Patrick J Lustman
Biographic Data
| ID | 7119763 |
|---|---|
| NAME | Patrick J Lustman |
| GIVEN NAMES | Patrick J |
| FAMILY NAME | Lustman |
| SIGNATURE | LUSTMAN P J |
| AFFILIATIONS | Washington University in St. Louis |
| VERIFIED | No |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1986 |
| LATEST PUBLICATION YEAR | 2021 |
| H-INDEX | 0 |
Opioid dosing among patients with 3 or more years of continuous prescription opioid use before and after the CDC opioid prescribing guideline
Association of Anxiety Disorders and Depression With Incident Heart Failure
OBJECTIVE: Depression has been associated with increased risk of heart failure (HF). Because anxiety is highly comorbid with depression, we sought to establish if anxiety, depression, or their co-occurrence is associated with incident HF. METHODS: A retrospective cohort (N = 236,079) including Veteran's Administration patients (age, 50-80 years) free of cardiovascular disease (CVD) at baseline was followed up between 2001 and 2007. Cox proportion…
Depression in Diabetes: The Chicken or the Egg
Department of Psychiatry, Washington University School of Medicine, Department of Veterans Affairs Medical Center, St. Louis, Missouri (Lustman) Department of Medicine, Washington University School of Medicine, St. Louis, Missouri (Clouse)
Predictors of Premature Antidepressant Discontinuation in Functional Gastrointestinal Disorders
OBJECTIVES: To identify factors responsible for premature antidepressant discontinuation that would assist in designing management strategies for patients with functional gastrointestinal disorders. Antidepressants are being used increasingly to manage patients with functional gastrointestinal disorders; poor patient adherence to treatment regimens, particularly in the period shortly after antidepressant initiation, is common and interferes with …
Depression, Anxiety, and Nonalcoholic Steatohepatitis
Objective: Nonalcoholic steatohepatitis (NASH) is a morbid liver disease with limited treatment. Depression and anxiety have been associated recently with insulin resistance and inflammatory states, factors that are relevant to the development of NASH. We hypothesized that depression and anxiety would be more prevalent in NASH patients and predict more severe histological findings on liver biopsy. Methods: Histories of major depressive disorder (…
Depression-Related Hyperglycemia in Type 1 Diabetes: A Mediational Approach
OBJECTIVE: Depression is linked with hyperglycemia and with an increased risk for diabetes complications, but the mechanisms underlying these relationships have not been established. In this study, we applied mediational analysis methods to determine whether the hyperglycemic effect of depression could be mediated by poor diabetes self-care. METHODS: Depression symptoms and diabetes self-care activity were assessed in a primary care sample of 188…
Depression and Coronary Heart Disease in Women With Diabetes
OBJECTIVE: The protective effects of female gender on the appearance and course of coronary heart disease (CHD) in nondiabetic subjects are diminished in the presence of diabetes. Depression predicts onset of and poor outcome from CHD in nondiabetic populations. We hypothesized that the doubled rates of depression in female diabetic patients could help explain the high prevalence of CHD in women with diabetes. METHOD: Seventy-six female type 1 an…
What Does the Keane PTSD Scale of the MMPI Measure? Repeated Measurements in a Group of Patients with Major Depression
We looked at a group of depressed patients in a treatment study, none of whom by study design had Posttraumatic Stress Disorder (PTSD). High scores on the PTSD (PK) scale could only be due to factors other than PTSD. Despite the absence of PTSD, we observed an extremely high false positive rate in a group given the MMPI on multiple occasions. 92% of the subjects had at least one T score at or above 65 on the PK scale. 44% of the men and the women…
The Prevalence of Comorbid Depression in Adults With Diabetes
OBJECTIVE—To estimate the odds and prevalence of clinically relevant depression in adults with type 1 or type 2 diabetes. Depression is associated with hyperglycemia and an increased risk for diabetic complications; relief of depression is associated with improved glycemic control. A more accurate estimate of depression prevalence than what is currently available is needed to gauge the potential impact of depression management in diabetes. RESEAR…
Association of Depression and Diabetes Complications: A Meta-Analysis
Depression and poor glycemic control: A meta-analytic review of the literature.
OBJECTIVE: Depression is common among patients with diabetes, but its relationship to glycemic control has not been systematically reviewed. Our objective was to determine whether depression is associated with poor glycemic control. RESEARCH DESIGN AND METHODS: Medline and PsycINFO databases and published reference lists were used to identify studies that measured the association of depression with glycemic control. Meta-analytic procedures were …
Screening for Depression in Diabetes Using the Beck Depression Inventory
OBJECTIVE: The purpose of this study was to determine the utility of the Beck Depression Inventory (BDI) as a screening tool for major depression in diabetes. METHOD: One hundred seventy-two diabetic outpatients (insulin-dependent diabetes mellitus [IDDM] = 59, or non-insulin-dependent diabetes mellitus [NIDDM] = 113) being evaluated for a treatment trial were studied. BDI scores were calculated for the complete 21-item measure as well as for the…
Effects of Nortriptyline on Depression and Glycemic Control in Diabetes: Results of a Double-blind, Placebo-controlled Trial
OBJECTIVE: Depression is a prevalent and chronic condition in diabetes and is associated with poor glucose regulation and poor compliance with diabetes treatment. This investigation evaluated the effects of nortriptyline on depression and glycemic control to see whether depression in diabetes is treatable and whether restoring mental health contributes to improved medical outcome. METHOD: Sixty-eight diabetic patients with poor glycemic control, …
Similarity of depression in diabetic and psychiatric patients
Diabetic and psychiatric out-patients were studied to determine whether the symptom profile of depression was similar in medically ill and medically well subjects. The diagnosis of major depression was determined using psychiatric interviews and DSM-IIIR criteria. The 21-item Beck Depression Inventory (BDI) was used to characterize the prevalence and severity of depression symptoms, and the measure was divided into cognitive (13 symptoms) and som…
Major depression in coronary artery disease patients with vs. without a prior history of depression
Major depression (MD) is common in patients with coronary artery disease (CAD). Some of these patients have a history of prior depressive episodes, whereas others experience their first episode around the same time that their CAD is diagnosed. The purpose of this study was to determine whether there are systematic differences between these two subgroups of depressed patients. Of 39 patients with recently diagnosed CAD who met DSM-III-R criteria f…
Relationship of personality characteristics to glucose regulation in adults with diabetes
Personality characteristics were assessed in 139 diabetic adults (insulin-dependent diabetes mellitus = 84, non-insulin-dependent diabetes mellitus = 55) to determine whether a relationship existed between glucose regulation and the measured psychological features. Cloninger's Tridimensional Personality Questionnaire (TPQ) was used to evaluate personality while glycated hemoglobin provided an estimate of recent glucose control. Mean glycated hemo…
Value of recent psychological symptoms in identifying patients with esophageal contraction abnormalities
One hundred thirty-six (136) patients referred for manometry were studied to see if a multidimensional psychometric inventory could differentiate those with esophageal contraction abnormalities from subjects with other manometric diagnoses. Contraction abnormalities are manometric findings commonly used to support the diagnosis of esophageal spasm syndrome. Recent psychological symptoms were determined using the Hopkins Symptom Checklist (SCL-90R…
Evaluating Stressful Life Events
This research examines the effects of combining existing stress measures into one psychometric hybrid assessment tool. This process uses the severity of experienced life events and individual perception of those events to assess an individual's current stress level. This stress level is reflected globally in a Total Change Scale and delimited by three scales-Negative Change, Positive Change, and Impact. The psychometric hybrid significantly predi…
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Evaluating Stressful Life Events
This research examines the effects of combining existing stress measures into one psychometric hybrid assessment tool. This process uses the severity of experienced life events and individual perception of those events to assess an individual's current stress level. This stress level is reflected globally in a Total Change Scale and delimited by three scales-Negative Change, Positive Change, and Impact. The psychometric hybrid significantly predi…
Value of recent psychological symptoms in identifying patients with esophageal contraction abnormalities
One hundred thirty-six (136) patients referred for manometry were studied to see if a multidimensional psychometric inventory could differentiate those with esophageal contraction abnormalities from subjects with other manometric diagnoses. Contraction abnormalities are manometric findings commonly used to support the diagnosis of esophageal spasm syndrome. Recent psychological symptoms were determined using the Hopkins Symptom Checklist (SCL-90R…
Relationship of personality characteristics to glucose regulation in adults with diabetes
Personality characteristics were assessed in 139 diabetic adults (insulin-dependent diabetes mellitus = 84, non-insulin-dependent diabetes mellitus = 55) to determine whether a relationship existed between glucose regulation and the measured psychological features. Cloninger's Tridimensional Personality Questionnaire (TPQ) was used to evaluate personality while glycated hemoglobin provided an estimate of recent glucose control. Mean glycated hemo…
Similarity of depression in diabetic and psychiatric patients
Diabetic and psychiatric out-patients were studied to determine whether the symptom profile of depression was similar in medically ill and medically well subjects. The diagnosis of major depression was determined using psychiatric interviews and DSM-IIIR criteria. The 21-item Beck Depression Inventory (BDI) was used to characterize the prevalence and severity of depression symptoms, and the measure was divided into cognitive (13 symptoms) and som…
Major depression in coronary artery disease patients with vs. without a prior history of depression
Major depression (MD) is common in patients with coronary artery disease (CAD). Some of these patients have a history of prior depressive episodes, whereas others experience their first episode around the same time that their CAD is diagnosed. The purpose of this study was to determine whether there are systematic differences between these two subgroups of depressed patients. Of 39 patients with recently diagnosed CAD who met DSM-III-R criteria f…
Screening for Depression in Diabetes Using the Beck Depression Inventory
OBJECTIVE: The purpose of this study was to determine the utility of the Beck Depression Inventory (BDI) as a screening tool for major depression in diabetes. METHOD: One hundred seventy-two diabetic outpatients (insulin-dependent diabetes mellitus [IDDM] = 59, or non-insulin-dependent diabetes mellitus [NIDDM] = 113) being evaluated for a treatment trial were studied. BDI scores were calculated for the complete 21-item measure as well as for the…
Effects of Nortriptyline on Depression and Glycemic Control in Diabetes: Results of a Double-blind, Placebo-controlled Trial
OBJECTIVE: Depression is a prevalent and chronic condition in diabetes and is associated with poor glucose regulation and poor compliance with diabetes treatment. This investigation evaluated the effects of nortriptyline on depression and glycemic control to see whether depression in diabetes is treatable and whether restoring mental health contributes to improved medical outcome. METHOD: Sixty-eight diabetic patients with poor glycemic control, …
Depression and poor glycemic control: A meta-analytic review of the literature.
OBJECTIVE: Depression is common among patients with diabetes, but its relationship to glycemic control has not been systematically reviewed. Our objective was to determine whether depression is associated with poor glycemic control. RESEARCH DESIGN AND METHODS: Medline and PsycINFO databases and published reference lists were used to identify studies that measured the association of depression with glycemic control. Meta-analytic procedures were …
The Prevalence of Comorbid Depression in Adults With Diabetes
OBJECTIVE—To estimate the odds and prevalence of clinically relevant depression in adults with type 1 or type 2 diabetes. Depression is associated with hyperglycemia and an increased risk for diabetic complications; relief of depression is associated with improved glycemic control. A more accurate estimate of depression prevalence than what is currently available is needed to gauge the potential impact of depression management in diabetes. RESEAR…
Association of Depression and Diabetes Complications: A Meta-Analysis
Depression and Coronary Heart Disease in Women With Diabetes
OBJECTIVE: The protective effects of female gender on the appearance and course of coronary heart disease (CHD) in nondiabetic subjects are diminished in the presence of diabetes. Depression predicts onset of and poor outcome from CHD in nondiabetic populations. We hypothesized that the doubled rates of depression in female diabetic patients could help explain the high prevalence of CHD in women with diabetes. METHOD: Seventy-six female type 1 an…
What Does the Keane PTSD Scale of the MMPI Measure? Repeated Measurements in a Group of Patients with Major Depression
We looked at a group of depressed patients in a treatment study, none of whom by study design had Posttraumatic Stress Disorder (PTSD). High scores on the PTSD (PK) scale could only be due to factors other than PTSD. Despite the absence of PTSD, we observed an extremely high false positive rate in a group given the MMPI on multiple occasions. 92% of the subjects had at least one T score at or above 65 on the PK scale. 44% of the men and the women…
Depression-Related Hyperglycemia in Type 1 Diabetes: A Mediational Approach
OBJECTIVE: Depression is linked with hyperglycemia and with an increased risk for diabetes complications, but the mechanisms underlying these relationships have not been established. In this study, we applied mediational analysis methods to determine whether the hyperglycemic effect of depression could be mediated by poor diabetes self-care. METHODS: Depression symptoms and diabetes self-care activity were assessed in a primary care sample of 188…
Depression, Anxiety, and Nonalcoholic Steatohepatitis
Objective: Nonalcoholic steatohepatitis (NASH) is a morbid liver disease with limited treatment. Depression and anxiety have been associated recently with insulin resistance and inflammatory states, factors that are relevant to the development of NASH. We hypothesized that depression and anxiety would be more prevalent in NASH patients and predict more severe histological findings on liver biopsy. Methods: Histories of major depressive disorder (…
Depression in Diabetes: The Chicken or the Egg
Department of Psychiatry, Washington University School of Medicine, Department of Veterans Affairs Medical Center, St. Louis, Missouri (Lustman) Department of Medicine, Washington University School of Medicine, St. Louis, Missouri (Clouse)
Predictors of Premature Antidepressant Discontinuation in Functional Gastrointestinal Disorders
OBJECTIVES: To identify factors responsible for premature antidepressant discontinuation that would assist in designing management strategies for patients with functional gastrointestinal disorders. Antidepressants are being used increasingly to manage patients with functional gastrointestinal disorders; poor patient adherence to treatment regimens, particularly in the period shortly after antidepressant initiation, is common and interferes with …
Association of Anxiety Disorders and Depression With Incident Heart Failure
OBJECTIVE: Depression has been associated with increased risk of heart failure (HF). Because anxiety is highly comorbid with depression, we sought to establish if anxiety, depression, or their co-occurrence is associated with incident HF. METHODS: A retrospective cohort (N = 236,079) including Veteran's Administration patients (age, 50-80 years) free of cardiovascular disease (CVD) at baseline was followed up between 2001 and 2007. Cox proportion…
Opioid dosing among patients with 3 or more years of continuous prescription opioid use before and after the CDC opioid prescribing guideline
Medicine (15 works) · Internal Medicine (13 works) · Depression (economics) (12 works) · Internal Medicine (12 works) · Diabetes mellitus (10 works) · Endocrinology (10 works) · Psychiatry (10 works) · Diabetes Management and Education (9 works) · Anxiety (8 works) · Endocrinology (8 works)