D C Poskanzer

Biographic Data

ID6160037
NAMED C Poskanzer
GIVEN NAMESD C
FAMILY NAMEPoskanzer
SIGNATUREPOSKANZER D C
AFFILIATIONSHarvard University
VERIFIEDNo
TOTAL WORKS8
TOTAL CITATIONS14
WORKS AS AUTHOR8
WORKS AS EDITOR0
FIRST PUBLICATION YEAR1979
LATEST PUBLICATION YEAR1983
H-INDEX3

  • Genetic analysis of multiple sclerosis in Shetland

    D F Roberts, Mark Roberts et al.ARTICLEJournal of Epidemiology and…1983References: 7

    In a family study of all patients with multiple sclerosis in Shetland the number of inbred patients, although high for Britain and higher than in Orkney, is not higher than the number among controls, and the inbreeding coefficients suggest that there is no recessive involvement of rare genes in the aetiology. The kinship coefficients show close interweaving of ancestries of patients and controls and eliminate from the aetiology any involvement of…

  • Multiple sclerosis in the Orkney and Shetland Islands. VI

    R Taylor, Rex N Taylor et al.ARTICLEJournal of Epidemiology and…1980Cited by: 1References: 2

    A number of studies have now shown a markedly higher prevalence of multiple sclerosis (MS) in northern Scotland.1 The prevalence rates appear particularly high in the islands, with Orkney having the highest rate reported anywhere in the world.2 3 Our specific task in this paper is to consider the possible effect of differential migration upon prevalence. The hypothesis is that part or all of the difference in prevalence may be the result of diffe…

  • Multiple sclerosis in the Orkney and Shetland Islands. III

    D C Poskanzer, Paul I Terasaki et al.ARTICLEJournal of Epidemiology and…1980Cited by: 1References: 11

    Histocompatibility testing was performed in 48 multiple sclerosis patients and two carefully matched control groups in Orkney Islands, an area of high multiple sclerosis prevalence. The frequency of HLA-A3, HLA-B7, and DW2 was comparable in patients and controls. However, HLA-B7 was significantly more common in female patients compared with male patients. A B-cell alloantigen (B-cell 4) was also as frequent in patients as among controls. Strong l…

  • Multiple sclerosis in the Orkney and Shetland Islands. IV

    D C Poskanzer, John L Sever et al.ARTICLEJournal of Epidemiology and…1980Cited by: 1References: 13

    A controlled serologic survey of antibody titres to 17 viruses was undertaken in multiple sclerosis patients in the Orkney and Shetland Islands. No consistent pattern of elevated antibody titre levels or the presence of antibody was noted in patients compared with two control groups. Because of the isolation of these islands, the mean age at acquisition of common childhood infections, including measles, was considerably older than that of inhabit…

  • Multiple sclerosis in the Orkney and Shetland Islands. V

    D C Poskanzer, John L Sever et al.ARTICLEJournal of Epidemiology and…1980References: 16

    HLA phenotypes were correlated with serum antibody titres to eight viruses in patients with multiple sclerosis and two matched control groups in the Orkney Islands. In patients, no specific HLA antigen was associated wtih increased or decreased viral titres. However, HLA-B7 was significantly correlated with higher measles titres in healthy controls. Furthermore, controls who had the HLA haplotypes, B7, DW2 ad B-cell 4, demonstrated significantly …

  • Multiple sclerosis in the Orkney and Shetland Islands. I

    D C Poskanzer, L B Prenney et al.ARTICLEJournal of Epidemiology and…1980Cited by: 5References: 8

    An epidemiological and clinical study of multiple sclerosis (MS) in the Orkney and Shetland Islands showed that the prevalence rate of the disease is the highest in the world (309 and 184/100 000, respectively). The clinical entity, MS, is similar to that found in other parts of the world, except that optic neuritis not followed by MS is rare. Analysis of death certificates indicated that MS has probably occurred at the same rate in these islands…

  • Multiple sclerosis in the Orkney and Shetland Islands. II

    D C Poskanzer, J L Sheridan et al.ARTICLEJournal of Epidemiology and…1980Cited by: 3References: 1

    In Orkney and Shetland, a survey of lifetime events was undertaken in multiple sclerosis patients and two control groups to define shared exposure to an exogenous agent or environmental insult. Analyses of demographic factors, diet, social class and occupation, housing and environment, animal exposure, schooling, travel, infectious disease, and medical history disclosed a remarkable similarity in responses between patients and controls for a majo…

  • Genetic analysis of multiple sclerosis in Orkney

    D F Roberts, Mark Roberts et al.ARTICLEJournal of Epidemiology and…1979Cited by: 3References: 9

    In a family study of all patients with multiple sclerosis (MS) in Orkney, the number of inbred among patients, although high for Britain, is not higher than the number among controls, and the inbreeding coefficients appear to eliminate recessive involvement of rare genes from the aetiology. The kinship coefficients show that the ancestries of patients and controls are closely enmeshed, and eliminate from the aetiology involvement of recently intr…