Naguib Mechawar
Biographic Data
| ID | 6538770 |
|---|---|
| NAME | Naguib Mechawar |
| GIVEN NAMES | Naguib |
| FAMILY NAME | Mechawar |
| SIGNATURE | MECHAWAR N |
| AFFILIATIONS | McGill University |
| ORCID | 0000-0003-4960-756X |
| VERIFIED | Yes |
| TOTAL WORKS | 5 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 5 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2013 |
| LATEST PUBLICATION YEAR | 2023 |
| H-INDEX | 0 |
DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex
Results from our study highlight that CUD is associated with epigenome-wide differences in DNAm levels in BA9 particularly related to synaptic signaling and neuroplasticity. This supports findings from previous studies that report on the strong impact of cocaine on neurocircuits in the human prefrontal cortex (PFC). Further studies are needed to follow up on the role of epigenetic alterations in CUD focusing on the integration of epigenetic signa…
Effects of Mindfulness-Based Cognitive Therapy on Peripheral Markers of Stress and Inflammation in Older-Adults With Depression and Anxiety
Background: Depression and anxiety are prevalent in older-adults and often difficult to treat: up to 55% of patients are unresponsive to pharmacotherapy. Mindfulness-Based Cognitive Therapy (MBCT) is a promising treatment, however, its biological mechanisms remain unknown in older-adults. Methods: We examined if, in older-adults, decreased depression and anxiety symptoms after MBCT are associated with changes in the expression levels of C-reactiv…
Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However, it remains unclear whether astrocytic subpopulations IR for other astrocytic markers are similarly affected. Astrocytes IR to vimentin (VIM) display different regional densities than GFAP-IR astrocytes in the healthy brain, and so may be differently altered in depre…
Cellular and Molecular Inflammatory Profile of the Choroid Plexus in Depression and Suicide
The inflammatory hypothesis of depression is one of the main theories that endeavors to explain and describe the underlying biological mechanisms of depression and suicide. While mounting evidence indicates altered peripheral and central inflammatory profiles in depressed patients and suicide completers, little is known about how peripheral and central inflammation might be linked in these contexts. The choroid plexus (ChP), a highly vascularized…
Ce que la microscopie peut nous apprendre sur le suicide
La neuroanatomie fine des troubles de l’humeur et du suicide est une discipline relativement récente. En complément à la neuroimagerie, à la biologie moléculaire et à la biochimie, les analyses histologiques post-mortem des circuiteries cérébrales impliquées dans la régulation de l’humeur permettent de mieux comprendre les mécanismes cellulaires et moléculaires qui sous-tendent la dépression majeure et le suicide. Dans cet article, je discute de …
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Ce que la microscopie peut nous apprendre sur le suicide
La neuroanatomie fine des troubles de l’humeur et du suicide est une discipline relativement récente. En complément à la neuroimagerie, à la biologie moléculaire et à la biochimie, les analyses histologiques post-mortem des circuiteries cérébrales impliquées dans la régulation de l’humeur permettent de mieux comprendre les mécanismes cellulaires et moléculaires qui sous-tendent la dépression majeure et le suicide. Dans cet article, je discute de …
Cellular and Molecular Inflammatory Profile of the Choroid Plexus in Depression and Suicide
The inflammatory hypothesis of depression is one of the main theories that endeavors to explain and describe the underlying biological mechanisms of depression and suicide. While mounting evidence indicates altered peripheral and central inflammatory profiles in depressed patients and suicide completers, little is known about how peripheral and central inflammation might be linked in these contexts. The choroid plexus (ChP), a highly vascularized…
Effects of Mindfulness-Based Cognitive Therapy on Peripheral Markers of Stress and Inflammation in Older-Adults With Depression and Anxiety
Background: Depression and anxiety are prevalent in older-adults and often difficult to treat: up to 55% of patients are unresponsive to pharmacotherapy. Mindfulness-Based Cognitive Therapy (MBCT) is a promising treatment, however, its biological mechanisms remain unknown in older-adults. Methods: We examined if, in older-adults, decreased depression and anxiety symptoms after MBCT are associated with changes in the expression levels of C-reactiv…
Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However, it remains unclear whether astrocytic subpopulations IR for other astrocytic markers are similarly affected. Astrocytes IR to vimentin (VIM) display different regional densities than GFAP-IR astrocytes in the healthy brain, and so may be differently altered in depre…
DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex
Results from our study highlight that CUD is associated with epigenome-wide differences in DNAm levels in BA9 particularly related to synaptic signaling and neuroplasticity. This supports findings from previous studies that report on the strong impact of cocaine on neurocircuits in the human prefrontal cortex (PFC). Further studies are needed to follow up on the role of epigenetic alterations in CUD focusing on the integration of epigenetic signa…
Biology (4 works) · Medicine (4 works) · Neuroscience (4 works) · Tryptophan and brain disorders (4 works) · Neuroinflammation and Neurodegeneration Mechanisms (3 works) · Psychology (3 works) · Anxiety (2 works) · Central nervous system (2 works) · Cognition (2 works) · Inflammation (2 works)