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Kirkby D Tickell

Dados Biográficos

ID7000255
NOMEKirkby D Tickell
PRENOMESKirkby D
SOBRENOMETickell
ASSINATURATICKELL K D
AFILIAÇÕESUniversity of Washington
ORCID0000-0002-4108-1236
VERIFICADOSim
TOTAL DE OBRAS7
TOTAL DE CITAÇÕES0
TOTAL COMO AUTOR7
TOTAL COMO EDITOR0
PRIMEIRO ANO DE PUBLICAÇÃO2023
ANO MAIS RECENTE DE PUBLICAÇÃO2026
ÍNDICE H0
  • Enteric dysfunction and enteropathogens among hospitalized south Asian and sub-Saharan African children

    Open Access•Abu Sadat Mohammad Sayeem Bin Shahid, Donna M Denno et al.•ARTICLE•PLOS Global Public Health•2026

    Enteropathogens and enteric dysfunction (ED) among acutely ill children in low-and-middle income countries (LMICs) may contribute to poor post-discharge outcomes. Enteropathogen prevalence and fecal ED biomarkers (myeloperoxidase, calprotectin, α-1-antitrypsin) from children aged 2–23 months hospitalized at nine LMIC facilities (n = 811) were compared to community children (n = 248). Host and pathogen correlates of ED biomarkers were identified t…

  • Effect of azithromycin on post-discharge growth in Kenyan children

    Open Access•Hannah E Atlas, Polycarp Mogeni et al.•ARTICLE•BMJ Global Health•2025

    INTRODUCTION: Children discharged following hospitalisation for acute illnesses in low- and middle-income settings are at increased risk of poor growth, particularly linear growth faltering. We aimed to determine the effect of azithromycin administered at hospital discharge on post-discharge growth. METHODS: Using data from the Toto Bora Trial (NCT02414399), a double-blind, placebo-controlled randomised trial of a 5-day course of azithromycin in …

  • Aflatoxin exposure and mortality in acutely ill children

    Open Access•Lei Xia, Hang Wu et al.•ARTICLE•BMJ Global Health•2025

    BACKGROUND: Chronic exposure to aflatoxins is associated with liver cancer, impaired child growth, and compromised immune function. The Childhood Acute Illness and Nutrition (CHAIN) Network cohort was established to identify risk factors for mortality in acutely ill children admitted to nine hospitals in four African and two South Asian countries. We examined the role of aflatoxin exposure in inpatient and post-discharge mortality. METHODS: In a …

  • The diagnosis and management of dehydration in children with wasting or nutritional edema

    Open Access•Adino Tesfahun Tsegaye, Patricia B Pavlinac et al.•ARTICLE•PLOS Global Public Health•2023

    Dehydration is a major cause of death among children with wasting and diarrhea. We reviewed the evidence for the identification and management of dehydration among these children. Two systematic reviews were conducted to assess 1) the diagnostic performance of clinical signs or algorithms intended to measure dehydration, and 2) the efficacy and safety of low-osmolarity ORS versus ReSoMal on mortality, treatment failure, time to full rehydration, …

  • Clinical epidemiology of Covid-19 among hospitalized children in rural western Kenya

    Open Access•Adino Tesfahun Tsegaye, Christina Sherry et al.•ARTICLE•PLOS Global Public Health•2023

    The epidemiology of pediatric COVID-19 in sub-Saharan Africa and the role of fecal-oral transmission in SARS-CoV-2 are poorly understood. Among children and adolescents in Kenya, we identify correlates of COVID-19 infection, document the clinical outcomes of infection, and evaluate the prevalence and viability of SARS-CoV-2 in stool. We recruited a prospective cohort of hospitalized children aged two months to 15 years in western Kenya between Ma…

  • Considering Risks to Researchers and Staff in Low-Resource Settings during Public Health Crises

    Open Access•Krystle Perez, Muhammad Asim et al.•ARTICLE•Children•2023

    Human subjects research protections have historically focused on mitigating risk of harm and promoting benefits for research participants. In many low-resource settings (LRS), complex and often severe challenges in daily living, poverty, geopolitical uprisings, sociopolitical, economic, and climate crises increase the burdens of even minimal risk research. While there has been important work to explore the scope of ethical responsibilities of res…

  • Minimizing error in estimates of the effect of interventions by accounting for baseline measurements

    Open Access•E Deichsel, Emily L Deichsel et al.•ARTICLE•Maternal and Child Nutrition•2023

    Interventions to reduce childhood stunting burden require clinical trials with a primary outcome of linear growth. When growth is measured longitudinally, there are several options for including baseline measurements in the analysis. This study compares the performance of several methods. Randomized controlled trials evaluating a hypothetical intervention to improve length-for-age z-score (LAZ) from birth through 24 months of age were simulated. …

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  • The diagnosis and management of dehydration in children with wasting or nutritional edema

    Open Access•Adino Tesfahun Tsegaye, Patricia B Pavlinac et al.•ARTICLE•PLOS Global Public Health•2023

    Dehydration is a major cause of death among children with wasting and diarrhea. We reviewed the evidence for the identification and management of dehydration among these children. Two systematic reviews were conducted to assess 1) the diagnostic performance of clinical signs or algorithms intended to measure dehydration, and 2) the efficacy and safety of low-osmolarity ORS versus ReSoMal on mortality, treatment failure, time to full rehydration, …

  • Clinical epidemiology of Covid-19 among hospitalized children in rural western Kenya

    Open Access•Adino Tesfahun Tsegaye, Christina Sherry et al.•ARTICLE•PLOS Global Public Health•2023

    The epidemiology of pediatric COVID-19 in sub-Saharan Africa and the role of fecal-oral transmission in SARS-CoV-2 are poorly understood. Among children and adolescents in Kenya, we identify correlates of COVID-19 infection, document the clinical outcomes of infection, and evaluate the prevalence and viability of SARS-CoV-2 in stool. We recruited a prospective cohort of hospitalized children aged two months to 15 years in western Kenya between Ma…

  • Considering Risks to Researchers and Staff in Low-Resource Settings during Public Health Crises

    Open Access•Krystle Perez, Muhammad Asim et al.•ARTICLE•Children•2023

    Human subjects research protections have historically focused on mitigating risk of harm and promoting benefits for research participants. In many low-resource settings (LRS), complex and often severe challenges in daily living, poverty, geopolitical uprisings, sociopolitical, economic, and climate crises increase the burdens of even minimal risk research. While there has been important work to explore the scope of ethical responsibilities of res…

  • Minimizing error in estimates of the effect of interventions by accounting for baseline measurements

    Open Access•E Deichsel, Emily L Deichsel et al.•ARTICLE•Maternal and Child Nutrition•2023

    Interventions to reduce childhood stunting burden require clinical trials with a primary outcome of linear growth. When growth is measured longitudinally, there are several options for including baseline measurements in the analysis. This study compares the performance of several methods. Randomized controlled trials evaluating a hypothetical intervention to improve length-for-age z-score (LAZ) from birth through 24 months of age were simulated. …

  • Effect of azithromycin on post-discharge growth in Kenyan children

    Open Access•Hannah E Atlas, Polycarp Mogeni et al.•ARTICLE•BMJ Global Health•2025

    INTRODUCTION: Children discharged following hospitalisation for acute illnesses in low- and middle-income settings are at increased risk of poor growth, particularly linear growth faltering. We aimed to determine the effect of azithromycin administered at hospital discharge on post-discharge growth. METHODS: Using data from the Toto Bora Trial (NCT02414399), a double-blind, placebo-controlled randomised trial of a 5-day course of azithromycin in …

  • Aflatoxin exposure and mortality in acutely ill children

    Open Access•Lei Xia, Hang Wu et al.•ARTICLE•BMJ Global Health•2025

    BACKGROUND: Chronic exposure to aflatoxins is associated with liver cancer, impaired child growth, and compromised immune function. The Childhood Acute Illness and Nutrition (CHAIN) Network cohort was established to identify risk factors for mortality in acutely ill children admitted to nine hospitals in four African and two South Asian countries. We examined the role of aflatoxin exposure in inpatient and post-discharge mortality. METHODS: In a …

  • Enteric dysfunction and enteropathogens among hospitalized south Asian and sub-Saharan African children

    Open Access•Abu Sadat Mohammad Sayeem Bin Shahid, Donna M Denno et al.•ARTICLE•PLOS Global Public Health•2026

    Enteropathogens and enteric dysfunction (ED) among acutely ill children in low-and-middle income countries (LMICs) may contribute to poor post-discharge outcomes. Enteropathogen prevalence and fecal ED biomarkers (myeloperoxidase, calprotectin, α-1-antitrypsin) from children aged 2–23 months hospitalized at nine LMIC facilities (n = 811) were compared to community children (n = 248). Host and pathogen correlates of ED biomarkers were identified t…

Medicine (4 obras) · Cohort (3 obras) · Child Nutrition and Water Access (2 obras) · Cohort study (2 obras) · Internal Medicine (2 obras) · Pediatrics (2 obras) · Public health (2 obras) · Aflatoxin (1 obras) · Antibiotics (1 obras) · Azithromycin (1 obras)

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