Pasquale De Fazio
Dados Biográficos
| ID | 7664679 |
|---|---|
| NOME | Pasquale De Fazio |
| PRENOMES | Pasquale |
| SOBRENOME | De Fazio |
| ASSINATURA | DE FAZIO P |
| AFILIAÇÕES | Magna Graecia University |
| ORCID | 0000-0001-5375-3565 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 13 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 13 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2014 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 0 |
Metabolomics biomarkers for precision psychiatry
Mental disorders remain diagnosed primarily through symptom-based classification systems that overlook biological heterogeneity, preventing the identification of mechanistically distinct patient subgroups and precluding pathophysiology-guided treatment selection. Metabolomics offers a promising pathway towards precision psychiatry by capturing dynamic biochemical readouts at the functional endpoint of the omics cascade, integrating genetic, envir…
Shared decision making in eating disorders
Patients with EDs perceive themselves as equally involved in treatment decision as those with other major mental disorders, yet clinicians report lower SDM in this group suggesting a perceptual gap. SDM in EDs is affected by socio-demographic and clinical variables. Further development of SDM techniques is crucial for improving the therapeutic alliance and addressing the cognitive and motivational features of EDs
Digital mental health in Italy
National initiatives should firstly address education and training needs of the youngest mental health professionals, particularly those without a mentor/supervisor experienced in providing DMH/DP and in educating younger professionals in the digital clinical practice. Sex-sensitive consolidating strategies should be implemented in those mental health services already digitalized. Longitudinal studies should evaluate the efficacy in the long-term…
Applying a clinical staging model in patients affected by schizophrenia spectrum disorder
Baseline predictors, such as familial predisposition to schizophrenia, neurodevelopmental impairment, childhood adversities, treatment delay, negative symptoms, neurological impairment, and inadequate early response to treatment, independently largely explained the staging variance. The clinical staging model, grounded in the extended course of psychosis, exhibited sound validity and feasibility, even without the use of biological or neuroimaging…
Tolerability profile of paliperidone palmitate formulations
Our analysis indicates that the tolerability and safety profiles of PP are in line with what is known for the other SGA-LAIs. However, differences regarding endocrine system ADRs have been noticed. The results presented in this work do not discourage the prescription of SGA-LAI formulations but aim to enhance their safety
Sleep Disturbances in Generalized Anxiety Disorder
Patients with a generalized anxiety disorder (GAD) often report preeminent sleep disturbances. Recently, calcium homeostasis gained interest because of its role in the regulation of sleep-wake rhythms and anxiety symptoms. This cross-sectional study aimed at investigating the association between calcium homeostasis imbalance, anxiety, and quality of sleep in patients with GAD. A total of 211 patients were assessed using the Hamilton Rating Scale …
Sex Differences in Bipolar Disorders
The clinical presentation of BD may differ depending on sex. The severity of BD should not be neglected among women, who may also display worse treatment response to anticonvulsants
Internalized-stigma and dissociative experiences in bipolar disorder
For the first time, our data suggests that self-stigma is associated to dissociative symptoms, reducing overall quality of life in BD. The early identification of at-risk patients with previous lifetime abuse and high perceived stigma could lead the way for an ever more precise tailoring of treatment management
Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression
Background: Binge eating disorder (BED) is clinically relevant by virtue of the global impairment, poor quality of life, and increased overall medical morbidity. The high comorbidity with psychiatric disorders, particularly depression, has received attention as a possible mediator of the poor outcome. Further, BED and depression share cognitive dysfunctions. This naturalistic and uncontrolled pilot study aimed at evaluating the efficacy of vortio…
Dissociative Symptoms in Bipolar Disorder
Background: Dissociative symptoms are under recognized and scarcely studied by clinicians and researchers in patients with bipolar disorder (BD). We examined the relationship between dissociative symptoms and the psychotic features in patients with BD and assessed clinical and socio-demographic characteristics more frequently associated with dissociative symptoms and treatment response. Methods: Participants were 100 adult outpatients with BD. Th…
The Detection of Malingering
Major depression is a high-prevalence mental disease with major socio-economic impact, for both the direct and the indirect costs. Major depression symptoms can be faked or exaggerated in order to obtain economic compensation from insurance companies. Critically, depression is potentially easily malingered, as the symptoms that characterize this psychiatric disorder are not difficult to emulate. Although some tools to assess malingering of psychi…
Perceived insecurity, mental health and urbanization
AIMS: This article aims to (1) explore the levels of perceived insecurity in a sample of patients with mood or anxiety disorders and (2) assess whether living in 'big cities' can influence the levels of patients' perceived insecurity and social contacts compared to living in a non-urbanized context. METHODS: A total of 24 Italian mental health centers (MHCs) have been invited to participate. Twenty patients consecutively accessing the MHC have be…
Pathways to mental health care in Italy
BACKGROUND AND AIMS: In Italy, the reform of the mental health system in 1978 should have drastically changed the provision of care and pathways of patients seeking to obtain it. The aim of this article is to examine the current pathways to psychiatric care in Italy. METHODS: We used a method developed in the World Health Organization international collaborative studies to investigate pathways to care in 15 Italian mental health centers. We recru…
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Pathways to mental health care in Italy
BACKGROUND AND AIMS: In Italy, the reform of the mental health system in 1978 should have drastically changed the provision of care and pathways of patients seeking to obtain it. The aim of this article is to examine the current pathways to psychiatric care in Italy. METHODS: We used a method developed in the World Health Organization international collaborative studies to investigate pathways to care in 15 Italian mental health centers. We recru…
Perceived insecurity, mental health and urbanization
AIMS: This article aims to (1) explore the levels of perceived insecurity in a sample of patients with mood or anxiety disorders and (2) assess whether living in 'big cities' can influence the levels of patients' perceived insecurity and social contacts compared to living in a non-urbanized context. METHODS: A total of 24 Italian mental health centers (MHCs) have been invited to participate. Twenty patients consecutively accessing the MHC have be…
The Detection of Malingering
Major depression is a high-prevalence mental disease with major socio-economic impact, for both the direct and the indirect costs. Major depression symptoms can be faked or exaggerated in order to obtain economic compensation from insurance companies. Critically, depression is potentially easily malingered, as the symptoms that characterize this psychiatric disorder are not difficult to emulate. Although some tools to assess malingering of psychi…
Naturalistic and Uncontrolled Pilot Study on the Efficacy of Vortioxetine in Binge Eating Disorder With Comorbid Depression
Background: Binge eating disorder (BED) is clinically relevant by virtue of the global impairment, poor quality of life, and increased overall medical morbidity. The high comorbidity with psychiatric disorders, particularly depression, has received attention as a possible mediator of the poor outcome. Further, BED and depression share cognitive dysfunctions. This naturalistic and uncontrolled pilot study aimed at evaluating the efficacy of vortio…
Dissociative Symptoms in Bipolar Disorder
Background: Dissociative symptoms are under recognized and scarcely studied by clinicians and researchers in patients with bipolar disorder (BD). We examined the relationship between dissociative symptoms and the psychotic features in patients with BD and assessed clinical and socio-demographic characteristics more frequently associated with dissociative symptoms and treatment response. Methods: Participants were 100 adult outpatients with BD. Th…
Sex Differences in Bipolar Disorders
The clinical presentation of BD may differ depending on sex. The severity of BD should not be neglected among women, who may also display worse treatment response to anticonvulsants
Internalized-stigma and dissociative experiences in bipolar disorder
For the first time, our data suggests that self-stigma is associated to dissociative symptoms, reducing overall quality of life in BD. The early identification of at-risk patients with previous lifetime abuse and high perceived stigma could lead the way for an ever more precise tailoring of treatment management
Tolerability profile of paliperidone palmitate formulations
Our analysis indicates that the tolerability and safety profiles of PP are in line with what is known for the other SGA-LAIs. However, differences regarding endocrine system ADRs have been noticed. The results presented in this work do not discourage the prescription of SGA-LAI formulations but aim to enhance their safety
Sleep Disturbances in Generalized Anxiety Disorder
Patients with a generalized anxiety disorder (GAD) often report preeminent sleep disturbances. Recently, calcium homeostasis gained interest because of its role in the regulation of sleep-wake rhythms and anxiety symptoms. This cross-sectional study aimed at investigating the association between calcium homeostasis imbalance, anxiety, and quality of sleep in patients with GAD. A total of 211 patients were assessed using the Hamilton Rating Scale …
Applying a clinical staging model in patients affected by schizophrenia spectrum disorder
Baseline predictors, such as familial predisposition to schizophrenia, neurodevelopmental impairment, childhood adversities, treatment delay, negative symptoms, neurological impairment, and inadequate early response to treatment, independently largely explained the staging variance. The clinical staging model, grounded in the extended course of psychosis, exhibited sound validity and feasibility, even without the use of biological or neuroimaging…
Digital mental health in Italy
National initiatives should firstly address education and training needs of the youngest mental health professionals, particularly those without a mentor/supervisor experienced in providing DMH/DP and in educating younger professionals in the digital clinical practice. Sex-sensitive consolidating strategies should be implemented in those mental health services already digitalized. Longitudinal studies should evaluate the efficacy in the long-term…
Metabolomics biomarkers for precision psychiatry
Mental disorders remain diagnosed primarily through symptom-based classification systems that overlook biological heterogeneity, preventing the identification of mechanistically distinct patient subgroups and precluding pathophysiology-guided treatment selection. Metabolomics offers a promising pathway towards precision psychiatry by capturing dynamic biochemical readouts at the functional endpoint of the omics cascade, integrating genetic, envir…
Shared decision making in eating disorders
Patients with EDs perceive themselves as equally involved in treatment decision as those with other major mental disorders, yet clinicians report lower SDM in this group suggesting a perceptual gap. SDM in EDs is affected by socio-demographic and clinical variables. Further development of SDM techniques is crucial for improving the therapeutic alliance and addressing the cognitive and motivational features of EDs
Psychiatry (11 obras) · Medicine (10 obras) · Psychology (10 obras) · Clinical Psychology (6 obras) · Clinical Psychology (6 obras) · Bipolar disorder (5 obras) · Mental health (4 obras) · Mental Health Treatment and Access (4 obras) · Schizophrenia (object-oriented programming (4 obras) · Schizophrenia research and treatment (4 obras)