Adrian Puren

Biographic Data

ID	6169781
NAME	Adrian Puren
GIVEN NAMES	Adrian
FAMILY NAME	Puren
SIGNATURE	PUREN A
AFFILIATIONS	National Health Laboratory Service
ORCID	0000-0001-7531-4010
VERIFIED	Yes
TOTAL WORKS	18
TOTAL CITATIONS	2
WORKS AS AUTHOR	18
WORKS AS EDITOR	0
FIRST PUBLICATION YEAR	2005
LATEST PUBLICATION YEAR	2025
H-INDEX	1

Psychosocial and behavioral factors associated with HIV among adolescent girls and young women in DREAMS districts in South Africa
Open AccessKaymarlin Govender, Sean Beckett et al.ARTICLEFrontiers in Public Health2025
Background High HIV prevalence among adolescent girls and young women (AGYW) in South Africa is driven by multiple interacting psychosocial risks. Some of these risks include socioeconomic deprivation, poor educational outcomes, poor mental health, alcohol and drug use which are associated with HIV-infection and sexual risk behavior. This article seeks to deepen our understanding of the role of psychosocial and behavioral factors in the HIV epide…
PrEP Awareness and Willingness to use Oral PrEP Among Males ≥ 18 Years Attending VMMC Services in Gauteng, South Africa
Open AccessNosipho Shangase, Ocean Tobaiwa et al.ARTICLEAIDS and Behavior2025
PrEP Awareness and Coverage
Open AccessNosipho Shangase, Tendesayi Kufa et al.ARTICLEAIDS and Behavior2025
Community-led cross-sectional study of social and employment circumstances, HIV and associated factors amongst female sex workers in South Africa
Open AccessMinja Milovanovic, Rachel Jewkes et al.ARTICLEGlobal Health Action2021
BACKGROUND: In South Africa, female sex workers (FSWs) are perceived to play a pivotal role in the country's HIV epidemic. Understanding their health status and risk factors for adverse health outcomes is foundational for developing evidence-based health care for this population. OBJECTIVE: Describe the methodology used to successfully implement a community-led study of social and employment circumstances, HIV and associated factors amongst FSWs …
Impact of breastfeeding, maternal antiretroviral treatment and health service factors on 18-month vertical transmission of HIV and HIV-free survival
Open AccessAmeena Ebrahim Goga, Chantal Lombard et al.ARTICLEJournal of Epidemiology and…2020References: 20
Background We analysed the impact of breastfeeding, antiretroviral drugs and health service factors on cumulative (6 weeks to 18 months) vertical transmission of HIV (MTCT) and ‘MTCT-or-death’, in South Africa, and compared estimates with global impact criteria to validate MTCT elimination: (1) Methods 9120 infants aged 6 weeks were enrolled in a nationally representative survey. Of 2811 HIV-exposed uninfected infants (HEU), 2644 enrolled into fo…
Feasibility of community-based HIV self-screening in South Africa
Open AccessLimakatso Lebina, Ntombexolo Seatlholo et al.ARTICLEBMC Public Health2019
Unsupervised HIVSS was by far the most selected and utilised HIVSS method. Linkages to primary and confirmatory testing for the unsupervised HIVSS and further care were low, despite home visits and telephonic reminders
Medical Male Circumcision and Associations Among Sexually Transmitted Infections Service Attendees
Open AccessTendesayi Kufa, Frans Radebe et al.ARTICLEAIDS and Behavior2019
Progress towards the Unaids 90–90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa
Open AccessHelena Huerga, Gilles van Cutsem et al.ARTICLEBMC Public Health2018
In this context of high HIV prevalence, significant progress has been achieved with regards to reaching the UNAIDS 90-90-90 targets. The third 90, viral suppression in people on ART, was achieved among women and men. However, gaps persist in HIV diagnosis and ART coverage particularly in men and individuals younger than 30 years. Achieving 90-90-90 is feasible but requires additional investment to reach youth and men
Beyond Social Desirability Bias
Open AccessAlyssa C Mooney, Alyssa Mooney et al.ARTICLEAIDS and Behavior2018
Toward elimination of mother–to–child transmission of HIV in South Africa
Open AccessGayle Sherman, Gayle G Sherman et al.ARTICLEJournal of Global Health2017
BACKGROUND: South Africa has utilized three independent data sources to measure the impact of its program for the prevention of mother-to-child transmission (PMTCT) of HIV. These include the South African National Health Laboratory Service (NHLS), the District Health Information System (DHIS), and South African PMTCT Evaluation (SAPMTCTE) surveys. We compare the results of each, outlining advantages and limitations, and make recommendations for m…
Population–level effectiveness of PMTCT Option A on early mother–to–child (MTCT) transmission of HIV in South Africa
Open AccessAmeena Ebrahim Goga, Thu-Ha Dinh et al.ARTICLEJournal of Global Health2016
BACKGROUND: Eliminating mother-to-child transmission of HIV (EMTCT), defined as ≤50 infant HIV infections per 100 000 live births, is a global priority. Since 2011 policies to prevent mother-to-child transmission of HIV (PMTCT) shifted from maternal antiretroviral (ARV) treatment or prophylaxis contingent on CD4 cell count to lifelong maternal ARV treatment (cART). We sought to measure progress with early (4-8 weeks postpartum) MTCT prevention an…
Strengthening HIV surveillance in the antiretroviral therapy era
Open AccessAyesha Bm Kharsany, Ayesha B M Kharsany et al.ARTICLEBMC Public Health2015
The results from HIPSS will provide critical data regarding HIV prevalence and incidence in this community and will establish whether HIV prevention and treatment efforts in a "real world", non-trial setting have an impact on HIV incidence at a population level. Importantly, the study design and methods will inform future methods for HIV surveillance
First population-level effectiveness evaluation of a national programme to prevent HIV transmission from mother to child, South Africa
Open AccessAmeena Ebrahim Goga, Thu-Ha Dinh et al.ARTICLEJournal of Epidemiology and…2015Cited by: 2References: 31
BACKGROUND: There is a paucity of data on the national population-level effectiveness of preventing mother-to-child transmission (PMTCT) programmes in high-HIV-prevalence, resource-limited settings. We assessed national PMTCT impact in South Africa (SA), 2010. METHODS: A facility-based survey was conducted using a stratified multistage, cluster sampling design. A nationally representative sample of 10 178 infants aged 4-8 weeks was recruited from…
Associations between childhood adversity and depression, substance abuse and HIV and HSV2 incident infections in rural South African youth
Open AccessRachel Jewkes, Rachel K Jewkes et al.ARTICLEChild Abuse & Neglect2010
Impact of Stepping Stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa
Open AccessRachel Jewkes, Mzikazi Nduna et al.ARTICLEBMJ2008
OBJECTIVE: To assess the impact of Stepping Stones, a HIV prevention programme, on incidence of HIV and herpes simplex type 2 (HSV-2) and sexual behaviour. DESIGN: Cluster randomised controlled trial. SETTING: 70 villages (clusters) in the Eastern Cape province of South Africa. PARTICIPANTS: 1360 men and 1416 women aged 15-26 years, who were mostly attending schools. INTERVENTION: Stepping Stones, a 50 hour programme, aims to improve sexual healt…
A cluster randomized‐controlled trial to determine the effectiveness of Stepping Stones in preventing HIV infections and promoting safer sexual behaviour amongst youth in the rural Eastern Cape, South…
Open AccessRachel Jewkes, Mzikazi Nduna et al.ARTICLETropical Medicine & International…2006
Objective To describe the study design, methods and baseline findings of a behavioural intervention trial aimed at reducing HIV incidence. Method A cluster randomized‐controlled trial (RCT) conducted in 70 villages in rural South Africa. A behavioural intervention, Stepping Stones, was implemented in 35 communities in two workshops of 20 men and 20 women in each community who met for 17 sessions (50 h) over a period of 3–12 weeks. Individuals in …
Factors associated with HIV sero-status in young rural South African women
Rachel Jewkes, Kristin Dunkle et al.ARTICLEInternational Journal of…2006
BACKGROUND: This paper aims to describe factors associated with HIV sero-status in young, rural South African women and the relationship between intimate partner violence (IPV) and HIV. METHODS: A total of 1295 sexually active female volunteers, aged 15-26, from 70 villages were recruited to participate in a cluster randomized controlled trial of an HIV behavioural intervention. The main measures were HIV sero-status, and IPV and sexual practices…
Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk
Open AccessBertran Auvert, Dirk Taljaard et al.ARTICLEPLoS Medicine2005
BACKGROUND: Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND FINDINGS: A total of 3,274 uncircumcised men, aged 18-24 y, were randomized to a control or an intervention group with follow-up visits at months 3, 12, and 21. Male circumcision was offered to the inte…

Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk
Open AccessBertran Auvert, Dirk Taljaard et al.ARTICLEPLoS Medicine2005
BACKGROUND: Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND FINDINGS: A total of 3,274 uncircumcised men, aged 18-24 y, were randomized to a control or an intervention group with follow-up visits at months 3, 12, and 21. Male circumcision was offered to the inte…
A cluster randomized‐controlled trial to determine the effectiveness of Stepping Stones in preventing HIV infections and promoting safer sexual behaviour amongst youth in the rural Eastern Cape, South…
Open AccessRachel Jewkes, Mzikazi Nduna et al.ARTICLETropical Medicine & International…2006
Objective To describe the study design, methods and baseline findings of a behavioural intervention trial aimed at reducing HIV incidence. Method A cluster randomized‐controlled trial (RCT) conducted in 70 villages in rural South Africa. A behavioural intervention, Stepping Stones, was implemented in 35 communities in two workshops of 20 men and 20 women in each community who met for 17 sessions (50 h) over a period of 3–12 weeks. Individuals in …
Factors associated with HIV sero-status in young rural South African women
Rachel Jewkes, Kristin Dunkle et al.ARTICLEInternational Journal of…2006
BACKGROUND: This paper aims to describe factors associated with HIV sero-status in young, rural South African women and the relationship between intimate partner violence (IPV) and HIV. METHODS: A total of 1295 sexually active female volunteers, aged 15-26, from 70 villages were recruited to participate in a cluster randomized controlled trial of an HIV behavioural intervention. The main measures were HIV sero-status, and IPV and sexual practices…
Impact of Stepping Stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa
Open AccessRachel Jewkes, Mzikazi Nduna et al.ARTICLEBMJ2008
OBJECTIVE: To assess the impact of Stepping Stones, a HIV prevention programme, on incidence of HIV and herpes simplex type 2 (HSV-2) and sexual behaviour. DESIGN: Cluster randomised controlled trial. SETTING: 70 villages (clusters) in the Eastern Cape province of South Africa. PARTICIPANTS: 1360 men and 1416 women aged 15-26 years, who were mostly attending schools. INTERVENTION: Stepping Stones, a 50 hour programme, aims to improve sexual healt…
Associations between childhood adversity and depression, substance abuse and HIV and HSV2 incident infections in rural South African youth
Open AccessRachel Jewkes, Rachel K Jewkes et al.ARTICLEChild Abuse & Neglect2010
Strengthening HIV surveillance in the antiretroviral therapy era
Open AccessAyesha Bm Kharsany, Ayesha B M Kharsany et al.ARTICLEBMC Public Health2015
The results from HIPSS will provide critical data regarding HIV prevalence and incidence in this community and will establish whether HIV prevention and treatment efforts in a "real world", non-trial setting have an impact on HIV incidence at a population level. Importantly, the study design and methods will inform future methods for HIV surveillance
First population-level effectiveness evaluation of a national programme to prevent HIV transmission from mother to child, South Africa
Open AccessAmeena Ebrahim Goga, Thu-Ha Dinh et al.ARTICLEJournal of Epidemiology and…2015Cited by: 2References: 31
BACKGROUND: There is a paucity of data on the national population-level effectiveness of preventing mother-to-child transmission (PMTCT) programmes in high-HIV-prevalence, resource-limited settings. We assessed national PMTCT impact in South Africa (SA), 2010. METHODS: A facility-based survey was conducted using a stratified multistage, cluster sampling design. A nationally representative sample of 10 178 infants aged 4-8 weeks was recruited from…
Population–level effectiveness of PMTCT Option A on early mother–to–child (MTCT) transmission of HIV in South Africa
Open AccessAmeena Ebrahim Goga, Thu-Ha Dinh et al.ARTICLEJournal of Global Health2016
BACKGROUND: Eliminating mother-to-child transmission of HIV (EMTCT), defined as ≤50 infant HIV infections per 100 000 live births, is a global priority. Since 2011 policies to prevent mother-to-child transmission of HIV (PMTCT) shifted from maternal antiretroviral (ARV) treatment or prophylaxis contingent on CD4 cell count to lifelong maternal ARV treatment (cART). We sought to measure progress with early (4-8 weeks postpartum) MTCT prevention an…
Toward elimination of mother–to–child transmission of HIV in South Africa
Open AccessGayle Sherman, Gayle G Sherman et al.ARTICLEJournal of Global Health2017
BACKGROUND: South Africa has utilized three independent data sources to measure the impact of its program for the prevention of mother-to-child transmission (PMTCT) of HIV. These include the South African National Health Laboratory Service (NHLS), the District Health Information System (DHIS), and South African PMTCT Evaluation (SAPMTCTE) surveys. We compare the results of each, outlining advantages and limitations, and make recommendations for m…
Progress towards the Unaids 90–90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa
Open AccessHelena Huerga, Gilles van Cutsem et al.ARTICLEBMC Public Health2018
In this context of high HIV prevalence, significant progress has been achieved with regards to reaching the UNAIDS 90-90-90 targets. The third 90, viral suppression in people on ART, was achieved among women and men. However, gaps persist in HIV diagnosis and ART coverage particularly in men and individuals younger than 30 years. Achieving 90-90-90 is feasible but requires additional investment to reach youth and men
Beyond Social Desirability Bias
Open AccessAlyssa C Mooney, Alyssa Mooney et al.ARTICLEAIDS and Behavior2018
Feasibility of community-based HIV self-screening in South Africa
Open AccessLimakatso Lebina, Ntombexolo Seatlholo et al.ARTICLEBMC Public Health2019
Unsupervised HIVSS was by far the most selected and utilised HIVSS method. Linkages to primary and confirmatory testing for the unsupervised HIVSS and further care were low, despite home visits and telephonic reminders
Medical Male Circumcision and Associations Among Sexually Transmitted Infections Service Attendees
Open AccessTendesayi Kufa, Frans Radebe et al.ARTICLEAIDS and Behavior2019
Impact of breastfeeding, maternal antiretroviral treatment and health service factors on 18-month vertical transmission of HIV and HIV-free survival
Open AccessAmeena Ebrahim Goga, Chantal Lombard et al.ARTICLEJournal of Epidemiology and…2020References: 20
Background We analysed the impact of breastfeeding, antiretroviral drugs and health service factors on cumulative (6 weeks to 18 months) vertical transmission of HIV (MTCT) and ‘MTCT-or-death’, in South Africa, and compared estimates with global impact criteria to validate MTCT elimination: (1) Methods 9120 infants aged 6 weeks were enrolled in a nationally representative survey. Of 2811 HIV-exposed uninfected infants (HEU), 2644 enrolled into fo…
Community-led cross-sectional study of social and employment circumstances, HIV and associated factors amongst female sex workers in South Africa
Open AccessMinja Milovanovic, Rachel Jewkes et al.ARTICLEGlobal Health Action2021
BACKGROUND: In South Africa, female sex workers (FSWs) are perceived to play a pivotal role in the country's HIV epidemic. Understanding their health status and risk factors for adverse health outcomes is foundational for developing evidence-based health care for this population. OBJECTIVE: Describe the methodology used to successfully implement a community-led study of social and employment circumstances, HIV and associated factors amongst FSWs …
Psychosocial and behavioral factors associated with HIV among adolescent girls and young women in DREAMS districts in South Africa
Open AccessKaymarlin Govender, Sean Beckett et al.ARTICLEFrontiers in Public Health2025
Background High HIV prevalence among adolescent girls and young women (AGYW) in South Africa is driven by multiple interacting psychosocial risks. Some of these risks include socioeconomic deprivation, poor educational outcomes, poor mental health, alcohol and drug use which are associated with HIV-infection and sexual risk behavior. This article seeks to deepen our understanding of the role of psychosocial and behavioral factors in the HIV epide…
PrEP Awareness and Willingness to use Oral PrEP Among Males ≥ 18 Years Attending VMMC Services in Gauteng, South Africa
Open AccessNosipho Shangase, Ocean Tobaiwa et al.ARTICLEAIDS and Behavior2025
PrEP Awareness and Coverage
Open AccessNosipho Shangase, Tendesayi Kufa et al.ARTICLEAIDS and Behavior2025