Mauro Pettorruso
Dados Biográficos
| ID | 7650699 |
|---|---|
| NOME | Mauro Pettorruso |
| PRENOMES | Mauro |
| SOBRENOME | Pettorruso |
| ASSINATURA | PETTORRUSO M |
| AFILIAÇÕES | University of Chieti-Pescara |
| ORCID | 0000-0002-4164-3040 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 21 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 21 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2012 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 0 |
Factors Influencing the Onset and Severity of Depressive Symptoms
Background: Depression is a leading global health concern and is projected to become one of the major contributors to the global burden of disease in the coming decades. Increasing evidence highlights the role of social determinants—including socioeconomic conditions, social relationships, life stressors, discrimination, and environmental influences—in shaping the risk and clinical expression of depressive disorders. This study aimed to investiga…
Cannabis-Induced Persistent Perceptual Disturbances
Cannabis use has been associated with persistent perceptual disturbances, but systematic clinical characterization remains limited, particularly regarding multimodal sensory involvement. To characterize persistent perceptual disturbances following cannabis use, focusing on symptom profiles, temporal patterns, and clinical features. This exploratory observational study was conducted across the Valle d'Aosta and Piemonte regions of Italy between 20…
Hell is other people”. Schizophrenia and urbanicity in the light of predictive coding theory
The Predictive Coding theory (Ford and Mathalon, 2019) posits that the brain constantly generates predictions about the environment, allocating neural resources primarily to processing stimuli that violate these predictions (i.e., prediction errors), in order to update the brain's predictive models of the environment. Sensory prediction is described as a hierarchical process, wherein neural activity encodes top-down expectations of sensory experi…
Digital mental health in Italy
National initiatives should firstly address education and training needs of the youngest mental health professionals, particularly those without a mentor/supervisor experienced in providing DMH/DP and in educating younger professionals in the digital clinical practice. Sex-sensitive consolidating strategies should be implemented in those mental health services already digitalized. Longitudinal studies should evaluate the efficacy in the long-term…
Bipolar disorder integrative staging
Bipolar disorder (BD) is a lifelong, recurrent condition with growing evidence supporting a neuroprogressive course, entailing the need to adopt staging models to guide stage-specific interventions. Although different approaches have been proposed, their application remains limited and largely based on clinical features. BOARDING-PASS is an Italian government-funded, multicenter, prospective, and observational study aimed at advancing current kno…
Treatment effectiveness and preference in patients with schizophrenia switched from oral standard of care atypical antipsychotics to aripiprazole once-monthly
Transitioning to AOM from oral antipsychotics in schizophrenia patients was associated with significant improvements in clinical outcomes, symptom severity, and treatment satisfaction, with a favorable safety and tolerability profile. These findings support the use of AOM in early-stage schizophrenia and highlight its potential to enhance long-term adherence and functional recovery. Further long-term studies are warranted to assess the durability…
Eco-Anxiety and Mental Health
Eco-anxiety in Italy is linked to socio-demographic vulnerabilities, disaster exposure, and impaired mental health. These findings highlight eco-anxiety as a pressing public health concern and stress the need for prevention and interventions that promote adaptive coping and engagement with climate change
Profiling and assessing the risks of image- and performance-enhancing drugs use during the Covid-19 lockdown
Background: Image and Performance-Enhancing Drugs (IPEDs) can enhance mental and physical capabilities and impact one's overall health. Initially confined in sport environments, IPEDs use has become increasingly widespread in a high-performing society. The present study was aimed at profiling IPEDs use during the COVID-19 lockdown among an international sample of young adults. Methods: A cross-sectional observational study was carried out in eigh…
Aberrant salience in cannabis-induced psychosis
This study may help understanding the role of AS in both non-substance-related and substance-induced psychosis. This knowledge may lead clinician to a better diagnosis and identify patient-tailored psychopharmacological treatment
Overcoming treatment-resistant depression with machine-learning based tools
Treatment-Resistant Depression (TRD) poses a substantial health and economic challenge, persisting as a major concern despite decades of extensive research into novel treatment modalities. The considerable heterogeneity in TRD's clinical manifestations and neurobiological bases has complicated efforts toward effective interventions. Recognizing the need for precise biomarkers to guide treatment choices in TRD, herein we introduce the SelecTool Pr…
Case report
Depressive disorders are leading contributors to the global mental health-related burden, and they represent a challenge for real-world clinicians, due to the low rates of remission despite the high availability of treatments. Often, depression shows in the context of multiple chronic comorbidities, thus requiring precise and accurate management of pharmacological treatments to avoid interactions and side effects. These criticalities call for the…
Unraveling the Link Between Complex Post-traumatic Stress Symptoms and Addictive Behaviors in Adolescents
A Possible Next Covid-19 Pandemic
Domenico De Berardis1,2*Giulia Gianfelice1Michele Fornaro2Federica Vellante3Antonio Ventriglio4Gabriella Marini5Mauro Pettorruso2Giovanni Martinotti2Silvia Fraticelli2Massimo Di Giannantonio2
Duration of Untreated Disorder and Cannabis Use
According to our study, cannabis use can be a predictor of FEP and DUP, and of disease outcome. However, several factors might influence the relationship between cannabis use and DUP. Preventing cannabis use and early diagnosis of psychotic disorders might impact the disease by reducing the persistence of symptoms and limiting dissociative experiences
Club Drugs and Psychiatric Sequelae
The pursuit of pleasure among clubbers and disco-goers often involves drug use. However, whether substance use may represent a relevant risk factor contributing to the development of psychiatric symptoms and of mental illness remains debated. The purposes of this study were to evaluate the percentage of subjects who developed long-lasting psychiatric symptoms in a sample of subjects reporting use of substances in nightclubs, and to evaluate the r…
Club Drugs
In this study, we described the acute psychiatric presentations related to recreational drug use in subjects on holiday in Ibiza. The use of psychoactive substances was characterized by poly-use of both traditional and novel substances, with several psychopathological consequences. Future research should focus on a better understanding of the psychopathological effects of specific substances, defining signs and symptoms to help make a differentia…
Prescription Drug Misuse in “Clubbers” and Disco Goers in Ibiza
Background: Prescription drug misuse and its related risks are considered a worldwide public health issue. Current trends show that the extent of such phenomenon may not be limited to subjects with psychiatric disorders, as it also spreads to dance party and nightclub attendees, who often consume prescription drugs in combination with alcohol and psychoactive substances. This study aims to report the sociodemographic data and the psychiatric and …
Does DRD2 Taq1A Mediate Aripiprazole-Induced Gambling Disorder? A Pharmacogenetic Hypothesis
Second-generation antipsychotics (SGA) are a pharmacological class widely used in psychiatry thanks to their efficacy and good tolerability profile. One of the most used SGA is aripiprazole (ARI) because of its several formulations and safe metabolic and cardiac profile. As reported in a recent review, there are growing numbers of reports about ARI-induced gambling disorder (ARI-induced GD) which should encourage clinicians to use ARI more cautio…
Psychopathological Burden and Quality of Life in Substance Users During the Covid-19 Lockdown Period in Italy
This study is the first attempt to collect Italian data regarding the effects of the rigid quarantine period, during the COVID-19 pandemic, on patients suffering from a SUD and/or behavioral addictions. The presence of a moderate psychopathological burden correlated to poor quality of life and low craving scores represented the main outcomes. Long-term studies, with follow-up after the end of the restrictive measures, should be considered to impl…
RTMS Reduces Psychopathological Burden and Cocaine Consumption in Treatment-Seeking Subjects With Cocaine Use Disorder
Introduction: Cocaine use disorder (CUD) currently represents a notable public health concern, linked with significant disability, high chances of chronicity, and lack of effective pharmacological or psychological treatments. Repetitive transcranial magnetic stimulation (rTMS) is supposed to be a potential therapeutic option for addictive disorders. Aim of this study was to evaluate the feasibility of rTMS on (1) cocaine craving and consumption a…
Amantadine in the Treatment of Pathological Gambling
Despite almost a decade of intense research, effective treatment strategies for Pathological Gambling (PG) remain very challenging. This paper details a case report suggesting that the treatment of PG may benefit from the use of the non-specific glutamate blocker amantadine. The drug was well-tolerated and effective, leading to a 43-64% reduction in severity of gambling symptoms (as measured with G-SAS). Our result is discussed in the context of …
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Amantadine in the Treatment of Pathological Gambling
Despite almost a decade of intense research, effective treatment strategies for Pathological Gambling (PG) remain very challenging. This paper details a case report suggesting that the treatment of PG may benefit from the use of the non-specific glutamate blocker amantadine. The drug was well-tolerated and effective, leading to a 43-64% reduction in severity of gambling symptoms (as measured with G-SAS). Our result is discussed in the context of …
RTMS Reduces Psychopathological Burden and Cocaine Consumption in Treatment-Seeking Subjects With Cocaine Use Disorder
Introduction: Cocaine use disorder (CUD) currently represents a notable public health concern, linked with significant disability, high chances of chronicity, and lack of effective pharmacological or psychological treatments. Repetitive transcranial magnetic stimulation (rTMS) is supposed to be a potential therapeutic option for addictive disorders. Aim of this study was to evaluate the feasibility of rTMS on (1) cocaine craving and consumption a…
Club Drugs
In this study, we described the acute psychiatric presentations related to recreational drug use in subjects on holiday in Ibiza. The use of psychoactive substances was characterized by poly-use of both traditional and novel substances, with several psychopathological consequences. Future research should focus on a better understanding of the psychopathological effects of specific substances, defining signs and symptoms to help make a differentia…
Prescription Drug Misuse in “Clubbers” and Disco Goers in Ibiza
Background: Prescription drug misuse and its related risks are considered a worldwide public health issue. Current trends show that the extent of such phenomenon may not be limited to subjects with psychiatric disorders, as it also spreads to dance party and nightclub attendees, who often consume prescription drugs in combination with alcohol and psychoactive substances. This study aims to report the sociodemographic data and the psychiatric and …
Does DRD2 Taq1A Mediate Aripiprazole-Induced Gambling Disorder? A Pharmacogenetic Hypothesis
Second-generation antipsychotics (SGA) are a pharmacological class widely used in psychiatry thanks to their efficacy and good tolerability profile. One of the most used SGA is aripiprazole (ARI) because of its several formulations and safe metabolic and cardiac profile. As reported in a recent review, there are growing numbers of reports about ARI-induced gambling disorder (ARI-induced GD) which should encourage clinicians to use ARI more cautio…
Psychopathological Burden and Quality of Life in Substance Users During the Covid-19 Lockdown Period in Italy
This study is the first attempt to collect Italian data regarding the effects of the rigid quarantine period, during the COVID-19 pandemic, on patients suffering from a SUD and/or behavioral addictions. The presence of a moderate psychopathological burden correlated to poor quality of life and low craving scores represented the main outcomes. Long-term studies, with follow-up after the end of the restrictive measures, should be considered to impl…
A Possible Next Covid-19 Pandemic
Domenico De Berardis1,2*Giulia Gianfelice1Michele Fornaro2Federica Vellante3Antonio Ventriglio4Gabriella Marini5Mauro Pettorruso2Giovanni Martinotti2Silvia Fraticelli2Massimo Di Giannantonio2
Duration of Untreated Disorder and Cannabis Use
According to our study, cannabis use can be a predictor of FEP and DUP, and of disease outcome. However, several factors might influence the relationship between cannabis use and DUP. Preventing cannabis use and early diagnosis of psychotic disorders might impact the disease by reducing the persistence of symptoms and limiting dissociative experiences
Club Drugs and Psychiatric Sequelae
The pursuit of pleasure among clubbers and disco-goers often involves drug use. However, whether substance use may represent a relevant risk factor contributing to the development of psychiatric symptoms and of mental illness remains debated. The purposes of this study were to evaluate the percentage of subjects who developed long-lasting psychiatric symptoms in a sample of subjects reporting use of substances in nightclubs, and to evaluate the r…
Profiling and assessing the risks of image- and performance-enhancing drugs use during the Covid-19 lockdown
Background: Image and Performance-Enhancing Drugs (IPEDs) can enhance mental and physical capabilities and impact one's overall health. Initially confined in sport environments, IPEDs use has become increasingly widespread in a high-performing society. The present study was aimed at profiling IPEDs use during the COVID-19 lockdown among an international sample of young adults. Methods: A cross-sectional observational study was carried out in eigh…
Aberrant salience in cannabis-induced psychosis
This study may help understanding the role of AS in both non-substance-related and substance-induced psychosis. This knowledge may lead clinician to a better diagnosis and identify patient-tailored psychopharmacological treatment
Overcoming treatment-resistant depression with machine-learning based tools
Treatment-Resistant Depression (TRD) poses a substantial health and economic challenge, persisting as a major concern despite decades of extensive research into novel treatment modalities. The considerable heterogeneity in TRD's clinical manifestations and neurobiological bases has complicated efforts toward effective interventions. Recognizing the need for precise biomarkers to guide treatment choices in TRD, herein we introduce the SelecTool Pr…
Case report
Depressive disorders are leading contributors to the global mental health-related burden, and they represent a challenge for real-world clinicians, due to the low rates of remission despite the high availability of treatments. Often, depression shows in the context of multiple chronic comorbidities, thus requiring precise and accurate management of pharmacological treatments to avoid interactions and side effects. These criticalities call for the…
Unraveling the Link Between Complex Post-traumatic Stress Symptoms and Addictive Behaviors in Adolescents
Hell is other people”. Schizophrenia and urbanicity in the light of predictive coding theory
The Predictive Coding theory (Ford and Mathalon, 2019) posits that the brain constantly generates predictions about the environment, allocating neural resources primarily to processing stimuli that violate these predictions (i.e., prediction errors), in order to update the brain's predictive models of the environment. Sensory prediction is described as a hierarchical process, wherein neural activity encodes top-down expectations of sensory experi…
Digital mental health in Italy
National initiatives should firstly address education and training needs of the youngest mental health professionals, particularly those without a mentor/supervisor experienced in providing DMH/DP and in educating younger professionals in the digital clinical practice. Sex-sensitive consolidating strategies should be implemented in those mental health services already digitalized. Longitudinal studies should evaluate the efficacy in the long-term…
Bipolar disorder integrative staging
Bipolar disorder (BD) is a lifelong, recurrent condition with growing evidence supporting a neuroprogressive course, entailing the need to adopt staging models to guide stage-specific interventions. Although different approaches have been proposed, their application remains limited and largely based on clinical features. BOARDING-PASS is an Italian government-funded, multicenter, prospective, and observational study aimed at advancing current kno…
Treatment effectiveness and preference in patients with schizophrenia switched from oral standard of care atypical antipsychotics to aripiprazole once-monthly
Transitioning to AOM from oral antipsychotics in schizophrenia patients was associated with significant improvements in clinical outcomes, symptom severity, and treatment satisfaction, with a favorable safety and tolerability profile. These findings support the use of AOM in early-stage schizophrenia and highlight its potential to enhance long-term adherence and functional recovery. Further long-term studies are warranted to assess the durability…
Eco-Anxiety and Mental Health
Eco-anxiety in Italy is linked to socio-demographic vulnerabilities, disaster exposure, and impaired mental health. These findings highlight eco-anxiety as a pressing public health concern and stress the need for prevention and interventions that promote adaptive coping and engagement with climate change
Factors Influencing the Onset and Severity of Depressive Symptoms
Background: Depression is a leading global health concern and is projected to become one of the major contributors to the global burden of disease in the coming decades. Increasing evidence highlights the role of social determinants—including socioeconomic conditions, social relationships, life stressors, discrimination, and environmental influences—in shaping the risk and clinical expression of depressive disorders. This study aimed to investiga…
Cannabis-Induced Persistent Perceptual Disturbances
Cannabis use has been associated with persistent perceptual disturbances, but systematic clinical characterization remains limited, particularly regarding multimodal sensory involvement. To characterize persistent perceptual disturbances following cannabis use, focusing on symptom profiles, temporal patterns, and clinical features. This exploratory observational study was conducted across the Valle d'Aosta and Piemonte regions of Italy between 20…
Psychiatry (16 obras) · Medicine (15 obras) · Psychology (12 obras) · Clinical Psychology (6 obras) · Clinical Psychology (6 obras) · Schizophrenia (object-oriented programming (6 obras) · Internal Medicine (5 obras) · Schizophrenia research and treatment (5 obras) · Addiction (4 obras) · Bipolar Disorder and Treatment (4 obras)