Panayotis K Thanos

Biographic Data

ID7380289
NAMEPanayotis K Thanos
GIVEN NAMESPanayotis K
FAMILY NAMEThanos
SIGNATURETHANOS P K
AFFILIATIONSUniversity at Buffalo, State University of New York
ORCID0000-0002-5663-3478
VERIFIEDYes
TOTAL WORKS9
TOTAL CITATIONS0
WORKS AS AUTHOR9
WORKS AS EDITOR0
FIRST PUBLICATION YEAR2011
LATEST PUBLICATION YEAR2026
H-INDEX0

  • The Emerging Crisis in Non-Prescribed Ketamine Use

    Open AccessKai Uwe Lewandrowski, Kenneth Blum et al.ARTICLESubstance Use & Misuse2026

    BACKGROUND: Since 2000, rates of suicide and opioid overdose have sharply increased. Approximately one-third of individuals with major depressive disorder (MDD) experience treatment-resistant depression (TRD), highlighting the urgent need for novel therapeutic approaches. OBJECTIVE: This review synthesizes pivotal preclinical and clinical findings on low-dose ketamine's rapid antidepressant effects and examines proposed mechanisms underlying its …

  • Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia

    Open AccessKai-Uwe Lewandrowski, Kenneth Blum et al.ARTICLEFrontiers in Public Health2025

    Since 1990, substantial evidence from association studies has identified the D(2) dopamine receptor (DRD2) gene as a factor in the development of alcoholism [1][2][3][4]. The DRD2 gene has also been linked to other substance use disorders, including dependencies on cocaine, nicotine, and opioids, as well as obesity [5][6][7][8][9][10][11]. Dopamine in the brain, often referred to as the "stressrelief molecule," plays a central role in managing st…

  • Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery

    Open AccessColin Hanna, Fiona Comstock et al.ARTICLEFrontiers in Public Health2025

    The obesity epidemic has become a global public health issue, impacting more than one billion people worldwide. 9% of the US population, or 28.8 million Americans will have an eating disorder in their lifetime. In fact, global eating disorder prevalence increased from 3.5% to 7.8% between 2000 and 2018. In spite of the fact that less than 6% of people with an eating disorder are medically underweight, it is indeed an important factor when conside…

  • Opioid use disorder

    Open AccessYu Kyung Lee, Mark S Gold et al.ARTICLEFrontiers in Public Health2024

    Opioid use disorder (OUD) is a major public health threat, contributing to morbidity and mortality from addiction, overdose, and related medical conditions. Despite our increasing knowledge about the pathophysiology and existing medical treatments of OUD, it has remained a relapsing and remitting disorder for decades, with rising deaths from overdoses, rather than declining. The COVID-19 pandemic has accelerated the increase in overall substance …

  • High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

    Open AccessJohn Tyler, Madeline Podaras et al.ARTICLEFrontiers in Public Health2023

    Background Previous research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and relapse prevention programs. However, we need to better understand different exercise regimens and determine which would be the most beneficial for SUDs. Recently, high intensity interval training (HI…

  • A Translational Perspective on Bariatric Surgery and Substance Use

    Open AccessA Hajnal, Elise R Orellana et al.ARTICLEAppetite2019

  • Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors

    Open AccessKenneth Blum, Marjorie C Gondré-Lewis et al.ARTICLEFrontiers in Psychiatry2018

    reward deficiency syndrome (RDS), dopamine homeostasis, genetic addiction risk score (GARS), comprehensive analysis of reported drugs (CARD), precision addiction management (PAM)

  • Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26

    Open AccessPanayotis K Thanos, Brendan H Clavin et al.ARTICLEFrontiers in Psychiatry2016

    The therapeutic properties of cannabinoids have been well demonstrated but are overshadowed by such adverse effects as cognitive and motor dysfunction, as well as their potential for addiction. Recent research on the natural lipid ligands of cannabinoid receptors, also known as endocannabinoids, has shed light on the mechanisms of intracellular transport of the endocannabinoid anandamide by fatty acid-binding proteins (FABPs) and subsequent catab…

  • Regional brain metabolic responses to food expectation predict food preference

    Open AccessMichael Michaelides, M L Miller et al.ARTICLEAppetite2011