Farzad Hadaegh
Biographic Data
| ID | 6166371 |
|---|---|
| NAME | Farzad Hadaegh |
| GIVEN NAMES | Farzad |
| FAMILY NAME | Hadaegh |
| SIGNATURE | HADAEGH F |
| AFFILIATIONS | Research Institute for Endocrine Sciences |
| ORCID | 0000-0002-8935-2744 |
| VERIFIED | Yes |
| TOTAL WORKS | 30 |
| TOTAL CITATIONS | 1 |
| AUTHOR COUNT | 30 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2008 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 1 |
Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
BACKGROUND: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. METHODS: ). For school-aged children and adolescents, we report thinness (BMI 2 SD above the median). FINDINGS: From 1990 to 20…
The impact of general and central obesity for all-cause hospitalization among Iranian adults: A 20 year follow-up-results from the TLGS cohort
Obesity and high WC were associated with increased hospitalization rates during long-term follow-up. Our findings suggests that successful obesity prevention programs may decrease the number of hospitalizations, particularly, in women
Resting heart rate and the risk of incident type 2 diabetes mellitus among non-diabetic and prediabetic Iranian adults: Tehran lipid and glucose study
Among men, being either non-diabetic or prediabetic at baseline, higher RHR can be associated with incident T2DM; however, women didn't show a significant association. Further studies are needed to determine the added value of RHR as a potential modifiable risk factor in screening and risk prediction of incident T2DM
The association between fasting plasma glucose variability and incident eGFR decline: Evidence from two cohort studies
Higher FPG variability was associated with an increased risk of eGFR decline in the diabetic American population; however, this unfavorable impact was found only among the non-diabetic Iranian population
Effect of family history of diabetes and obesity status on lifetime risk of type 2 diabetes in the Iranian population
Background: Data are scarce for the lifetime risk of diabetes in the Middle East and North Africa region countries. We estimated the lifetime risk of type 2 diabetes among Iranian adults at age 20 and 40 years, and their variation by family history of diabetes and body mass index (BMI). Methods: The data from 8435 diabetes-free participants from the Tehran Lipid and Glucose study were used in this analysis. We estimated the lifetime risk of diabe…
Three-year weight change and risk of all-cause, cardiovascular, and cancer mortality among Iranian adults: Over a decade of follow-up in the Tehran Lipid and Glucose Study
Our findings showed a U-shaped association across weight change categories for all-cause mortality risk with over 5% weight gain and loss causing higher risk. Moreover, weight loss can have adverse impact on CV and cancer mortality events
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: A gender-stratified 15.5-year follow-up
Wrist circumference significantly predicts the transition from MHO to MUO phenotype in adults of both genders. However, it is an independent predictor of the transition only in females. Future studies are warranted to clarify the role of wrist circumference mechanisms on metabolic risk deterioration
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: A pooled analysis of 2181 population-based studies with 65 million p…
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Sex-specific prevalence of coronary heart disease among Tehranian adult population across different glycemic status: Tehran lipid and glucose study, 2008–2011
The high prevalence of CHD, especially among diabetic populations, necessitates the urgent implementation of behavioral interventions in the Tehranian population, according to evidence-based guidelines for the clinical management of diabetic patients
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean B…
Incidence and associated risk factors for premature death in the Tehran Lipid and Glucose Study cohort, Iran
Controlling three modifiable risk factors including diabetes, hypertension and smoking might potentially reduce mortality events by over 40%, and among these, prevention of diabetes should be prioritized to decrease burden of events. We didn't confirm a negative impact of overweight and obesity status on premature mortality events
Smoking habits and incidence of cardiovascular diseases in men and women: Findings of a 12 year follow up among an urban Eastern-Mediterranean population
An increased risk of incidence of CVD/CHD was found in current male smokers. To confirm and further elaborate these findings, more data of sex-specific studies are required from culturally diverse urban and rural areas of Iran
Optimal cut-points of different anthropometric indices and their joint effect in prediction of type 2 diabetes: Results of a cohort study
Our derived cut-points differ between both sexes and are different from other ethnicities
Worldwide trends in blood pressure from 1975 to 2015: A pooled analysis of 1479 population-based measurement studies with 19·1 million participants
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and …
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
White rice intake and incidence of type-2 diabetes: Analysis of two prospective cohort studies from Iran
We observed an increased lieklihood of T2DM associated with high white rice intake among residents of Tehran and no association in Golestan. Our findings, if further supported by other studies, have important public health implications especially for countries where white rice is a major staple and diabetes is increasing rapidly incidence is high. Further research is needed to investigate lack of an association between lower levels of white rice …
Predictors of early adulthood hypertension during adolescence: A population-based cohort study
Wrist circumferences and TC had significant roles in predicting hypertension through adolescence to adulthood
The impact of smoking status on 9.3 years incidence of cardiovascular and all-cause mortality among Iranian men
The findings indicate that smoking increases the risk of incident CVD/CHD, total and CVD mortality, particularly CVD mortality. These outcomes were attributable to the daily amount of cigarettes smoked. Past smokers still had higher risk for CVD events, which cessation may not reduce
Does an electrocardiogram add predictive value to the rose angina questionnaire for future coronary heart disease? 10-year follow-up in a Middle East population
BACKGROUND: To evaluate the power of abnormal resting ECG versus Rose Questionnaire angina and its additive value in predicting 10-year coronary heart disease (CHD) risk in an Iranian urban population with high prevalence of CHD. METHODS: There were 5101 subjects ≥30 years (2900 women), free of CHD at baseline; they were categorised in to four groups according to their Rose Angina and ECG status for ischaemia as Rose-/ECG-, Rose+/ECG-, Rose-/ECG+…
Predictability of body mass index for diabetes: Affected by the presence of metabolic syndrome
This study highlights the importance of screening for MetS in normal weight individuals. Obesity increases diabetes risk in the absence of MetS, underscores the need for more stringent criteria to define healthy metabolic state among obese individuals. Weight reduction measures, thus, should be encouraged in conjunction with achieving metabolic targets not addressed by current definition of MetS, both in every day encounter and public health sett…
SP1-81 An approach to compare the importance of different cardiovascular exposures as continuous variables
Introduction Attributable Fraction is the commonest method of describing the proportion of a health outcome attributable to an exposure in an exposed group. It applies to binary variables. Many variables are continuous; changing them to binary variables results in loss of information. Using traditional analyses we compared the importance of cardiovascular disease (CVD) risk factors in a continuous form. Methods A population based cohort study inc…
P1-31 Clinical usefulness of Framingham cardiovascular risk profile during a 10-year follow-up in Iran
Introduction Clinical usefulness of a risk function is a new concept that should be considered beyond the traditional checking of discrimination and calibration for performance of a model. Framingham risk score (FRS) for cardiovascular disease is a widely used one which has been validated in different countries but its clinical usefulness has been neglected. Methods We checked discrimination of FRS and so its calibration and clinical usefulness b…
SP1-62 Rose Angina vs silent ischaemia in prediction of coronary heart disease: Tehran lipid and glucose study
Introduction Coronary heart disease (CHD) is one of the most common causes of morbidity and mortality in Iran. The aim of this cohort study is evaluating the ability of Rose questionnaire (WHO angina questionnaire) and ECG to predict 10-year CHD events in a population with high prevalence of CHD. Methods Study population included 5652 subjects ≥30 years (3244 females), free of self reported CHD at the baseline. Subjects were categorised to four g…
SP1-84 Different methods to calculate population attributable fraction of risk factors for cardiovascular diseases: Tehran lipid and glucose study (TLGS)
Background The population attributable fraction (PAF) that estimates potentially community-level effect of risk factors can be useful in planning public health interventions. This study compared different methods for calculating adjusted PAFs for cardiovascular diseases (CVD) in a cohort study with 10 years of follow-up. Methods Baseline data were employed from 6630 participants (3746 women) above 30 years old and 558 CVD events (238 women) detec…
Does an electrocardiogram add predictive value to the rose angina questionnaire for future coronary heart disease? 10-year follow-up in a Middle East population
BACKGROUND: To evaluate the power of abnormal resting ECG versus Rose Questionnaire angina and its additive value in predicting 10-year coronary heart disease (CHD) risk in an Iranian urban population with high prevalence of CHD. METHODS: There were 5101 subjects ≥30 years (2900 women), free of CHD at baseline; they were categorised in to four groups according to their Rose Angina and ECG status for ischaemia as Rose-/ECG-, Rose+/ECG-, Rose-/ECG+…
High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study
In conclusion, about one third of Tehranian adults had disturbed glucose tolerance or diabetes. One- third of total cases with diabetes were undiagnosed. Screening individuals with BMI > or = 25 kg/m2 (men), hypertension (men), abdominal obesity (women) and family history of diabetes may be more efficient
Weight change and incident metabolic syndrome in Iranian men and women; a 3 year follow-up study
Weight change showed different effects on MetS in men and women. In women, mild WG predicted MetS; however, mild weight loss was protective against MetS in men and high WC in both genders
Population-based incidence of Type 2 diabetes and its associated risk factors: Results from a six-year cohort study in Iran
More than 1% of the Iranian urban population older than 20 years develops Type 2 diabetes each year. Combination of IFG and IGT was the strongest predictor of incident diabetes among the modifiable risk factors
A new approach to compare the predictive power of metabolic syndrome defined by a joint interim statement versus its components for incident cardiovascular disease in Middle East Caucasian residents i…
In the Middle East population, MS did not provide CVD predictive risk information beyond its individual components; clinical focus should remain on hypertension in both sexes, high FPG in women and central adiposity in men rather than MS
Predictability of body mass index for diabetes: Affected by the presence of metabolic syndrome
This study highlights the importance of screening for MetS in normal weight individuals. Obesity increases diabetes risk in the absence of MetS, underscores the need for more stringent criteria to define healthy metabolic state among obese individuals. Weight reduction measures, thus, should be encouraged in conjunction with achieving metabolic targets not addressed by current definition of MetS, both in every day encounter and public health sett…
SP1-81 An approach to compare the importance of different cardiovascular exposures as continuous variables
Introduction Attributable Fraction is the commonest method of describing the proportion of a health outcome attributable to an exposure in an exposed group. It applies to binary variables. Many variables are continuous; changing them to binary variables results in loss of information. Using traditional analyses we compared the importance of cardiovascular disease (CVD) risk factors in a continuous form. Methods A population based cohort study inc…
P1-31 Clinical usefulness of Framingham cardiovascular risk profile during a 10-year follow-up in Iran
Introduction Clinical usefulness of a risk function is a new concept that should be considered beyond the traditional checking of discrimination and calibration for performance of a model. Framingham risk score (FRS) for cardiovascular disease is a widely used one which has been validated in different countries but its clinical usefulness has been neglected. Methods We checked discrimination of FRS and so its calibration and clinical usefulness b…
SP1-62 Rose Angina vs silent ischaemia in prediction of coronary heart disease: Tehran lipid and glucose study
Introduction Coronary heart disease (CHD) is one of the most common causes of morbidity and mortality in Iran. The aim of this cohort study is evaluating the ability of Rose questionnaire (WHO angina questionnaire) and ECG to predict 10-year CHD events in a population with high prevalence of CHD. Methods Study population included 5652 subjects ≥30 years (3244 females), free of self reported CHD at the baseline. Subjects were categorised to four g…
SP1-84 Different methods to calculate population attributable fraction of risk factors for cardiovascular diseases: Tehran lipid and glucose study (TLGS)
Background The population attributable fraction (PAF) that estimates potentially community-level effect of risk factors can be useful in planning public health interventions. This study compared different methods for calculating adjusted PAFs for cardiovascular diseases (CVD) in a cohort study with 10 years of follow-up. Methods Baseline data were employed from 6630 participants (3746 women) above 30 years old and 558 CVD events (238 women) detec…
P2-136 Family history of diabetes modifies the effect of blood pressure for incident diabetes in Middle Eastern women: Tehran Lipid and Glucose Study
Introduction Elevated blood pressure may lead to incident diabetes. Yet, data about the effect of different blood pressure components on incident diabetes in Middle Eastern women is lacking. Methods we evaluated systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) and mean arterial pressure (MAP) as independent predictors of diabetes in Iranian women. We performed a population-based prospective study among 3028 non-d…
Does an electrocardiogram add predictive value to the rose angina questionnaire for future coronary heart disease? 10-year follow-up in a Middle East population
BACKGROUND: To evaluate the power of abnormal resting ECG versus Rose Questionnaire angina and its additive value in predicting 10-year coronary heart disease (CHD) risk in an Iranian urban population with high prevalence of CHD. METHODS: There were 5101 subjects ≥30 years (2900 women), free of CHD at baseline; they were categorised in to four groups according to their Rose Angina and ECG status for ischaemia as Rose-/ECG-, Rose+/ECG-, Rose-/ECG+…
The impact of smoking status on 9.3 years incidence of cardiovascular and all-cause mortality among Iranian men
The findings indicate that smoking increases the risk of incident CVD/CHD, total and CVD mortality, particularly CVD mortality. These outcomes were attributable to the daily amount of cigarettes smoked. Past smokers still had higher risk for CVD events, which cessation may not reduce
Worldwide trends in blood pressure from 1975 to 2015: A pooled analysis of 1479 population-based measurement studies with 19·1 million participants
BACKGROUND: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. METHODS: For this analysis, we pooled national, subnational, or comm…
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and …
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height…
White rice intake and incidence of type-2 diabetes: Analysis of two prospective cohort studies from Iran
We observed an increased lieklihood of T2DM associated with high white rice intake among residents of Tehran and no association in Golestan. Our findings, if further supported by other studies, have important public health implications especially for countries where white rice is a major staple and diabetes is increasing rapidly incidence is high. Further research is needed to investigate lack of an association between lower levels of white rice …
Predictors of early adulthood hypertension during adolescence: A population-based cohort study
Wrist circumferences and TC had significant roles in predicting hypertension through adolescence to adulthood
Optimal cut-points of different anthropometric indices and their joint effect in prediction of type 2 diabetes: Results of a cohort study
Our derived cut-points differ between both sexes and are different from other ethnicities
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean B…
Incidence and associated risk factors for premature death in the Tehran Lipid and Glucose Study cohort, Iran
Controlling three modifiable risk factors including diabetes, hypertension and smoking might potentially reduce mortality events by over 40%, and among these, prevention of diabetes should be prioritized to decrease burden of events. We didn't confirm a negative impact of overweight and obesity status on premature mortality events
Smoking habits and incidence of cardiovascular diseases in men and women: Findings of a 12 year follow up among an urban Eastern-Mediterranean population
An increased risk of incidence of CVD/CHD was found in current male smokers. To confirm and further elaborate these findings, more data of sex-specific studies are required from culturally diverse urban and rural areas of Iran
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: A pooled analysis of 2181 population-based studies with 65 million p…
BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease …
Sex-specific prevalence of coronary heart disease among Tehranian adult population across different glycemic status: Tehran lipid and glucose study, 2008–2011
The high prevalence of CHD, especially among diabetic populations, necessitates the urgent implementation of behavioral interventions in the Tehranian population, according to evidence-based guidelines for the clinical management of diabetic patients
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blo…
Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: A gender-stratified 15.5-year follow-up
Wrist circumference significantly predicts the transition from MHO to MUO phenotype in adults of both genders. However, it is an independent predictor of the transition only in females. Future studies are warranted to clarify the role of wrist circumference mechanisms on metabolic risk deterioration
Effect of family history of diabetes and obesity status on lifetime risk of type 2 diabetes in the Iranian population
Background: Data are scarce for the lifetime risk of diabetes in the Middle East and North Africa region countries. We estimated the lifetime risk of type 2 diabetes among Iranian adults at age 20 and 40 years, and their variation by family history of diabetes and body mass index (BMI). Methods: The data from 8435 diabetes-free participants from the Tehran Lipid and Glucose study were used in this analysis. We estimated the lifetime risk of diabe…
Medicine (30 works) · Internal Medicine (24 works) · Environmental health (22 works) · Population (21 works) · Demography (19 works) · Body mass index (14 works) · Diabetes, Cardiovascular Risks, and Lipoproteins (14 works) · Obesity (12 works) · Endocrinology (11 works) · Confidence interval (10 works)