Zhiyu Chen
Biographic Data
| ID | 6577397 |
|---|---|
| NAME | Zhiyu Chen |
| GIVEN NAMES | Zhiyu |
| FAMILY NAME | Chen |
| SIGNATURE | CHEN Z |
| AFFILIATIONS | Hangzhou Seventh Peoples Hospital |
| ORCID | 0000-0001-7937-642X |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 16 |
| WORKS AS AUTHOR | 14 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2011 |
| LATEST PUBLICATION YEAR | 2027 |
| H-INDEX | 1 |
Celastrol targets FGFR1 to attenuate synovial inflammation and joint destruction in rheumatoid arthritis
ETHNOPHARMACOLOGICAL RELEVANCE: Natural products from traditional medicinal plants are valuable sources for discovering bioactive molecules targeting disease-relevant pathways. Tripterygium wilfordii Hook. f. has been traditionally used in Chinese medicine for rheumatic and inflammatory disorders. In this study, celastrol, a pentacyclic triterpenoid originally isolated from T. wilfordii, was identified through target-oriented natural product scre…
Reforming the white coat economy
Objective This study aimed to construct a reproducible sample of judicially visible healthcare corruption in China, identify its typologies, risk nodes, actor structures, and elucidate the institutional mechanisms underlying representative cases. Methods An explanatory sequential mixed-methods design was used. Criminal judgments with dates from 1 September 2019 to 31 December 2025 were retrieved from China Judgments Online in January 2026 and scr…
Association Between Adverse Childhood Experiences and Diabetes in Chinese Adults
The correlation between adverse childhood experiences (ACEs) and both diabetes mellitus (DM) prevalence and comorbidity is an underexplored research area in China. Understanding the mechanisms by which this relationship might be attenuated or mitigated is crucial. This study examines the correlation between ACEs and DM, including its comorbidities, and assesses whether lifestyle factors mediate this relationship in a Chinese population. Data were…
A w-ACT model for sarcopenia among community-dwelling older adults based on National Basic Public Health Services
Background: Sarcopenia leads to substantial health and well-being impairments in older adults, underscoring the need for early detection to facilitate intervention. Despite its importance, community settings face challenges with data accessibility, model interpretability, and predictive accuracy. Objective: To develop a local, data-driven, machine learning-based predictive model aimed at identifying high-risk sarcopenia populations among communit…
KGNext
The next point-of-interest (POI) recommendation aims to predict users’ future movements based on their historical trajectories. However, in reality, users may provide uncertain check-in records, resulting in uploaded data that lack precise location information and is instead ambiguous. Despite this challenge, only a limited number of studies have addressed this issue, often overlooking the intricate interactions among users, POIs, and POI categor…
Using a longitudinal network structure to subgroup depressive symptoms among adolescents
Background Network modeling has been proposed as an effective approach to examine complex associations among antecedents, mediators and symptoms. This study aimed to investigate whether the severity of depressive symptoms affects the multivariate relationships among symptoms and mediating factors over a 2-year longitudinal follow-up. Methods We recruited a school-based cohort of 1480 primary and secondary school students over four semesters from …
Effects of aripiprazole on prolactin levels and differences in effectiveness in patients with schizophrenia
In this real-world study, for patients with acute schizophrenia, aripiprazole was effective in lowering the proportion of patients with abnormal prolactin levels, while it had no significant effect on patients with normal baseline prolactin. After adjusting for factors such as sex, age, prior antipsychotic drugs use history and disease severity, effectiveness and safety of aripiprazole in patients with normal baseline prolactin was significantly …
The Terminalia chebula Retz extract treats hyperuricemic nephropathy by inhibiting TLR4/MyD88/NF-κB axis
Adoption Intention and Factors Influencing the Use of Gerontechnology in Chinese Community-Dwelling Older Adults
Objective: To explore the Chinese community-dwelling intention of older adults to adopt gerontechnology and its influencing factors. Design: A mixed-methods sequential explanatory design with an inductive approach was employed. In phase 1, a self-made questionnaire was administered from August 2018 to December 2019. Multifactor logistic regression was used to analyze the adoption intention and factors influencing the use of gerontechnology. In ph…
Disturbances of Dynamic Function in Patients With Bipolar Disorder I and Its Relationship With Executive-Function Deficit
Abnormity in brain regional function and inter-regional cooperation have been linked with the dysfunction during cognitive and emotional processing in bipolar disorder (BD) patients. Recent evidences have suggested that brain function is not static but temporal dynamic. In present study, we aimed to characterize the temporal dynamics of regional function and inter-regional cooperation in BD and its relationship with executive dysfunction, an impo…
Health-related quality of life and its influencing factors in Chinese with knee osteoarthritis
Risk Factors for Recent Suicide Attempts in Major Depressive Disorder Patients in China
Objective: To analyze the factors associated with recent suicide attempts including socio-demographic and clinical characteristics in major depressive disorder (MDD) patients in China. Methods: The data were from a nationwide sample from 13 major psychiatric hospitals or the psychiatric units of general hospitals in China, from September 1, 2010 to February 28, 2011. Melancholic features and suicide attempts in the past month were defined accordi…
A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice
The role of the family in institutional long‐term care
Zhan HJ, The role of the family in institutional long‐term care – cultural management of filial piety in China Int J Soc Welfare 2011: 20: S121–S134 © 2011 The Author(s), International Journal of Social Welfare © 2011 Blackwell Publishing Ltd and the International Journal of Social Welfare. This study used both qualitative and quantitative data collected in Nanjing, China, from 2008 to 2009, to examine the role of the family in long‐term institut…
The role of the family in institutional long‐term care
Zhan HJ, The role of the family in institutional long‐term care – cultural management of filial piety in China Int J Soc Welfare 2011: 20: S121–S134 © 2011 The Author(s), International Journal of Social Welfare © 2011 Blackwell Publishing Ltd and the International Journal of Social Welfare. This study used both qualitative and quantitative data collected in Nanjing, China, from 2008 to 2009, to examine the role of the family in long‐term institut…
The role of the family in institutional long‐term care
Zhan HJ, The role of the family in institutional long‐term care – cultural management of filial piety in China Int J Soc Welfare 2011: 20: S121–S134 © 2011 The Author(s), International Journal of Social Welfare © 2011 Blackwell Publishing Ltd and the International Journal of Social Welfare. This study used both qualitative and quantitative data collected in Nanjing, China, from 2008 to 2009, to examine the role of the family in long‐term institut…
A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice
Risk Factors for Recent Suicide Attempts in Major Depressive Disorder Patients in China
Objective: To analyze the factors associated with recent suicide attempts including socio-demographic and clinical characteristics in major depressive disorder (MDD) patients in China. Methods: The data were from a nationwide sample from 13 major psychiatric hospitals or the psychiatric units of general hospitals in China, from September 1, 2010 to February 28, 2011. Melancholic features and suicide attempts in the past month were defined accordi…
Disturbances of Dynamic Function in Patients With Bipolar Disorder I and Its Relationship With Executive-Function Deficit
Abnormity in brain regional function and inter-regional cooperation have been linked with the dysfunction during cognitive and emotional processing in bipolar disorder (BD) patients. Recent evidences have suggested that brain function is not static but temporal dynamic. In present study, we aimed to characterize the temporal dynamics of regional function and inter-regional cooperation in BD and its relationship with executive dysfunction, an impo…
Health-related quality of life and its influencing factors in Chinese with knee osteoarthritis
Adoption Intention and Factors Influencing the Use of Gerontechnology in Chinese Community-Dwelling Older Adults
Objective: To explore the Chinese community-dwelling intention of older adults to adopt gerontechnology and its influencing factors. Design: A mixed-methods sequential explanatory design with an inductive approach was employed. In phase 1, a self-made questionnaire was administered from August 2018 to December 2019. Multifactor logistic regression was used to analyze the adoption intention and factors influencing the use of gerontechnology. In ph…
KGNext
The next point-of-interest (POI) recommendation aims to predict users’ future movements based on their historical trajectories. However, in reality, users may provide uncertain check-in records, resulting in uploaded data that lack precise location information and is instead ambiguous. Despite this challenge, only a limited number of studies have addressed this issue, often overlooking the intricate interactions among users, POIs, and POI categor…
Using a longitudinal network structure to subgroup depressive symptoms among adolescents
Background Network modeling has been proposed as an effective approach to examine complex associations among antecedents, mediators and symptoms. This study aimed to investigate whether the severity of depressive symptoms affects the multivariate relationships among symptoms and mediating factors over a 2-year longitudinal follow-up. Methods We recruited a school-based cohort of 1480 primary and secondary school students over four semesters from …
Effects of aripiprazole on prolactin levels and differences in effectiveness in patients with schizophrenia
In this real-world study, for patients with acute schizophrenia, aripiprazole was effective in lowering the proportion of patients with abnormal prolactin levels, while it had no significant effect on patients with normal baseline prolactin. After adjusting for factors such as sex, age, prior antipsychotic drugs use history and disease severity, effectiveness and safety of aripiprazole in patients with normal baseline prolactin was significantly …
The Terminalia chebula Retz extract treats hyperuricemic nephropathy by inhibiting TLR4/MyD88/NF-κB axis
A w-ACT model for sarcopenia among community-dwelling older adults based on National Basic Public Health Services
Background: Sarcopenia leads to substantial health and well-being impairments in older adults, underscoring the need for early detection to facilitate intervention. Despite its importance, community settings face challenges with data accessibility, model interpretability, and predictive accuracy. Objective: To develop a local, data-driven, machine learning-based predictive model aimed at identifying high-risk sarcopenia populations among communit…
Reforming the white coat economy
Objective This study aimed to construct a reproducible sample of judicially visible healthcare corruption in China, identify its typologies, risk nodes, actor structures, and elucidate the institutional mechanisms underlying representative cases. Methods An explanatory sequential mixed-methods design was used. Criminal judgments with dates from 1 September 2019 to 31 December 2025 were retrieved from China Judgments Online in January 2026 and scr…
Association Between Adverse Childhood Experiences and Diabetes in Chinese Adults
The correlation between adverse childhood experiences (ACEs) and both diabetes mellitus (DM) prevalence and comorbidity is an underexplored research area in China. Understanding the mechanisms by which this relationship might be attenuated or mitigated is crucial. This study examines the correlation between ACEs and DM, including its comorbidities, and assesses whether lifestyle factors mediate this relationship in a Chinese population. Data were…
Celastrol targets FGFR1 to attenuate synovial inflammation and joint destruction in rheumatoid arthritis
ETHNOPHARMACOLOGICAL RELEVANCE: Natural products from traditional medicinal plants are valuable sources for discovering bioactive molecules targeting disease-relevant pathways. Tripterygium wilfordii Hook. f. has been traditionally used in Chinese medicine for rheumatic and inflammatory disorders. In this study, celastrol, a pentacyclic triterpenoid originally isolated from T. wilfordii, was identified through target-oriented natural product scre…
Medicine (10 works) · Psychology (7 works) · Internal Medicine (6 works) · Psychiatry (5 works) · Gerontology (4 works) · Diabetes mellitus (3 works) · Endocrinology (3 works) · Bipolar Disorder and Treatment (2 works) · China (2 works) · Clinical Psychology (2 works)