Anneke C Hesseling

Dados Biográficos

ID6077905
NOMEAnneke C Hesseling
PRENOMESAnneke C
SOBRENOMEHesseling
ASSINATURAHESSELING A C
AFILIAÇÕESDesmond Tutu HIV Foundation
ORCID0000-0001-9399-9834
VERIFICADOSim
TOTAL DE OBRAS13
TOTAL DE CITAÇÕES0
TOTAL COMO AUTOR13
TOTAL COMO EDITOR0
PRIMEIRO ANO DE PUBLICAÇÃO2009
ANO MAIS RECENTE DE PUBLICAÇÃO2026
ÍNDICE H0

  • Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis

    Open AccessMegan Palmer, Ineke Derks et al.ARTICLEPLOS Global Public Health2026

    Implementation of the World Health Organization’s (WHO) recommended shorter 4-month treatment regimen for non-severe tuberculosis (TB) in children requires classification of disease severity on chest X-ray (CXR). Access to specialists for CXR interpretation is limited. We explored the use of computer-aided detection of CXR (“CAD”) to automate CXR classification of radiological disease severity. To do this, we combined three CXR datasets from chil…

  • Maternal and health worker preferences for paediatric antiretroviral formulations in neonates exposed to HIV

    Open AccessCharlene Purdy, C W Purdy et al.ARTICLEAIDS Care2026

    Oral liquid formulations of zidovudine (ZDV) and nevirapine (NVP) are the main antiretrovirals (ARVs) for neonates born to mothers living with HIV, but they have limitations including poor palatability, short shelf-life, frequent dosing and supply challenges. Understanding caregiver and provider preferences for infant ARV formulations is essential to guide the development of acceptable alternatives. Within the PETITE-DTG trial in South Africa (NC…

  • A historical narrative review of the emerging priority of acceptability in tuberculosis treatment in children

    Open AccessDillon T Wademan, H Simon Schaaf et al.ARTICLESocial Sciences & Humanities Open2025

    Children affected by tuberculosis (TB) are a historically neglected group. In the past two decades, researchers have made significant advances towards developing new drugs and formulations for treating and preventing TB in children. Organizations like the World Health Organization (WHO) and Stop TB Partnership have advocated for the development of child-friendly antituberculosis treatment (ATT) regimens. However, ATT is notoriously unpalatable, t…

  • Children, caregivers and health workers’ perceptions and experiences of the XTEMP-R tool to improve tuberculosis treatment

    Open AccessDillon T Wademan, Willdon J Filander et al.ARTICLEPLOS Global Public Health2025

    Treating drug-resistant tuberculosis (DR-TB) in children remains a significant challenge for patients, caregivers, and health systems, despite advances in child-friendly drug formulations. While new formulations offer benefits, their widespread availability is limited, and many exhibit poor palatability. A key strategy to improve administration and mask the taste of paediatric TB medications involves creating extemporaneous suspensions. However, …

  • Tuberculosis healthcare service disruptions during the Covid-19 pandemic in Brazil, India and South Africa

    Open AccessAbigail K de Villiers, Muhammad Osman et al.ARTICLEPLOS Global Public Health2025

    Tuberculosis (TB) is the leading infectious disease cause of death worldwide. In recent years, stringent measures to contain the spread of SARS-CoV-2 have led to considerable disruptions of healthcare services for TB in many countries. The extent to which these measures have affected TB testing, treatment initiation and outcomes has not been comprehensively assessed. We aimed to estimate TB healthcare service disruptions occurring during the COVI…

  • Holistic acceptability of an adult levofloxacin formulation in children and adolescents on a tuberculosis preventive treatment trial

    Open AccessSusan E Purchase, Dillon T Wademan et al.ARTICLEPLOS Global Public Health2024

    Drug-resistant tuberculosis (TB) is threatening global TB control. Although formulations designed for children are a priority, adult levofloxacin formulations are widely used in TB treatment and prevention. TB-CHAMP was a cluster-randomised, placebo-controlled trial evaluating the efficacy and safety of 24 weeks of daily levofloxacin to prevent TB in child and adolescent household contacts of adults with infectious multidrug-resistant TB. Nested …

  • Optimising computer aided detection to identify intra-thoracic tuberculosis on chest x-ray in South African children

    Open AccessMegan Palmer, James A Seddon et al.ARTICLEPLOS Global Public Health2023

    Diagnostic tools for paediatric tuberculosis remain limited, with heavy reliance on clinical algorithms which include chest x-ray. Computer aided detection (CAD) for tuberculosis on chest x-ray has shown promise in adults. We aimed to measure and optimise the performance of an adult CAD system, CAD4TB, to identify tuberculosis on chest x-rays from children with presumptive tuberculosis. Chest x-rays from 620 children

  • A scoping review of patient-centred tuberculosis care interventions

    Open AccessHanlie Myburgh, Dzunisani Patience Baloyi et al.ARTICLEPLOS Global Public Health2023

    Tuberculosis (TB) is a leading cause of death globally. In 2015, the World Health Organization hailed patient-centred care as the first of three pillars in the End TB strategy. Few examples of how to deliver patient-centred care in TB programmes exist in practice; TB control efforts have historically prioritised health systems structures and processes, with little consideration for the experiences of people affected by TB. We aimed to describe ho…

  • Toward a conceptual framework of the acceptability of tuberculosis treatment in children using a theory generative approach

    Open AccessDillon T Wademan, Megan Palmer et al.ARTICLEPLOS Global Public Health2022

    To describe an early-stage holistic framework towards evaluating factors that impact the overall acceptability of TB treatment along the TB care cascade in children. We developed a conceptual framework utilising a theory generative approach. Domains were developed through review of existing definitions and analysis of existing qualitative data undertaken in acceptability studies of TB treatment in children. Clarity of domain definitions was achie…

  • Protecting children in low-income and middle-income countries from Covid-19

    Open AccessSalahuddin Ahmed, Tisungane Mvalo et al.ARTICLEBMJ Global Health2020

    A saving grace of the COVID-19 pandemic in high-income and upper middle-income countries has been the relative sparing of children. As the disease spreads across low-income and middle-income countries (LMICs), long-standing system vulnerabilities may tragically manifest, and we worry that children will be increasingly impacted, both directly and indirectly. Drawing on our shared child pneumonia experience globally, we highlight these potential im…

  • Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children

    Open AccessKaren Du Preez, H Simon Schaaf et al.ARTICLEBMC Public Health2018

    The burden and spectrum of childhood TB disease managed at referral hospital level in high burden settings is substantial. Hospital-based surveillance in addition to routine TB surveillance is essential to provide a complete picture of the burden, spectrum and impact of childhood TB in settings where hospitals are not TB reporting units

  • Operational challenges in managing Isoniazid Preventive Therapy in child contacts

    Open AccessSusan S van Wyk, Anthony Reid et al.ARTICLEBMC Public Health2011

    IPT delivery to children remains an operational challenge, especially in high TB-HIV burden communities. A tool to improve IPT management and targeting sputum smear and/or culture-positive TB child contacts may overcome some of these challenges and should be developed and piloted in such settings

  • Surveillance of Antituberculosis Drug Resistance Among Children From the Western Cape Province of South Africa—An Upward Trend

    H Simon Schaaf, Benjamin Marais et al.ARTICLEAmerican Journal of Public Health2009Referências: 14

    Objectives. We assessed the prevalence of antituberculosis drug resistance among children with tuberculosis (TB) in the Western Cape Province of South Africa. Methods. Drug susceptibility testing for isoniazid and rifampin was prospectively done on all children with culture-confirmed TB at Tygerberg Children's Hospital, Cape Town, from March 2005 through February 2007. Survey results were compared with results from 2 previous surveys. Results. We…