Ambrose Agweyu
Biographic Data
| ID | 6333598 |
|---|---|
| NAME | Ambrose Agweyu |
| GIVEN NAMES | Ambrose |
| FAMILY NAME | Agweyu |
| SIGNATURE | AGWEYU A |
| AFFILIATIONS | Kenya Medical Research Institute |
| ORCID | 0000-0001-8760-1279 |
| VERIFIED | Yes |
| TOTAL WORKS | 17 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 17 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2020 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Innovative approaches for engaging adolescents in Primary HIV prevention
BACKGROUND: The involvement and engagement of adolescents in community-based HIV prevention programmes are crucial for enhancing the effectiveness and sustainability of these programmes yet few programmes have documented their engagement strategies. This study aimed to describe and innovative approaches used to actively engage adolescents in HIV prevention health education programmes designed to increase awareness of HIV prevention methods, reduc…
Multimodal pulse oximeters to support the integrated management of childhood illnesses
Nearly 5 million children die each year of preventable causes, with pneumonia being a key contributor. The Integrated Management of Childhood Illnesses guidelines improve health care workers’ diagnostic and management capabilities by relying mostly on clinical signs. Though there have been successes, challenges in the consistent application of IMCI and the accurate diagnosis of conditions like hypoxemia remain. Next generation pulse oximeters add…
Measuring and monitoring child health and well-being—an integral part of the climate change agenda
Climate change has far-reaching consequences for all aspects of human society (Romanello et al. 2023). Children are uniquely vulnerable to climate change for a multitude of physiological and developmental reasons as well as because of distinctive behaviors such as outdoor play that increase their exposure to climate-related stressors (EPA 2023). Several reviews have summarized the multiple direct and indirect pathways through which climate change…
Addressing the challenges of estimating the target population in calculation of routine infant immunization coverage in Kenya
Target population estimation for immunization coverage calculations from census data is often inaccurate. This study aimed to evaluate the accuracy of the traditional census extrapolation method in comparison with three alternative approaches: the Cohort-Component Population Projections Method (CCPPM), using the Expanded Program on Immunisation (EPI) numerators – BCG and DTP1 doses as denominators, and estimates derived from first antenatal care …
Active vaccine safety surveillance
Although active vaccine safety surveillance (VSS) can complement passive VSS while overcoming the inherent limitations of spontaneous safety monitoring, it remains rare in sub-Saharan Africa. We conducted post-authorization active VSS of COVID-19 vaccines in Kilifi, Kenya using a cohort event monitoring study design. Participants were followed weekly over 13 weeks for adverse events. A subset was followed daily for one week for solicited systemic…
Perceived accuracy and utilisation of DHIS2 data for health decision making and advocacy in Kenya
Reliable health information systems (HIS) are critical for effective decision-making in the delivery of Primary Health Care and Reproductive, Maternal, Newborn, Child, Adolescent Health and Nutrition (PHC/RMNCAH+N) services. In Kenya, the District Health Information Software 2 (DHIS2) platform serves as the primary HIS for tracking health indicators. This qualitative study explored perceptions of DHIS2 data accuracy and use for decision-making am…
Evaluating the level of knowledge of HIV prevention methods and associated socio-demographic factors among adolescents before and after participating in health education in Nimule town of South Sudan
The increase in knowledge of at least three methods of HIV prevention at the endline survey highlights the important role peer-led health education programs plays in closing gaps in HIV prevention among adolescents in conflict-affected settings like South Sudan
Characteristics of children readmitted with severe pneumonia in Kenyan hospitals
Children readmitted with severe pneumonia account for a substantial proportion of pneumonia hospitalisations and deaths. Further research is required to develop evidence-based approaches to screening, case management, and follow-up of children with severe pneumonia, prioritising those with underlying risk factors for readmission and mortality
Clinical epidemiology of Covid-19 among hospitalized children in rural western Kenya
The epidemiology of pediatric COVID-19 in sub-Saharan Africa and the role of fecal-oral transmission in SARS-CoV-2 are poorly understood. Among children and adolescents in Kenya, we identify correlates of COVID-19 infection, document the clinical outcomes of infection, and evaluate the prevalence and viability of SARS-CoV-2 in stool. We recruited a prospective cohort of hospitalized children aged two months to 15 years in western Kenya between Ma…
Epidemiological impact and cost-effectiveness analysis of Covid-19 vaccination in Kenya
BACKGROUND: A few studies have assessed the epidemiological impact and the cost-effectiveness of COVID-19 vaccines in settings where most of the population had been exposed to SARS-CoV-2 infection. METHODS: We conducted a cost-effectiveness analysis of COVID-19 vaccine in Kenya from a societal perspective over a 1.5-year time frame. An age-structured transmission model assumed at least 80% of the population to have prior natural immunity when an …
Sars-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021
Background Most of the studies that have informed the public health response to the COVID-19 pandemic in Kenya have relied on samples that are not representative of the general population. We conducted population-based serosurveys at three Health and Demographic Surveillance Systems (HDSSs) to determine the cumulative incidence of infection with SARS-CoV-2. Methods We selected random age-stratified population-based samples at HDSSs in Kisumu, Nai…
Modelling the cost-effectiveness of essential and advanced critical care for Covid-19 patients in Kenya
BACKGROUND: Case management of symptomatic COVID-19 patients is a key health system intervention. The Kenyan government embarked to fill capacity gaps in essential and advanced critical care (ACC) needed for the management of severe and critical COVID-19. However, given scarce resources, gaps in both essential and ACC persist. This study assessed the cost-effectiveness of investments in essential and ACC to inform the prioritisation of investment…
Employing learning health system principles to advance research on severe neonatal and paediatric illness in Kenya
We have worked to develop a Clinical Information Network (CIN) in Kenya as an early form of learning health systems (LHS) focused on paediatric and neonatal care that now spans 22 hospitals. CIN’s aim was to examine important outcomes of hospitalisation at scale, identify and ultimately solve practical problems of service delivery, drive improvements in quality and test interventions. By including multiple routine settings in research, we aimed t…
Neonatal mortality in Kenyan hospitals
BACKGROUND: Most of the deaths among neonates in low-income and middle-income countries (LMICs) can be prevented through universal access to basic high-quality health services including essential facility-based inpatient care. However, poor routine data undermines data-informed efforts to monitor and promote improvements in the quality of newborn care across hospitals. METHODS: Continuously collected routine patients' data from structured paper r…
Revitalizing child health
Essential health, education and other service disruptions arising from the COVID-19 pandemic risk reversing some of the hard-won gains in improving child survival over the past 40 years. Although children have milder symptoms of COVID-19 disease than adults, pandemic control measures in many countries have disrupted health, education and other services for children, often leaving them without access to birth and postnatal care, vaccinations and e…
Protecting children in low-income and middle-income countries from Covid-19
A saving grace of the COVID-19 pandemic in high-income and upper middle-income countries has been the relative sparing of children. As the disease spreads across low-income and middle-income countries (LMICs), long-standing system vulnerabilities may tragically manifest, and we worry that children will be increasingly impacted, both directly and indirectly. Drawing on our shared child pneumonia experience globally, we highlight these potential im…
Extending the measurement of quality beyond service delivery indicators
Assessing the quality of healthcare services is a priority in low-resource and high-resource settings alike. It is, however, a complex endeavour. Outcome measures are subject to case-mix variation, often require lengthy follow-up periods to manifest, and are generally costly to monitor. Therefore, structure and process measures are routinely considered reliable alternatives under the assumption of a causal link between the provision of care and i…
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Protecting children in low-income and middle-income countries from Covid-19
A saving grace of the COVID-19 pandemic in high-income and upper middle-income countries has been the relative sparing of children. As the disease spreads across low-income and middle-income countries (LMICs), long-standing system vulnerabilities may tragically manifest, and we worry that children will be increasingly impacted, both directly and indirectly. Drawing on our shared child pneumonia experience globally, we highlight these potential im…
Extending the measurement of quality beyond service delivery indicators
Assessing the quality of healthcare services is a priority in low-resource and high-resource settings alike. It is, however, a complex endeavour. Outcome measures are subject to case-mix variation, often require lengthy follow-up periods to manifest, and are generally costly to monitor. Therefore, structure and process measures are routinely considered reliable alternatives under the assumption of a causal link between the provision of care and i…
Modelling the cost-effectiveness of essential and advanced critical care for Covid-19 patients in Kenya
BACKGROUND: Case management of symptomatic COVID-19 patients is a key health system intervention. The Kenyan government embarked to fill capacity gaps in essential and advanced critical care (ACC) needed for the management of severe and critical COVID-19. However, given scarce resources, gaps in both essential and ACC persist. This study assessed the cost-effectiveness of investments in essential and ACC to inform the prioritisation of investment…
Employing learning health system principles to advance research on severe neonatal and paediatric illness in Kenya
We have worked to develop a Clinical Information Network (CIN) in Kenya as an early form of learning health systems (LHS) focused on paediatric and neonatal care that now spans 22 hospitals. CIN’s aim was to examine important outcomes of hospitalisation at scale, identify and ultimately solve practical problems of service delivery, drive improvements in quality and test interventions. By including multiple routine settings in research, we aimed t…
Neonatal mortality in Kenyan hospitals
BACKGROUND: Most of the deaths among neonates in low-income and middle-income countries (LMICs) can be prevented through universal access to basic high-quality health services including essential facility-based inpatient care. However, poor routine data undermines data-informed efforts to monitor and promote improvements in the quality of newborn care across hospitals. METHODS: Continuously collected routine patients' data from structured paper r…
Revitalizing child health
Essential health, education and other service disruptions arising from the COVID-19 pandemic risk reversing some of the hard-won gains in improving child survival over the past 40 years. Although children have milder symptoms of COVID-19 disease than adults, pandemic control measures in many countries have disrupted health, education and other services for children, often leaving them without access to birth and postnatal care, vaccinations and e…
Epidemiological impact and cost-effectiveness analysis of Covid-19 vaccination in Kenya
BACKGROUND: A few studies have assessed the epidemiological impact and the cost-effectiveness of COVID-19 vaccines in settings where most of the population had been exposed to SARS-CoV-2 infection. METHODS: We conducted a cost-effectiveness analysis of COVID-19 vaccine in Kenya from a societal perspective over a 1.5-year time frame. An age-structured transmission model assumed at least 80% of the population to have prior natural immunity when an …
Sars-CoV-2 seroprevalence in three Kenyan health and demographic surveillance sites, December 2020-May 2021
Background Most of the studies that have informed the public health response to the COVID-19 pandemic in Kenya have relied on samples that are not representative of the general population. We conducted population-based serosurveys at three Health and Demographic Surveillance Systems (HDSSs) to determine the cumulative incidence of infection with SARS-CoV-2. Methods We selected random age-stratified population-based samples at HDSSs in Kisumu, Nai…
Clinical epidemiology of Covid-19 among hospitalized children in rural western Kenya
The epidemiology of pediatric COVID-19 in sub-Saharan Africa and the role of fecal-oral transmission in SARS-CoV-2 are poorly understood. Among children and adolescents in Kenya, we identify correlates of COVID-19 infection, document the clinical outcomes of infection, and evaluate the prevalence and viability of SARS-CoV-2 in stool. We recruited a prospective cohort of hospitalized children aged two months to 15 years in western Kenya between Ma…
Characteristics of children readmitted with severe pneumonia in Kenyan hospitals
Children readmitted with severe pneumonia account for a substantial proportion of pneumonia hospitalisations and deaths. Further research is required to develop evidence-based approaches to screening, case management, and follow-up of children with severe pneumonia, prioritising those with underlying risk factors for readmission and mortality
Addressing the challenges of estimating the target population in calculation of routine infant immunization coverage in Kenya
Target population estimation for immunization coverage calculations from census data is often inaccurate. This study aimed to evaluate the accuracy of the traditional census extrapolation method in comparison with three alternative approaches: the Cohort-Component Population Projections Method (CCPPM), using the Expanded Program on Immunisation (EPI) numerators – BCG and DTP1 doses as denominators, and estimates derived from first antenatal care …
Active vaccine safety surveillance
Although active vaccine safety surveillance (VSS) can complement passive VSS while overcoming the inherent limitations of spontaneous safety monitoring, it remains rare in sub-Saharan Africa. We conducted post-authorization active VSS of COVID-19 vaccines in Kilifi, Kenya using a cohort event monitoring study design. Participants were followed weekly over 13 weeks for adverse events. A subset was followed daily for one week for solicited systemic…
Perceived accuracy and utilisation of DHIS2 data for health decision making and advocacy in Kenya
Reliable health information systems (HIS) are critical for effective decision-making in the delivery of Primary Health Care and Reproductive, Maternal, Newborn, Child, Adolescent Health and Nutrition (PHC/RMNCAH+N) services. In Kenya, the District Health Information Software 2 (DHIS2) platform serves as the primary HIS for tracking health indicators. This qualitative study explored perceptions of DHIS2 data accuracy and use for decision-making am…
Evaluating the level of knowledge of HIV prevention methods and associated socio-demographic factors among adolescents before and after participating in health education in Nimule town of South Sudan
The increase in knowledge of at least three methods of HIV prevention at the endline survey highlights the important role peer-led health education programs plays in closing gaps in HIV prevention among adolescents in conflict-affected settings like South Sudan
Innovative approaches for engaging adolescents in Primary HIV prevention
BACKGROUND: The involvement and engagement of adolescents in community-based HIV prevention programmes are crucial for enhancing the effectiveness and sustainability of these programmes yet few programmes have documented their engagement strategies. This study aimed to describe and innovative approaches used to actively engage adolescents in HIV prevention health education programmes designed to increase awareness of HIV prevention methods, reduc…
Multimodal pulse oximeters to support the integrated management of childhood illnesses
Nearly 5 million children die each year of preventable causes, with pneumonia being a key contributor. The Integrated Management of Childhood Illnesses guidelines improve health care workers’ diagnostic and management capabilities by relying mostly on clinical signs. Though there have been successes, challenges in the consistent application of IMCI and the accurate diagnosis of conditions like hypoxemia remain. Next generation pulse oximeters add…
Measuring and monitoring child health and well-being—an integral part of the climate change agenda
Climate change has far-reaching consequences for all aspects of human society (Romanello et al. 2023). Children are uniquely vulnerable to climate change for a multitude of physiological and developmental reasons as well as because of distinctive behaviors such as outdoor play that increase their exposure to climate-related stressors (EPA 2023). Several reviews have summarized the multiple direct and indirect pathways through which climate change…
Medicine (12 works) · Environmental health (8 works) · Population (6 works) · Global Maternal and Child Health (5 works) · Immunology (4 works) · Internal Medicine (4 works) · Pediatrics (4 works) · Public health (4 works) · SARS-CoV-2 and COVID-19 Research (4 works) · 2019-20 coronavirus outbreak (3 works)