Reinhold J Hutz
Biographic Data
| ID | 6216164 |
|---|---|
| NAME | Reinhold J Hutz |
| GIVEN NAMES | Reinhold J |
| FAMILY NAME | Hutz |
| SIGNATURE | HUTZ R J |
| AFFILIATIONS | University of Wisconsin–Milwaukee |
| VERIFIED | No |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 1 |
| WORKS AS AUTHOR | 14 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1983 |
| LATEST PUBLICATION YEAR | 2007 |
| H-INDEX | 1 |
Autoradiographic localization of aromatic hydrocarbon receptor (AHR) in rhesus monkey ovary
2,3,7,8‐Tetrachlorodibenzo‐ p ‐dioxin (TCDD) is the most toxic congener of a large class of manmade pollutants that persist in the environment. TCDD exerts its toxic effects, in part, by binding to its receptor known as the aromatic hydrocarbon receptor (AHR). TCDD is estrogen modulatory and in some systems its receptor associates directly with estrogen receptors via co‐activator molecules. TCDD inhibits steroid synthesis in human ovarian granulo…
International directory of primatology
Incidence of atresia or of luteinization without rupture of the dominant ovarian follicle in rhesus monkeys treated with estradiol‐17β on day 8 of the menstrual cycle
Previous results have established that 17β‐estradiol (E 2 ) administered in capsules for 24 h on Day 6 of the menstrual cycle results in atresia of the dominant follicle (DF). The present experiment was designed to determine if atresia could be induced similarly as late as Day 8, when the DF is presumably larger, to facilitate biochemical analyses. On the morning of Day 8, laparoscopy was used to confirm the presence of the DF, and 4, 6, or 8 Sil…
Technologic advances in the imaging of ovarian morphology and their roles in ascertaining follicular growth and development in the rhesus monkey
Localization of estrogen receptors in rhesus monkey ovary
We have previously demonstrated that the exogenous administration of estradiol‐17β (E 2 ) to rhesus monkeys induces atresia of the dominant preovulatory follicle (DF); and that this effect is mediated centrally, via the inhibition of follicle‐stimulating hormone, and is also exerted directly at the level of the ovarian granulosa cell. We wished to investigate whether the local effect of E 2 is transduced through interaction with the nuclear recep…
Estradiol‐induced follicular atresia in rhesus monkeys is not prevented by exogenous gonadotropins
Estradiol‐17β (E 2 ) induces atresia of the dominant preovulatory follicle (DF) when administered on day 6 of the menstrual cycle. The present study was designed to determine whether the atretogenic effect of E 2 could be averted by the administration of exogenous gonadotropins, in an attempt to determine whether E 2 ‐induced atresia in primates is due to a direct action at the ovarian level or is mediated via pituitary secretion. After identific…
Direct effect of estradiol‐17β on progesterone accumulation by ovarian granulosa cells from rhesus monkeys
We have previously demonstrated that estradiol‐17β (E 2 ) administered in vivo induces atresia of the dominant ovarian follicle (DF). Whether this effect is exerted directly at the ovarian level or by central mediation has not been confirmed. The present study was designed to assess whether E 2 in amounts similar to those found in monkey follicular fluid (FF) directly alters in vitro progesterone (P) accumulation by granulosa cells (GC) aspirated…
Atresia of the dominant ovarian follicle in rhesus monkeys is detected within 24 hours of estradiol treatment
Following treatment with estradiol‐17β (E 2 ) on day 6 of the menstrual cycle, degenerative alterations in the microenvironment of the dominant follicle (DF) (follicular fluid [FF], granulosa cells [GC], and oocyte) are readily apparent on day 10, or 96 h after E 2 administration. The present study was designed to determine how early such changes could be detected and which indices of atresia were observed first. The DF was identified during lapa…
Induction of atresia of the dominant follicle in rhesus monkeys ( Macaca mulatta ) by the local application of estradiol‐17β
Estradiol‐17β (E 2 ), administered systemically to rhesus monkeys during the follicular phase of the menstrual cycle, induces atretic changes in the microenvironment of the dominant follicle (DF), which results in its demise. It has been proposed that this effect of E 2 represents a direct action at the ovarian level. The present study was designed to test this hypothesis, using local treatment with E 2 . After identification of the DF during lap…
Menstrual cycles in rhesus monkeys ( Macaca mulatta ) are unaffected by a single dose of the anesthetics ketamine and xylazine administered during the midfollicular phase at laparoscopy
To identify an anesthetic regimen that produces more complete relaxation and analgesia than ketamine hydrochloride (Ketaset®) alone, a combination of ketamine (15 mg/kg body weight) and the hypnotic xylazine (Rompun®, 0.33 mg/kg) was evaluated. Since the desired experimental application required that the anesthetic not interfere with normal hormonal events during the menstrual cycle, this combination administered on day 6 of the cycle was tested …
Atretogenic action of estrogen in rhesus monkeys
The effects of 17β‐estradiol (E 2 ), administered in Silastic capsules for 24 hours at intervals of 10 or 14 days, on follicular development and menstrual cycle characteristics were studied in 13 rhesus monkeys. In seven monkeys receiving E 2 at l0‐day intervals for 50 treatment periods, new follicles frequently developed between treatments but usually regressed. In seven instances, the follicles persisted longer than expected but were steroidoge…
Temporal and endocrine sequelae of aspirating follicular contents in rhesus monkeys
Aspiration of ovarian follicular contents in humans is a well‐established procedure used to obtain oocytes for fertilization in vitro (IVF). However, the effects of aspiration on the menstrual cycle and resulting luteal function have been incompletely characterized. The present study was designed to investigate alterations in the temporal and endocrine characteristics of menstrual cycles following aspiration of contents of the dominant preovulato…
Accumulation of 2‐deoxy‐D‐glucose by primate oocytes fertilized in vitro
The present study was designed to investigate the accumulation of 2‐deoxy‐D‐glucose (2‐DG) by squirrel monkey oocytes fertilized in vitro; to assess the effects of insulin addition to the medium on 2‐DG accumulation; and, finally, to evaluate the use of 2‐DG in viability determinations of oocytes. Accumulation of 2‐DG by unfertilized oocytes from squirrel monkeys was 13.94 fmol/oocyte/3 h and was not affected by the addition of either 10 nM or 1 …
Brief report
The time between administration of human chorionic gonadotropin (hCG) and follicle aspiration was analyzed for alterations in [ 3 H]uridine incorporation [as an indicator of relative synthesis of ribonucleic acid (RNA)] of oocytes from squirrel monkeys and humans. There was a significant decline in both the uptake and incorporation of [ 3 H]uridine in squirrel monkey oocytes by 36 hr following hCG administration to the animals, as compared with 1…
Brief report
The time between administration of human chorionic gonadotropin (hCG) and follicle aspiration was analyzed for alterations in [ 3 H]uridine incorporation [as an indicator of relative synthesis of ribonucleic acid (RNA)] of oocytes from squirrel monkeys and humans. There was a significant decline in both the uptake and incorporation of [ 3 H]uridine in squirrel monkey oocytes by 36 hr following hCG administration to the animals, as compared with 1…
Accumulation of 2‐deoxy‐D‐glucose by primate oocytes fertilized in vitro
The present study was designed to investigate the accumulation of 2‐deoxy‐D‐glucose (2‐DG) by squirrel monkey oocytes fertilized in vitro; to assess the effects of insulin addition to the medium on 2‐DG accumulation; and, finally, to evaluate the use of 2‐DG in viability determinations of oocytes. Accumulation of 2‐DG by unfertilized oocytes from squirrel monkeys was 13.94 fmol/oocyte/3 h and was not affected by the addition of either 10 nM or 1 …
Atretogenic action of estrogen in rhesus monkeys
The effects of 17β‐estradiol (E 2 ), administered in Silastic capsules for 24 hours at intervals of 10 or 14 days, on follicular development and menstrual cycle characteristics were studied in 13 rhesus monkeys. In seven monkeys receiving E 2 at l0‐day intervals for 50 treatment periods, new follicles frequently developed between treatments but usually regressed. In seven instances, the follicles persisted longer than expected but were steroidoge…
Temporal and endocrine sequelae of aspirating follicular contents in rhesus monkeys
Aspiration of ovarian follicular contents in humans is a well‐established procedure used to obtain oocytes for fertilization in vitro (IVF). However, the effects of aspiration on the menstrual cycle and resulting luteal function have been incompletely characterized. The present study was designed to investigate alterations in the temporal and endocrine characteristics of menstrual cycles following aspiration of contents of the dominant preovulato…
Induction of atresia of the dominant follicle in rhesus monkeys ( Macaca mulatta ) by the local application of estradiol‐17β
Estradiol‐17β (E 2 ), administered systemically to rhesus monkeys during the follicular phase of the menstrual cycle, induces atretic changes in the microenvironment of the dominant follicle (DF), which results in its demise. It has been proposed that this effect of E 2 represents a direct action at the ovarian level. The present study was designed to test this hypothesis, using local treatment with E 2 . After identification of the DF during lap…
Menstrual cycles in rhesus monkeys ( Macaca mulatta ) are unaffected by a single dose of the anesthetics ketamine and xylazine administered during the midfollicular phase at laparoscopy
To identify an anesthetic regimen that produces more complete relaxation and analgesia than ketamine hydrochloride (Ketaset®) alone, a combination of ketamine (15 mg/kg body weight) and the hypnotic xylazine (Rompun®, 0.33 mg/kg) was evaluated. Since the desired experimental application required that the anesthetic not interfere with normal hormonal events during the menstrual cycle, this combination administered on day 6 of the cycle was tested …
Direct effect of estradiol‐17β on progesterone accumulation by ovarian granulosa cells from rhesus monkeys
We have previously demonstrated that estradiol‐17β (E 2 ) administered in vivo induces atresia of the dominant ovarian follicle (DF). Whether this effect is exerted directly at the ovarian level or by central mediation has not been confirmed. The present study was designed to assess whether E 2 in amounts similar to those found in monkey follicular fluid (FF) directly alters in vitro progesterone (P) accumulation by granulosa cells (GC) aspirated…
Atresia of the dominant ovarian follicle in rhesus monkeys is detected within 24 hours of estradiol treatment
Following treatment with estradiol‐17β (E 2 ) on day 6 of the menstrual cycle, degenerative alterations in the microenvironment of the dominant follicle (DF) (follicular fluid [FF], granulosa cells [GC], and oocyte) are readily apparent on day 10, or 96 h after E 2 administration. The present study was designed to determine how early such changes could be detected and which indices of atresia were observed first. The DF was identified during lapa…
Estradiol‐induced follicular atresia in rhesus monkeys is not prevented by exogenous gonadotropins
Estradiol‐17β (E 2 ) induces atresia of the dominant preovulatory follicle (DF) when administered on day 6 of the menstrual cycle. The present study was designed to determine whether the atretogenic effect of E 2 could be averted by the administration of exogenous gonadotropins, in an attempt to determine whether E 2 ‐induced atresia in primates is due to a direct action at the ovarian level or is mediated via pituitary secretion. After identific…
Localization of estrogen receptors in rhesus monkey ovary
We have previously demonstrated that the exogenous administration of estradiol‐17β (E 2 ) to rhesus monkeys induces atresia of the dominant preovulatory follicle (DF); and that this effect is mediated centrally, via the inhibition of follicle‐stimulating hormone, and is also exerted directly at the level of the ovarian granulosa cell. We wished to investigate whether the local effect of E 2 is transduced through interaction with the nuclear recep…
Incidence of atresia or of luteinization without rupture of the dominant ovarian follicle in rhesus monkeys treated with estradiol‐17β on day 8 of the menstrual cycle
Previous results have established that 17β‐estradiol (E 2 ) administered in capsules for 24 h on Day 6 of the menstrual cycle results in atresia of the dominant follicle (DF). The present experiment was designed to determine if atresia could be induced similarly as late as Day 8, when the DF is presumably larger, to facilitate biochemical analyses. On the morning of Day 8, laparoscopy was used to confirm the presence of the DF, and 4, 6, or 8 Sil…
Technologic advances in the imaging of ovarian morphology and their roles in ascertaining follicular growth and development in the rhesus monkey
International directory of primatology
Autoradiographic localization of aromatic hydrocarbon receptor (AHR) in rhesus monkey ovary
2,3,7,8‐Tetrachlorodibenzo‐ p ‐dioxin (TCDD) is the most toxic congener of a large class of manmade pollutants that persist in the environment. TCDD exerts its toxic effects, in part, by binding to its receptor known as the aromatic hydrocarbon receptor (AHR). TCDD is estrogen modulatory and in some systems its receptor associates directly with estrogen receptors via co‐activator molecules. TCDD inhibits steroid synthesis in human ovarian granulo…
Biology (13 works) · Endocrinology (13 works) · Medicine (13 works) · Internal Medicine (12 works) · Reproductive Biology and Fertility (10 works) · Estrogen (9 works) · Follicular phase (9 works) · Hormone (9 works) · Ovarian function and disorders (9 works) · Ovary (8 works)