Rieke van der Graaf
Biographic Data
| ID | 7581237 |
|---|---|
| NAME | Rieke van der Graaf |
| GIVEN NAMES | Rieke |
| FAMILY NAME | van der Graaf |
| SIGNATURE | VAN DER GRAAF R |
| AFFILIATIONS | University Medical Center Utrecht |
| ORCID | 0000-0003-4907-7044 |
| VERIFIED | Yes |
| TOTAL WORKS | 9 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 9 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2015 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Moral Attitudes on Somatic Gene Editing for Inherited Cardiomyopathy
This qualitative study aims to understand the moral attitudes of key stakeholders toward the development of somatic gene editing for inherited cardiomyopathy. Patients are waiting on effective treatment for inherited cardiomyopathies, including those caused by PLN and LMNA mutations. Somatic gene editing, particularly prime and base editing, is being explored as a potential therapeutic strategy. Development of these technologies requires insight …
Strengthening an Ethical Framework and Research Practice to Better Link Global Health Research to Health Equity
An ethical framework titled “Research for Health Justice” has been developed that provides global health researchers with guidance on how to design their research to promote health equity and global justice. This study sought to test the framework’s guidance by comparing it to the governance and experiences of the “Severe Pre-eclampsia adverse Outcome Triage” (SPOT)-Impact consortium—a transdisciplinary maternal health research consortium. The ai…
Reimagining Social Value to Consider the Environment
Growing recognition of intersections between our health and the environment, healthcare systems and the environment, and health research and the environment has led bioethics scholars to advocate that the field readopt a broader perspective that considers nature. As part of doing so, we urgently need to reimagine research ethics concepts and frameworks so that they account for the environment. This paper focuses on how we should reinterpret the e…
What is a cure through gene therapy? An analysis and evaluation of the use of “cure”
The development of gene therapy has always come with the expectation that it will offer a cure for various disorders, of which hemophilia is a paradigm example. However, although the term is used regularly, it is unclear what exactly is meant with “cure”. Therefore, the aim of this paper is to analyse how the concept of cure is used in practice and evaluate which of the interpretations is most suitable in discussions surrounding gene therapy. We …
Unfair knowledge practices in global health
Unfair knowledge practices easily beset our efforts to achieve health equity within and between countries. Enacted by people from a distance and from a position of power (‘the centre’) on behalf of and alongside people with less power (‘the periphery’), these unfair practices have generated a complex literature of complaints across various axes of inequity. We identified a sample of this literature from 12 journals and systematized it using the r…
The boundary problem
Despite widespread and worldwide efforts to eradicate vector‐borne diseases such as malaria, these diseases continue to have an enormous negative impact on public health. For this reason, scientists are working on novel control strategies, such as gene drive technologies (GDTs). As GDT research advances, researchers are contemplating the potential next step of conducting field trials. An important point of discussion regarding these field trials …
The ethics of ethics conferences
The next World Congress of Bioethics will be held in Doha, Qatar. Although this location provides opportunities to interact with a more culturally diverse audience, to advance dialogue between cultures and religions, offer opportunities for mutual learning, there are also huge moral concerns. Qatar is known for violations of human rights ‐ including the treatment of migrant workers and the rights of women ‐ corruption, criminalization of LGBTQI+ …
Power Difference and Risk Perception
To address the burden of maternal morbidity and mortality in low- and middle-income countries (LMICs), research with pregnant women in these settings is increasingly common. Pregnant women in LMIC-context may experience vulnerability related to giving consent to participate in a clinical trial. To recognize possible layers of vulnerability this study aims to identify factors that influence the decision process towards clinical trial participation…
Placebo-Controlled Trials, Ethics of
No prominent works on this page.
Placebo-Controlled Trials, Ethics of
Power Difference and Risk Perception
To address the burden of maternal morbidity and mortality in low- and middle-income countries (LMICs), research with pregnant women in these settings is increasingly common. Pregnant women in LMIC-context may experience vulnerability related to giving consent to participate in a clinical trial. To recognize possible layers of vulnerability this study aims to identify factors that influence the decision process towards clinical trial participation…
The boundary problem
Despite widespread and worldwide efforts to eradicate vector‐borne diseases such as malaria, these diseases continue to have an enormous negative impact on public health. For this reason, scientists are working on novel control strategies, such as gene drive technologies (GDTs). As GDT research advances, researchers are contemplating the potential next step of conducting field trials. An important point of discussion regarding these field trials …
The ethics of ethics conferences
The next World Congress of Bioethics will be held in Doha, Qatar. Although this location provides opportunities to interact with a more culturally diverse audience, to advance dialogue between cultures and religions, offer opportunities for mutual learning, there are also huge moral concerns. Qatar is known for violations of human rights ‐ including the treatment of migrant workers and the rights of women ‐ corruption, criminalization of LGBTQI+ …
What is a cure through gene therapy? An analysis and evaluation of the use of “cure”
The development of gene therapy has always come with the expectation that it will offer a cure for various disorders, of which hemophilia is a paradigm example. However, although the term is used regularly, it is unclear what exactly is meant with “cure”. Therefore, the aim of this paper is to analyse how the concept of cure is used in practice and evaluate which of the interpretations is most suitable in discussions surrounding gene therapy. We …
Unfair knowledge practices in global health
Unfair knowledge practices easily beset our efforts to achieve health equity within and between countries. Enacted by people from a distance and from a position of power (‘the centre’) on behalf of and alongside people with less power (‘the periphery’), these unfair practices have generated a complex literature of complaints across various axes of inequity. We identified a sample of this literature from 12 journals and systematized it using the r…
Reimagining Social Value to Consider the Environment
Growing recognition of intersections between our health and the environment, healthcare systems and the environment, and health research and the environment has led bioethics scholars to advocate that the field readopt a broader perspective that considers nature. As part of doing so, we urgently need to reimagine research ethics concepts and frameworks so that they account for the environment. This paper focuses on how we should reinterpret the e…
Moral Attitudes on Somatic Gene Editing for Inherited Cardiomyopathy
This qualitative study aims to understand the moral attitudes of key stakeholders toward the development of somatic gene editing for inherited cardiomyopathy. Patients are waiting on effective treatment for inherited cardiomyopathies, including those caused by PLN and LMNA mutations. Somatic gene editing, particularly prime and base editing, is being explored as a potential therapeutic strategy. Development of these technologies requires insight …
Strengthening an Ethical Framework and Research Practice to Better Link Global Health Research to Health Equity
An ethical framework titled “Research for Health Justice” has been developed that provides global health researchers with guidance on how to design their research to promote health equity and global justice. This study sought to test the framework’s guidance by comparing it to the governance and experiences of the “Severe Pre-eclampsia adverse Outcome Triage” (SPOT)-Impact consortium—a transdisciplinary maternal health research consortium. The ai…
Political science (4 works) · Sociology (4 works) · Bioethics (3 works) · Biomedical Ethics and Regulation (3 works) · Ethics in Clinical Research (3 works) · Global Maternal and Child Health (3 works) · Law (3 works) · Medicine (3 works) · Psychology (3 works) · Alternative medicine (2 works)