Jessica D Faul
Datos Biográficos
| ID | 644119 |
|---|---|
| NOMBRE | Jessica D Faul |
| NOMBRES | Jessica D |
| APELLIDO | Faul |
| FIRMA | FAUL J D |
| AFILIACIONES | University of Michigan |
| ORCID | 0000-0002-6969-6478 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 24 |
| TOTAL DE CITAS | 26 |
| TOTAL COMO AUTOR | 24 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2013 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 3 |
How “Clocking in” Ages Us
Consistent employment, especially secure, high-wage employment, has well-documented associations with lower risk of later-life morbidity and mortality, and accelerated biological aging may underlie these associations. Although research evaluating employment and accelerated epigenetic aging is growing, questions remain about the implications of chronic work-related exposures for accelerated aging. This study uses longitudinal data from the Health …
Does volunteering reduce epigenetic age acceleration among retired and working older adults? Results from the Health and Retirement Study
Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries
Dried blood spot based biomarkers in the Health and Retirement Study
INTRODUCTION: The Health and Retirement Study (HRS) has collected biomarker data over multiple waves. Such data can help improve our understanding of health changes in individuals and the causal pathways related to health. There are, however, technical challenges to using the HRS dried blood spots (DBS) biomarker data due to changes over time in assay protocols, platforms, and laboratories. We provide technical and summary information on biologic…
The Mode Effect of Web-Based Surveying on the 2018 U.S. Health and Retirement Study Measure of Cognitive Functioning
The difference in mode may be nonignorable for many uses of the HRS cognitive measure. In particular, it may require reconsideration of some cutscore-based approaches to identify impairment
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Socioeconomic status and immune aging in older US adults in the health and retirement study
Socioeconomic and demographic factors including educational attainment, race and ethnicity, and childhood socioeconomic status (SES) are powerful predictors of inequalities in aging, morbidity, and mortality. Immune aging, including accumulation of late-differentiated, senescent-like lymphocytes and lower levels of naïve lymphocytes, may play a role in the development of the age-related health inequalities. This study used nationally representati…
Dementia Diagnosis Disparities by Race and Ethnicity
BACKGROUND: Dementia is often underdiagnosed and this problem is more common among some ethnoracial groups. OBJECTIVE: The objective of this study was to examine racial and ethnic disparities in the timeliness of receiving a clinical diagnosis of dementia. RESEARCH DESIGN: This was a prospective cohort study. SUBJECTS: A total of 3966 participants age 70 years and above with probable dementia in the Health and Retirement Study, linked with their …
Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population
Dried blood spots
OBJECTIVES: This study investigates how factors related to collection, storage, transport time, and environmental conditions affect the quality and accuracy of analyses of dried blood spot (DBS) samples. METHODS: Data come from the 2016 Health and Retirement Study (HRS) DBS laboratory reports and the HRS merged with the National Climatic Data Center (NCDC) Global Historical Climate Network Daily (NCDC GHCN-Daily) and the NCDC Local Climatological…
The Effect of Childhood Socioeconomic Position and Social Mobility on Cognitive Function and Change Among Older Adults
These findings emphasize the impact of childhood SEP on cognitive trajectories among older adults. Upward mobility may partially compensate for disadvantage early in life but does not protect against cognitive decline
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012
Importance: The aging of the US population is expected to lead to a large increase in the number of adults with dementia, but some recent studies in the United States and other high-income countries suggest that the age-specific risk of dementia may have declined over the past 25 years. Clarifying current and future population trends in dementia prevalence and risk has important implications for patients, families, and government programs. Object…
Interaction between Social/Psychosocial Factors and Genetic Variants on Body Mass Index
Obesity, which develops over time, is one of the leading causes of chronic diseases such as cardiovascular disease. However, hundreds of BMI (body mass index)-associated genetic loci identified through large-scale genome-wide association studies (GWAS) only explain about 2.7% of BMI variation. Most common human traits are believed to be influenced by both genetic and environmental factors. Past studies suggest a variety of environmental features …
Predicting Receipt of Social Security Administration Disability Benefits Using Biomarkers and Other Physiological Measures
Physiological measures have moderate power to predict SSA disability benefit receipt
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Estimating Telomere Length Heritability in an Unrelated Sample of Adults
Telomere length (TL) is a widely used marker of biological aging and is associated with an increased risk of morbidity and mortality. Recently, there has been evidence for an association between TL and socioeconomic status (SES), particularly for measures of education and childhood SES. Individual differences in TL are also influenced by genetic factors, with heritability estimates from twin and sibling studies ranging from 34 to 82 percent. Yet …
Genetic studies of body mass index yield new insights for obesity biology
Mental work demands, retirement, and longitudinal trajectories of cognitive functioning.
Age-related changes in cognitive abilities are well-documented, and a very important indicator of health, functioning, and decline in later life. However, less is known about the course of cognitive functioning before and after retirement and specifically whether job characteristics during one's time of employment (i.e., higher vs. lower levels of mental work demands) moderate how cognition changes both before and after the transition to retireme…
Cohort Profile
The Health and Retirement Study (HRS) is a nationally representative longitudinal survey of more than 37 000 individuals over age 50 in 23 000 households in the USA. The survey, which has been fielded every 2 years since 1992, was established to provide a national resource for data on the changing health and economic circumstances associated with ageing at both individual and population levels. Its multidisciplinary approach is focused on four br…
Validation of Blood-Based Assays Using Dried Blood Spots for Use in Large Population Studies
Assessment of health in large population studies has increasingly incorporated measures of blood-based biomarkers based on the use of dried blood spots (DBS). The validity of DBS assessments made by labs used by large studies is addressed by comparing assay values from DBS collected using conditions similar to those used in the field with values from whole blood samples. The DBS approach generates values that are strongly related to whole blood l…
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
Validation of Blood-Based Assays Using Dried Blood Spots for Use in Large Population Studies
Assessment of health in large population studies has increasingly incorporated measures of blood-based biomarkers based on the use of dried blood spots (DBS). The validity of DBS assessments made by labs used by large studies is addressed by comparing assay values from DBS collected using conditions similar to those used in the field with values from whole blood samples. The DBS approach generates values that are strongly related to whole blood l…
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population
The Effect of Childhood Socioeconomic Position and Social Mobility on Cognitive Function and Change Among Older Adults
These findings emphasize the impact of childhood SEP on cognitive trajectories among older adults. Upward mobility may partially compensate for disadvantage early in life but does not protect against cognitive decline
Does volunteering reduce epigenetic age acceleration among retired and working older adults? Results from the Health and Retirement Study
The Mode Effect of Web-Based Surveying on the 2018 U.S. Health and Retirement Study Measure of Cognitive Functioning
The difference in mode may be nonignorable for many uses of the HRS cognitive measure. In particular, it may require reconsideration of some cutscore-based approaches to identify impairment
Socioeconomic status and immune aging in older US adults in the health and retirement study
Socioeconomic and demographic factors including educational attainment, race and ethnicity, and childhood socioeconomic status (SES) are powerful predictors of inequalities in aging, morbidity, and mortality. Immune aging, including accumulation of late-differentiated, senescent-like lymphocytes and lower levels of naïve lymphocytes, may play a role in the development of the age-related health inequalities. This study used nationally representati…
Predicting Receipt of Social Security Administration Disability Benefits Using Biomarkers and Other Physiological Measures
Physiological measures have moderate power to predict SSA disability benefit receipt
Estimating Telomere Length Heritability in an Unrelated Sample of Adults
Telomere length (TL) is a widely used marker of biological aging and is associated with an increased risk of morbidity and mortality. Recently, there has been evidence for an association between TL and socioeconomic status (SES), particularly for measures of education and childhood SES. Individual differences in TL are also influenced by genetic factors, with heritability estimates from twin and sibling studies ranging from 34 to 82 percent. Yet …
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
Mental work demands, retirement, and longitudinal trajectories of cognitive functioning.
Age-related changes in cognitive abilities are well-documented, and a very important indicator of health, functioning, and decline in later life. However, less is known about the course of cognitive functioning before and after retirement and specifically whether job characteristics during one's time of employment (i.e., higher vs. lower levels of mental work demands) moderate how cognition changes both before and after the transition to retireme…
Cohort Profile
The Health and Retirement Study (HRS) is a nationally representative longitudinal survey of more than 37 000 individuals over age 50 in 23 000 households in the USA. The survey, which has been fielded every 2 years since 1992, was established to provide a national resource for data on the changing health and economic circumstances associated with ageing at both individual and population levels. Its multidisciplinary approach is focused on four br…
Validation of Blood-Based Assays Using Dried Blood Spots for Use in Large Population Studies
Assessment of health in large population studies has increasingly incorporated measures of blood-based biomarkers based on the use of dried blood spots (DBS). The validity of DBS assessments made by labs used by large studies is addressed by comparing assay values from DBS collected using conditions similar to those used in the field with values from whole blood samples. The DBS approach generates values that are strongly related to whole blood l…
Genetic studies of body mass index yield new insights for obesity biology
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genome-wide association study identifies 74 loci associated with educational attainment
Estimating Telomere Length Heritability in an Unrelated Sample of Adults
Telomere length (TL) is a widely used marker of biological aging and is associated with an increased risk of morbidity and mortality. Recently, there has been evidence for an association between TL and socioeconomic status (SES), particularly for measures of education and childhood SES. Individual differences in TL are also influenced by genetic factors, with heritability estimates from twin and sibling studies ranging from 34 to 82 percent. Yet …
A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012
Importance: The aging of the US population is expected to lead to a large increase in the number of adults with dementia, but some recent studies in the United States and other high-income countries suggest that the age-specific risk of dementia may have declined over the past 25 years. Clarifying current and future population trends in dementia prevalence and risk has important implications for patients, families, and government programs. Object…
Interaction between Social/Psychosocial Factors and Genetic Variants on Body Mass Index
Obesity, which develops over time, is one of the leading causes of chronic diseases such as cardiovascular disease. However, hundreds of BMI (body mass index)-associated genetic loci identified through large-scale genome-wide association studies (GWAS) only explain about 2.7% of BMI variation. Most common human traits are believed to be influenced by both genetic and environmental factors. Past studies suggest a variety of environmental features …
Predicting Receipt of Social Security Administration Disability Benefits Using Biomarkers and Other Physiological Measures
Physiological measures have moderate power to predict SSA disability benefit receipt
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Dried blood spots
OBJECTIVES: This study investigates how factors related to collection, storage, transport time, and environmental conditions affect the quality and accuracy of analyses of dried blood spot (DBS) samples. METHODS: Data come from the 2016 Health and Retirement Study (HRS) DBS laboratory reports and the HRS merged with the National Climatic Data Center (NCDC) Global Historical Climate Network Daily (NCDC GHCN-Daily) and the NCDC Local Climatological…
The Effect of Childhood Socioeconomic Position and Social Mobility on Cognitive Function and Change Among Older Adults
These findings emphasize the impact of childhood SEP on cognitive trajectories among older adults. Upward mobility may partially compensate for disadvantage early in life but does not protect against cognitive decline
Dementia Diagnosis Disparities by Race and Ethnicity
BACKGROUND: Dementia is often underdiagnosed and this problem is more common among some ethnoracial groups. OBJECTIVE: The objective of this study was to examine racial and ethnic disparities in the timeliness of receiving a clinical diagnosis of dementia. RESEARCH DESIGN: This was a prospective cohort study. SUBJECTS: A total of 3966 participants age 70 years and above with probable dementia in the Health and Retirement Study, linked with their …
Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Socioeconomic status and immune aging in older US adults in the health and retirement study
Socioeconomic and demographic factors including educational attainment, race and ethnicity, and childhood socioeconomic status (SES) are powerful predictors of inequalities in aging, morbidity, and mortality. Immune aging, including accumulation of late-differentiated, senescent-like lymphocytes and lower levels of naïve lymphocytes, may play a role in the development of the age-related health inequalities. This study used nationally representati…
The Mode Effect of Web-Based Surveying on the 2018 U.S. Health and Retirement Study Measure of Cognitive Functioning
The difference in mode may be nonignorable for many uses of the HRS cognitive measure. In particular, it may require reconsideration of some cutscore-based approaches to identify impairment
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Dried blood spot based biomarkers in the Health and Retirement Study
INTRODUCTION: The Health and Retirement Study (HRS) has collected biomarker data over multiple waves. Such data can help improve our understanding of health changes in individuals and the causal pathways related to health. There are, however, technical challenges to using the HRS dried blood spots (DBS) biomarker data due to changes over time in assay protocols, platforms, and laboratories. We provide technical and summary information on biologic…
Does volunteering reduce epigenetic age acceleration among retired and working older adults? Results from the Health and Retirement Study
Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries
How “Clocking in” Ages Us
Consistent employment, especially secure, high-wage employment, has well-documented associations with lower risk of later-life morbidity and mortality, and accelerated biological aging may underlie these associations. Although research evaluating employment and accelerated epigenetic aging is growing, questions remain about the implications of chronic work-related exposures for accelerated aging. This study uses longitudinal data from the Health …
Medicine (16 obras) · Biology (12 obras) · Genetic Associations and Epidemiology (9 obras) · Gerontology (9 obras) · Population (9 obras) · Psychology (9 obras) · Birth, Development, and Health (8 obras) · Demography (8 obras) · Gene (8 obras) · Genome-wide association study (7 obras)