Nigel A Cunliffe
Biographic Data
| ID | 6167606 |
|---|---|
| NAME | Nigel A Cunliffe |
| GIVEN NAMES | Nigel A |
| FAMILY NAME | Cunliffe |
| SIGNATURE | CUNLIFFE N A |
| AFFILIATIONS | University of Liverpool |
| ORCID | 0000-0002-5449-4988 |
| VERIFIED | Yes |
| TOTAL WORKS | 8 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 8 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2019 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Risk factors associated with Shigella diarrhea in 6–35-month-olds
Diarrhea due to Shigella causes 60,000 deaths annually among children under five in low- and middle-income countries. This Enterics for Global Health sub-study examined host, clinical, and environmental factors linked to Shigella -attributable diarrhea in Malawian children and assessed seasonal variations. Data from 1,399 children aged 6–35 months presenting with diarrhea at a health centre in Blantyre, Southern Malawi from August 3, 2022, throug…
Caregiver dynamics and factors affecting health-seeking behaviors for childhood diarrhea in Mukuru informal settlements in Nairobi, Kenya
Background Diarrheal disease is the third leading cause of morbidity and mortality in children under 5 years globally. Approximately 1.7 billion diarrheal cases are reported annually resulting in more than 400,000 deaths in children under five. Sub-Saharan Africa still harbors populations with the highest global mortality rates for diarrhea accounting for approximately 60% of all diarrheal deaths in this age group. In Kenya, diarrhea significantl…
Cost-effectiveness analysis of alternative infant and neonatal rotavirus vaccination schedules in Malawi
Rotavirus is the leading cause of severe diarrhea among children under five worldwide, especially in low- and middle-income countries (LMICs). Although vaccination is the best strategy to prevent rotavirus, obstacles leading to poor vaccine effectiveness undermine its impact in LMICs. This study aimed to identify the optimal rotavirus vaccination strategy for Malawi by modeling vaccine impact and cost-effectiveness, comparing the current two-dose…
Evidence needs and community involvement in policy decisions for vaccine-preventable diarrhoeal infections among children under the age of five years
Diarrhoeal diseases are a leading cause of morbidity and mortality among children under five years in low- and middle-income countries (LMICs) with Shigella and Enterotoxigenic Escherichia coli (ETEC), both targets of ongoing vaccine development, playing major roles. To inform the introduction of vaccines against these pathogens in Ethiopia, Kenya, and Malawi, we assessed evidence needs for technical policy decisions and community engagement in n…
Public acceptability of a technology-mediated stool sample collection platform to inform community-based surveillance of infectious intestinal disease
This pilot study assessed the acceptability of technology-mediated platforms for reporting IID and provision of stool samples in the community. Respondents were biased towards younger, technologically inclined, more affluent and educated populations. Acceptability for reporting illness and providing a stool sample through technology-mediated platforms was high. While older populations were under-represented, they were more likely to agree to prov…
Understanding norovirus reporting patterns in England
We identified substantial variability in reporting patterns of norovirus by age and by region of England. Our findings highlight the importance of considering uncertainty in the design of forecasting tools for norovirus, and to inform the development of more targeted risk management approaches for norovirus disease
Population impact and effectiveness of sequential 13-valent pneumococcal conjugate and monovalent rotavirus vaccine introduction on infant mortality
BACKGROUND: Pneumococcal conjugate vaccine (PCV) and rotavirus vaccine (RV) are key tools for reducing common causes of infant mortality. However, measurement of population-level mortality impact is lacking from sub-Saharan Africa. We evaluated mortality impact and vaccine effectiveness (VE) of PCV13 introduced in November 2011, with subsequent RV1 roll-out in October 2012, in Malawi. METHODS: We conducted two independent community-based birth co…
Reduction in hospitalisations for acute gastroenteritis-associated childhood seizures since introduction of rotavirus vaccination
INTRODUCTION: The incidence of severe childhood diarrhoea has fallen substantially following the introduction of rotavirus vaccine in the UK in July 2013. Since children with rotavirus infection may experience febrile and afebrile seizures, we evaluated the impact of rotavirus vaccination on seizure hospitalisations in children in England. METHODS: Using data from Hospital Episode Statistics, we employed interrupted time-series analyses to assess…
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Reduction in hospitalisations for acute gastroenteritis-associated childhood seizures since introduction of rotavirus vaccination
INTRODUCTION: The incidence of severe childhood diarrhoea has fallen substantially following the introduction of rotavirus vaccine in the UK in July 2013. Since children with rotavirus infection may experience febrile and afebrile seizures, we evaluated the impact of rotavirus vaccination on seizure hospitalisations in children in England. METHODS: Using data from Hospital Episode Statistics, we employed interrupted time-series analyses to assess…
Population impact and effectiveness of sequential 13-valent pneumococcal conjugate and monovalent rotavirus vaccine introduction on infant mortality
BACKGROUND: Pneumococcal conjugate vaccine (PCV) and rotavirus vaccine (RV) are key tools for reducing common causes of infant mortality. However, measurement of population-level mortality impact is lacking from sub-Saharan Africa. We evaluated mortality impact and vaccine effectiveness (VE) of PCV13 introduced in November 2011, with subsequent RV1 roll-out in October 2012, in Malawi. METHODS: We conducted two independent community-based birth co…
Understanding norovirus reporting patterns in England
We identified substantial variability in reporting patterns of norovirus by age and by region of England. Our findings highlight the importance of considering uncertainty in the design of forecasting tools for norovirus, and to inform the development of more targeted risk management approaches for norovirus disease
Public acceptability of a technology-mediated stool sample collection platform to inform community-based surveillance of infectious intestinal disease
This pilot study assessed the acceptability of technology-mediated platforms for reporting IID and provision of stool samples in the community. Respondents were biased towards younger, technologically inclined, more affluent and educated populations. Acceptability for reporting illness and providing a stool sample through technology-mediated platforms was high. While older populations were under-represented, they were more likely to agree to prov…
Caregiver dynamics and factors affecting health-seeking behaviors for childhood diarrhea in Mukuru informal settlements in Nairobi, Kenya
Background Diarrheal disease is the third leading cause of morbidity and mortality in children under 5 years globally. Approximately 1.7 billion diarrheal cases are reported annually resulting in more than 400,000 deaths in children under five. Sub-Saharan Africa still harbors populations with the highest global mortality rates for diarrhea accounting for approximately 60% of all diarrheal deaths in this age group. In Kenya, diarrhea significantl…
Cost-effectiveness analysis of alternative infant and neonatal rotavirus vaccination schedules in Malawi
Rotavirus is the leading cause of severe diarrhea among children under five worldwide, especially in low- and middle-income countries (LMICs). Although vaccination is the best strategy to prevent rotavirus, obstacles leading to poor vaccine effectiveness undermine its impact in LMICs. This study aimed to identify the optimal rotavirus vaccination strategy for Malawi by modeling vaccine impact and cost-effectiveness, comparing the current two-dose…
Evidence needs and community involvement in policy decisions for vaccine-preventable diarrhoeal infections among children under the age of five years
Diarrhoeal diseases are a leading cause of morbidity and mortality among children under five years in low- and middle-income countries (LMICs) with Shigella and Enterotoxigenic Escherichia coli (ETEC), both targets of ongoing vaccine development, playing major roles. To inform the introduction of vaccines against these pathogens in Ethiopia, Kenya, and Malawi, we assessed evidence needs for technical policy decisions and community engagement in n…
Risk factors associated with Shigella diarrhea in 6–35-month-olds
Diarrhea due to Shigella causes 60,000 deaths annually among children under five in low- and middle-income countries. This Enterics for Global Health sub-study examined host, clinical, and environmental factors linked to Shigella -attributable diarrhea in Malawian children and assessed seasonal variations. Data from 1,399 children aged 6–35 months presenting with diarrhea at a health centre in Blantyre, Southern Malawi from August 3, 2022, throug…
Viral gastroenteritis research and epidemiology (6 works) · Diarrhea (5 works) · Medicine (5 works) · Vaccination (5 works) · Environmental health (4 works) · Internal Medicine (4 works) · Child Nutrition and Water Access (3 works) · Demography (3 works) · Immunology (3 works) · Pediatrics (3 works)