Helena Huerga
Biographic Data
| ID | 7018377 |
|---|---|
| NAME | Helena Huerga |
| GIVEN NAMES | Helena |
| FAMILY NAME | Huerga |
| SIGNATURE | HUERGA H |
| AFFILIATIONS | Epicentre, Paris, France |
| ORCID | 0000-0003-0302-9063 |
| VERIFIED | Yes |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 10 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2018 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Implementing computer‐aided detection for TB active case finding
Tuberculosis (TB) remains the leading cause of death from a single infectious agent, with over 1.23 million deaths globally in 2024. Despite available treatment and prevention strategies, timely and accurate detection remains challenging, particularly in high-burden settings such as the Philippines, which accounted for 6.8% of the global burden of TB in 2024. Computer-aided detection (CAD) software integrated with digital chest X-ray offers enhan…
Computer-aided detection pragmatic threshold calibration in TB active case finding
We developed a pragmatic approach to calibrating computer-aided detection (CAD) thresholds in a tuberculosis (TB) active case finding (ACF) project in the Philippines, assessing its feasibility and acceptability in a high-burden urban setting. CAD4TB v.7 (Delft Imaging, Netherlands) software was integrated into ACF activities targeting individuals aged ≥15 years in Tondo, Manila, from November 2022. Referrals for sputum collection and Xpert testi…
Covid-19, tuberculosis, and HIV triad
People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVID-19 present with overlapping symptoms and co-infection can lead to poor outcomes. We assessed the frequency of SARS-CoV-2 positive serology and SARS-CoV-2 infection and the risk of mortality at 6 months in PLHIV with TB disease and SARS-CoV-2 infection. This multi-country, prospective, observational study, conducted between 7 th September 2…
Behavioral HIV-serosurvey reveals clustering of risk factors likely plays a key role in sustaining HIV epidemic in rural KwaZulu-Natal, South Africa
New Human immunodeficiency virus (HIV) infections among adults have decreased in the last ten years in high HIV prevalent countries. However, unsuppressed individuals with high-risk sexual practices can play a key role in transmitting HIV and maintaining the HIV epidemic. We assessed the association between sexual behavior, HIV awareness, antiretroviral therapy (ART) intake and viral suppression, and the age-gender groups most at risk of maintain…
Comparative effectiveness of adding delamanid to a multidrug-resistant tuberculosis regimen comprised of three drugs likely to be effective
Clarity about the role of delamanid in longer regimens for multidrug-resistant TB is needed after discordant Phase IIb and Phase III randomized controlled trial results. The Phase IIb trial found that the addition of delamanid to a background regimen hastened culture conversion; the results of the Phase III trial were equivocal. We evaluated the effect of adding delamanid for 24 weeks to three-drug MDR/RR-TB regimens on two- and six-month culture…
Adolescents and young adults are the most undiagnosed of HIV and virally unsuppressed in Eastern and Southern Africa
Age and gender disparities within the HIV cascade of care are critical to focus interventions efficiently. We assessed gender-age groups at the highest probability of unfavorable outcomes in the HIV cascade in five HIV prevalent settings. We performed pooled data analyses from population-based surveys conducted in Kenya, South Africa, Malawi and Zimbabwe between 2012 and 2016. Individuals aged 15–59 years were eligible. Participants were tested f…
HIV epidemic and cascade of care in 12 east African rural fishing communities
HIV prevalence was high in these fishing communities, particularly among women and fishermen. Important progress has been made along the HIV treatment cascade, and the UNAIDS goal for viral suppression in population was achieved. However, gaps remain and HIV care strategies focusing on young people are urgently needed. HIV preventive interventions should target particularly women, young people and fishermen though HIV preventive and care services…
Distribution of advanced HIV disease from three high HIV prevalence settings in Sub-Saharan Africa
In our study, about 1 in 10 PLHIV had advanced HIV with nearly 40% of them unaware of their HIV status. However, a substantial proportion of patients with advanced HIV were established on ART. Our findings suggest the need for a dual focus on alternative testing strategies to identify PLHIV earlier as well as improving ART retention
Feasibility of using Determine TB-LAM to diagnose tuberculosis in HIV-positive patients in programmatic conditions
Background: Determine TB-LAM is a urine-based point-of-care assay for diagnosis of tuberculosis (TB).Objective: To assess the feasibility of using LAM to diagnose TB in adult HIV-positive patients in resource-limited settings.Methods: We performed a multi-centric mixed-methods cross-sectional descriptive study in the Democratic Republic of Congo, Malawi, and Mozambique. We used the study and program monitoring tools to estimate user workload, tur…
Progress towards the Unaids 90–90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa
In this context of high HIV prevalence, significant progress has been achieved with regards to reaching the UNAIDS 90-90-90 targets. The third 90, viral suppression in people on ART, was achieved among women and men. However, gaps persist in HIV diagnosis and ART coverage particularly in men and individuals younger than 30 years. Achieving 90-90-90 is feasible but requires additional investment to reach youth and men
No prominent works on this page.
Progress towards the Unaids 90–90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa
In this context of high HIV prevalence, significant progress has been achieved with regards to reaching the UNAIDS 90-90-90 targets. The third 90, viral suppression in people on ART, was achieved among women and men. However, gaps persist in HIV diagnosis and ART coverage particularly in men and individuals younger than 30 years. Achieving 90-90-90 is feasible but requires additional investment to reach youth and men
Distribution of advanced HIV disease from three high HIV prevalence settings in Sub-Saharan Africa
In our study, about 1 in 10 PLHIV had advanced HIV with nearly 40% of them unaware of their HIV status. However, a substantial proportion of patients with advanced HIV were established on ART. Our findings suggest the need for a dual focus on alternative testing strategies to identify PLHIV earlier as well as improving ART retention
Feasibility of using Determine TB-LAM to diagnose tuberculosis in HIV-positive patients in programmatic conditions
Background: Determine TB-LAM is a urine-based point-of-care assay for diagnosis of tuberculosis (TB).Objective: To assess the feasibility of using LAM to diagnose TB in adult HIV-positive patients in resource-limited settings.Methods: We performed a multi-centric mixed-methods cross-sectional descriptive study in the Democratic Republic of Congo, Malawi, and Mozambique. We used the study and program monitoring tools to estimate user workload, tur…
HIV epidemic and cascade of care in 12 east African rural fishing communities
HIV prevalence was high in these fishing communities, particularly among women and fishermen. Important progress has been made along the HIV treatment cascade, and the UNAIDS goal for viral suppression in population was achieved. However, gaps remain and HIV care strategies focusing on young people are urgently needed. HIV preventive interventions should target particularly women, young people and fishermen though HIV preventive and care services…
Comparative effectiveness of adding delamanid to a multidrug-resistant tuberculosis regimen comprised of three drugs likely to be effective
Clarity about the role of delamanid in longer regimens for multidrug-resistant TB is needed after discordant Phase IIb and Phase III randomized controlled trial results. The Phase IIb trial found that the addition of delamanid to a background regimen hastened culture conversion; the results of the Phase III trial were equivocal. We evaluated the effect of adding delamanid for 24 weeks to three-drug MDR/RR-TB regimens on two- and six-month culture…
Adolescents and young adults are the most undiagnosed of HIV and virally unsuppressed in Eastern and Southern Africa
Age and gender disparities within the HIV cascade of care are critical to focus interventions efficiently. We assessed gender-age groups at the highest probability of unfavorable outcomes in the HIV cascade in five HIV prevalent settings. We performed pooled data analyses from population-based surveys conducted in Kenya, South Africa, Malawi and Zimbabwe between 2012 and 2016. Individuals aged 15–59 years were eligible. Participants were tested f…
Covid-19, tuberculosis, and HIV triad
People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVID-19 present with overlapping symptoms and co-infection can lead to poor outcomes. We assessed the frequency of SARS-CoV-2 positive serology and SARS-CoV-2 infection and the risk of mortality at 6 months in PLHIV with TB disease and SARS-CoV-2 infection. This multi-country, prospective, observational study, conducted between 7 th September 2…
Behavioral HIV-serosurvey reveals clustering of risk factors likely plays a key role in sustaining HIV epidemic in rural KwaZulu-Natal, South Africa
New Human immunodeficiency virus (HIV) infections among adults have decreased in the last ten years in high HIV prevalent countries. However, unsuppressed individuals with high-risk sexual practices can play a key role in transmitting HIV and maintaining the HIV epidemic. We assessed the association between sexual behavior, HIV awareness, antiretroviral therapy (ART) intake and viral suppression, and the age-gender groups most at risk of maintain…
Implementing computer‐aided detection for TB active case finding
Tuberculosis (TB) remains the leading cause of death from a single infectious agent, with over 1.23 million deaths globally in 2024. Despite available treatment and prevention strategies, timely and accurate detection remains challenging, particularly in high-burden settings such as the Philippines, which accounted for 6.8% of the global burden of TB in 2024. Computer-aided detection (CAD) software integrated with digital chest X-ray offers enhan…
Computer-aided detection pragmatic threshold calibration in TB active case finding
We developed a pragmatic approach to calibrating computer-aided detection (CAD) thresholds in a tuberculosis (TB) active case finding (ACF) project in the Philippines, assessing its feasibility and acceptability in a high-burden urban setting. CAD4TB v.7 (Delft Imaging, Netherlands) software was integrated into ACF activities targeting individuals aged ≥15 years in Tondo, Manila, from November 2022. Referrals for sputum collection and Xpert testi…
Internal Medicine (7 works) · Medicine (7 works) · Cross-sectional study (5 works) · HIV/AIDS Research and Interventions (5 works) · Tuberculosis Research and Epidemiology (5 works) · Adolescent Sexual and Reproductive Health (4 works) · Demography (4 works) · Immunology (4 works) · Tuberculosis (4 works) · Viral load (4 works)