Klaus-Peter Lesch

Datos Biográficos

ID7369362
NOMBREKlaus-Peter Lesch
NOMBRESKlaus-Peter
APELLIDOLesch
FIRMALESCH K
AFILIACIONESSechenov University
ORCID0000-0001-8348-153X
VERIFICADOSí
TOTAL DE OBRAS7
TOTAL DE CITAS0
TOTAL COMO AUTOR7
TOTAL COMO EDITOR0
PRIMER AÑO DE PUBLICACIÓN1996
AÑO MÁS RECIENTE DE PUBLICACIÓN2023
ÍNDICE H0

  • Genome‐wide DNA methylation analysis of aggressive behaviour

    Open AccessEhsan Pishva, Daniel L A van den Hove et al.ARTICLEJournal of Child Psychology and…2023

    BACKGROUND: Human aggression is influenced by an interplay between genetic predisposition and experience across the life span. This interaction is thought to occur through epigenetic mechanisms, inducing differential gene expression, thereby moderating neuronal cell and circuit function, and thus shaping aggressive behaviour. METHODS: Genome-wide DNA methylation (DNAm) levels were measured in peripheral blood obtained from 95 individuals particip…

  • Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

    Open AccessMerel C Postema, Martine Hoogman et al.ARTICLEJournal of Child Psychology and…2021

    OBJECTIVE: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. METHODS: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 una…

  • Impulsivity and Venturesomeness in an Adult ADHD Sample

    Open AccessO Grimm, Heike Weber et al.ARTICLEFrontiers in Psychiatry2020

    While impulsivity is a basic feature of attention-deficit/hyperactivity disorder (ADHD), no study explored the effect of different components of the Impulsiveness (Imp) and Venturesomeness (Vent) scale (IV7) on psychiatric comorbidities and an ADHD polygenic risk score (PRS). We used the IV7 self-report scale in an adult ADHD sample of 903 patients, 70% suffering from additional comorbid disorders, and in a subsample of 435 genotyped patients. Ve…

  • Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

    Open AccessDitte Demontis, 23andMe Research Team et al.ARTICLENature Genetics2019

    Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in…

  • Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan

    Open AccessBarbara Franke, Giorgia Michelini et al.ARTICLEEuropean Neuropsychopharmacology2018

    Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptom…

  • Expression of Monoamine Transporters, Nitric Oxide Synthase 3, and Neurotrophin Genes in Antidepressant-Stimulated Astrocytes

    Open AccessSarah Kittel‐Schneider, Sarah Kittel-Schneider et al.ARTICLEFrontiers in Psychiatry2012

    These data provide further evidence for a role of astroglial cells in the molecular mechanisms of action of antidepressants

  • Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

    Open AccessKlaus-Peter Lesch, Dietmar Bengel et al.ARTICLEScience1996

    Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene pr…