healthy young adults, identify critical periods during which stress could influence antibody response, and delineate behavioral and biological pathways that might explain relations between stress and antibody. METHODS: A cohort of 83 healthy young adults underwent 13 days of ambulatory monitoring b…
Loneliness, Social Network Size, and Immune Response to Influenza Vaccination in College Freshmen.
Antibody response to the influenza immunization was investigated in 83 1st-semester healthy university freshmen. Elevated levels of loneliness throughout the semester and small social networks were independently associated with poorer antibody response to 1 component of the vaccine. Those with both high levels of loneliness and a small social network had the lowest antibody response. Loneliness was also associated with greater psychological stres…
The Effect of Sunlight on Postoperative Analgesic Medication Use
Objective: Exposure to natural sunlight has been associated with improvement in mood, reduced mortality among patients with cancer, and reduced length of hospitalization for patients who have experienced myocardial infarction. Our aim was to evaluate whether the amount of sunlight in a hospital room modifies a patient’s psychosocial health, the quantity of analgesic medication used, and the pain medication cost. Methods: A prospective study of pa…
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to down-regulate inflammatory response. Here we test the model in two viral-challenge studies. In study 1, we assessed stressful life events, GCR, and control variables including baseline antibody to the challenge virus, age, body mass index (BMI), season, race, sex, education, and virus type in 276 healthy adult volunte…
Medicine (15 works) · Stress Responses and Cortisol (13 works) · Immunology (11 works) · Immune system (10 works) · Immunology (10 works) · Psychology (10 works) · Internal Medicine (8 works) · Clinical Psychology (7 works) · Internal Medicine (7 works) · Tryptophan and brain disorders (7 works)