Laurent Excoffier
Biographic Data
| ID | 625560 |
|---|---|
| NAME | Laurent Excoffier |
| GIVEN NAMES | Laurent |
| FAMILY NAME | Excoffier |
| SIGNATURE | EXCOFFIER L |
| AFFILIATIONS | University of Bern |
| ORCID | 0000-0002-7507-6494 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 29 |
| AUTHOR COUNT | 14 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1987 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 2 |
Rise and fall of deleterious variants: The Origins of Modern Genetic Diseases
For two decades, sequencing genomes has significantly helped to identify genetic causes of diseases observed in modern humans, leading to the emergence of genetic medicine. This raises questions about the presence of deleterious variants, and consequently diseases, in ancient humans too, as well as when and where these variants first appeared during human evolution. As the Neolithic transition brought a major change in diet and life style in West…
The population history of northeastern Siberia since the Pleistocene
Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers
How early human groups were organized Sequencing ancient hominid remains has provided insights into the relatedness between individuals. However, it is not clear whether ancient humans bred among close relatives, as is common in some modern human cultures. Sikora et al. report genome sequences from four early humans buried close together in western Russia about 34,000 years ago (see the Perspective by Bergström and Tyler-Smith). The individuals c…
A genomic history of Aboriginal Australia
The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama–Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25–40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania).…
Reconstructing Native American population history
Arlequin suite ver 3.5: A new series of programs to perform population genetics analyses under Linux and Windows
We present here a new version of the Arlequin program available under three different forms: a Windows graphical version (W inarl35 ), a console version of Arlequin ( arlecore ), and a specific console version to compute summary statistics ( arlsumstat ). The command‐line versions run under both Linux and Windows. The main innovations of the new version include enhanced outputs in XML format, the possibility to embed graphics displaying computati…
Securing the Conservation of Biodiversity across Administrative Levels and Spatial, Temporal, and Ecological Scales – Research Needs and Approaches of the SCALES Project
Biodiversity conservation measures and biological processes often do not match in scale. The EU funded project SCALES ( Securing the Conservation of biodiversity across Administrative Levels and spatial, temporal, and Ecological Scales ) is intended to solve this challenge. SCALES analyses how selected pressures (climate change, habitat loss, fragmentation, disturbance), their drivers, and their impacts on biodiversity change with spatial and tem…
Geographic Patterns of Genome Admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for…
Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower gen…
Reconstructing the demography of prehistoric human populations from molecular data
Génétique, linguistique et histoire des peuplements humains
Recent and independent progresses achieved in population genetics and historical linguistics led to the comparison of their results on the origins and migrations of modern humans. Here we present and discuss several studies that show evidence for a strong link between genetic and linguistic differentiation among human populations at the continental scale. We further present the first results of our "boundaries" method, a new interdisciplinary app…
Analysis of molecular variance inferred from metric distances among DNA haplotypes: Application to human mitochondrial DNA restriction data.
We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-distances among all pairs of haplotypes. This analysis of molecular variance (AMOVA) produces estimates of variance components and F-statistic analogs, designated here as phi-statistics, reflecting the correlation of haplotypic divers…
Origine et évolution de l'ADN mitochondrial humain: Le Paradigme Perdu
Excoffier Laurent, Roessli David. Origine et évolution de l'ADN mitochondrial humain : le paradigme perdu. In: Bulletins et Mémoires de la Société d'anthropologie de Paris, Nouvelle Série. Tome 2 fascicule 1, 1990. pp. 25-41
Genetics and history of sub-Saharan Africa
This paper aims to review the contribution of genetic data to the prehistory and history of sub-Saharan African peoples. The authors review briefly paleontologic data, which give limited information about modern Homo sapiens sapiens origins and isolation of present African gene pools. Most linguistic and archaeological theories about African peoples' prehistory are then confronted with the most informative genetic data available. Rhesus, Gm, HLA,…
Genetics and history of sub-Saharan Africa
This paper aims to review the contribution of genetic data to the prehistory and history of sub-Saharan African peoples. The authors review briefly paleontologic data, which give limited information about modern Homo sapiens sapiens origins and isolation of present African gene pools. Most linguistic and archaeological theories about African peoples' prehistory are then confronted with the most informative genetic data available. Rhesus, Gm, HLA,…
Origine et évolution de l'ADN mitochondrial humain: Le Paradigme Perdu
Excoffier Laurent, Roessli David. Origine et évolution de l'ADN mitochondrial humain : le paradigme perdu. In: Bulletins et Mémoires de la Société d'anthropologie de Paris, Nouvelle Série. Tome 2 fascicule 1, 1990. pp. 25-41
Genetics and history of sub-Saharan Africa
This paper aims to review the contribution of genetic data to the prehistory and history of sub-Saharan African peoples. The authors review briefly paleontologic data, which give limited information about modern Homo sapiens sapiens origins and isolation of present African gene pools. Most linguistic and archaeological theories about African peoples' prehistory are then confronted with the most informative genetic data available. Rhesus, Gm, HLA,…
Origine et évolution de l'ADN mitochondrial humain: Le Paradigme Perdu
Excoffier Laurent, Roessli David. Origine et évolution de l'ADN mitochondrial humain : le paradigme perdu. In: Bulletins et Mémoires de la Société d'anthropologie de Paris, Nouvelle Série. Tome 2 fascicule 1, 1990. pp. 25-41
Analysis of molecular variance inferred from metric distances among DNA haplotypes: Application to human mitochondrial DNA restriction data.
We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-distances among all pairs of haplotypes. This analysis of molecular variance (AMOVA) produces estimates of variance components and F-statistic analogs, designated here as phi-statistics, reflecting the correlation of haplotypic divers…
Génétique, linguistique et histoire des peuplements humains
Recent and independent progresses achieved in population genetics and historical linguistics led to the comparison of their results on the origins and migrations of modern humans. Here we present and discuss several studies that show evidence for a strong link between genetic and linguistic differentiation among human populations at the continental scale. We further present the first results of our "boundaries" method, a new interdisciplinary app…
Reconstructing the demography of prehistoric human populations from molecular data
Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower gen…
Geographic Patterns of Genome Admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for…
Arlequin suite ver 3.5: A new series of programs to perform population genetics analyses under Linux and Windows
We present here a new version of the Arlequin program available under three different forms: a Windows graphical version (W inarl35 ), a console version of Arlequin ( arlecore ), and a specific console version to compute summary statistics ( arlsumstat ). The command‐line versions run under both Linux and Windows. The main innovations of the new version include enhanced outputs in XML format, the possibility to embed graphics displaying computati…
Securing the Conservation of Biodiversity across Administrative Levels and Spatial, Temporal, and Ecological Scales – Research Needs and Approaches of the SCALES Project
Biodiversity conservation measures and biological processes often do not match in scale. The EU funded project SCALES ( Securing the Conservation of biodiversity across Administrative Levels and spatial, temporal, and Ecological Scales ) is intended to solve this challenge. SCALES analyses how selected pressures (climate change, habitat loss, fragmentation, disturbance), their drivers, and their impacts on biodiversity change with spatial and tem…
Reconstructing Native American population history
A genomic history of Aboriginal Australia
The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama–Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25–40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania).…
Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers
How early human groups were organized Sequencing ancient hominid remains has provided insights into the relatedness between individuals. However, it is not clear whether ancient humans bred among close relatives, as is common in some modern human cultures. Sikora et al. report genome sequences from four early humans buried close together in western Russia about 34,000 years ago (see the Perspective by Bergström and Tyler-Smith). The individuals c…
The population history of northeastern Siberia since the Pleistocene
Rise and fall of deleterious variants: The Origins of Modern Genetic Diseases
For two decades, sequencing genomes has significantly helped to identify genetic causes of diseases observed in modern humans, leading to the emergence of genetic medicine. This raises questions about the presence of deleterious variants, and consequently diseases, in ancient humans too, as well as when and where these variants first appeared during human evolution. As the Neolithic transition brought a major change in diet and life style in West…
Biology (9 works) · Population (9 works) · Geography (8 works) · Demography (7 works) · Forensic and Genetic Research (7 works) · Evolutionary biology (6 works) · Genetics (6 works) · Archaeology (5 works) · Gene (5 works) · Forensic Anthropology and Bioarchaeology Studies (4 works)