Takahiko Nagamine
Biographic Data
| ID | 6514573 |
|---|---|
| NAME | Takahiko Nagamine |
| GIVEN NAMES | Takahiko |
| FAMILY NAME | Nagamine |
| SIGNATURE | NAGAMINE T |
| AFFILIATIONS | Sunlight Brain Research Center Hofu Yamaguchi Japan |
| ORCID | 0000-0002-0690-6271 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 1 |
| AUTHOR COUNT | 14 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1988 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Tongue Pressure: A Critical Bridge Between Oral Frailty and Systemic Longevity in Older Adults
Incorporating tongue pressure as an indicator of oral frailty allows for a comprehensive approach to frailty management in older adults.
Beyond Policy Interventions: Addressing the Persistence of Hypnotic Use and Polypharmacy in Japan's Aging Population
I read with great interest the article by Kimura et al. regarding the impact of medical fee revisions on long-term hypnotic prescriptions in Japan [1]. While the authors conclude that policy interventions significantly redirected prescription trends toward a decline, a more nuanced interpretation is required. Evidence from additional nationwide databases and disparate analytical methodologies indicates that the phenomenon of hypnotic utilization …
Integrating a Biopsychosocial and Neuroscientific Perspective Into Satoyama‐Based Frailty Research
Research into the relationship between Satoyama activities and the health status of older people should be conducted scientifically based on the biopsychosocial model, with appropriate control groups and neuroscience-based monitoring of changes in brain function.
Noise Pareidolia Test for Delirium Prediction: Considering the Role of Dopaminergic Basal Ganglia Circuitry
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
Loneliness as a Relational Barometer: A Dyadic Perspective on Caregiver Burden
It is important to shift our view of loneliness from a "secondary stressor" to a "barometer of relationships." Based on interactions between caregivers and care recipients, we should focus on "resilient pairs" and study the innate human need for connection.
The Contralateral Muscle Reserve: Rethinking Post‐Operative Risk Stratification and Discharge Trajectories in Acute Hip Fracture Care
The non-affected thigh reflects the patient's true muscle reserve and helps predict functional recovery after hip fracture surgery. This can be used to study how often patients are able to leave facilities and return home, which is related to their quality of life.
Beyond Prescriptions: Addressing Stagnation in Benzodiazepine Reduction in Acute Care Geriatric Wards in Japan
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
The Gut–Muscle Axis in Sarcopenia: From Parallel Aging to a Self‐Perpetuating Vicious Cycle
Sarcopenia and gut dysbiosis form a bidirectional vicious cycle where microbial changes drive systemic inflammation and muscle loss. Conversely, declining muscle metabolism further disrupts the microbiome. While "bottom-up" microbial interventions show promise in restoring muscle integrity, more research is needed on "top-down" muscle rejuvenation to fully confirm this interaction.
Longitudinal trends in blood concentrations of clozapine and norclozapine, inflammatory markers, and clinical outcomes in Japanese patients: A 12-week prospective study
A "start low, go slow" titration approach can effectively achieve therapeutic concentrations even without real-time therapeutic drug monitoring. However, the significantly higher concentrations observed in female subjects suggest that more cautious dose titration is necessary for female patients, likely due to hormonal influences on metabolic enzymes. Further research is needed on the relationship between clozapine dosage, plasma concentrations a…
Accuracy of functional near-infrared diffuse optical spectroscopy to aid in the differentiation of depressive symptoms
Mental health disorders represent a growing public health concern, yet their clinical evaluation 10 frequently relies on subjective questionnaires. Functional near-infrared spectroscopy (fNIRS) offers a 11 more quantitative approach by measuring cerebral hemodynamics (e.g., blood oxygenation, blood flow, 12 etc.), which are linked to brain function and psychiatric symptoms. The present editorial, published in 13 this journal (continued in Volume …
Case Report: Challenges of orthodontic treatment in patients with autism spectrum disorders diagnosed in adulthood
Patients with autism spectrum disorders (ASDs) occasionally have difficulties in dental settings owing to specific features, including hypersensitivity and restrictive persistence. When features of ASD remain unnoticed until adulthood, dental procedures would be provided without considering the patient's potential ASD traits. Herein, we present three cases of ASD diagnosed in adulthood that experienced difficulties during orthodontic treatment, r…
Case series of drug-induced open bite: Extrapyramidal symptoms related to psychotropic medications
Although a drug-induced open bite is a rare symptom, prudent medical interviews about symptoms, psychiatric comorbidities, and psychotropic medication history besides oral assessment are necessary to provide a precise diagnosis and appropriate management in collaboration between dentists and psychiatrists
Case report: Open bite as an extrapyramidal side effect with aripiprazole, a dopamine partial agonist
Long-term, fixed-point posttreatment observation of orthodontically treated patients provided us with the opportunity to capture the onset, development, and improvement of open bite, a type of malocclusion. Based on the chronological sequence of events, i.e., a tendency for open bite to worsen with increasing aripiprazole dosage and to improve with decreasing dosage, it was inferred that the onset of malocclusion was caused by extrapyramidal symp…
Attitudes toward death in rural areas of Japan
Attitudes toward death in rural areas of Japan were investigated by means of a questionnaire. One hundred and sixty out of the 319 families residing on a small island were randomly chosen and 94 percent of them (average age 48 years, male 57 percent; living with parents 41 percent) responded. The respondents did not clearly distinguish the dead from the living in their life-styles. They seemed to recognize a continuity between living and death. T…
Attitudes toward death in rural areas of Japan
Attitudes toward death in rural areas of Japan were investigated by means of a questionnaire. One hundred and sixty out of the 319 families residing on a small island were randomly chosen and 94 percent of them (average age 48 years, male 57 percent; living with parents 41 percent) responded. The respondents did not clearly distinguish the dead from the living in their life-styles. They seemed to recognize a continuity between living and death. T…
Attitudes toward death in rural areas of Japan
Attitudes toward death in rural areas of Japan were investigated by means of a questionnaire. One hundred and sixty out of the 319 families residing on a small island were randomly chosen and 94 percent of them (average age 48 years, male 57 percent; living with parents 41 percent) responded. The respondents did not clearly distinguish the dead from the living in their life-styles. They seemed to recognize a continuity between living and death. T…
Case report: Open bite as an extrapyramidal side effect with aripiprazole, a dopamine partial agonist
Long-term, fixed-point posttreatment observation of orthodontically treated patients provided us with the opportunity to capture the onset, development, and improvement of open bite, a type of malocclusion. Based on the chronological sequence of events, i.e., a tendency for open bite to worsen with increasing aripiprazole dosage and to improve with decreasing dosage, it was inferred that the onset of malocclusion was caused by extrapyramidal symp…
Case series of drug-induced open bite: Extrapyramidal symptoms related to psychotropic medications
Although a drug-induced open bite is a rare symptom, prudent medical interviews about symptoms, psychiatric comorbidities, and psychotropic medication history besides oral assessment are necessary to provide a precise diagnosis and appropriate management in collaboration between dentists and psychiatrists
Accuracy of functional near-infrared diffuse optical spectroscopy to aid in the differentiation of depressive symptoms
Mental health disorders represent a growing public health concern, yet their clinical evaluation 10 frequently relies on subjective questionnaires. Functional near-infrared spectroscopy (fNIRS) offers a 11 more quantitative approach by measuring cerebral hemodynamics (e.g., blood oxygenation, blood flow, 12 etc.), which are linked to brain function and psychiatric symptoms. The present editorial, published in 13 this journal (continued in Volume …
Case Report: Challenges of orthodontic treatment in patients with autism spectrum disorders diagnosed in adulthood
Patients with autism spectrum disorders (ASDs) occasionally have difficulties in dental settings owing to specific features, including hypersensitivity and restrictive persistence. When features of ASD remain unnoticed until adulthood, dental procedures would be provided without considering the patient's potential ASD traits. Herein, we present three cases of ASD diagnosed in adulthood that experienced difficulties during orthodontic treatment, r…
Tongue Pressure: A Critical Bridge Between Oral Frailty and Systemic Longevity in Older Adults
Incorporating tongue pressure as an indicator of oral frailty allows for a comprehensive approach to frailty management in older adults.
Beyond Policy Interventions: Addressing the Persistence of Hypnotic Use and Polypharmacy in Japan's Aging Population
I read with great interest the article by Kimura et al. regarding the impact of medical fee revisions on long-term hypnotic prescriptions in Japan [1]. While the authors conclude that policy interventions significantly redirected prescription trends toward a decline, a more nuanced interpretation is required. Evidence from additional nationwide databases and disparate analytical methodologies indicates that the phenomenon of hypnotic utilization …
Integrating a Biopsychosocial and Neuroscientific Perspective Into Satoyama‐Based Frailty Research
Research into the relationship between Satoyama activities and the health status of older people should be conducted scientifically based on the biopsychosocial model, with appropriate control groups and neuroscience-based monitoring of changes in brain function.
Noise Pareidolia Test for Delirium Prediction: Considering the Role of Dopaminergic Basal Ganglia Circuitry
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
Loneliness as a Relational Barometer: A Dyadic Perspective on Caregiver Burden
It is important to shift our view of loneliness from a "secondary stressor" to a "barometer of relationships." Based on interactions between caregivers and care recipients, we should focus on "resilient pairs" and study the innate human need for connection.
The Contralateral Muscle Reserve: Rethinking Post‐Operative Risk Stratification and Discharge Trajectories in Acute Hip Fracture Care
The non-affected thigh reflects the patient's true muscle reserve and helps predict functional recovery after hip fracture surgery. This can be used to study how often patients are able to leave facilities and return home, which is related to their quality of life.
Beyond Prescriptions: Addressing Stagnation in Benzodiazepine Reduction in Acute Care Geriatric Wards in Japan
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
The Gut–Muscle Axis in Sarcopenia: From Parallel Aging to a Self‐Perpetuating Vicious Cycle
Sarcopenia and gut dysbiosis form a bidirectional vicious cycle where microbial changes drive systemic inflammation and muscle loss. Conversely, declining muscle metabolism further disrupts the microbiome. While "bottom-up" microbial interventions show promise in restoring muscle integrity, more research is needed on "top-down" muscle rejuvenation to fully confirm this interaction.
Longitudinal trends in blood concentrations of clozapine and norclozapine, inflammatory markers, and clinical outcomes in Japanese patients: A 12-week prospective study
A "start low, go slow" titration approach can effectively achieve therapeutic concentrations even without real-time therapeutic drug monitoring. However, the significantly higher concentrations observed in female subjects suggest that more cautious dose titration is necessary for female patients, likely due to hormonal influences on metabolic enzymes. Further research is needed on the relationship between clozapine dosage, plasma concentrations a…
Medicine (5 works) · Psychiatry (4 works) · Schizophrenia (object-oriented programming (3 works) · Acute care (2 works) · Adverse effect (2 works) · Antipsychotic (2 works) · Botulinum Toxin and Related Neurological Disorders (2 works) · Cognition (2 works) · Delirium (2 works) · Disease (2 works)