Leo P ten Kate
Biographic Data
| ID | 7621387 |
|---|---|
| NAME | Leo P ten Kate |
| GIVEN NAMES | Leo P ten |
| FAMILY NAME | Kate |
| SIGNATURE | TEN KATE L P |
| AFFILIATIONS | Amsterdam UMC Location Vrije Universiteit Amsterdam |
| VERIFIED | No |
| TOTAL WORKS | 9 |
| TOTAL CITATIONS | 2 |
| AUTHOR COUNT | 9 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1998 |
| LATEST PUBLICATION YEAR | 2017 |
| H-INDEX | 1 |
With expanded carrier screening, founder populations run the risk of being overlooked
Genetically isolated populations exist worldwide. Specific genetic disorders, including rare autosomal recessive disorders may have high prevalences in these populations. We searched for Dutch genetically isolated populations and their autosomal recessive founder mutations. We investigated whether these founder mutations are covered in the (preconception) expanded carrier screening tests of five carrier screening providers. Our results show that …
Genetic risk
In this paper I will review different aspects of genetic risk in the context of preconception care. I restrict myself to the knowledge of risk which is relevant for care and/or enables reproductive choice. The paper deals with chromosomes, genes and the genetic classification of diseases, and it explains why Mendelian disorders frequently do not show the expected pattern of occurrence in families. Factors that amplify genetic risk are also discus…
Earliest trace, so far, of community genetics as a distinct concept
According to Modell and Kuliev (1998), the history of community genetics as a distinct concept in medicine started in 1981 with WHO in Geneva. This was about the same time that community genetics was introduced in biology for research on interacting populations in a shared environment (Ten Kate et al. 2010). We do not know whether either or both of these early uses can be traced back to even earlier usage
General practitioner management of genetic aspects of a cardiac disease
It is increasingly recognised that genetics will have to be integrated into all parts of primary health care. Previous research has demonstrated that involvement and confidence in genetics varies amongst primary care providers. We aimed to analyse perceptions of primary care providers regarding responsibility for genetic tasks and factors affecting those perceptions. Postal questionnaire including a hypothetical case management scenario of a card…
Community genetics. Its definition 2010
This paper presents a definition of the medical field of community genetics. It starts with a brief historical overview, defines the requirements for an adequate definition, presents the definition, and discusses the constituent parts of the definition
Confidence of primary care physicians in their ability to carry out basic medical genetic tasks—a European survey in five countries—Part 1
The journal of community genetics
P~i~nvJc~ sine~sis.Mr Gregory's paper is already i~ ~ype; but owing to its Iength and to delay incidental to preparation of the coloured Plates illustrating it, we have been obliged to hold it over for %he next number of the Journag.~EDD
Autosomal recessive disease in children of consanguineous parents
This short communication deals with the questions of how to calculate the expected proportion of compound heterozygous patients among affected offspring of consanguineous parents, and how, from an observed proportion of compound heterozygotes, to calculate both the proportion of homozygotes not identical by descent and the frequency of pathogenic alleles in the population. This estimate of allele frequency may be useful when dealing with populati…
Costs, effects, and savings of screening for cystic fibrosis gene carriers
STUDY OBJECTIVE: Evaluating the costs, effects, and savings of several strategies for cystic fibrosis (CF) gene carrier screening. DESIGN: A general model for evaluating prenatal, preconceptional, school, and neonatal carrier screening was constructed. For prenatal and preconceptional screening, two strategies were evaluated: single entry and double entry two step couple screening. Firstly, the Dutch situation was evaluated prospectively; subsequ…
Costs, effects, and savings of screening for cystic fibrosis gene carriers
STUDY OBJECTIVE: Evaluating the costs, effects, and savings of several strategies for cystic fibrosis (CF) gene carrier screening. DESIGN: A general model for evaluating prenatal, preconceptional, school, and neonatal carrier screening was constructed. For prenatal and preconceptional screening, two strategies were evaluated: single entry and double entry two step couple screening. Firstly, the Dutch situation was evaluated prospectively; subsequ…
Costs, effects, and savings of screening for cystic fibrosis gene carriers
STUDY OBJECTIVE: Evaluating the costs, effects, and savings of several strategies for cystic fibrosis (CF) gene carrier screening. DESIGN: A general model for evaluating prenatal, preconceptional, school, and neonatal carrier screening was constructed. For prenatal and preconceptional screening, two strategies were evaluated: single entry and double entry two step couple screening. Firstly, the Dutch situation was evaluated prospectively; subsequ…
General practitioner management of genetic aspects of a cardiac disease
It is increasingly recognised that genetics will have to be integrated into all parts of primary health care. Previous research has demonstrated that involvement and confidence in genetics varies amongst primary care providers. We aimed to analyse perceptions of primary care providers regarding responsibility for genetic tasks and factors affecting those perceptions. Postal questionnaire including a hypothetical case management scenario of a card…
Community genetics. Its definition 2010
This paper presents a definition of the medical field of community genetics. It starts with a brief historical overview, defines the requirements for an adequate definition, presents the definition, and discusses the constituent parts of the definition
Confidence of primary care physicians in their ability to carry out basic medical genetic tasks—a European survey in five countries—Part 1
The journal of community genetics
P~i~nvJc~ sine~sis.Mr Gregory's paper is already i~ ~ype; but owing to its Iength and to delay incidental to preparation of the coloured Plates illustrating it, we have been obliged to hold it over for %he next number of the Journag.~EDD
Autosomal recessive disease in children of consanguineous parents
This short communication deals with the questions of how to calculate the expected proportion of compound heterozygous patients among affected offspring of consanguineous parents, and how, from an observed proportion of compound heterozygotes, to calculate both the proportion of homozygotes not identical by descent and the frequency of pathogenic alleles in the population. This estimate of allele frequency may be useful when dealing with populati…
Genetic risk
In this paper I will review different aspects of genetic risk in the context of preconception care. I restrict myself to the knowledge of risk which is relevant for care and/or enables reproductive choice. The paper deals with chromosomes, genes and the genetic classification of diseases, and it explains why Mendelian disorders frequently do not show the expected pattern of occurrence in families. Factors that amplify genetic risk are also discus…
Earliest trace, so far, of community genetics as a distinct concept
According to Modell and Kuliev (1998), the history of community genetics as a distinct concept in medicine started in 1981 with WHO in Geneva. This was about the same time that community genetics was introduced in biology for research on interacting populations in a shared environment (Ten Kate et al. 2010). We do not know whether either or both of these early uses can be traced back to even earlier usage
With expanded carrier screening, founder populations run the risk of being overlooked
Genetically isolated populations exist worldwide. Specific genetic disorders, including rare autosomal recessive disorders may have high prevalences in these populations. We searched for Dutch genetically isolated populations and their autosomal recessive founder mutations. We investigated whether these founder mutations are covered in the (preconception) expanded carrier screening tests of five carrier screening providers. Our results show that …
Medicine (9 works) · Genetics (8 works) · Biology (7 works) · Public health (5 works) · BRCA gene mutations in cancer (4 works) · Gene (4 works) · Pathology (4 works) · Genomics and Rare Diseases (3 works) · Human genetics (3 works) · Nutrition, Genetics, and Disease (3 works)